{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:32:05Z","timestamp":1792017125909,"version":"4.4.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03919"],"award-info":[{"award-number":["22H03919"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07706"],"award-info":[{"award-number":["19K07706"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22gm1210011"],"award-info":[{"award-number":["JP22gm1210011"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["DNW-19016"],"award-info":[{"award-number":["DNW-19016"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-69369-5","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T20:30:04Z","timestamp":1723149004000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Confocal microscopic oxygen imaging of xenograft tumors using Ir(III) complexes as in vivo intravascular and intracellular probes"],"prefix":"10.1038","volume":"14","author":[{"given":"Toshitada","family":"Yoshihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuto","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Shiozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Chieh","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Kakuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Rokudai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"69369_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ctrv.2010.05.001","volume":"37","author":"DW Siemann","year":"2011","unstructured":"Siemann, D. W. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents. Cancer Treat. Rev. 37, 63\u201374 (2011).","journal-title":"Cancer Treat. Rev."},{"key":"69369_CR2","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1002\/ijc.32759","volume":"146","author":"F Bochner","year":"2020","unstructured":"Bochner, F. et al. Intravital imaging of vascular anomalies and extracellular matrix remodeling in orthotopic pancreatic tumors. Int. J. Cancer 146, 2209\u20132217 (2020).","journal-title":"Int. J. Cancer"},{"key":"69369_CR3","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","volume":"8","author":"Z Chen","year":"2023","unstructured":"Chen, Z., Han, F., Du, Y., Shi, H. & Zhou, W. Hypoxic microenvironment in cancer: Molecular mechanisms and therapeutic interventions. Signal Transduct. Target. Ther. 8, 70 (2023).","journal-title":"Signal Transduct. Target. Ther."},{"key":"69369_CR4","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10555-007-9055-1","volume":"26","author":"P Vaupel","year":"2007","unstructured":"Vaupel, P. & Mayer, A. Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev. 26, 225\u2013239 (2007).","journal-title":"Cancer Metastasis Rev."},{"key":"69369_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.613114","volume":"11","author":"RA Khouzam","year":"2021","unstructured":"Khouzam, R. A. et al. Tumor hypoxia regulates immune escape\/invasion: Influence on angiogenesis and potential impact of hypoxic biomarkers on cancer therapies. Front. Immunol. 11, 613114 (2021).","journal-title":"Front. Immunol."},{"key":"69369_CR6","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1007\/s11307-021-01615-y","volume":"23","author":"LM Zopf","year":"2021","unstructured":"Zopf, L. M. et al. Cross-modality imaging of murine tumor vasculature: A feasibility study. Mol. Imaging Biol. 23, 874\u2013893 (2021).","journal-title":"Mol. Imaging Biol."},{"key":"69369_CR7","doi-asserted-by":"publisher","first-page":"4609","DOI":"10.1126\/sciadv.abq4609","volume":"8","author":"M Alilou","year":"2022","unstructured":"Alilou, M. et al. A tumor vasculature-based imaging biomarker for predicting response and survival in patients with lung cancer treated with checkpoint inhibitors. Sci. Adv. 8, 4609 (2022).","journal-title":"Sci. Adv."},{"key":"69369_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2660(10)69010-4","volume":"69","author":"AP Pathak","year":"2010","unstructured":"Pathak, A. P., Penet, M.-F. & Bhujwalla, Z. M. MR molecular imaging of tumor vasculature and vascular targets. Adv. Genet. 69, 1\u201330 (2010).","journal-title":"Adv. Genet."},{"key":"69369_CR9","doi-asserted-by":"publisher","first-page":"41970","DOI":"10.1038\/srep41970","volume":"7","author":"M Toi","year":"2017","unstructured":"Toi, M. et al. Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array. Sci. Rep. 7, 41970 (2017).","journal-title":"Sci. Rep."},{"key":"69369_CR10","doi-asserted-by":"publisher","first-page":"5266","DOI":"10.1158\/0008-5472.CAN-15-3534","volume":"76","author":"F Yamauchi","year":"2016","unstructured":"Yamauchi, F., Kamioka, Y., Yano, T. & Matsuda, M. In vivo FRET imaging of tumor endothelial cells highlights a role of low PKA activity in vascular hyperpermeability. Cancer Res. 76, 5266\u20135276 (2016).","journal-title":"Cancer Res."