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Here, we examined the risk of drug use for CA-AKI by using exhaustive pre-diagnostic prescription data. We included 78,754 working-age healthy individuals who underwent an annual health checkup program. We conducted a cohort study to assess the association between prevalent drug use and subsequent CA-AKI incidence using the Cox proportional hazard model. Subsequently, we conducted a case-crossover study to compare the new drug use in the case period directly before the CA-AKI incidence (\u2212\u20093 to 0\u00a0months) with that in the control period far before the CA-AKI incidence (\u2212\u200915 to \u2212\u200912\u00a0months and \u2212\u20099 to \u2212\u20096\u00a0months) using the conditional Poisson regression model. The prevalent use of renin\u2013angiotensin\u2013aldosterone system (RAAS) inhibitors was associated with an increased CA-AKI incidence, but the new use was not. The new use of diuretics, anti-infectious drugs, and contrast medium was also associated with an increased CA-AKI incidence. These results suggest we need to pay attention for the incidence of AKI among the general population taking those common drugs.<\/jats:p>","DOI":"10.1038\/s41598-024-66532-w","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T11:33:17Z","timestamp":1722598397000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalent and new use of common drugs for the incidence of community-acquired acute kidney injury: cohort and case-crossover study"],"prefix":"10.1038","volume":"14","author":[{"given":"Miho","family":"Kimachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyoshi","family":"Ikenoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Fukuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"66532_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","volume":"382","author":"NH Lameire","year":"2013","unstructured":"Lameire, N. 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