{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:12:59Z","timestamp":1790187179707,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Key Scientific Research Project of Henan Province University","award":["24A320031"],"award-info":[{"award-number":["24A320031"]}]},{"name":"Key project of Henan Provincial Natural Science Foundation","award":["HNSZRKXJJZDXM2023019"],"award-info":[{"award-number":["HNSZRKXJJZDXM2023019"]}]},{"name":"Central Plains Talent Program-Central Plains Youth Top Talents, Young and Middle-aged Academic Leaders of Henan Provincial Health Commission","award":["HNSWJW-2022013"],"award-info":[{"award-number":["HNSWJW-2022013"]}]},{"name":"Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University","award":["QNCXTD2023002"],"award-info":[{"award-number":["QNCXTD2023002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-68966-8","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T09:03:28Z","timestamp":1724058208000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Alterations in serum metabolomics during the first seizure and after effective control of epilepsy"],"prefix":"10.1038","volume":"14","author":[{"given":"Xiaolei","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"68966_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2174\/1570159x15666170504123316","volume":"16","author":"J Sheng","year":"2018","unstructured":"Sheng, J., Liu, S., Qin, H., Li, B. & Zhang, X. Drug-resistant epilepsy and surgery. Curr. Neuropharmacol. 16, 17\u201328. https:\/\/doi.org\/10.2174\/1570159x15666170504123316 (2018).","journal-title":"Curr. Neuropharmacol."},{"key":"68966_CR2","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2022.6.02","author":"X Liu","year":"2022","unstructured":"Liu, X. & Chen, J. Research progress on ferroptosis and its role in epilepsy. J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc. https:\/\/doi.org\/10.26402\/jpp.2022.6.02 (2022).","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"68966_CR3","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/s0140-6736(18)32596-0","volume":"393","author":"RD Thijs","year":"2019","unstructured":"Thijs, R. D., Surges, R., O\u2019Brien, T. J. & Sander, J. W. Epilepsy in adults. Lancet (London, England) 393, 689\u2013701. https:\/\/doi.org\/10.1016\/s0140-6736(18)32596-0 (2019).","journal-title":"Lancet (London, England)"},{"key":"68966_CR4","doi-asserted-by":"publisher","first-page":"18024","DOI":"10.1038\/nrdp.2018.24","volume":"4","author":"O Devinsky","year":"2018","unstructured":"Devinsky, O. et al. Epilepsy. Nat. Rev. Dis. Primers 4, 18024. https:\/\/doi.org\/10.1038\/nrdp.2018.24 (2018).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"68966_CR5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibtech.2004.03.007","volume":"22","author":"R Goodacre","year":"2004","unstructured":"Goodacre, R., Vaidyanathan, S., Dunn, W. B., Harrigan, G. G. & Kell, D. B. Metabolomics by numbers: Acquiring and understanding global metabolite data. Trends Biotechnol. 22, 245\u2013252. https:\/\/doi.org\/10.1016\/j.tibtech.2004.03.007 (2004).","journal-title":"Trends Biotechnol."},{"key":"68966_CR6","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1021\/acs.jproteome.6b00779","volume":"16","author":"P Liu","year":"2017","unstructured":"Liu, P. et al. Discovery of metabolite biomarkers for acute ischemic stroke progression. J. Proteome Res. 16, 773\u2013779. https:\/\/doi.org\/10.1021\/acs.jproteome.6b00779 (2017).","journal-title":"J. Proteome Res."},{"key":"68966_CR7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10545-015-9876-y","volume":"39","author":"L Abela","year":"2016","unstructured":"Abela, L. et al. N(8)-acetylspermidine as a potential plasma biomarker for Snyder-Robinson syndrome identified by clinical metabolomics. J. Inherit. Metab. Dis. 39, 131\u2013137. https:\/\/doi.org\/10.1007\/s10545-015-9876-y (2016).","journal-title":"J. Inherit. Metab. Dis."