{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:51:14Z","timestamp":1791327074394,"version":"4.3.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Trauma Treatment Project of 900th Hospital Directive Program","award":["2022ZL07"],"award-info":[{"award-number":["2022ZL07"]}]},{"name":"Joint Medical Specialty Project","award":["LQZD-SW"],"award-info":[{"award-number":["LQZD-SW"]}]},{"name":"Fujian Science and Technology Innovation Platform Project","award":["2019Y9045, 2022Y2017"],"award-info":[{"award-number":["2019Y9045, 2022Y2017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rapid perfusion of cerebral arteries leads to a significant increase in intracranial blood volume, exposing patients with traumatic brain injury to the risk of diffuse brain swelling or malignant brain herniation during decompressive craniectomy. The microcirculation and venous system are also involved in this process, but the precise mechanisms remain unclear. A physiological model of extremely high intracranial pressure was created in rats. This development triggered the TNF-\u03b1\/NF-\u03baB\/iNOS axis in microglia, and released many inflammatory factors and reactive oxygen species\/reactive nitrogen species, generating an excessive amount of peroxynitrite. Subsequently, the capillary wall cells especially pericytes exhibited severe degeneration and injury, the blood\u2013brain barrier was disrupted, and a large number of blood cells were deposited within the microcirculation, resulting in a significant delay in the recovery of the microcirculation and venous blood flow compared to arterial flow, and this still persisted after decompressive craniectomy. Infliximab is a monoclonal antibody bound to TNF-\u03b1 that effectively reduces the activity of TNF-\u03b1\/NF-\u03baB\/iNOS axis. Treatment with Infliximab resulted in downregulation of inflammatory and oxidative\u2013nitrative stress related factors, attenuation of capillary wall cells injury, and relative reduction of capillary hemostasis. These improved the delay in recovery of microcirculation and venous blood flow.<\/jats:p>","DOI":"10.1038\/s41598-024-64940-6","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T15:01:53Z","timestamp":1719241313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of cerebrovascular alterations induced by inflammatory response and oxidative\u2013nitrative stress after traumatic intracranial hypertension and a potential mitigation strategy"],"prefix":"10.1038","volume":"14","author":[{"given":"Shangming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangfeng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shousen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"issue":"2","key":"64940_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.mcna.2019.11.001","volume":"104","author":"A Capizzi","year":"2020","unstructured":"Capizzi, A., Woo, J. & Verduzco-Gutierrez, M. Traumatic brain injury: An overview of epidemiology, pathophysiology, and medical management. Med. Clin. N. Am. 104(2), 213\u2013238. https:\/\/doi.org\/10.1016\/j.mcna.2019.11.001 (2020).","journal-title":"Med. Clin. N. Am."},{"key":"64940_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2022.109493","volume":"372","author":"SM Schwarzmaier","year":"2022","unstructured":"Schwarzmaier, S. M. et al. Perfusion pressure determines vascular integrity and histomorphological quality following perfusion fixation of the brain. J. Neurosci. Methods 372, 109493. https:\/\/doi.org\/10.1016\/j.jneumeth.2022.109493 (2022).","journal-title":"J. Neurosci. Methods"},{"issue":"9","key":"64940_CR3","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1007\/s00113-017-0388-0","volume":"120","author":"D Lahner","year":"2017","unstructured":"Lahner, D. & Fritsch, G. Pathophysiologie intrakranieller Verletzungen [Pathophysiology of intracranial injuries]. Unfallchirurg. 120(9), 728\u2013733. https:\/\/doi.org\/10.1007\/s00113-017-0388-0 (2017).","journal-title":"Unfallchirurg."