{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:58:32Z","timestamp":1788476312781,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"],"award-info":[{"award-number":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"],"award-info":[{"award-number":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"],"award-info":[{"award-number":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"],"award-info":[{"award-number":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"],"award-info":[{"award-number":["No. 2023YFS0027, 2023YFS0240, 2023YFS0074, 2023NSFSC1652, 2022YFS0279, 2021YFQ0062, 2022JDRC0148"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["No. ZH2022-101"],"award-info":[{"award-number":["No. ZH2022-101"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["No. ZH2022-101"],"award-info":[{"award-number":["No. ZH2022-101"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["No. ZH2022-101"],"award-info":[{"award-number":["No. ZH2022-101"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["No. ZH2022-101"],"award-info":[{"award-number":["No. ZH2022-101"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["No. ZH2022-101"],"award-info":[{"award-number":["No. ZH2022-101"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan University West China Nursing Discipline Development Special Fund Project","award":["No. HXHL21016"],"award-info":[{"award-number":["No. HXHL21016"]}]},{"name":"Sichuan University West China Nursing Discipline Development Special Fund Project","award":["No. HXHL21016"],"award-info":[{"award-number":["No. HXHL21016"]}]},{"name":"Sichuan University West China Nursing Discipline Development Special Fund Project","award":["No. HXHL21016"],"award-info":[{"award-number":["No. HXHL21016"]}]},{"name":"Sichuan University West China Nursing Discipline Development Special Fund Project","award":["No. HXHL21016"],"award-info":[{"award-number":["No. HXHL21016"]}]},{"name":"Sichuan University West China Nursing Discipline Development Special Fund Project","award":["No. HXHL21016"],"award-info":[{"award-number":["No. HXHL21016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-68724-w","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T10:12:46Z","timestamp":1722247966000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic inflammation in midlife is associated with late-life functional limitations"],"prefix":"10.1038","volume":"14","author":[{"given":"Yao","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aobo","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"68724_CR1","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1093\/gerona\/glp095","volume":"64","author":"VA Freedman","year":"2009","unstructured":"Freedman, V. A. Adopting the ICF language for studying late-life disability: A field of dreams?. J. Gerontol. A Biol. Sci. Med. Sci. 64, 1172\u20131174 (2009).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"68724_CR2","doi-asserted-by":"crossref","unstructured":"Holmes, J., Powell-Griner, E., Lethbridge-Cejku, M. & Heyman, K. Aging differently: Physical limitations among adults aged 50 years and over: United States, 2001\u20132007. NCHS Data Brief, 1\u20138 (2009).","DOI":"10.1037\/e665252010-001"},{"key":"68724_CR3","unstructured":"Ervin, R. B. Prevalence of functional limitations among adults 60 years of age and over: United States, 1999\u20132002. Adv. Data (375), 1\u20137 (2006). https:\/\/stacks.cdc.gov\/view\/cdc\/84014\/cdc_84014_DS1.pdf"},{"key":"68724_CR4","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1532-5415.2000.tb04791.x","volume":"48","author":"Y Ostchega","year":"2000","unstructured":"Ostchega, Y., Harris, T. B., Hirsch, R., Parsons, V. L. & Kington, R. The prevalence of functional limitations and disability in older persons in the US: Data from the national health and nutrition examination survey III. J. Am. Geriatr. Soc. 48, 1132\u20131135 (2000).","journal-title":"J. Am. Geriatr. Soc."},{"key":"68724_CR5","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1093\/gerona\/glp093","volume":"64","author":"AM Jette","year":"2009","unstructured":"Jette, A. M. Toward a common language of disablement. J. Gerontol. A Biol. Sci. Med. Sci. 64, 1165\u20131168 (2009).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"68724_CR6","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1007\/s11136-012-0315-3","volume":"22","author":"JP Bentley","year":"2013","unstructured":"Bentley, J. P. et al. Functional status, life-space mobility, and quality of life: A longitudinal mediation analysis. Qual. Life Res. 22, 1621\u20131632 (2013).","journal-title":"Qual. Life Res."