{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:03:11Z","timestamp":1785499391141,"version":"3.56.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Natural Science Foundation of China Research Fund for Young International Scientist","award":["82150410450"],"award-info":[{"award-number":["82150410450"]}]},{"name":"National Natural Science Foundation of China Research Fund for Young International Scientist","award":["82150410450"],"award-info":[{"award-number":["82150410450"]}]},{"name":"National Natural Science Foundation of China Research Fund for Young International Scientist","award":["82150410450"],"award-info":[{"award-number":["82150410450"]}]},{"name":"Key Project of Medical Science and Technology Development in Nanjing","award":["ZKX11178"],"award-info":[{"award-number":["ZKX11178"]}]},{"name":"Key Project of Medical Science and Technology Development in Nanjing","award":["ZKX11178"],"award-info":[{"award-number":["ZKX11178"]}]},{"name":"Key Project of Medical Science and Technology Development in Nanjing","award":["ZKX11178"],"award-info":[{"award-number":["ZKX11178"]}]},{"name":"Key Project of Medical Science and Technology Development in Nanjing","award":["ZKX11178"],"award-info":[{"award-number":["ZKX11178"]}]},{"name":"Key Project of Medical Science and Technology Development in Nanjing","award":["ZKX11178"],"award-info":[{"award-number":["ZKX11178"]}]},{"name":"Key Project of Medical Science and Technology Development in Nanjing","award":["ZKX11178"],"award-info":[{"award-number":["ZKX11178"]}]},{"name":"Key Project of Medical Science and Technology Development in Nanjing","award":["ZKX11178"],"award-info":[{"award-number":["ZKX11178"]}]},{"name":"Key Project of Medical Science and Technology Development in Nanjing","award":["ZKX11178"],"award-info":[{"award-number":["ZKX11178"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-64574-8","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T16:04:41Z","timestamp":1722441881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["GC\u2013MS-based untargeted plasma metabolomics identifies a 2-biomarker panel for possible diagnosis of precancerous cervical intraepithelial neoplasia stages from cervical cancer"],"prefix":"10.1038","volume":"14","author":[{"given":"Gloria F.","family":"Nuer-Allornuvor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael N.","family":"Alolga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Jingjing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Qun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jiangli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vendish Kweku","family":"Ennin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuomin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"issue":"10167","key":"64574_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","volume":"393","author":"PA Cohen","year":"2019","unstructured":"Cohen, P. A. et al. Cervical cancer. Lancet 393(10167), 169\u2013182 (2019).","journal-title":"Lancet"},{"issue":"2","key":"64574_CR2","doi-asserted-by":"publisher","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","volume":"8","author":"M Arbyn","year":"2020","unstructured":"Arbyn, M. et al. Estimates of incidence and mortality of cervical cancer in 2018: A worldwide analysis. Lancet Glob. Health 8(2), e191\u2013e203 (2020).","journal-title":"Lancet Glob. Health"},{"issue":"10","key":"64574_CR3","doi-asserted-by":"publisher","first-page":"5217","DOI":"10.1002\/cam4.1501","volume":"7","author":"Z Hu","year":"2018","unstructured":"Hu, Z. & Ma, D. The precision prevention and therapy of HPV-related cervical cancer: New concepts and clinical implications. Cancer Med. 7(10), 5217\u20135236 (2018).","journal-title":"Cancer Med."},{"issue":"6","key":"64574_CR4","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68(6), 394\u2013424 (2018).","journal-title":"CA Cancer J. Clin."},{"issue":"13","key":"64574_CR5","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1002\/cncr.30667","volume":"123","author":"W Small Jr","year":"2017","unstructured":"Small, W. Jr. et al. Cervical cancer: A global health crisis. Cancer 123(13), 2404\u20132412 (2017).","journal-title":"Cancer"},{"issue":"7","key":"64574_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55070384","volume":"55","author":"SD Balasubramaniam","year":"2019","unstructured":"Balasubramaniam, S. D. et al. Key molecular events in cervical cancer development. Medicina (Kaunas) 55(7), 384 (2019).","journal-title":"Medicina (Kaunas)"},{"key":"64574_CR7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/2046-4053-2-35","volume":"2","author":"L Peirson","year":"2013","unstructured":"Peirson, L. et al. Screening for cervical cancer: A systematic review and meta-analysis. Syst. Rev. 2, 35 (2013).","journal-title":"Syst. Rev."