},{"issue":"4","key":"64940_CR4","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1089\/neu.2016.4464","volume":"34","author":"D Jussen","year":"2017","unstructured":"Jussen, D. et al. Blood aggravates histological and functional damage after acute subdural hematoma in rats. J. Neurotrauma 34(4), 906\u2013913. https:\/\/doi.org\/10.1089\/neu.2016.4464 (2017).","journal-title":"J. Neurotrauma"},{"key":"64940_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.brainresbull.2017.01.003","volume":"130","author":"W Chen","year":"2017","unstructured":"Chen, W. et al. Early stage alterations of catecholamine and adrenocorticotropic hormone levels in posttraumatic acute diffuse brain swelling. Brain Res. Bull. 130, 47\u201352. https:\/\/doi.org\/10.1016\/j.brainresbull.2017.01.003 (2017).","journal-title":"Brain Res. Bull."},{"issue":"1","key":"64940_CR6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10143-024-02292-5","volume":"47","author":"MA Habibi","year":"2024","unstructured":"Habibi, M. A. et al. A comprehensive systematic review and meta-analysis study in comparing decompressive craniectomy versus craniotomy in patients with acute subdural hematoma. Neurosurg. Rev. 47(1), 77. https:\/\/doi.org\/10.1007\/s10143-024-02292-5 (2024).","journal-title":"Neurosurg. Rev."},{"key":"64940_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146901","volume":"1742","author":"C Wang","year":"2020","unstructured":"Wang, C. et al. Visualization of cortical cerebral blood flow dynamics during craniotomy in acute subdural hematoma using laser speckle imaging in a rat model. Brain Res. 1742, 146901. https:\/\/doi.org\/10.1016\/j.brainres.2020.146901 (2020).","journal-title":"Brain Res."},{"issue":"5","key":"64940_CR8","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3390\/cells11050813","volume":"11","author":"S Takahashi","year":"2022","unstructured":"Takahashi, S. Metabolic contribution and cerebral blood flow regulation by astrocytes in the neurovascular unit. Cells 11(5), 813. https:\/\/doi.org\/10.3390\/cells11050813 (2022).","journal-title":"Cells"},{"key":"64940_CR9","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fncel.2019.00282","volume":"13","author":"LS Brown","year":"2019","unstructured":"Brown, L. S. et al. Pericytes and neurovascular function in the healthy and diseased brain. Front. Cell Neurosci. 13, 282. https:\/\/doi.org\/10.3389\/fncel.2019.00282 (2019).","journal-title":"Front. Cell Neurosci."},{"key":"64940_CR10","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1146\/annurev-physiol-061121-040127","volume":"84","author":"DA Hartmann","year":"2022","unstructured":"Hartmann, D. A., Coelho-Santos, V. & Shih, A. Y. Pericyte control of blood flow across microvascular zones in the central nervous system. Annu. Rev. Physiol. 84, 331\u2013354. https:\/\/doi.org\/10.1146\/annurev-physiol-061121-040127 (2022).","journal-title":"Annu. Rev. Physiol."},{"issue":"6","key":"64940_CR11","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nn.4288","volume":"19","author":"MDAS Sweeney","year":"2016","unstructured":"Sweeney, M. D. A. S. & Zlokovic, B. V. Pericytes of the neurovascular unit: Key functions and signaling pathways. Nat. Neurosci. 19(6), 771\u2013783. https:\/\/doi.org\/10.1038\/nn.4288 (2016).","journal-title":"Nat. Neurosci."},{"issue":"9","key":"64940_CR12","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/nm.2022","volume":"15","author":"M Yemisci","year":"2009","unstructured":"Yemisci, M. et al. Pericyte contraction induced by oxidative\u2013nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat. Med. 15(9), 1031\u20131037. https:\/\/doi.org\/10.1038\/nm.2022 (2009).","journal-title":"Nat. Med."},{"key":"64940_CR13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.expneurol.2019.03.014","volume":"317","author":"S Bhowmick","year":"2019","unstructured":"Bhowmick, S., D\u2019Mello, V., Caruso, D., Wallerstein, A. & Abdul-Muneer, P. M. Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury. Exp. Neurol. 