},{"key":"69369_CR11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41598-017-18635-w","volume":"8","author":"V Demidov","year":"2018","unstructured":"Demidov, V. et al. Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography. Sci. Rep. 8, 38 (2018).","journal-title":"Sci. Rep."},{"key":"69369_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201800379","volume":"12","author":"K Karrobi","year":"2019","unstructured":"Karrobi, K., Tank, A., Tabassum, S., Pera, V. & Roblyer, D. Diffuse and nonlinear imaging of multiscale vascular parameters for in vivo monitoring of preclinical mammary tumors. J. Biophotonics 12, e201800379 (2019).","journal-title":"J. Biophotonics"},{"key":"69369_CR13","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00723-021-01383-6","volume":"52","author":"P Vaupel","year":"2021","unstructured":"Vaupel, P., Flood, A. B. & Swartz, H. M. Oxygenation status of malignant tumors vs. normal tissues: Critical evaluation and updated data source based on direct measurements with pO2 microsensors. Appl. Magn. Reson. 52, 1451\u20131479 (2021).","journal-title":"Appl. Magn. Reson."},{"key":"69369_CR14","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14541","volume":"8","author":"HM Swartz","year":"2020","unstructured":"Swartz, H. M. et al. How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen-dependent pathologies. Physiol. Rep. 8, e14541 (2020).","journal-title":"Physiol. Rep."},{"key":"69369_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106687","volume":"139","author":"S Mittal","year":"2023","unstructured":"Mittal, S. & Mallia, M. B. Molecular imaging of tumor hypoxia: Evolution of nitroimidazole radiopharmaceuticals and insights for future development. Bioorg. Chem. 139, 106687 (2023).","journal-title":"Bioorg. Chem."},{"key":"69369_CR16","first-page":"3988","volume":"52","author":"DF Wilson","year":"1992","unstructured":"Wilson, D. F. & Cerniglia, G. L. Localization of tumors and evaluation of their state of oxygenation by phosphorescence imaging. Cancer Res. 52, 3988\u20133993 (1992).","journal-title":"Cancer Res."},{"key":"69369_CR17","doi-asserted-by":"publisher","first-page":"6160","DOI":"10.1021\/acs.chemrev.6b00525","volume":"117","author":"JN Liu","year":"2017","unstructured":"Liu, J. N., Bu, W. & Shi, J. Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia. Chem Rev. 117, 6160\u20136224 (2017).","journal-title":"Chem Rev."},{"key":"69369_CR18","doi-asserted-by":"publisher","first-page":"4787","DOI":"10.1158\/0008-5472.CAN-19-0530","volume":"79","author":"X Zheng","year":"2019","unstructured":"Zheng, X. et al. A near-infrared phosphorescent nanoprobe enables quantitative, longitudinal imaging of tumor hypoxia dynamics during radiotherapy. Cancer Res. 79, 4787\u20134797 (2019).","journal-title":"Cancer Res."},{"key":"69369_CR19","doi-asserted-by":"publisher","first-page":"18732","DOI":"10.1038\/s41598-023-46224-7","volume":"13","author":"AV Zhdanov","year":"2023","unstructured":"Zhdanov, A. V. et al. Analysis of tumour oxygenation in model animals on a phosphorescence lifetime based macro-imager. Sci. Rep. 13, 18732 (2023).","journal-title":"Sci. Rep."},{"key":"69369_CR20","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.cmet.2018.12.022","volume":"29","author":"TV Esipova","year":"2019","unstructured":"Esipova, T. V. et al. Oxyphor 2P: A high-performance probe for deep-tissue longitudinal oxygen imaging. Cell Metab. 29, 736-744.e7 (2019).","journal-title":"Cell Metab."},{"key":"69369_CR21","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nature13034","volume":"508","author":"JA Spencer","year":"2014","unstructured":"Spencer, J. A. et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 508, 269\u2013273 (2014).","journal-title":"Nature"},{"key":"69369_CR22","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/s41586-020-1971-z","volume":"578","author":"C Christodoulou","year":"2020","unstructured":"Christodoulou, C. et al. Live-animal imaging of native haematopoietic stem and progenitor cells. Nature 578, 278\u2013283 (2020).","journal-title":"Nature"},{"key":"69369_CR23","volume":"23","author":"I \u015eencan","year":"2018","unstructured":"\u015eencan, I. et al. Two-photon phosphorescence lifetime microscopy of retinal capillary plexus oxygenation in mice. J. Biomed. Opt. 23, 126501 (2018).","journal-title":"J. Biomed. Opt."},{"key":"69369_CR24","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/s41467-020-14415-9","volume":"11","author":"X Cao","year":"2020","unstructured":"Cao, X. et al. Tissue pO2 distributions in xenograft tumors dynamically imaged by Cherenkov-excited phosphorescence during fractionated radiation therapy. Nat. Commun. 