},{"issue":"2","key":"64574_CR8","first-page":"320","volume":"21","author":"P Tsikouras","year":"2016","unstructured":"Tsikouras, P. et al. Cervical cancer: Screening, diagnosis and staging. J. Buon 21(2), 320\u2013325 (2016).","journal-title":"J. Buon"},{"issue":"1","key":"64574_CR9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12672-022-00551-9","volume":"13","author":"M Arip","year":"2022","unstructured":"Arip, M. et al. Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: A review. Discov. Oncol. 13(1), 91 (2022).","journal-title":"Discov. Oncol."},{"issue":"6","key":"64574_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9060108","volume":"9","author":"FR Pinu","year":"2019","unstructured":"Pinu, F. R., Goldansaz, S. A. & Jaine, J. Translational metabolomics: Current challenges and future opportunities. Metabolites 9(6), 108 (2019).","journal-title":"Metabolites"},{"issue":"4","key":"64574_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9040076","volume":"9","author":"FR Pinu","year":"2019","unstructured":"Pinu, F. R. et al. Systems biology and multi-omics integration: Viewpoints from the metabolomics research community. Metabolites 9(4), 76 (2019).","journal-title":"Metabolites"},{"issue":"4","key":"64574_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040511","volume":"11","author":"I Khan","year":"2019","unstructured":"Khan, I. et al. LC\/MS-based polar metabolite profiling identified unique biomarker signatures for cervical cancer and cervical intraepithelial neoplasia using global and targeted metabolomics. Cancers (Basel) 11(4), 511 (2019).","journal-title":"Cancers (Basel)"},{"issue":"26","key":"64574_CR13","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016192","volume":"98","author":"H Zhou","year":"2019","unstructured":"Zhou, H. et al. Prognostic biomarkers of cervical squamous cell carcinoma identified via plasma metabolomics. Medicine (Baltimore) 98(26), e16192 (2019).","journal-title":"Medicine (Baltimore)"},{"key":"64574_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/srep43353","volume":"7","author":"K Yang","year":"2017","unstructured":"Yang, K. et al. A comprehensive analysis of metabolomics and transcriptomics in cervical cancer. Sci. Rep. 7, 43353 (2017).","journal-title":"Sci. Rep."},{"issue":"12","key":"64574_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209936","volume":"13","author":"F Godoy-Vitorino","year":"2018","unstructured":"Godoy-Vitorino, F. et al. Discriminating high-risk cervical Human Papilloma Virus infections with urinary biomarkers via non-targeted GC-MS-based metabolomics. PLoS ONE 13(12), e0209936 (2018).","journal-title":"PLoS ONE"},{"issue":"1","key":"64574_CR16","first-page":"78","volume":"20","author":"A Abudula","year":"2020","unstructured":"Abudula, A. et al. Tissue-based metabolomics reveals potential biomarkers for cervical carcinoma and HPV infection. Bosn. J. Basic Med. Sci. 20(1), 78\u201387 (2020).","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"64574_CR17","doi-asserted-by":"publisher","first-page":"30.4.1","DOI":"10.1002\/0471142727.mb3004s114","volume":"114","author":"O Fiehn","year":"2016","unstructured":"Fiehn, O. Metabolomics by gas chromatography\u2013mass spectrometry: Combined targeted and untargeted profiling. Curr. Protoc. Mol. Biol. 114, 30.4.1-30.4.32 (2016).","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"64574_CR18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-1-4939-7643-0_9","volume":"1738","author":"MP Papadimitropoulos","year":"2018","unstructured":"Papadimitropoulos, M. P. et al. Untargeted GC\u2013MS metabolomics. Methods Mol. Biol. 1738, 133\u2013147 (2018).","journal-title":"Methods Mol. Biol."},{"key":"64574_CR19","doi-asserted-by":"publisher","first-page":"754","DOI":"10.2174\/1386207326666230504124030","volume":"27","author":"Z Yin","year":"2023","unstructured":"Yin, Z., Hua, X. & Lu, M. Integrated network pharmacology and metabolomics to dissect the mechanisms of naringin for treating cervical cancer. Comb. Chem. High Throughput Screen 27, 754\u2013764 (2023).","journal-title":"Comb. Chem. High Throughput Screen"},{"issue":"1","key":"64574_CR20","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1021\/acs.jproteome.0c00640","volume":"20","author":"M Nam","year":"2021","unstructured":"Nam, M. et al. Comparable plasma lipid changes in patients with high-grade cervical intraepithelial neoplasia and patients with cervical cancer. J. Proteome Res. 20(1), 740\u2013750 (2021).","journal-title":"J. Proteome Res."},{"key":"64574_CR21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fonc.2018.00099","volume":"8","author":"AM Porcari","year":"2018","unstructured":"Porcari, A. M. et al. Molecular signatures of high-grade cervical lesions. Front. Oncol. 