},{"key":"68724_CR7","doi-asserted-by":"publisher","first-page":"M569","DOI":"10.1093\/gerona\/57.9.M569","volume":"57","author":"J McCusker","year":"2002","unstructured":"McCusker, J., Kakuma, R. & Abrahamowicz, M. Predictors of functional decline in hospitalized elderly patients: A systematic review. J. Gerontol. A Biol. Sci. Med. Sci. 57, M569-577 (2002).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"68724_CR8","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1093\/gerona\/60.9.1180","volume":"60","author":"R Rozzini","year":"2005","unstructured":"Rozzini, R. et al. Relationship between functional loss before hospital admission and mortality in elderly persons with medical illness. J. Gerontol. A Biol. Sci. Med. Sci. 60, 1180\u20131183 (2005).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"68724_CR9","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1007\/s11606-016-3590-9","volume":"31","author":"SM Koroukian","year":"2016","unstructured":"Koroukian, S. M. et al. Combinations of chronic conditions, functional limitations, and geriatric syndromes that predict health outcomes. J. Gen. Intern. Med. 31, 630\u2013637 (2016).","journal-title":"J. Gen. Intern. Med."},{"key":"68724_CR10","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00108-012-3135-1","volume":"54","author":"E Marker-Hermann","year":"2013","unstructured":"Marker-Hermann, E. Systemic inflammation. Internist 54, 397\u2013398 (2013).","journal-title":"Internist"},{"key":"68724_CR11","doi-asserted-by":"publisher","first-page":"M201","DOI":"10.1093\/gerona\/52A.4.M201","volume":"52","author":"HJ Cohen","year":"1997","unstructured":"Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. & Currie, M. S. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J. Gerontol. A Biol. Sci. Med. Sci. 52, M201-208 (1997).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"68724_CR12","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/j.1532-5415.1999.tb01583.x","volume":"47","author":"L Ferrucci","year":"1999","unstructured":"Ferrucci, L. et al. Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 47, 639\u2013646 (1999).","journal-title":"J. Am. Geriatr. Soc."},{"key":"68724_CR13","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/j.1532-5415.2004.52308.x","volume":"52","author":"BW Penninx","year":"2004","unstructured":"Penninx, B. W. et al. Inflammatory markers and incident mobility limitation in the elderly. J. Am. Geriatr. Soc. 52, 1105\u20131113 (2004).","journal-title":"J. Am. Geriatr. Soc."},{"key":"68724_CR14","doi-asserted-by":"publisher","first-page":"M649","DOI":"10.1093\/gerona\/55.11.M649","volume":"55","author":"CF Pieper","year":"2000","unstructured":"Pieper, C. F., Rao, K. M., Currie, M. S., Harris, T. B. & Cohen, H. J. Age, functional status, and racial differences in plasma D-dimer levels in community-dwelling elderly persons. J. Gerontol. A Biol. Sci. Med. Sci. 55, M649-657 (2000).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"68724_CR15","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1196\/annals.1332.007","volume":"1035","author":"PL McGeer","year":"2004","unstructured":"McGeer, P. L. & McGeer, E. G. Inflammation and the degenerative diseases of aging. Ann. N. Y. Acad. Sci. 1035, 104\u2013116 (2004).","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"Suppl","key":"68724_CR16","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1016\/j.ypmed.2011.11.011","volume":"54","author":"S Prasad","year":"2012","unstructured":"Prasad, S., Sung, B. & Aggarwal, B. B. Age-associated chronic diseases require age-old medicine: Role of chronic inflammation. Prev. Med. 54(Suppl), S29-37 (2012).","journal-title":"Prev. Med."},{"key":"68724_CR17","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","volume":"25","author":"D Furman","year":"2019","unstructured":"Furman, D. et al. Chronic inflammation in the etiology of disease across the life span. Nat. Med. 25, 1822\u20131832 (2019).","journal-title":"Nat. Med."},{"key":"68724_CR18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jacc.2021.12.017","volume":"79","author":"L Liberale","year":"2022","unstructured":"Liberale, L. et al. Inflammation, aging, and cardiovascular disease: JACC review topic of the week. J. Am. Coll. Cardiol. 79, 837\u2013847 (2022).","journal-title":"J. Am. Coll. Cardiol."