{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:54:53Z","timestamp":1788260093882,"version":"build-2803163510"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medical University of Bialystok","award":["SUB\/1\/DN\/22\/001\/1208"],"award-info":[{"award-number":["SUB\/1\/DN\/22\/001\/1208"]}]},{"name":"Diabetes Poland"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to investigate the relation between thyroid autoimmunity (TAI), reflected as the presence of thyroid peroxidase antibodies (TPOAb), and parameters of ovarian reserve in women with type 1 diabetes (T1DM) and polycystic ovary syndrome (PCOS). We studied 83 euthyroid women with T1DM (age \u2013 26\u2009\u00b1\u20095\u00a0years, BMI \u2013 24\u2009\u00b1\u20093\u00a0kg\/m<jats:sup>2<\/jats:sup>) \u2013 12 with PCOS and positive TPOAb (PCOS\u2009+\u2009TPOAb), 29 with PCOS with negative TPOAb (PCOS\u2009+\u2009noTPOAb), 18 without PCOS with positive TPOAb (noPCOS\u2009+\u2009TPOAb), 24 without PCOS with negative TPOAb (noPCOS\u2009+\u2009noTPOAb). Serum concentrations of anti-M\u00fcllerian hormone (AMH), sex hormones, TSH, thyroid hormones and TPOAb were assessed. The prevalence of TAI was comparable between PCOS and noPCOS. We did not observe differences in hormonal profile or AMH concentration between two PCOS groups\u2014PCOS\u2009+\u2009TPOAb and PCOS\u2009+\u2009noTPOAb (p\u2009&gt;\u20090.05). Women with PCOS\u2009+\u2009TPOAb had lower FSH concentration and higher LH\/FSH index than noPCOS\u2009+\u2009noTPOAb (p\u2009=\u20090.027; p\u2009=\u20090.019, respectively). Moreover, PCOS\u2009+\u2009TPOAb had lower oestradiol level than noPCOS\u2009+\u2009TPOAb (p\u2009=\u20090.041). AMH concentration was higher in both groups with PCOS, independent of TPOAb presence, than in noPCOS\u2009+\u2009noTPOAb (both p\u2009&lt;\u20090.001). The presence of positive TPOAb titre was not related to the studied parameters of ovarian reserve \u2013 AMH and ovarian follicle number. In multiple linear regression analysis, the only significant predictor of AMH in the whole studied group with T1DM was total daily insulin dose U\/kg (\u03b2\u2009=\u2009\u2212\u00a00.264; p\u2009=\u20090.022). The presence of TAI did not affect the hormonal profile or ovarian reserve in women with T1DM with and without PCOS.<\/jats:p>","DOI":"10.1038\/s41598-024-63741-1","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T18:01:44Z","timestamp":1717869704000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The association of thyroid autoimmunity with ovarian reserve in women with type 1 diabetes with and without polycystic ovary syndrome"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-0629","authenticated-orcid":false,"given":"Agnieszka","family":"\u0141ebkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Krentowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Adamska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Uruska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Rogowicz-Frontczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Araszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"O\u017cegowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Le\u015bniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Sowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wender-O\u017cegowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Zozuli\u0144ska-Zi\u00f3\u0142kiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kowalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"issue":"4","key":"63741_CR1","doi-asserted-by":"publisher","first-page":"639","DOI":"10.2337\/dc15-2577","volume":"39","author":"HF Escobar-Morreale","year":"2016","unstructured":"Escobar-Morreale, H. 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