11, 573 (2020).","journal-title":"Nat. Commun."},{"key":"69369_CR25","doi-asserted-by":"publisher","first-page":"8700","DOI":"10.1039\/c3cs60131e","volume":"42","author":"DB Papkovsky","year":"2013","unstructured":"Papkovsky, D. B. & Dmitriev, R. Biological detection by optical oxygen sensing. Chem Soc. Rev. 42, 8700\u20138732 (2013).","journal-title":"Chem Soc. Rev."},{"key":"69369_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cbpa.2016.05.017","volume":"33","author":"S Tobita","year":"2016","unstructured":"Tobita, S. & Yoshihara, T. Intracellular and in vivo oxygen sensing using phosphorescent iridium(III) complexes. Curr. Opin. Chem. Biol. 33, 39\u201345 (2016).","journal-title":"Curr. Opin. Chem. Biol."},{"key":"69369_CR27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jphotochemrev.2017.01.001","volume":"30","author":"T Yoshihara","year":"2017","unstructured":"Yoshihara, T., Hirakawa, Y., Hosaka, M., Nangaku, M. & Tobita, S. Oxygen imaging of living cells and tissues using luminescent molecular probes. J. Photochem. Photobiol. C 30, 71\u201395 (2017).","journal-title":"J. Photochem. Photobiol. C"},{"key":"69369_CR28","doi-asserted-by":"publisher","first-page":"7827","DOI":"10.1021\/jacs.8b02492","volume":"140","author":"KY Zhang","year":"2018","unstructured":"Zhang, K. Y. et al. Dual-phosphorescent iridium(III) complexes extending oxygen sensing from hypoxia to hyperoxia. J. Am. Chem. Soc. 140, 7827\u20137834 (2018).","journal-title":"J. Am. Chem. Soc."},{"key":"69369_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213344","volume":"416","author":"S Shaikh","year":"2020","unstructured":"Shaikh, S., Wang, Y., Rehman, F. U., Jiang, H. & Wang, X. Phosphorescent Ir(III) complexes as cellular staining agents for biomedical molecular imaging. Coord. Chem. Rev. 416, 213344 (2020).","journal-title":"Coord. Chem. Rev."},{"key":"69369_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214334","volume":"453","author":"J Zhou","year":"2022","unstructured":"Zhou, J., Li, J., Zhang, K. Y., Liu, S. & Zhao, Q. Phosphorescent iridium(III) complexes as lifetime-based biological sensors for photoluminescence lifetime imaging microscopy. Coord. Chem. Rev. 453, 214334 (2022).","journal-title":"Coord. Chem. Rev."},{"key":"69369_CR31","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3390\/bios13070680","volume":"13","author":"M Samandarsangari","year":"2023","unstructured":"Samandarsangari, M. et al. Biocompatible phosphorescent O2 sensors based on Ir(III) complexes for in vivo hypoxia imaging. Biosensors 13, 680 (2023).","journal-title":"Biosensors"},{"key":"69369_CR32","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/j.kint.2018.01.015","volume":"93","author":"Y Hirakawa","year":"2018","unstructured":"Hirakawa, Y. et al. Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia. Kidney. Int. 93, 1483\u20131489 (2018).","journal-title":"Kidney. Int."},{"key":"69369_CR33","doi-asserted-by":"publisher","first-page":"21053","DOI":"10.1038\/s41598-020-76878-6","volume":"10","author":"K Mizukami","year":"2020","unstructured":"Mizukami, K. et al. In vivo O2 imaging in hepatic tissues by phosphorescence lifetime imaging microscopy using Ir(III) complexes as intracellular probes. Sci. Rep. 10, 21053 (2020).","journal-title":"Sci. Rep."},{"key":"69369_CR34","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1021\/acs.analchem.1c04271","volume":"94","author":"K Mizukami","year":"2022","unstructured":"Mizukami, K., Muraoka, T., Shiozaki, S., Tobita, S. & Yoshihara, T. Near-infrared emitting Ir(III) complexes bearing a dipyrromethene ligand for oxygen imaging of deeper tissues in vivo. Anal. Chem. 94, 2794\u20132802 (2022).","journal-title":"Anal. Chem."},{"key":"69369_CR35","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1021\/acssensors.1c02379","volume":"7","author":"T Yoshihara","year":"2022","unstructured":"Yoshihara, T., Matsumura, N., Tamura, T., Shiozaki, S. & Tobita, S. Intracellular and intravascular oxygen sensing of pancreatic tissues based on phosphorescence lifetime imaging microscopy using lipophilic and hydrophilic iridium(III) complexes. ACS Sens. 7, 545\u2013554 (2022).","journal-title":"ACS Sens."},{"key":"69369_CR36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1039\/9781788013451-00071","volume-title":"RSC Detection Science: Quenched-Phosphorescence Detection of Molecular Oxygen: Application in Life Sciences","author":"T Yoshihara","year":"2018","unstructured":"Yoshihara, T., Hirakawa, Y., Nangaku, M. & Tobita, S. Hydrophilic Ir(III) complexes for in vitro and in vivo oxygen imaging. In RSC Detection Science: Quenched-Phosphorescence Detection of Molecular Oxygen: Application in Life Sciences (eds Papkovsky, D. B. & Dmitriev, R. I.) 71\u201390 (Royal Society of Chemistry, 2018)."