{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:35:14Z","timestamp":1787315714029,"version":"build-2736575974"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Marie Sk\u0142odowska-Curie Initial Training Network nEUROinflammation","award":["607962"],"award-info":[{"award-number":["607962"]}]},{"name":"European Commission Seventh Framework Programme (FP7) for Research and Technological Development"},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014438","name":"Business Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-68986-4","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T15:02:13Z","timestamp":1722610933000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Benserazide is neuroprotective and improves functional recovery after experimental ischemic stroke by altering the immune response"],"prefix":"10.1038","volume":"14","author":[{"given":"Meike Hedwig","family":"Keuters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velta","family":"Keksa-Goldsteine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisia","family":"R\u00f5lova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja","family":"Jaronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinja","family":"Kettunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Halkoluoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gundars","family":"Goldsteins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Koistinaho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiramani","family":"Dhungana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"68986_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s10198-018-0984-0","volume":"20","author":"S Rajsic","year":"2019","unstructured":"Rajsic, S. et al. Economic burden of stroke: A systematic review on post-stroke care. Eur. J. Health Econ. 20, 107\u2013134 (2019).","journal-title":"Eur. J. Health Econ."},{"key":"68986_CR2","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/S1474-4422(16)30177-6","volume":"15","author":"S Bracard","year":"2016","unstructured":"Bracard, S. et al. Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): A randomised controlled trial. Lancet Neurol. 15, 1138\u20131147 (2016).","journal-title":"Lancet Neurol."},{"key":"68986_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000338389","volume":"1","author":"X Liu","year":"2012","unstructured":"Liu, X. Beyond the time window of intravenous thrombolysis: standing by or by stenting?. Interv Neurol. 1, 3\u201315 (2012).","journal-title":"Interv Neurol."},{"key":"68986_CR4","first-page":"616","volume":"12","author":"JE Jones","year":"2009","unstructured":"Jones, J. E. et al. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr. Opin. Drug. Discov. Devel. 12, 616\u2013627 (2009).","journal-title":"Curr. Opin. Drug. Discov. Devel."},{"key":"68986_CR5","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/jcbfm.2015.45","volume":"35","author":"GC Jickling","year":"2015","unstructured":"Jickling, G. C. et al. Targeting neutrophils in ischemic stroke: Translational insights from experimental studies. J. Cereb. Blood Flow Metab. 35, 888\u2013901 (2015).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"68986_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","volume":"16","author":"ZG Fridlender","year":"2009","unstructured":"Fridlender, Z. G. et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN. Cancer Cell 16, 183\u2013194 (2009).","journal-title":"Cancer Cell"},{"key":"68986_CR7","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1161\/STROKEAHA.113.002470","volume":"44","author":"MI Cuartero","year":"2013","unstructured":"Cuartero, M. I. et al. N2 neutrophils, novel players in brain inflammation after stroke: Modulation by the PPAR\u03b3 agonist rosiglitazone. Stroke 44, 3498\u20133508 (2013).","journal-title":"Stroke"},{"key":"68986_CR8","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jneuroim.2018.04.015","volume":"321","author":"DM Hermann","year":"2018","unstructured":"Hermann, D. M. et al. Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target. J. Neuroimmunol. 321, 138\u2013143 (2018).","journal-title":"J. Neuroimmunol."},{"key":"68986_CR9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00702-013-1008-y","volume":"120","author":"C Ossig","year":"2013","unstructured":"Ossig, C. & Reichmann, H. Treatment of Parkinson\u2019s disease in the advanced stage. J. Neural Transm. (Vienna) 120, 523\u2013529 (2013).","journal-title":"J. Neural Transm. (Vienna)"},{"key":"68986_CR10","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1001\/jamainternmed.2013.3733","volume":"173","author":"TJ Wilt","year":"2013","unstructured":"Wilt, T. J. et al. Pharmacologic therapy for primary restless legs syndrome: A systematic review and meta-analysis. JAMA Intern. Med. 173, 496\u2013505 (2013).","journal-title":"JAMA Intern. Med."},{"key":"68986_CR11","unstructured":"Wilt, T.J., et al. AHRQ comparative effectiveness reviews. In Treatment for restless legs syndrome (Agency for Healthcare Research and Quality (US), Rockville (MD), 2012)."