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A total of 270 participants (136 males, 50.4% and 134 females, 49.6%) with a mean age of 28.22\u2009\u00b1\u20099.01\u00a0years were assessed, diagnosed under the criteria put forth by Dry Eye Workshop completed the Chinese translated version of the OSDI-12 questionnaire (C-OSDI-12). Validity and psychometric properties were analyzed using the study data on the selected items (a new approach called virtual validation). The six items were extracted from the C-OSDI-12 as suggested by the authors of OSDI-6 and compared. The total scores of C-OSDI-12 and C-OSDI-6 were 30.27\u2009\u00b1\u200913.19 and 6.95\u2009\u00b1\u20093.53, respectively. Significant reliability was found between the total C-OSDI-6 score and the total C-OSDI-12 score (r\u2009=\u20090.865, p\u2009&lt;\u20090.001). Infits and outfits of the C-OSDI-6 were between 1.26 and 0.78.The C-OSDI-6 proved valid and psychometrically responsive in Chinese adult dry eye participants. 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