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A retrospective comparative clinical study, which compares the outcomes of 24 eyes treated with Exc-DALK (<jats:italic>G1<\/jats:italic>) against matched group of 43 eyes treated with Exc-PKP (<jats:italic>G2<\/jats:italic>) at both 2\u00a0months (<jats:italic>T1<\/jats:italic>) and 2\u00a0years (<jats:italic>T2<\/jats:italic>) postoperatively. Main outcomes included best-corrected visual acuity (BCVA), central macular thickness (CMT), and SFCT. Preoperatively, there were no significant differences between both groups regarding BCVA, CMT or SFCT (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). There were no significant differences between both groups regarding BCVA at both follow-ups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). There were no significant differences between both groups regarding CMT at both follow-ups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). SFCT was higher in G2 than G1 at both follow-ups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Compared to preoperative SFCT, there were no significant changes in SFCT in G1 at both follow-ups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). In G2, SFCT increased significantly at T1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and did not differ significantly at T2 (<jats:italic>p<\/jats:italic>\u2009=\u20090.17). SFCT increased significantly after Exc-PKP but not after Exc-DALK, which might indicate that Exc-DALK affects the choroid less and thus could represent a less traumatic approach to ocular tissue than Exc-PKP.<\/jats:p>","DOI":"10.1038\/s41598-024-66225-4","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T16:10:10Z","timestamp":1720023010000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subfoveal choroidal thickness increases after excimer laser-assisted penetrating keratoplasty but not after excimer laser-assisted deep anterior lamellar keratoplasty"],"prefix":"10.1038","volume":"14","author":[{"given":"Wissam","family":"Aljundi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loay","family":"Daas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Munteanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa Din","family":"Abdin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"66225_CR1","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s00347-013-2822-1","volume":"110","author":"B Seitz","year":"2013","unstructured":"Seitz, B. et al. 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