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This prospective observational study included 29 patients who underwent HD for ESKD. ONH parameters including neural canal diameter (NCD), peripapillary vertical height (PVH), and anterior LC depth (LCD), were assessed using SS-OCT. Changes in the ONH parameters before and after HD were statistically analysed. Correlations between changes in the LCD and other ocular and systemic measurements were identified using Pearson\u2019s correlation analyses. The mean anterior LCD significantly decreased from 441.6\u2009\u00b1\u2009139.8\u00a0\u03bcm before HD to 413.5\u2009\u00b1\u2009141.7\u00a0\u03bcm after HD (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Mean NCD and PVH did not show significant changes after HD (<jats:italic>P<\/jats:italic>\u2009=\u20090.841 and <jats:italic>P<\/jats:italic>\u2009=\u20090.574, respectively). A significant correlation was found between changes in the anterior LCD and the mean ocular perfusion pressure (r\u2009=\u20090.397, <jats:italic>P<\/jats:italic>\u2009=\u20090.036). We observed a significant decrease in anterior LCD after HD. Our study suggests that HD can influence the ONH, especially in the LC.<\/jats:p>","DOI":"10.1038\/s41598-024-65700-2","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T22:01:43Z","timestamp":1719957703000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hemodialysis-induced positional changes in lamina cribrosa"],"prefix":"10.1038","volume":"14","author":[{"given":"Ji Hong","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Chan","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Un","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won June","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"65700_CR1","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/s0140-6736(16)32064-5","volume":"389","author":"AC Webster","year":"2017","unstructured":"Webster, A. 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