{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:54:40Z","timestamp":1787003680119,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Johann Wolfgang Goethe-Universit\u00e4t, Frankfurt am Main"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In contrast to transplant recipients, there is a paucity of data regarding frequency and clinical significance of viraemia in children receiving conventional chemotherapy. In a prospective observational study, we assessed the frequency of and clinical impact of viraemia with cytomegalovirus (CMV), Epstein-Barr virus (EBV), adenovirus, human herpesvirus-6 (HHV6) and herpes-simplex virus 1\/2 (HSV1\/2) in paediatric cancer patients at diagnosis, at a routine examination during intensive chemotherapy, and during febrile neutropenia (FN). Seventy-nine patients (median age 6\u00a0years; 66 children with haematological malignancies) were included in the study. Overall, 362 blood samples were analysed, 72 from the time at diagnosis (11.1% with positive PCR result), 118 during a regular control after chemotherapy (11.0% positive), and 159 during FN (8.8% positive). The overall positivity rate was 9.6% (CMV 3.3%, HHV6 2.7%, HSV 2.2%, EBV 0.8% and adenovirus 0.3%). There were no significant differences between FN episodes with and without viraemia in terms of duration of fever or neutropenia\/lymphopenia, severity of mucositis (&gt;\u2009II\n                    <jats:sup>0<\/jats:sup>\n                    ), incidence of diarrhea and ICU admission. Our results indicate that viraemia in paediatric cancer patients generally does not have a major clinical impact, and may help in the decision regarding the indication of routine evaluation for viraemia in febrile neutropenic, but otherwise asymptomatic children.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-65641-w","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T12:19:45Z","timestamp":1719490785000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Frequency and clinical impact of viraemia in paediatric patients undergoing therapy for cancer"],"prefix":"10.1038","volume":"14","author":[{"given":"Anke","family":"Barnbrock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchior","family":"Lauten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Demmert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Henning","family":"Klusmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ciesek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Bochennek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-3439","authenticated-orcid":false,"given":"Thomas","family":"Lehrnbecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"65641_CR1","doi-asserted-by":"publisher","first-page":"e382","DOI":"10.1038\/bcj.2015.110","volume":"6","author":"K Bochennek","year":"2016","unstructured":"Bochennek, K. et al. Infectious complications in children with acute myeloid leukemia: Decreased mortality in multicenter trial AML-BFM 2004. Blood Cancer J. 6, e382 (2016).","journal-title":"Blood Cancer J."},{"key":"65641_CR2","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.3390\/cancers13091990","volume":"13","author":"D Willmer","year":"2021","unstructured":"Willmer, D. et al. Infectious morbidity in Pediatric patients receiving neoadjuvant chemotherapy for sarcoma. Cancers 13, 1990 (2021).","journal-title":"Cancers"},{"key":"65641_CR3","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1200\/JCO.22.02224","volume":"41","author":"T Lehrnbecher","year":"2023","unstructured":"Lehrnbecher, T. et al. Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update. J. Clin. Oncol. 41, 1774\u20131785 (2023).","journal-title":"J. Clin. 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Efficacy and safety of withholding antimicrobial treatment in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial. Clin. Microbiol. Infect. 23, 173\u2013178 (2017).","journal-title":"Clin. Microbiol. Infect."},{"key":"65641_CR7","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1055\/s-0043-103086","volume":"229","author":"T Simon","year":"2017","unstructured":"Simon, T. et al. 2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors. Klin. Padiatr. 229, 147\u2013167 (2017).","journal-title":"Klin. Padiatr."},{"key":"65641_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/cyto.a.22520","volume":"87","author":"F Tosato","year":"2015","unstructured":"Tosato, F. et al. Lymphocytes subsets reference values in childhood. 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J.H.K has advisory roles for Bluebird Bio, Novartis, Roche and Jazz Pharmaceuticals. S.C. has received a grant from Roche Diagnostics, and served at the speaker\u00b4s bureau of Sanofi. K.B. served at the speaker\u00b4s bureau of MSD. T.L. has received a grant from Gilead Sciences, has served as consultant to Gilead Sciences, Merck\/MSD, Pfizer, Astellas, AstraZeneca, EUSA Pharma and Roche, and served at the speaker\u00b4s bureau of Gilead Sciences, Merck\/MSD, Astellas, Pfizer and GSK and EUSA Pharma. None of the other authors has to declare a conflict of interest regarding this work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14867"}}