},{"key":"68986_CR12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12974-014-0145-z","volume":"11","author":"E Kuric","year":"2014","unstructured":"Kuric, E. & Ruscher, K. Dynamics of major histocompatibility complex class II-positive cells in the postischemic brain\u2013influence of levodopa treatment. J. Neuroinflamm. 11, 145 (2014).","journal-title":"J. Neuroinflamm."},{"key":"68986_CR13","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1111\/ejn.12598","volume":"40","author":"E Kuric","year":"2014","unstructured":"Kuric, E. & Ruscher, K. Reduction of rat brain CD8+ T-cells by levodopa\/benserazide treatment after experimental stroke. Eur. J. Neurosci. 40, 2463\u20132470 (2014).","journal-title":"Eur. J. Neurosci."},{"key":"68986_CR14","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1161\/STROKEAHA.111.638767","volume":"43","author":"K Ruscher","year":"2012","unstructured":"Ruscher, K. et al. Levodopa treatment improves functional recovery after experimental stroke. Stroke 43, 507\u2013513 (2012).","journal-title":"Stroke"},{"key":"68986_CR15","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1038\/nprot.2012.116","volume":"7","author":"Y Shi","year":"2012","unstructured":"Shi, Y. et al. Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks. Nat. Protoc. 7, 1836\u20131846 (2012).","journal-title":"Nat. Protoc."},{"key":"68986_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s13311-016-0504-9","volume":"14","author":"MT Huuskonen","year":"2017","unstructured":"Huuskonen, M. T. et al. The copper bis(thiosemicarbazone) complex Cu(II)(atsm) Is protective against cerebral ischemia through modulation of the inflammatory milieu. Neurotherapeutics 14, 519\u2013532 (2017).","journal-title":"Neurotherapeutics"},{"key":"68986_CR17","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1111\/acel.12106","volume":"12","author":"H Dhungana","year":"2013","unstructured":"Dhungana, H. et al. Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection. Aging Cell 12, 842\u2013850 (2013).","journal-title":"Aging Cell"},{"key":"68986_CR18","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/jcbfm.1994.59","volume":"14","author":"H Kamii","year":"1994","unstructured":"Kamii, H. et al. Prolonged expression of hsp70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase. J. Cereb. Blood Flow Metab. 14, 478\u2013486 (1994).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"68986_CR19","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1161\/01.STR.0000039405.31526.06","volume":"33","author":"A Shuaib","year":"2002","unstructured":"Shuaib, A. et al. Effects of nonpeptide V(1) vasopressin receptor antagonist SR-49059 on infarction volume and recovery of function in a focal embolic stroke model. Stroke 33, 3033\u20133037 (2002).","journal-title":"Stroke"},{"key":"68986_CR20","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1161\/CIRCULATIONAHA.112.103051","volume":"126","author":"F Orsini","year":"2012","unstructured":"Orsini, F. et al. Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia. Circulation 126, 1484\u20131494 (2012).","journal-title":"Circulation"},{"key":"68986_CR21","first-page":"410972","volume":"2013","author":"S Parkkinen","year":"2013","unstructured":"Parkkinen, S. et al. Gait impairment in a rat model of focal cerebral ischemia. Stroke Res. Treat. 2013, 410972 (2013).","journal-title":"Stroke Res. Treat."},{"key":"68986_CR22","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nm.1886","volume":"15","author":"S Gross","year":"2009","unstructured":"Gross, S. et al. Bioluminescence imaging of myeloperoxidase activity in vivo. Nat. Med. 15, 455\u2013461 (2009).","journal-title":"Nat. Med."},{"key":"68986_CR23","doi-asserted-by":"publisher","first-page":"e24437","DOI":"10.7554\/eLife.24437","volume":"6","author":"EF Kenny","year":"2017","unstructured":"Kenny, E. F. et al. Diverse stimuli engage different neutrophil extracellular trap pathways. Elife 6, e24437 (2017).","journal-title":"Elife"},{"key":"68986_CR24","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1183\/09031936.94.07081425","volume":"7","author":"S Nordman","year":"1994","unstructured":"Nordman, S. et al. Increased PMA-induced chemiluminescence from whole blood of patients with bronchial hyperreactivity. Eur. Respir. J. 7, 1425\u20131430 (1994).","journal-title":"Eur. Respir. J."},{"key":"68986_CR25","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/cdd.2011.1","volume":"18","author":"Q Remijsen","year":"2011","unstructured":"Remijsen, Q. et al. Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ. 18, 581\u2013588 (2011).","journal-title":"Cell Death Differ."},{"key":"68986_CR26","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/cr.2010.150","volume":"21","author":"Q Remijsen","year":"2011","unstructured":"Remijsen, Q. et al. Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res. 21, 290\u2013304 (2011).","journal-title":"Cell Res."