317, 260\u2013270. https:\/\/doi.org\/10.1016\/j.expneurol.2019.03.014 (2019).","journal-title":"Exp. Neurol."},{"key":"64940_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuroscience.2018.06.046","volume":"405","author":"H Thurgur","year":"2019","unstructured":"Thurgur, H. & Pinteaux, E. Microglia in the neurovascular unit: Blood\u2013brain barrier\u2013microglia interactions after central nervous system disorders. Neuroscience 405, 55\u201367. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.06.046 (2019).","journal-title":"Neuroscience"},{"key":"64940_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108574","volume":"207","author":"A Gomez","year":"2021","unstructured":"Gomez, A. et al. Tumor necrosis factor-alpha and interferon-gamma induce inflammasome-mediated corneal endothelial cell death. Exp. Eye Res. 207, 108574. https:\/\/doi.org\/10.1016\/j.exer.2021.108574 (2021).","journal-title":"Exp. Eye Res."},{"key":"64940_CR16","doi-asserted-by":"publisher","first-page":"901117","DOI":"10.3389\/fnagi.2022.901117","volume":"14","author":"YF Li","year":"2022","unstructured":"Li, Y. F., Ren, X., Zhang, L., Wang, Y. H. & Chen, T. Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals. Front. Aging Neurosci. 14, 901117. https:\/\/doi.org\/10.3389\/fnagi.2022.901117 (2022).","journal-title":"Front. Aging Neurosci."},{"issue":"6","key":"64940_CR17","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1007\/s12035-021-02293-1","volume":"58","author":"Y Zhou","year":"2021","unstructured":"Zhou, Y., Fan, R., Botchway, B. O. A., Zhang, Y. & Liu, X. Infliximab can improve traumatic brain injury by suppressing the tumor necrosis factor alpha pathway. Mol. Neurobiol. 58(6), 2803\u20132811. https:\/\/doi.org\/10.1007\/s12035-021-02293-1 (2021).","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"64940_CR18","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41419-019-1716-9","volume":"10","author":"AQ Chen","year":"2019","unstructured":"Chen, A. Q. et al. Microglia-derived TNF-\u03b1 mediates endothelial necroptosis aggravating blood brain\u2013barrier disruption after ischemic stroke. Cell Death Dis. 10(7), 487. https:\/\/doi.org\/10.1038\/s41419-019-1716-9 (2019).","journal-title":"Cell Death Dis."},{"issue":"8","key":"64940_CR19","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1080\/1028415X.2021.1901047","volume":"25","author":"X Chen","year":"2022","unstructured":"Chen, X., Famurewa, A. C., Tang, J., Olatunde, O. O. & Olatunji, O. J. Hyperoside attenuates neuroinflammation, cognitive impairment and oxidative stress via suppressing TNF-\u03b1\/NF-\u03baB\/caspase-3 signaling in type 2 diabetes rats. Nutr. Neurosci. 25(8), 1774\u20131784. https:\/\/doi.org\/10.1080\/1028415X.2021.1901047 (2022).","journal-title":"Nutr. Neurosci."},{"issue":"1","key":"64940_CR20","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s40478-019-0761-z","volume":"7","author":"L Alarcon-Martinez","year":"2019","unstructured":"Alarcon-Martinez, L. et al. Retinal ischemia induces \u03b1-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion. Acta Neuropathol. Commun. 7(1), 134. https:\/\/doi.org\/10.1186\/s40478-019-0761-z (2019).","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"64940_CR21","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.tcb.2023.06.001","volume":"34","author":"H van Splunder","year":"2024","unstructured":"van Splunder, H., Villacampa, P., Mart\u00ednez-Romero, A. & Graupera, M. Pericytes in the disease spotlight. Trends Cell Biol. 34(1), 58\u201371. https:\/\/doi.org\/10.1016\/j.tcb.2023.06.001 (2024).","journal-title":"Trends Cell Biol."},{"key":"64940_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.brainres.2015.03.047","volume":"1623","author":"T Dalkara","year":"2015","unstructured":"Dalkara, T. & Alarcon-Martinez, L. Cerebral microvascular pericytes and neurogliovascular signaling in health and disease. Brain Res. 1623, 3\u201317. https:\/\/doi.org\/10.1016\/j.brainres.2015.03.047 (2015).","journal-title":"Brain Res."