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The effect of fibrin glue can vary significantly based on the device used. This study assessed the efficacy of fibrin glue based on the type of devices used in an ex vivo system. The rabbit\u2019s abdominal wall was trimmed to a size of 3.0\u2009\u00d7\u20096.0 cm and was secured at the edges with metal fixtures. To measure the maximum tensile strength at the point of adhesion failure, the hernia mesh was fixed to the rabbit\u2019s abdominal wall using fibrin glue in a 2\u00a0cm square area, left for 3 min, and then pulled at a speed of 50 cm\/min. The test was conducted 10 times for each group. The median (minimum\u2013maximum) tensile strength values using the spraying, two-liquid mixing, and sequential layering methods were 3.58 (1.99\u20134.95), 0.51 (0.27\u20131.89), and 1.32 (0.63\u20131.66) N, respectively. The spraying method had predominantly higher tensile strength values than the two-liquid mixing and sequential layering methods (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In conclusion, in hernia mesh fixation, the spraying method can be adopted to achieve appropriate adhesive effects.<\/jats:p>","DOI":"10.1038\/s41598-024-63682-9","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T08:13:25Z","timestamp":1717488805000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of different fibrin glue application methods on inguinal hernia mesh fixation capability"],"prefix":"10.1038","volume":"14","author":[{"given":"Yoshitaka","family":"Takegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"63682_CR1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1159\/000370249","volume":"31","author":"H Liu","year":"2014","unstructured":"Liu, H., Zheng, X., Gu, Y. & Guo, S. 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The fibrin glue (BOLHEAL\u00ae) used in this article is manufactured by KM Biologics Co., Ltd. N.T. has no conflicts of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12773"}}