},{"key":"68986_CR27","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3233\/JPD-130186","volume":"3","author":"D Salat","year":"2013","unstructured":"Salat, D. & Tolosa, E. Levodopa in the treatment of Parkinson\u2019s disease: current status and new developments. J. Parkinsons Dis. 3, 255\u2013269 (2013).","journal-title":"J. Parkinsons Dis."},{"key":"68986_CR28","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13046-017-0530-4","volume":"36","author":"W Li","year":"2017","unstructured":"Li, W. et al. Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2. J. Exp. Clin. Cancer Res. 36, 58 (2017).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"68986_CR29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s12035-019-01763-x","volume":"57","author":"G Oxenkrug","year":"2020","unstructured":"Oxenkrug, G. & Summergrad, P. Benserazide, an inhibitor of peripheral kynurenine metabolism, attenuates olanzapine-induced weight gain, insulin resistance, and dyslipidemia in C57Bl\/6j mice. Mol. Neurobiol. 57, 135\u2013138 (2020).","journal-title":"Mol. Neurobiol."},{"key":"68986_CR30","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3389\/fnins.2019.00595","volume":"13","author":"A Shimozawa","year":"2019","unstructured":"Shimozawa, A. et al. Effect of L-DOPA\/benserazide on propagation of pathological \u03b1-synuclein. Front. Neurosci. 13, 595 (2019).","journal-title":"Front. Neurosci."},{"key":"68986_CR31","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/0014-2999(72)90084-2","volume":"19","author":"J Hyttel","year":"1972","unstructured":"Hyttel, J. & Fjalland, B. Central 5-HTP decarboxylase inhibiting properties of Ro 4-4602 in relation to 5-HTP potentiation in mice. Eur. J. Pharmacol. 19, 112\u2013114 (1972).","journal-title":"Eur. J. Pharmacol."},{"key":"68986_CR32","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s12975-019-00694-y","volume":"11","author":"W Cai","year":"2020","unstructured":"Cai, W. et al. Functional dynamics of neutrophils after ischemic stroke. Transl. Stroke Res. 11, 108\u2013121 (2020).","journal-title":"Transl. Stroke Res."},{"key":"68986_CR33","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00401-014-1381-0","volume":"129","author":"I Perez-de-Puig","year":"2015","unstructured":"Perez-de-Puig, I. et al. Neutrophil recruitment to the brain in mouse and human ischemic stroke. Acta Neuropathol. 129, 239\u2013257 (2015).","journal-title":"Acta Neuropathol."},{"key":"68986_CR34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3389\/fnins.2015.00147","volume":"9","author":"D Amantea","year":"2015","unstructured":"Amantea, D. et al. Rational modulation of the innate immune system for neuroprotection in ischemic stroke. Front. Neurosci. 9, 147 (2015).","journal-title":"Front. Neurosci."},{"key":"68986_CR35","doi-asserted-by":"publisher","first-page":"381","DOI":"10.4049\/jimmunol.1200409","volume":"189","author":"C Allen","year":"2012","unstructured":"Allen, C. et al. Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. J. Immunol. 189, 381\u2013392 (2012).","journal-title":"J. Immunol."},{"key":"68986_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1161\/01.STR.31.1.193","volume":"31","author":"SH Ahmed","year":"2000","unstructured":"Ahmed, S. H. et al. Effects of lipopolysaccharide priming on acute ischemic brain injury. Stroke 31, 193\u2013199 (2000).","journal-title":"Stroke"},{"key":"68986_CR37","doi-asserted-by":"publisher","first-page":"e64034","DOI":"10.1371\/journal.pone.0064034","volume":"8","author":"A \u00dcllen","year":"2013","unstructured":"\u00dcllen, A. et al. Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo. PLoS ONE 8, e64034 (2013).","journal-title":"PLoS ONE"},{"key":"68986_CR38","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1161\/STROKEAHA.107.490193","volume":"38","author":"J Bardutzky","year":"2007","unstructured":"Bardutzky, J. & Schwab, S. Antiedema therapy in ischemic stroke. Stroke 38, 3084\u20133094 (2007).","journal-title":"Stroke"},{"key":"68986_CR39","doi-asserted-by":"publisher","first-page":"339","DOI":"10.5455\/medarh.2016.70.339-341","volume":"70","author":"Z Dostovic","year":"2016","unstructured":"Dostovic, Z. et al. Brain edema after ischaemic stroke. Med. Arch. 70, 339\u2013341 (2016).","journal-title":"Med. Arch."},{"key":"68986_CR40","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S0377-1237(03)80147-8","volume":"59","author":"SK Jha","year":"2003","unstructured":"Jha, S. K. Cerebral edema and its management. Med. J. Armed Forces India 59, 326\u2013331 (2003).","journal-title":"Med. J. Armed Forces India"},{"key":"68986_CR41","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3389\/fphys.2018.01021","volume":"9","author":"S Li","year":"2018","unstructured":"Li, S. et al. Post-stroke hemiplegic gait: New perspective and insights. Front. Physiol. 9, 1021 (2018).","journal-title":"Front. Physiol."