},{"key":"68966_CR8","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/epi.16839","volume":"62","author":"E Beamer","year":"2021","unstructured":"Beamer, E. et al. Elevated blood purine levels as a biomarker of seizures and epilepsy. Epilepsia 62, 817\u2013828. https:\/\/doi.org\/10.1111\/epi.16839 (2021).","journal-title":"Epilepsia"},{"key":"68966_CR9","doi-asserted-by":"publisher","DOI":"10.1172\/jci148272","author":"UF Engelke","year":"2021","unstructured":"Engelke, U. F. et al. Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy. J. Clin. Investing. https:\/\/doi.org\/10.1172\/jci148272 (2021).","journal-title":"J. Clin. Investing."},{"key":"68966_CR10","doi-asserted-by":"publisher","first-page":"449","DOI":"10.21037\/atm-22-1219","volume":"10","author":"D Niu","year":"2022","unstructured":"Niu, D., Sun, P., Zhang, F. & Song, F. Metabonomic analysis of cerebrospinal fluid in epilepsy. Ann. Transl. Med. 10, 449. https:\/\/doi.org\/10.21037\/atm-22-1219 (2022).","journal-title":"Ann. Transl. Med."},{"key":"68966_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10100389","author":"A Donatti","year":"2020","unstructured":"Donatti, A., Canto, A. M., Godoi, A. B., da Rosa, D. C. & Lopes-Cendes, I. Circulating metabolites as potential biomarkers for neurological disorders-metabolites in neurological disorders. Metabolites https:\/\/doi.org\/10.3390\/metabo10100389 (2020).","journal-title":"Metabolites"},{"key":"68966_CR12","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3389\/fneur.2017.00459","volume":"8","author":"F Murgia","year":"2017","unstructured":"Murgia, F. et al. Metabolomics as a tool for the characterization of drug-resistant epilepsy. Front. Neurol. 8, 459. https:\/\/doi.org\/10.3389\/fneur.2017.00459 (2017).","journal-title":"Front. Neurol."},{"key":"68966_CR13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/15357597221074518","volume":"22","author":"T Eid","year":"2022","unstructured":"Eid, T. Harnessing metabolomics to advance epilepsy research. Epilepsy Curr. 22, 123\u2013129. https:\/\/doi.org\/10.1177\/15357597221074518 (2022).","journal-title":"Epilepsy Curr."},{"key":"68966_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2021.102271","volume":"167","author":"NR Abuknesha","year":"2021","unstructured":"Abuknesha, N. R. et al. Plasma fatty acid abnormality in Sudanese drug-resistant epileptic patients. Prostaglandins Leukot. Essent. Fatty Acids 167, 102271. https:\/\/doi.org\/10.1016\/j.plefa.2021.102271 (2021).","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"68966_CR15","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1111\/j.1528-1167.2010.02654.x","volume":"51","author":"AY Taha","year":"2010","unstructured":"Taha, A. Y., Burnham, W. M. & Auvin, S. Polyunsaturated fatty acids and epilepsy. Epilepsia 51, 1348\u20131358. https:\/\/doi.org\/10.1111\/j.1528-1167.2010.02654.x (2010).","journal-title":"Epilepsia"},{"key":"68966_CR16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.phrs.2014.03.009","volume":"86","author":"M Melis","year":"2014","unstructured":"Melis, M. & Pistis, M. Targeting the interaction between fatty acid ethanolamides and nicotinic receptors: Therapeutic perspectives. Pharmacol. Res. 86, 42\u201349. https:\/\/doi.org\/10.1016\/j.phrs.2014.03.009 (2014).","journal-title":"Pharmacol. Res."},{"key":"68966_CR17","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/s0896-6273(00)00042-8","volume":"27","author":"HD Mansvelder","year":"2000","unstructured":"Mansvelder, H. D. & McGehee, D. S. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron 27, 349\u2013357. https:\/\/doi.org\/10.1016\/s0896-6273(00)00042-8 (2000).","journal-title":"Neuron"},{"key":"68966_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102105","volume":"204","author":"E Beamer","year":"2021","unstructured":"Beamer, E., Kuchukulla, M., Boison, D. & Engel, T. ATP and adenosine-Two players in the control of seizures and epilepsy development. Prog. Neurobiol. 204, 102105. https:\/\/doi.org\/10.1016\/j.pneurobio.2021.102105 (2021).","journal-title":"Prog. Neurobiol."},{"key":"68966_CR19","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/epi4.12712","volume":"8","author":"HL Guo","year":"2023","unstructured":"Guo, H. L. et al. Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug-refractory epilepsy. Epilepsia open 8, 466\u2013478. https:\/\/doi.org\/10.1002\/epi4.12712 (2023).","journal-title":"Epilepsia open"},{"key":"68966_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/jnc.15044","volume":"158","author":"M Alaamery","year":"2021","unstructured":"Alaamery, M. et al. Role of sphingolipid metabolism in neurodegeneration. J. Neurochem. 158, 25\u201335. https:\/\/doi.org\/10.1111\/jnc.15044 (2021).","journal-title":"J. Neurochem."},{"key":"68966_CR21","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.1021\/acs.jproteome.7b00168","volume":"16","author":"L Song","year":"2017","unstructured":"Song, L. et al. Urine metabonomics reveals early biomarkers in diabetic cognitive dysfunction. J. Proteome Res. 16, 3180\u20133189. https:\/\/doi.org\/10.1021\/acs.jproteome.7b00168 (2017).","journal-title":"J. Proteome Res."},{"key":"68966_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cca.2017.08.022","volume":"473","author":"S Qi","year":"2017","unstructured":"Qi, S. et al. Metabonomics screening of serum identifies pyroglutamate as a diagnostic biomarker for nonalcoholic steatohepatitis. Clin. Chim. Acta Int. J. Clin. CHEM. 473, 89\u201395. https:\/\/doi.org\/10.1016\/j.cca.2017.08.022 (2017).","journal-title":"Clin. Chim. Acta Int. J. Clin. CHEM."},{"key":"68966_CR23","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.1021\/acs.jproteome.5b00354","volume":"14","author":"EA Th\u00e9venot","year":"2015","unstructured":"Th\u00e9venot, E. A., Roux, A., Xu, Y., Ezan, E. & Junot, C. Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. J. Proteome Res. 14, 3322\u20133335. https:\/\/doi.org\/10.1021\/acs.jproteome.5b00354 (2015).","journal-title":"J. Proteome Res."},{"key":"68966_CR24","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/cpbi.86","volume":"68","author":"J Chong","year":"2019","unstructured":"Chong, J., Wishart, D. S. & Xia, J. Using MetaboAnalyst 4.0 for comprehensive and integrative metabolomics data analysis. Curr. Protoc. Bioinf. 68, 86. https:\/\/doi.org\/10.1002\/cpbi.86 (2019).","journal-title":"Curr. Protoc. Bioinf."},{"key":"68966_CR25","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3389\/fcimb.2020.00342","volume":"10","author":"J Lou","year":"2020","unstructured":"Lou, J. et al. Fecal microbiomes distinguish patients with autoimmune hepatitis from healthy individuals. Front. Cell. Infect. Microbial. 10, 342. https:\/\/doi.org\/10.3389\/fcimb.2020.00342 (2020).","journal-title":"Front. Cell. Infect. Microbial."},{"key":"68966_CR26","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/978-1-0716-3072-3_19","volume":"2649","author":"A Coleman","year":"2023","unstructured":"Coleman, A., Bose, A. & Mitra, S. Metagenomics data visualization using R. Methods Mol. Boil. (Clifton, N.J.) 2649, 359\u2013392. https:\/\/doi.org\/10.1007\/978-1-0716-3072-3_19 (2023).","journal-title":"Methods Mol. Boil. (Clifton, N.J.)"},{"key":"68966_CR27","doi-asserted-by":"publisher","first-page":"461","DOI":"10.4037\/ajcc2018525","volume":"27","author":"J Alderden","year":"2018","unstructured":"Alderden, J. et al. Predicting pressure injury in critical care patients: A machine-learning model. Am. J. Crit. Care Off. Pub. Am. Assoc. Crit. Care Nurses 27, 461\u2013468. https:\/\/doi.org\/10.4037\/ajcc2018525 (2018).","journal-title":"Am. J. Crit. Care Off. Pub. Am. Assoc. Crit. Care Nurses"},{"key":"68966_CR28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin, X. et al. pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinf. 12, 77. https:\/\/doi.org\/10.1186\/1471-2105-12-77 (2011).","journal-title":"BMC Bioinf."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68966-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68966-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68966-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T09:06:28Z","timestamp":1724058388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68966-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["68966"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-68966-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]},"assertion":[{"value":"5 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19180"}}