{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:32:04Z","timestamp":1771579924279,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-69388-2","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:02:18Z","timestamp":1723539738000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility, safety and outcomes of conduction system pacing for bradycardia amongst the very elderly"],"prefix":"10.1038","volume":"14","author":[{"given":"Eugene S. J.","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney","family":"Soh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-Ying","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Boey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew-Pang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swee-Chong","family":"Seow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa J. T.","family":"Teo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vern Hsen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pipin","family":"Kojodjojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"69388_CR1","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1016\/j.jacc.2018.03.019","volume":"71","author":"AB Curtis","year":"2018","unstructured":"Curtis, A. B., Karki, R., Hattoum, A. & Sharma, U. C. Arrhythmias in patients \u2265 80 years of age: Pathophysiology, management, and outcomes. J. Am. Coll. Cardiol. 71, 2041\u20132057 (2018).","journal-title":"J. Am. Coll. Cardiol."},{"key":"69388_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s40675-021-00212-3","volume":"7","author":"ESJ Tan","year":"2021","unstructured":"Tan, E. S. J. & Lee, C.-H. Obstructive sleep apnea and arrhythmias in the elderly. Curr. Sleep Med. Rep. 7, 197\u2013205 (2021).","journal-title":"Curr. Sleep Med. Rep."},{"key":"69388_CR3","first-page":"1144","volume":"25","author":"J Vespa","year":"2020","unstructured":"Vespa, J., Medina, L. & Armstrong, D. Demographic turning points for the United States: \u201cPopulation projections for 2020 to 2060. Curr. Popul. Rep. US Census Bureau 25, 1144 (2020).","journal-title":"Curr. Popul. Rep. US Census Bureau"},{"key":"69388_CR4","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/pace.14161","volume":"44","author":"S Westaway","year":"2021","unstructured":"Westaway, S. et al. Trends in the use, complications, and costs of permanent pacemakers in Australia: A nationwide study from 2008 to 2017. Pacing Clin. Electrophysiol. 44, 266\u2013273 (2021).","journal-title":"Pacing Clin. Electrophysiol."},{"key":"69388_CR5","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.cjca.2014.04.010","volume":"30","author":"TF Chao","year":"2014","unstructured":"Chao, T. F. et al. Long-term prognosis of patients older than ninety years after permanent pacemaker implantation: Does the procedure save the patients?. Can. J. Cardiol. 30, 1196\u20131201 (2014).","journal-title":"Can. J. Cardiol."},{"key":"69388_CR6","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1002\/clc.23083","volume":"41","author":"D Dang","year":"2018","unstructured":"Dang, D. et al. Procedural safety and long-term follow-up after pacemaker implantation in nonagenarians. Clin. Cardiol. 41, 1315\u20131321 (2018).","journal-title":"Clin. Cardiol."},{"key":"69388_CR7","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1056\/NEJM199804163381602","volume":"338","author":"GA Lamas","year":"1998","unstructured":"Lamas, G. A. et al. Quality of life and clinical outcomes in elderly patients treated with ventricular pacing as compared with dual-chamber pacing. Pacemaker selection in the elderly investigators. N. Engl. J. Med. 338, 1097\u20131104 (1998).","journal-title":"N. Engl. J. Med."},{"key":"69388_CR8","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1161\/CIRCULATIONAHA.113.001434","volume":"127","author":"A Mandawat","year":"2013","unstructured":"Mandawat, A., Curtis, J. P., Mandawat, A., Njike, V. Y. & Lampert, R. Safety of pacemaker implantation in nonagenarians: An analysis of the healthcare cost and utilization project-nationwide inpatient sample. Circulation 127, 1453\u20131465 (2013).","journal-title":"Circulation"},{"key":"69388_CR9","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/S0002-8703(03)00453-8","volume":"146","author":"B Schmidt","year":"2003","unstructured":"Schmidt, B. et al. Pacemaker therapy in very elderly patients: long-term survival and prognostic parameters. Am. Heart J. 146, 908\u2013913 (2003).","journal-title":"Am. Heart J."