},{"issue":"1\u20132","key":"64940_CR23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1089\/neu.2020.7545","volume":"39","author":"M Amoo","year":"2022","unstructured":"Amoo, M. et al. Permeability of the blood\u2013brain barrier after traumatic brain injury: Radiological considerations. J. Neurotrauma 39(1\u20132), 20\u201334. https:\/\/doi.org\/10.1089\/neu.2020.7545 (2022).","journal-title":"J. Neurotrauma"},{"issue":"7","key":"64940_CR24","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S1474-4422(22)00166-1","volume":"21","author":"TA van Essen","year":"2022","unstructured":"van Essen, T. A. et al. Surgery versus conservative treatment for traumatic acute subdural haematoma: A prospective, multicentre, observational, comparative effectiveness study. Lancet Neurol. 21(7), 620\u2013631. https:\/\/doi.org\/10.1016\/S1474-4422(22)00166-1 (2022).","journal-title":"Lancet Neurol."},{"issue":"2","key":"64940_CR25","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1017\/cjn.2021.518","volume":"50","author":"M Kia","year":"2023","unstructured":"Kia, M., Saluja, R. S. & Marcoux, J. Acute traumatic subdural hematoma and anticoagulation risk. Can. J. Neurol. Sci. 50(2), 188\u2013193. https:\/\/doi.org\/10.1017\/cjn.2021.518 (2023).","journal-title":"Can. J. Neurol. Sci."},{"key":"64940_CR26","doi-asserted-by":"publisher","first-page":"424","DOI":"10.25259\/SNI-490-2021","volume":"12","author":"LF Bocca","year":"2021","unstructured":"Bocca, L. F., Lima, J. V. F., Suriano, I. C., Cavalheiro, S. & Rodrigues, T. P. Traumatic acute subdural hematoma and coma: Retrospective cohort of surgically treated patients. Surg. Neurol. Int. 12, 424. https:\/\/doi.org\/10.25259\/SNI-490-2021 (2021).","journal-title":"Surg. Neurol. Int."},{"issue":"1","key":"64940_CR27","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s40001-023-01100-y","volume":"28","author":"S Zhang","year":"2023","unstructured":"Zhang, S. et al. Acute subdural haematoma exacerbates cerebral blood flow disorder and promotes the development of intraoperative brain bulge in patients with severe traumatic brain injury. Eur. J. Med. Res. 28(1), 138. https:\/\/doi.org\/10.1186\/s40001-023-01100-y (2023).","journal-title":"Eur. J. Med. Res."},{"issue":"2","key":"64940_CR28","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s12028-019-00873-7","volume":"32","author":"NT Hamahata","year":"2020","unstructured":"Hamahata, N. T. & Nakagawa, K. Regional cerebral hypoperfusion from acute subdural hematoma. Neurocrit. Care 32(2), 633\u2013635. https:\/\/doi.org\/10.1007\/s12028-019-00873-7 (2020).","journal-title":"Neurocrit. Care"},{"issue":"3","key":"64940_CR29","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1093\/neuros\/nyaa278","volume":"87","author":"GWJ Hawryluk","year":"2020","unstructured":"Hawryluk, G. W. J. et al. Guidelines for the management of severe traumatic brain injury: 2020 update of the decompressive craniectomy recommendations. Neurosurgery 87(3), 427\u2013434. https:\/\/doi.org\/10.1093\/neuros\/nyaa278 (2020).","journal-title":"Neurosurgery"},{"issue":"Pt 1","key":"64940_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/brain\/aws342","volume":"136","author":"ED Bigler","year":"2013","unstructured":"Bigler, E. D. Neuroinflammation and the dynamic lesion in traumatic brain injury. Brain 136(Pt 1), 9\u201311. https:\/\/doi.org\/10.1093\/brain\/aws342 (2013).","journal-title":"Brain"},{"issue":"12","key":"64940_CR31","doi-asserted-by":"publisher","first-page":"CD003983","DOI":"10.1002\/14651858","volume":"12","author":"J Sahuquillo","year":"2019","unstructured":"Sahuquillo, J. & Dennis, J. A. Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury. Cochrane Database Syst. Rev. 12(12), CD003983. https:\/\/doi.org\/10.1002\/14651858 (2019).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2","key":"64940_CR32","doi-asserted-by":"publisher","first-page":"214","DOI":"10.5137\/1019-5149.JTN.8135-13.1","volume":"24","author":"Y Wang","year":"2014","unstructured":"Wang, Y. et al. Controlled decompression for the treatment of severe head injury: A preliminary study. Turk. Neurosurg. 