},{"key":"68724_CR19","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1093\/geront\/45.2.222","volume":"45","author":"HH Dodge","year":"2005","unstructured":"Dodge, H. H. et al. Cognitive impairment as a strong predictor of incident disability in specific ADL-IADL tasks among community-dwelling elders: The Azuchi study. Gerontologist 45, 222\u2013230 (2005).","journal-title":"Gerontologist"},{"key":"68724_CR20","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S0277-9536(98)00370-0","volume":"48","author":"AE Stuck","year":"1999","unstructured":"Stuck, A. E. et al. Risk factors for functional status decline in community-living elderly people: A systematic literature review. Soc. Sci. Med. 48, 445\u2013469 (1999).","journal-title":"Soc. Sci. Med."},{"key":"68724_CR21","doi-asserted-by":"publisher","first-page":"841","DOI":"10.2105\/AJPH.82.6.841","volume":"82","author":"M Kelly-Hayes","year":"1992","unstructured":"Kelly-Hayes, M., Jette, A. M., Wolf, P. A., D\u2019Agostino, R. B. & Odell, P. M. Functional limitations and disability among elders in the Framingham study. Am. J. Publ. Health 82, 841\u2013845 (1992).","journal-title":"Am. J. Publ. Health"},{"key":"68724_CR22","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ypmed.2006.11.007","volume":"44","author":"U Tas","year":"2007","unstructured":"Tas, U. et al. Incidence and risk factors of disability in the elderly: The Rotterdam study. Prev. Med. 44, 272\u2013278 (2007).","journal-title":"Prev. Med."},{"issue":"10","key":"68724_CR23","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/0895-4356(93)90112-E","volume":"46","author":"LF Berkman","year":"1993","unstructured":"Berkman, L. F. et al. High, usual and impaired functioning in community-dwelling older men and women: Findings from the MacArthur foundation research network on successful aging. J. Clin. Epidemiol. 46(10), 1129\u20131140 (1993).","journal-title":"J. Clin. Epidemiol."},{"key":"68724_CR24","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.rmed.2016.06.003","volume":"117","author":"F Vermeulen","year":"2016","unstructured":"Vermeulen, F., Garcia, G., Ninane, V. & Laveneziana, P. Activity limitation and exertional dyspnea in adult asthmatic patients: What do we know?. Respir. Med. 117, 122\u2013130 (2016).","journal-title":"Respir. Med."},{"key":"68724_CR25","first-page":"1358323","volume":"15","author":"M Llansola","year":"2024","unstructured":"Llansola, M. et al. Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mech. Ther. Implications. Front. Pharmacol. 15, 1358323 (2024).","journal-title":"Mech. Ther. Implications. Front. Pharmacol."},{"issue":"2","key":"68724_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13270","volume":"226","author":"A Cabrera-Pastor","year":"2019","unstructured":"Cabrera-Pastor, A. et al. Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications. Acta Physiol. 226(2), e13270 (2019).","journal-title":"Acta Physiol."},{"issue":"1","key":"68724_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13195-020-00729-9","volume":"13","author":"M Wang","year":"2021","unstructured":"Wang, M. et al. Kidney function and dementia risk in community-dwelling older adults: The Shanghai aging study. Alzheimers. Res. Ther. 13(1), 21 (2021).","journal-title":"Alzheimers. Res. Ther."},{"issue":"5","key":"68724_CR28","doi-asserted-by":"publisher","first-page":"F856","DOI":"10.1152\/ajprenal.00317.2018","volume":"316","author":"MJ Clarkson","year":"2019","unstructured":"Clarkson, M. J., Bennett, P. N., Fraser, S. F. & Warmington, S. A. Exercise interventions for improving objective physical function in patients with end-stage kidney disease on dialysis: A systematic review and meta-analysis. Am. J. Physiol. Renal. Physiol. 316(5), F856\u2013F872 (2019).","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"68724_CR29","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/oxfordjournals.aje.a115184","volume":"129","author":"design and objectives","year":"1989","unstructured":"design and objectives. The Atherosclerosis risk in communities (ARIC) study The ARIC investigators. Am. J. Epidemiol. 129, 687\u2013702 (1989).","journal-title":"Am. J. Epidemiol."},{"key":"68724_CR30","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neubiorev.2009.10.002","volume":"35","author":"RP Juster","year":"2010","unstructured":"Juster, R. P., McEwen, B. S. & Lupien, S. J. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci. Biobehav. Rev. 35, 2\u201316 (2010).