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Night shift medical workers (group A, 25 workers) and non-night shift workers (group B, 25 workers) were recruited. The images of macula and optic nerve head were obtained by swept-source OCT-angiography. Vessel density of retina, choriocapillaris (CC), choriocapillaris flow deficit (CC FD), choroidal thickness (CT) and choroidal vascularity index (CVI) were measured. 6-sulfatoxymelatonin concentration was analyzed from the morning urine. CC FD and CVI were significantly decreased and CT was significantly increased in group A (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). 6-sulfatoxymelatonin concentration was significantly lower in group A (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), which was significantly positively correlated with CC FD size (<jats:italic>r<\/jats:italic>\u2009=\u20090.318, <jats:italic>P<\/jats:italic>\u2009=\u20090.024) and CVI of the most regions (maximum <jats:italic>r<\/jats:italic>-value was 0.482, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and was significantly negatively associated with CT of all regions (maximum <jats:italic>r<\/jats:italic>-value was \u2212\u00a00.477, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In night shift medical workers, the reduction of melatonin was significantly correlated with CT thickening, CVI reduction and CC FD reduction, which suggested that they might have a higher risk of eye diseases. CC FD could be a sensitive and accurate indicator to reflect CC perfusion.<\/jats:p>","DOI":"10.1038\/s41598-024-62863-w","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T15:03:21Z","timestamp":1717427001000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of retinal and choroidal microvasculature in night shift medical workers by OCT angiography"],"prefix":"10.1038","volume":"14","author":[{"given":"Congbi","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishuang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsai","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dihao","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"62863_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.smrv.2012.02.002","volume":"17","author":"KP Wright Jr","year":"2013","unstructured":"Wright, K. 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