24(2), 214\u2013220. https:\/\/doi.org\/10.5137\/1019-5149.JTN.8135-13.1 (2014).","journal-title":"Turk. Neurosurg."},{"issue":"10","key":"64940_CR33","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/jcbfm.2014.131","volume":"34","author":"L \u00d8stergaard","year":"2014","unstructured":"\u00d8stergaard, L. et al. Capillary transit time heterogeneity and flow-metabolism coupling after traumatic brain injury. J. Cereb. Blood Flow Metab. 34(10), 1585\u20131598. https:\/\/doi.org\/10.1038\/jcbfm.2014.131 (2014).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"64940_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.expneurol.2017.10.023","volume":"300","author":"M Tachibana","year":"2018","unstructured":"Tachibana, M., Yamazaki, Y., Liu, C. C., Bu, G. & Kanekiyo, T. Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-\u03b2 pathology in amyloid model mice. Exp. Neurol. 300, 13\u201321. https:\/\/doi.org\/10.1016\/j.expneurol.2017.10.023 (2018).","journal-title":"Exp. Neurol."},{"issue":"3","key":"64940_CR35","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/0271678X17732229","volume":"39","author":"RI Grant","year":"2019","unstructured":"Grant, R. I. et al. Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex. J. Cereb. Blood Flow Metab. 39(3), 411\u2013425. https:\/\/doi.org\/10.1177\/0271678X17732229 (2019).","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"5","key":"64940_CR36","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1161\/01.str.31.5.1153","volume":"31","author":"LS Ritter","year":"2000","unstructured":"Ritter, L. S., Orozco, J. A., Coull, B. M., McDonagh, P. F. & Rosenblum, W. I. Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke. Stroke 31(5), 1153\u20131161. https:\/\/doi.org\/10.1161\/01.str.31.5.1153 (2000).","journal-title":"Stroke"},{"issue":"10","key":"64940_CR37","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1097\/01.wcb.0000037998.34930.83","volume":"22","author":"S Liu","year":"2002","unstructured":"Liu, S., Connor, J., Peterson, S., Shuttleworth, C. W. & Liu, K. J. Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion. J. Cereb. Blood Flow Metab. 22(10), 1222\u20131230. https:\/\/doi.org\/10.1097\/01.wcb.0000037998.34930.83 (2002).","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3\u20134","key":"64940_CR38","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1089\/neu.2022.0016","volume":"40","author":"S Zheng","year":"2023","unstructured":"Zheng, S. et al. TNF-\u03b1 impairs pericyte-mediated cerebral microcirculation via the NF-\u03baB\/iNOS axis after experimental traumatic brain injury. J. Neurotrauma 40(3\u20134), 349\u2013364. https:\/\/doi.org\/10.1089\/neu.2022.0016 (2023).","journal-title":"J. Neurotrauma"},{"issue":"1_suppl","key":"64940_CR39","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1177\/0271678X20951995","volume":"40","author":"PT Ronaldson","year":"2020","unstructured":"Ronaldson, P. T. & Davis, T. P. Regulation of blood\u2013brain barrier integrity by microglia in health and disease: A therapeutic opportunity. J. Cereb. Blood Flow Metab. 40(1_suppl), S6\u2013S24. https:\/\/doi.org\/10.1177\/0271678X20951995 (2020).","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"8","key":"64940_CR40","first-page":"3275","volume":"13","author":"C Gan","year":"2023","unstructured":"Gan, C. et al. Advances in the study of the molecular biological mechanisms of radiation-induced brain injury. Am. J. Cancer Res. 13(8), 3275\u20133299 (2023).","journal-title":"Am. J. Cancer Res."},{"key":"64940_CR41","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fnmol.2015.00077","volume":"8","author":"RH Shih","year":"2015","unstructured":"Shih, R. H., Wang, C. Y. & Yang, C. M. NF-kappaB signaling pathways in neurological inflammation: A mini review. Front. Mol. Neurosci. 8, 77. https:\/\/doi.org\/10.3389\/fnmol.2015.00077 (2015).","journal-title":"Front. Mol. Neurosci."