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The adhesives Syntac and Scotchbond MP were used as controls (Groups 1 and 3) or in combination with Icon (Groups 2 and 4). A split-tooth design using healthy third molars from 20 donors resulted in 20 prepared dentine cavities per experimental group. The cavity surfaces (n\u2009=\u200980) were etched (37% H<jats:sub>3<\/jats:sub>PO<jats:sub>4<\/jats:sub>), rinsed, and air-dried. Rewetting with ethanol was followed by application of the respective primers. After labeling with fluorescent dyes, either Syntac Adhesive\/Heliobond or Scotchbond MP Adhesive was used alone or supplemented with Icon. HLT, as evaluated by scanning electron microscopy, did not significantly differ (P\u2009&gt;\u20090.05), and confocal laser scanning microscopy revealed homogeneously mixed\/polymerized resin-dentine interdiffusion zones in all groups. Icon can be successfully integrated into an ethanol-wet dentine bonding strategy, and will result in compact and homogeneous hybrid layers of comparable thickness considered equivalent to the non-Icon controls, thus allowing for preservation of the tooth\u2019s marginal ridge and interdental space in the case of internal\/external infiltration of proximal caries.<\/jats:p>","DOI":"10.1038\/s41598-024-63289-0","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T10:40:26Z","timestamp":1717065626000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Equivalence study of the resin-dentine interface of internal tunnel restorations when using an enamel infiltrant resin with ethanol-wet dentine bonding"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-2175","authenticated-orcid":false,"given":"Andrej M.","family":"Kielbassa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-8638","authenticated-orcid":false,"given":"Sabrina","family":"Summer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9422-4647","authenticated-orcid":false,"given":"Wilhelm","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1350-3016","authenticated-orcid":false,"given":"Edward","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-7732","authenticated-orcid":false,"given":"Julia-Susanne","family":"Batzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"63289_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.13140\/RG.2.2.36646.37443","volume":"16","author":"AM Kielbassa","year":"2010","unstructured":"Kielbassa, A. 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