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For this reason, it was decided to investigate whether a single intensive exercise until exhaustion applied after a 2-week rest period would result in a violation of the pro-oxidant-antioxidant balance. Twenty-seven trained female basketball players (age: 16.55\u2009\u00b1\u20090.96\u00a0years, body mass: 66.40\u2009\u00b1\u200913.68\u00a0kg, height: 173.45\u2009\u00b1\u20095.14\u00a0cm) were enrolled to the study following the application of inclusion and exclusion criteria. Study was conducted at the end of the competitive training phase. Participants underwent incremental treadmill exercise, with blood samples collected before the test, immediately post-exercise, and after a 3-h restitution period. Total antioxidant capacity (TAC) levels increased significantly after exercise and remained unchanged after 3\u00a0h. Concentration of interleukin-10 (IL-10) and creatine kinase (CK) significantly increased after exercise and then decreased. Concentration of interleukin-2 (IL-2) was significantly reduced immediately and 3\u00a0h after exercise, while interleukin-13 (IL-13), interleukin-1\u03b1 (IL-1\u03b1), and tryptophan (TRP) decreased 3\u00a0h after exercise. No significant changes were observed in other biochemical parameters. Obtained results show an increased antioxidant capacity which reduced oxidative stress and inflammation in response to intense exercise indicating that rested athletes have a high adaptation and elevated tolerance to effort.<\/jats:p>","DOI":"10.1038\/s41598-024-65309-5","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T04:01:41Z","timestamp":1719288101000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of 2\u00a0weeks rest-pause on oxidative stress and inflammation in female basketball players"],"prefix":"10.1038","volume":"14","author":[{"given":"Justyna","family":"Cicho\u0144-Wo\u017aniak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ostapiuk-Karolczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142awa","family":"Cie\u015blicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Dziewiecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Basta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Maciejewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Skarpa\u0144ska-Stejnborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"65309_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1177\/1941738111434406","volume":"4","author":"JB Kreher","year":"2012","unstructured":"Kreher, J. 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