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"68724_CR31","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1212\/WNL.0000000000004688","volume":"89","author":"KA Walker","year":"2017","unstructured":"Walker, K. A. et al. Midlife systemic inflammatory markers are associated with late-life brain volume: The ARIC study. Neurology 89, 2262\u20132270 (2017).","journal-title":"Neurology"},{"issue":"6","key":"68724_CR32","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1056\/NEJM199902113400607","volume":"340","author":"C Gabay","year":"1999","unstructured":"Gabay, C. & Kushner, I. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340(6), 448\u2013454 (1999).","journal-title":"N. Engl. J. Med."},{"issue":"25","key":"68724_CR33","doi-asserted-by":"publisher","first-page":"e560","DOI":"10.1161\/01.CIR.0000148983.88334.80","volume":"110","author":"LM Biasucci","year":"2004","unstructured":"Biasucci, L. M. CDC\/AHA workshop on markers of inflammation and cardiovascular disease: Application to clinical and public health practice: Clinical use of inflammatory markers in patients with cardiovascular diseases: A background paper. Circulation. 110(25), e560\u2013e567 (2004).","journal-title":"Circulation."},{"key":"68724_CR34","doi-asserted-by":"publisher","first-page":"439","DOI":"10.2307\/3349677","volume":"54","author":"SZ Nagi","year":"1976","unstructured":"Nagi, S. Z. An epidemiology of disability among adults in the United States. Milbank Mem. Fund. Q Health Soc. 54, 439\u2013467 (1976).","journal-title":"Milbank Mem. Fund. Q Health Soc."},{"key":"68724_CR35","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1093\/geronj\/21.4.556","volume":"21","author":"I Rosow","year":"1966","unstructured":"Rosow, I. & Breslau, N. A Guttman health scale for the aged. J. Gerontol. 21, 556\u2013559 (1966).","journal-title":"J. Gerontol."},{"issue":"12","key":"68724_CR36","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","volume":"185","author":"S Katz","year":"1963","unstructured":"Katz, S., Ford, A. B., Moskowitz, R. W., Jackson, B. A. & Jaffe, M. W. Studies of illness in the aged: The index of ADL: A standardized measure of biological and psychosocial function. Jama. 185(12), 914\u2013919 (1963).","journal-title":"Jama."},{"key":"68724_CR37","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1093\/ajcn\/nqaa048","volume":"111","author":"D Li","year":"2020","unstructured":"Li, D. et al. Plasma phospholipid very-long-chain SFAs in midlife and 20-year cognitive change in the atherosclerosis risk in communities (ARIC): A cohort study. Am. J. Clin. Nutr. 111, 1252\u20131258 (2020).","journal-title":"Am. J. Clin. Nutr."},{"key":"68724_CR38","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1001\/archneur.1989.00520380041011","volume":"46","author":"DS Knopman","year":"1989","unstructured":"Knopman, D. S. & Ryberg, S. A verbal memory test with high predictive accuracy for dementia of the Alzheimer type. Arch. Neurol. 46, 141\u2013145 (1989).","journal-title":"Arch. Neurol."},{"key":"68724_CR39","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/JCP.0000000000000941","volume":"38","author":"J Jaeger","year":"2018","unstructured":"Jaeger, J. Digit symbol substitution test: The case for sensitivity over specificity in neuropsychological testing. J. Clin. Psychopharmacol. 38, 513\u2013519 (2018).","journal-title":"J. Clin. Psychopharmacol."},{"key":"68724_CR40","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1080\/01688638208401139","volume":"4","author":"MG Pendleton","year":"1982","unstructured":"Pendleton, M. G., Heaton, R. K., Lehman, R. A. & Hulihan, D. Diagnostic utility of the thurstone word fluency test in neuropsychological evaluations. J. Clin. Neuropsychol. 4, 307\u2013317 (1982).","journal-title":"J. Clin. Neuropsychol."},{"key":"68724_CR41","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","volume":"176","author":"KF Rabe","year":"2007","unstructured":"Rabe, K. F. et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care. Med. 176, 532\u2013555 (2007).","journal-title":"Am. J. Respir. Crit. Care. Med."},{"issue":"5","key":"68724_CR42","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1053\/j.ajkd.2013.12.006","volume":"63","author":"AS Levey","year":"2014","unstructured":"Levey, A. S., Inker, L. A. & Coresh, J. GFR estimation: From physiology to public health. Am. J. Kidney Dis. 63(5), 820\u2013834 (2014).","journal-title":"Am. J. Kidney Dis."