},{"key":"64940_CR42","doi-asserted-by":"publisher","first-page":"7106525","DOI":"10.1155\/2020\/7106525","volume":"2020","author":"M Wang","year":"2020","unstructured":"Wang, M. et al. Vagus nerve stimulation ameliorates renal ischemia-reperfusion injury through inhibiting NF-\u03baB activation and iNOS protein expression. Oxid. Med. Cell Longev. 2020, 7106525. https:\/\/doi.org\/10.1155\/2020\/7106525 (2020).","journal-title":"Oxid. Med. Cell Longev."},{"key":"64940_CR43","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.3389\/fimmu.2019.01043","volume":"10","author":"EC Dresselhaus","year":"2019","unstructured":"Dresselhaus, E. C. & Meffert, M. K. Cellular specificity of NF-\u03baB function in the nervous system. Front. Immunol. 10, 1043. https:\/\/doi.org\/10.3389\/fimmu.2019.01043 (2019).","journal-title":"Front. Immunol."},{"issue":"2","key":"64940_CR44","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/15321819.2019.1583109","volume":"40","author":"R Ahmad","year":"2019","unstructured":"Ahmad, R., Hussain, A. & Ahsan, H. Peroxynitrite: Cellular pathology and implications in autoimmunity. J. Immunoassay Immunochem. 40(2), 123\u2013138. https:\/\/doi.org\/10.1080\/15321819.2019.1583109 (2019).","journal-title":"J. Immunoassay Immunochem."},{"key":"64940_CR45","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.brainresbull.2017.05.008","volume":"133","author":"K Ramdial","year":"2017","unstructured":"Ramdial, K., Franco, M. C. & Estevez, A. G. Cellular mechanisms of peroxynitrite-induced neuronal death. Brain Res. Bull. 133, 4\u201311. https:\/\/doi.org\/10.1016\/j.brainresbull.2017.05.008 (2017).","journal-title":"Brain Res. Bull."},{"issue":"1\u20132","key":"64940_CR46","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ymgme.2018.07.007","volume":"125","author":"S Madan","year":"2018","unstructured":"Madan, S. et al. Arginase overexpression in neurons and its effect on traumatic brain injury. Mol. Genet. Metab. 125(1\u20132), 112\u2013117. https:\/\/doi.org\/10.1016\/j.ymgme.2018.07.007 (2018).","journal-title":"Mol. Genet. Metab."},{"key":"64940_CR47","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/164_2020_426","volume":"273","author":"W Li","year":"2022","unstructured":"Li, W. et al. Blood\u2013brain barrier mechanisms in stroke and trauma. Handb. Exp. Pharmacol. 273, 267\u2013293. https:\/\/doi.org\/10.1007\/164_2020_426 (2022).","journal-title":"Handb. Exp. Pharmacol."},{"key":"64940_CR48","doi-asserted-by":"publisher","first-page":"13497","DOI":"10.1038\/srep13497","volume":"5","author":"CM Zehendner","year":"2015","unstructured":"Zehendner, C. M. et al. Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex. Sci. Rep. 5, 13497. https:\/\/doi.org\/10.1038\/srep13497 (2015).","journal-title":"Sci. Rep."},{"key":"64940_CR49","doi-asserted-by":"publisher","first-page":"102727","DOI":"10.1016\/j.bas.2023.102727","volume":"4","author":"AO Trofimov","year":"2023","unstructured":"Trofimov, A. O. et al. Intracranial dynamics biomarkers at traumatic cerebral vasospasm. Brain Spine 4, 102727. https:\/\/doi.org\/10.1016\/j.bas.2023.102727 (2023).","journal-title":"Brain Spine"},{"key":"64940_CR50","doi-asserted-by":"publisher","first-page":"815226","DOI":"10.3389\/fneur.2022.815226","volume":"13","author":"L Xian","year":"2022","unstructured":"Xian, L., Wang, C., Wei, L. & Wang, S. Cerebral blood flow disorder in acute subdural hematoma and acute intraoperative brain bulge. Front. Neurol. 13, 815226. https:\/\/doi.org\/10.3389\/fneur.2022.815226 (2022).","journal-title":"Front. Neurol."