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The current work aimed to compare the therapeutic effect of platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) on torsion\/detorsion (T\/D) injury in rats. Forty mature male Wister rats were arranged into 4 groups; (1) Control, (2) T\/D, (3) T\/D\u2009+\u2009PRP, and (4) T\/D+\u2009i-PRF. The right testis was twisting 1080\u00b0 clockwise for 3\u00a0h in groups 2, 3 and 4, then 10\u00a0\u03bcl of PRP or i-PRF was injected intra-testicular 3\u00a0h after detorsion in groups 3 and 4, respectively. After 30 days postoperatively, the semen quality and hormonal assay were improved in PRP and i-PRF-treated groups with superiority of i-PRF (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). High significance of Catalase, Glutathione Peroxidase (GPx), Superoxide Dismutase, Interleukin-1\u03b2 (IL-1\u03b2), Caspase-3 and Tumor necrosis factor-\u03b1 (TNF-\u03b1) was reported in treated rats with PRP and i-PRF (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with superiority to i-PRF-treated rats (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Testicular histoarchitectures were improved in PRP and i-PRF-treated rats with superiority of i-PRF-treated rats. It was concluded that PRP and i-PRF have regenerative efficacy on testicular damage after induced T\/D injury with a superior efficacy of i-PRF.<\/jats:p>","DOI":"10.1038\/s41598-024-67704-4","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T04:02:13Z","timestamp":1722830533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of the therapeutic effect of platelet-rich plasma and injectable platelet-rich fibrin on testicular torsion\/detorsion injury in rats"],"prefix":"10.1038","volume":"14","author":[{"given":"Eslam F. M.","family":"Eisa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa A. 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