},{"key":"68724_CR43","doi-asserted-by":"publisher","DOI":"10.1017\/SJP.2021.46","volume":"24","author":"JJ Igartua","year":"2021","unstructured":"Igartua, J. J. & Hayes, A. F. Mediation, moderation, and conditional process analysis: Concepts, computations, and some common confusions. Span J. Psychol. 24, e49 (2021).","journal-title":"Span J. Psychol."},{"issue":"5","key":"68724_CR44","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1213\/ANE.0000000000006356","volume":"136","author":"KA Tanaka","year":"2023","unstructured":"Tanaka, K. A., Terada, R., Butt, A. L., Mazzeffi, M. A. & McNeil, J. S. Factor VIII: A dynamic modulator of hemostasis and thrombosis in trauma. Anesth. Analg. 136(5), 894\u2013904 (2023).","journal-title":"Anesth. Analg."},{"issue":"3","key":"68724_CR45","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S0950-3536(89)80037-X","volume":"2","author":"D Baruch","year":"1989","unstructured":"Baruch, D., Bahnak, B., Girma, J. P. & Meyer, D. von Willebrand factor and platelet function. Baillieres Clin. Haematol. 2(3), 627\u2013672 (1989).","journal-title":"Baillieres Clin. Haematol."},{"issue":"3","key":"68724_CR46","doi-asserted-by":"publisher","first-page":"e188","DOI":"10.1016\/j.thromres.2010.05.029","volume":"126","author":"J Bach","year":"2010","unstructured":"Bach, J., Haubelt, H. & Hellstern, P. Sources of variation in factor VIII, von Willebrand factor and fibrinogen measurements: Implications for detecting deficiencies and increased plasma levels. Thromb. Res. 126(3), e188\u2013e195 (2010).","journal-title":"Thromb. Res."},{"key":"68724_CR47","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.arr.2010.11.002","volume":"10","author":"T Singh","year":"2011","unstructured":"Singh, T. & Newman, A. B. Inflammatory markers in population studies of aging. Ageing Res. Rev. 10, 319\u2013329 (2011).","journal-title":"Ageing Res. Rev."},{"key":"68724_CR48","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s40520-015-0419-z","volume":"28","author":"K Mekli","year":"2016","unstructured":"Mekli, K., Nazroo, J. Y., Marshall, A. D., Kumari, M. & Pendleton, N. Proinflammatory genotype is associated with the frailty phenotype in the English longitudinal study of ageing. Aging Clin. Exp. Res. 28, 413\u2013421 (2016).","journal-title":"Aging Clin. Exp. Res."},{"key":"68724_CR49","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s10522-010-9286-3","volume":"11","author":"G Candore","year":"2010","unstructured":"Candore, G., Caruso, C. & Colonna-Romano, G. Inflammation, genetic background and longevity. Biogerontology 11, 565\u2013573 (2010).","journal-title":"Biogerontology"},{"key":"68724_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218462","volume":"14","author":"AR Quinones","year":"2019","unstructured":"Quinones, A. R. et al. Racial\/ethnic differences in multimorbidity development and chronic disease accumulation for middle-aged adults. PLoS One 14, e0218462 (2019).","journal-title":"PLoS One"},{"key":"68724_CR51","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1001\/jama.2021.9907","volume":"326","author":"S Mahajan","year":"2021","unstructured":"Mahajan, S. et al. Trends in differences in health status and health care access and affordability by race and ethnicity in the United States, 1999\u20132018. JAMA 326, 637\u2013648 (2021).","journal-title":"JAMA"},{"key":"68724_CR52","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1177\/0898264315569453","volume":"27","author":"EM Friedman","year":"2015","unstructured":"Friedman, E. M., Christ, S. L. & Mroczek, D. K. Inflammation partially mediates the association of multimorbidity and functional limitations in a national sample of middle-aged and older adults: The MIDUS study. J. Aging Health 27, 843\u2013863 (2015).","journal-title":"J. Aging Health"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68724-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68724-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68724-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T10:17:05Z","timestamp":1722248225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68724-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["68724"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-68724-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3794413\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"23 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17434"}}