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One hundred twenty-three (n\u2009=\u2009123) women with FMS completed demographic (age, height, weight), clinical (years with pain, intensity of pain at rest and during daily living activities), functional (quality of life, physical function), sensory-related (sensitization-associated and neuropathic-associated symptoms), psychophysical (pressure pain thresholds), psychological (sleep quality, depressive and anxiety level) and cognitive (pain catastrophizing, kinesiophobia) variables. Those three genotypes of the <jats:italic>OPRM1 rs1799971, HTR1B rs6296<\/jats:italic> and <jats:italic>COMT rs4680<\/jats:italic> single nucleotide polymorphisms were obtained by polymerase chain reactions from no-stimulated whole saliva collection. No significant differences in demographic, clinical, functional, sensory-related, psychophysical, psychological and cognitive variables according to <jats:italic>OPRM1 rs1799971, HTR1B rs6296<\/jats:italic> or <jats:italic>COMT rs4680<\/jats:italic> genotype were identified in our sample of women with FMS. A multilevel analysis did not either reveal any significant gene-to-gene interaction between <jats:italic>OPRM1 rs1799971 x HTR1B rs6296<\/jats:italic>, <jats:italic>OPRM1 rs1799971 x COMT rs4680<\/jats:italic> and <jats:italic>HTR1B rs6296 x COMT rs4680<\/jats:italic> for any of the investigated outcomes. This study revealed that three single nucleotide polymorphisms, <jats:italic>OPRM1 rs1799971, HTR1B rs6296<\/jats:italic> or <jats:italic>COMT rs4680,<\/jats:italic> mostly associated with chronic pain were not involved in phenotyping features of FMS. Potential gene-to-gene interaction and their association with clinical phenotype in women with FMS should be further investigated in future studies including large sample sizes.<\/jats:p>","DOI":"10.1038\/s41598-024-62240-7","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T07:02:53Z","timestamp":1715929373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia"],"prefix":"10.1038","volume":"14","author":[{"given":"C\u00e9sar","family":"Fern\u00e1ndez-de-las-Pe\u00f1as","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ambite-Quesada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Fern\u00e1ndez-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Jim\u00e9nez-Antona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"G\u00f3mez-Calero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Pocinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Valera-Calero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Cigar\u00e1n-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Arendt-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"issue":"4","key":"62240_CR1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.rbre.2017.01.005","volume":"57","author":"AP Marques","year":"2017","unstructured":"Marques, A. 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