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However, we know relatively little about trends in males. This study describes United Kingdom (UK) secular trends in breast cancer from 2000 to 2021 for both sexes. We describe a population-based cohort study using UK primary care Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases. There were 5,848,436 eligible females and 5,539,681 males aged 18+\u2009years, with\u2009\u2265\u2009one year of prior data availability in the study period. We estimated\u00a0crude breast cancer incidence rates (IR), prevalence and survival probability at one-, five- and 10-years after diagnosis using the Kaplan\u2013Meier method. Analyses were further stratified by age. Crude\u00a0IR of breast cancer from 2000 to 2021 was 194.4 per 100,000 person-years for females and 1.16 for males. Crude\u00a0prevalence in 2021 was 2.1% for females and 0.009% for males. Both sexes have seen around a 2.5-fold increase in prevalence across time. Incidence increased with age for both sexes, peaking in females aged 60\u201369\u00a0years and males 90+\u2009. There was a drop in incidence for females aged 70\u201379\u00a0years. From 2003\u20132019, incidence increased\u2009&gt;\u2009twofold in younger females (aged 18\u201329: IR 2.12 in 2003 vs. 4.58 in 2018); decreased in females aged 50\u201369\u00a0years; and further declined from 2015 onwards in females aged 70\u201389\u00a0years. Survival probability for females after one-, five-, and ten-years after diagnosis was 95.1%, 80.2%, and 68.4%, and for males 92.9%, 69.0%, and 51.3%. Survival probability at one-year increased by 2.08% points, and survival at five years increased by 5.39% from 2000\u20132004 to 2015\u20132019 for females, particularly those aged 50\u201370\u00a0years. For males, there were no clear time-trends for short-term and long-term survival probability. Changes in incidence of breast cancer in females largely reflect the success of screening programmes, as rates rise and fall in synchronicity with ages of eligibility for such programmes. Overall survival from breast cancer for females has improved from 2000 to 2021, again reflecting the success of screening programmes, early diagnosis, and improvements in treatments. Male breast cancer patients have worse survival outcomes compared to females, highlighting the need to develop male-specific diagnosis and treatment strategies to improve long-term survival in line with females.<\/jats:p>","DOI":"10.1038\/s41598-024-69006-1","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T09:02:37Z","timestamp":1723885357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021"],"prefix":"10.1038","volume":"14","author":[{"given":"Nicola 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