},{"issue":"2","key":"64940_CR51","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s12028-019-00733-4","volume":"31","author":"M Unnerb\u00e4ck","year":"2019","unstructured":"Unnerb\u00e4ck, M., Ottesen, J. T. & Reinstrup, P. Increased intracranial pressure attenuates the pulsating component of cerebral venous outflow. Neurocrit. Care 31(2), 273\u2013279. https:\/\/doi.org\/10.1007\/s12028-019-00733-4 (2019).","journal-title":"Neurocrit. Care"},{"issue":"3","key":"64940_CR52","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/micc.12199","volume":"22","author":"DG Welsh","year":"2015","unstructured":"Welsh, D. G. & Ledoux, J. Feed the brain: Insights into the study of neurovascular coupling. Microcirculation 22(3), 157\u2013158. https:\/\/doi.org\/10.1111\/micc.12199 (2015).","journal-title":"Microcirculation"},{"issue":"7","key":"64940_CR53","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/s41593-019-0434-z","volume":"22","author":"AM Nikolakopoulou","year":"2019","unstructured":"Nikolakopoulou, A. M. et al. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat. Neurosci. 22(7), 1089\u20131098. https:\/\/doi.org\/10.1038\/s41593-019-0434-z (2019).","journal-title":"Nat. Neurosci."},{"issue":"10","key":"64940_CR54","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/j.neuron.2022.02.017","volume":"110","author":"S Ayloo","year":"2022","unstructured":"Ayloo, S. et al. Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier. Neuron 110(10), 1641-1655.e6. https:\/\/doi.org\/10.1016\/j.neuron.2022.02.017 (2022).","journal-title":"Neuron"},{"issue":"5","key":"64940_CR55","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s40265-017-0701-9","volume":"77","author":"S Banerjee","year":"2017","unstructured":"Banerjee, S., Biehl, A., Gadina, M., Hasni, S. & Schwartz, D. M. JAK-STAT signaling as a target for inflammatory and autoimmune diseases: Current and future prospects. Drugs 77(5), 521\u2013546. https:\/\/doi.org\/10.1007\/s40265-017-0701-9 (2017).","journal-title":"Drugs"},{"issue":"2","key":"64940_CR56","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s11064-019-02718-3","volume":"44","author":"M Zhang","year":"2019","unstructured":"Zhang, M. et al. Correction to: Isoliquiritigenin provides protection and attenuates oxidative stress-induced injuries via the Nrf2-ARE signaling pathway after traumatic brain injury. Neurochem. Res. 44(2), 510\u2013511. https:\/\/doi.org\/10.1007\/s11064-019-02718-3 (2019).","journal-title":"Neurochem. Res."},{"issue":"6","key":"64940_CR57","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biol. 8(6), e1000412. https:\/\/doi.org\/10.1371\/journal.pbio.1000412 (2010).","journal-title":"PLoS Biol."},{"key":"64940_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2021.109075","volume":"351","author":"L Xian","year":"2021","unstructured":"Xian, L. et al. The construction of an improved model of acute subdural hematoma in rats. J. Neurosci. Methods 351, 109075. https:\/\/doi.org\/10.1016\/j.jneumeth.2021.109075 (2021).","journal-title":"J. Neurosci. Methods"},{"issue":"12","key":"64940_CR59","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3109\/00207454.2014.980906","volume":"125","author":"CA Arango-D\u00e1vila","year":"2015","unstructured":"Arango-D\u00e1vila, C. A. et al. Soluble or soluble\/membrane TNF-\u03b1 inhibitors protect the brain from focal ischemic injury in rats. Int J Neurosci. 125(12), 936\u2013940. https:\/\/doi.org\/10.3109\/00207454.2014.980906 (2015).","journal-title":"Int J Neurosci."},{"issue":"3","key":"64940_CR60","doi-asserted-by":"publisher","first-page":"R75","DOI":"10.1186\/cc4922","volume":"10","author":"BE Friesenecker","year":"2006","unstructured":"Friesenecker, B. E. et al. Arteriolar vasoconstrictive response: Comparing the effects of arginine vasopressin and norepinephrine. Crit. Care 10(3), R75. https:\/\/doi.org\/10.1186\/cc4922 (2006).","journal-title":"Crit. Care"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-64940-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-64940-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-64940-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T15:07:08Z","timestamp":1719241628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-64940-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["64940"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-64940-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,24]]},"assertion":[{"value":"14 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14535"}}