8, 99 (2018).","journal-title":"Front. Oncol."},{"key":"64574_CR22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/B978-0-12-801028-0.00227-0","volume-title":"Handbook of Hormones","author":"T Sato","year":"2016","unstructured":"Sato, T., Miyagawa, S. & Iguchi, T. Subchapter 94H\u2014Estrone. In Handbook of Hormones (eds Takei, Y. et al.) 523\u2013524 (Academic Press, 2016)."},{"key":"64574_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106187","volume":"174","author":"Q Li","year":"2022","unstructured":"Li, Q. et al. Estrone-targeted PEGylated liposomal nanoparticles for cisplatin (DDP) delivery in cervical cancer. Eur. J. Pharm. Sci. 174, 106187 (2022).","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"64574_CR24","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3390\/ijms24021221","volume":"24","author":"AB Diaz-Ruano","year":"2023","unstructured":"Diaz-Ruano, A. B. et al. Estradiol and estrone have different biological functions to induce NF-\u03baB-driven inflammation, EMT and stemness in ER+ cancer cells. Int. J. Mol. Sci. 24(2), 1221 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"64574_CR25","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.biopha.2015.04.018","volume":"72","author":"A Tomaszewska","year":"2015","unstructured":"Tomaszewska, A. et al. Increased 17\u00df-hydroxysteroid dehydrogenase type 1 levels in primary cervical cancer. Biomed. Pharmacother. 72, 179\u2013183 (2015).","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"64574_CR26","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s12253-016-0103-4","volume":"23","author":"A Lutkowska","year":"2017","unstructured":"Lutkowska, A., Roszak, A. & Jagodzi\u0144ski, P. P. 17\u03b2-hydroxysteroid dehydrogenase type Gene 1937 A > G polymorphism as a risk factor for cervical cancer progression in the Polish population. Pathol. Oncol. Res. 23(2), 317\u2013322 (2017).","journal-title":"Pathol. Oncol. Res."},{"issue":"1","key":"64574_CR27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/sj.bjc.6601514","volume":"90","author":"TS Shields","year":"2004","unstructured":"Shields, T. S. et al. A case-control study of endogenous hormones and cervical cancer. Br. J. Cancer 90(1), 146\u2013152 (2004).","journal-title":"Br. J. Cancer"},{"issue":"12","key":"64574_CR28","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1158\/1055-9965.EPI-11-0753","volume":"20","author":"S Rinaldi","year":"2011","unstructured":"Rinaldi, S. et al. Endogenous sex steroids and risk of cervical carcinoma: Results from the EPIC study. Cancer Epidemiol. Biomark. Prev. 20(12), 2532\u20132540 (2011).","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"2","key":"64574_CR29","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1046\/j.1365-2958.2002.03169.x","volume":"46","author":"RP Garg","year":"2002","unstructured":"Garg, R. P. et al. Molecular characterization and analysis of the biosynthetic gene cluster for the azoxy antibiotic valanimycin. Mol. Microbiol. 46(2), 505\u2013517 (2002).","journal-title":"Mol. Microbiol."},{"issue":"5","key":"64574_CR30","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/tpj.13295","volume":"88","author":"L Rizhsky","year":"2016","unstructured":"Rizhsky, L. et al. Integrating metabolomics and transcriptomics data to discover a biocatalyst that can generate the amine precursors for alkamide biosynthesis. Plant J. 88(5), 775\u2013793 (2016).","journal-title":"Plant J."},{"issue":"5","key":"64574_CR31","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1172\/JCI109382","volume":"63","author":"KC Chen","year":"1979","unstructured":"Chen, K. C. et al. Amine content of vaginal fluid from untreated and treated patients with nonspecific vaginitis. J. Clin. Investig. 63(5), 828\u2013835 (1979).","journal-title":"J. Clin. Investig."},{"issue":"11","key":"64574_CR32","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1128\/JCM.39.11.4026-4031.2001","volume":"39","author":"H Wolrath","year":"2001","unstructured":"Wolrath, H. et al. Analysis of bacterial vaginosis-related amines in vaginal fluid by gas chromatography and mass spectrometry. J. Clin. Microbiol. 39(11), 4026\u20134031 (2001).","journal-title":"J. Clin. Microbiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-64574-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-64574-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-64574-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T16:27:39Z","timestamp":1722443259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-64574-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["64574"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-64574-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"16 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17649"}}