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RP may cause extensive tissue destruction and is associated with significant morbidity and mortality. In this multicenter study, we considered the remission status and long-term outcomes of RP in patients who were followed-up in six referral rheumatology centers in Iran. Outcomes of disease was assessed by remission status and RP induced damage. A total of 29 patients with RP were examined for enrollment in the study, and 26 patients with a minimum follow-up period of 6 months were included in the RP outcome analysis. Median time to control of symptoms and sustained remission were 5 and 23 weeks, respectively. Prednisolone was discontinued in 8 (30.8%) patients and medication-free remission was achieved in 7 (23.1%) patients. Regarding the disease course, 34.6% of patients had a relapsing\u2013remitting course, 42.3% had a monophasic course, and 23.1% had an always-active course. Despite extensive treatment with immunosuppressive medications, RP induced damage was developed in 21 (80.8%) patients. Ear deformity and osteoporosis were the most common RP induced damage. Long-term remission and medications-free remission in RP is accessible. However, RP related damage occur in majority of patients.<\/jats:p>","DOI":"10.1038\/s41598-024-67530-8","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:01:55Z","timestamp":1721174515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A multicenter study of long-term outcomes of relapsing polychondritis in Iran"],"prefix":"10.1038","volume":"14","author":[{"given":"Mehdi","family":"Jafarpour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Saberivand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Saemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Sahebari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedmostafa","family":"Seyedmardani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Salesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hosseinpoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahereh","family":"Faezi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Esalatmanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrzad","family":"Hajialilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sousan","family":"Kolahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Myrfeizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Khabbazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"67530_CR1","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.autrev.2010.02.016","volume":"9","author":"T Lahmer","year":"2010","unstructured":"Lahmer, T. et al. Relapsing polychondritis: An autoimmune disease with many faces. Autoimmun. Rev. 9, 540\u2013546 (2010).","journal-title":"Autoimmun. Rev."},{"key":"67530_CR2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/biomedicines6030084","volume":"6","author":"F Borgia","year":"2018","unstructured":"Borgia, F., Giuffrida, R., Guarneri, F. & Cannav\u00f2, S. P. Relapsing polychondritis: An updated review. Biomedicines 6, 84 (2018).","journal-title":"Biomedicines"},{"key":"67530_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2147\/CLEP.S91439","volume":"8","author":"A Horv\u00e1th","year":"2016","unstructured":"Horv\u00e1th, A. et al. A nationwide study of the epidemiology of relapsing polychondritis. Clin. Epidemiol. 8, 211\u2013230 (2016).","journal-title":"Clin. 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Risk factors for the recurrence of relapsing polychondritis. Arthritis Res. Ther. 24, 127 (2022).","journal-title":"Arthritis Res. Ther."},{"key":"67530_CR9","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jbspin.2018.11.001","volume":"86","author":"P Mertz","year":"2019","unstructured":"Mertz, P. et al. The relapsing polychondritis damage index (RPDAM): Development of a disease-specific damage score for relapsing polychondritis. Jt. Bone Spine 86, 363\u2013368 (2019).","journal-title":"Jt. Bone Spine"},{"key":"67530_CR10","doi-asserted-by":"publisher","first-page":"74","DOI":"10.7326\/0003-4819-104-1-74","volume":"104","author":"CJ Michet","year":"1986","unstructured":"Michet, C. J., McKenna, C. H., Luthra, H. S. & O\u2019Fallon, W. M. Relapsing polychondritis. Survival and predictive role of early disease manifestations. Ann. Intern. Med. 104, 74\u201378 (1986).","journal-title":"Ann. Intern. 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