},{"key":"68986_CR42","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/jcbfm.2012.185","volume":"33","author":"M Balkaya","year":"2013","unstructured":"Balkaya, M. et al. Assessing post-stroke behavior in mouse models of focal ischemia. J. Cereb. Blood Flow Metab. 33, 330\u2013338 (2013).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"68986_CR43","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jneumeth.2012.02.001","volume":"206","author":"S Hetze","year":"2012","unstructured":"Hetze, S. et al. Gait analysis as a method for assessing neurological outcome in a mouse model of stroke. J. Neurosci. Methods 206, 7\u201314 (2012).","journal-title":"J. Neurosci. Methods"},{"key":"68986_CR44","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1161\/STROKEAHA.111.619163","volume":"42","author":"N Scherbakov","year":"2011","unstructured":"Scherbakov, N. et al. Body weight after stroke: Lessons from the obesity paradox. Stroke 42, 3646\u20133650 (2011).","journal-title":"Stroke"},{"key":"68986_CR45","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1007\/s13311-019-00761-0","volume":"16","author":"N Kolosowska","year":"2019","unstructured":"Kolosowska, N. et al. Peripheral administration of IL-13 induces anti-inflammatory microglial\/macrophage responses and provides neuroprotection in ischemic stroke. Neurotherapeutics 16, 1304\u20131319 (2019).","journal-title":"Neurotherapeutics"},{"key":"68986_CR46","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.bbi.2015.06.013","volume":"49","author":"P Korhonen","year":"2015","unstructured":"Korhonen, P. et al. Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation. Brain Behav. Immun. 49, 322\u2013336 (2015).","journal-title":"Brain Behav. Immun."},{"key":"68986_CR47","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.pneurobio.2007.07.008","volume":"83","author":"W Pan","year":"2007","unstructured":"Pan, W. & Kastin, A. J. Tumor necrosis factor and stroke: Role of the blood-brain barrier. Prog. Neurobiol. 83, 363\u2013374 (2007).","journal-title":"Prog. Neurobiol."},{"key":"68986_CR48","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","volume":"46","author":"SA Liddelow","year":"2017","unstructured":"Liddelow, S. A. & Barres, B. A. Reactive astrocytes: production, function, and therapeutic potential. Immunity 46, 957\u2013967 (2017).","journal-title":"Immunity"},{"key":"68986_CR49","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.neuint.2016.12.016","volume":"107","author":"NR Sims","year":"2017","unstructured":"Sims, N. R. & Yew, W. P. Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function. Neurochem. Int. 107, 88\u2013103 (2017).","journal-title":"Neurochem. Int."},{"key":"68986_CR50","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1523\/JNEUROSCI.18-06-02075.1998","volume":"18","author":"X Wang","year":"1998","unstructured":"Wang, X. et al. Delayed expression of osteopontin after focal stroke in the rat. J. Neurosci. 18, 2075\u20132083 (1998).","journal-title":"J. Neurosci."},{"key":"68986_CR51","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1111\/j.1460-9568.1996.tb01190.x","volume":"8","author":"J Koistinaho","year":"1996","unstructured":"Koistinaho, J. et al. Long-term induction of haem oxygenase-1 (HSP-32) in astrocytes and microglia following transient focal brain ischaemia in the rat. Eur. J. Neurosci. 8, 2265\u20132272 (1996).","journal-title":"Eur. J. Neurosci."},{"key":"68986_CR52","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.2174\/1381612824666180717101104","volume":"24","author":"D Bereczki Jr","year":"2018","unstructured":"Bereczki, D. Jr. et al. Heme oxygenase-1: Clinical relevance in ischemic stroke. Curr. Pharm. Des. 24, 2229\u20132235 (2018).","journal-title":"Curr. Pharm. Des."},{"key":"68986_CR53","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1038\/s41467-020-16191-y","volume":"11","author":"L Kang","year":"2020","unstructured":"Kang, L. et al. Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat. Commun. 11, 2488 (2020).","journal-title":"Nat. Commun."},{"key":"68986_CR54","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s12035-021-02635-z","volume":"59","author":"C Li","year":"2022","unstructured":"Li, C. et al. Neutrophil extracellular traps exacerbate ischemic brain damage. Mol. Neurobiol. 59, 643\u2013656 (2022).","journal-title":"Mol. Neurobiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68986-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68986-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68986-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T16:34:50Z","timestamp":1722616490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-68986-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,2]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["68986"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-68986-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,2]]},"assertion":[{"value":"15 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17949"}}