},{"key":"69369_CR37","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1021\/ar900035f","volume":"42","author":"ME Fox","year":"2009","unstructured":"Fox, M. E., Szoka, F. C. & Fr\u00e9chet, J. M. J. Soluble polymer carriers for the treatment of cancer: The importance of molecular architecture. Acc. Chem. Res. 42, 1141\u20131151 (2009).","journal-title":"Acc. Chem. Res."},{"key":"69369_CR38","doi-asserted-by":"publisher","first-page":"12369","DOI":"10.1073\/pnas.0913667107","volume":"107","author":"A Ruggiero","year":"2010","unstructured":"Ruggiero, A. et al. Paradoxical glomerular filtration of carbon nanotubes. Proc. Natl. Acad. Sci. U. S. A. 107, 12369\u201312374 (2010).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"69369_CR39","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1152\/physrev.00055.2006","volume":"88","author":"B Haraldsson","year":"2008","unstructured":"Haraldsson, B., Nystr\u00f6m, J. & Deen, W. M. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol. Rev. 88, 451\u2013487 (2008).","journal-title":"Physiol. Rev."},{"key":"69369_CR40","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1021\/la990423i","volume":"16","author":"A Valstar","year":"2000","unstructured":"Valstar, A., Almgren, M., Brown, W. & Vasilescu, M. The interaction of bovine serum albumin with surfactants studied by light scattering. Langmuir 16, 922\u2013927 (2000).","journal-title":"Langmuir"},{"key":"69369_CR41","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0376-7388(97)00329-3","volume":"142","author":"S Singh","year":"1998","unstructured":"Singh, S., Khulbe, K. C., Matsuura, T. & Ramamurthy, P. Membrane characterization by solute transport and atomic force microscopy. J. Membr. Sci. 142, 111\u2013127 (1998).","journal-title":"J. Membr. Sci."},{"key":"69369_CR42","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrc1367","volume":"4","author":"JM Brown","year":"2004","unstructured":"Brown, J. M. & Wilson, W. R. Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer 4, 437\u2013447 (2004).","journal-title":"Nat. Rev. Cancer"},{"key":"69369_CR43","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.1021\/ac5040067","volume":"87","author":"T Yoshihara","year":"2015","unstructured":"Yoshihara, T. et al. Intracellular and in vivo oxygen sensing using phosphorescent Ir(III) complexes with a modified acetylacetonato ligand. Anal. Chem. 87, 2710\u20132717 (2015).","journal-title":"Anal. Chem."},{"key":"69369_CR44","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fchem.2018.00027","volume":"6","author":"V Mirabello","year":"2018","unstructured":"Mirabello, V., Cortezon-Tamarit, F. & Pascu, S. L. Oxygen sensing, hypoxia tracing and in vivo imaging with functional metalloprobes for the early detection of non-communicable diseases. Front. Chem. 6, 27 (2018).","journal-title":"Front. Chem."},{"key":"69369_CR45","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.3390\/cancers13061233","volume":"13","author":"H Takahashi","year":"2021","unstructured":"Takahashi, H. et al. AKT3 is a novel regulator of cancer-associated fibroblasts in head and neck squamous cell carcinoma. Cancers 13, 1233 (2021).","journal-title":"Cancers"},{"key":"69369_CR46","doi-asserted-by":"publisher","first-page":"153303382110630","DOI":"10.1177\/15330338211036304","volume":"20","author":"Y Li","year":"2021","unstructured":"Li, Y., Zhao, L. & Li, X.-F. Hypoxia and the tumor microenvironment. Technol. Cancer Res. Treat. 20, 1533033821106304 (2021).","journal-title":"Technol. Cancer Res. Treat."},{"key":"69369_CR47","doi-asserted-by":"publisher","first-page":"9850","DOI":"10.1039\/b912178a","volume":"11","author":"K Suzuki","year":"2009","unstructured":"Suzuki, K. et al. Reevaluation of absolute luminescence quantum yields of standard solutions using a spectrometer with an integrating sphere and a back-thinned CCD detector. Phys. Chem. Chem. Phys. 11, 9850\u20139860 (2009).","journal-title":"Phys. Chem. Chem. Phys."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69369-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69369-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69369-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T21:03:51Z","timestamp":1723151031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69369-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["69369"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-69369-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"assertion":[{"value":"8 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18443"}}