},{"key":"69388_CR10","doi-asserted-by":"publisher","first-page":"476","DOI":"10.7326\/0003-4819-125-6-199609150-00008","volume":"125","author":"WK Shen","year":"1996","unstructured":"Shen, W. K. et al. Survival and functional independence after implantation of a permanent pacemaker in octogenarians and nonagenarians. A population-based study. Ann. Intern. Med. 125, 476\u2013480 (1996).","journal-title":"Ann. Intern. Med."},{"key":"69388_CR11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1093\/europace\/eur329","volume":"14","author":"EO Udo","year":"2012","unstructured":"Udo, E. O. et al. Long-term outcome of cardiac pacing in octogenarians and nonagenarians. Europace 14, 502\u2013508 (2012).","journal-title":"Europace"},{"key":"69388_CR12","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.jacep.2022.10.016","volume":"9","author":"ESJ Tan","year":"2023","unstructured":"Tan, E. S. J. et al. Clinical outcomes in conduction system pacing compared to right ventricular pacing in bradycardia. JACC Clin. Electrophysiol. 9, 992\u20131001 (2023).","journal-title":"JACC Clin. Electrophysiol."},{"key":"69388_CR13","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1016\/j.jacc.2018.02.048","volume":"71","author":"M Abdelrahman","year":"2018","unstructured":"Abdelrahman, M. et al. Clinical outcomes of his bundle pacing compared to right ventricular pacing. J. Am. Coll. Cardiol. 71, 2319\u20132330 (2018).","journal-title":"J. Am. Coll. Cardiol."},{"key":"69388_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.hrthm.2021.08.033","volume":"19","author":"PS Sharma","year":"2022","unstructured":"Sharma, P. S. et al. Clinical outcomes of left bundle branch area pacing compared to right ventricular pacing: Results from the Geisinger-Rush Conduction System Pacing Registry. Heart Rhythm 19, 3\u201311 (2022).","journal-title":"Heart Rhythm"},{"key":"69388_CR15","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/j.jacep.2022.12.022","volume":"9","author":"ESJ Tan","year":"2023","unstructured":"Tan, E. S. J. et al. Comparison of pacing performance and clinical outcomes between left bundle branch and his bundle pacing. JACC Clin. Electrophysiol. 9, 1393\u20131403 (2023).","journal-title":"JACC Clin. Electrophysiol."},{"key":"69388_CR16","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1093\/europace\/euab278","volume":"24","author":"J De Leon","year":"2022","unstructured":"De Leon, J. et al. Adopting permanent His bundle pacing: Learning curves and medium-term outcomes. Europace 24, 606\u2013613 (2022).","journal-title":"Europace"},{"key":"69388_CR17","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1111\/jce.15528","volume":"33","author":"ESJ Tan","year":"2022","unstructured":"Tan, E. S. J. et al. Use of extendable helix leads for conduction system pacing: Differences in lead handling and performance lead design impacts conduction system pacing. J. Cardiovasc. Electrophysiol. 33, 1550\u20131557 (2022).","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"69388_CR18","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/jce.15881","volume":"34","author":"ESJ Tan","year":"2023","unstructured":"Tan, E. S. J. et al. Conduction system versus biventricular pacing in heart failure with non-left bundle branch block. J. Cardiovasc. Electrophysiol. 34, 976\u2013983 (2023).","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"69388_CR19","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.hrthm.2023.01.031","volume":"20","author":"ESJ Tan","year":"2023","unstructured":"Tan, E. S. J. et al. Simplifying follow-up of left bundle branch pacing leads: Assessment of left bundle branch capture using a programmer only. Heart Rhythm 20, 777\u2013778 (2023).","journal-title":"Heart Rhythm"},{"key":"69388_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1540-8159.2011.03240.x","volume":"35","author":"LV Armaganijan","year":"2012","unstructured":"Armaganijan, L. V. et al. Are elderly patients at increased risk of complications following pacemaker implantation? A meta-analysis of randomized trials. Pacing Clin. Electrophysiol. 35, 131\u2013134 (2012).","journal-title":"Pacing Clin. Electrophysiol."},{"key":"69388_CR21","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1093\/europace\/eus313","volume":"15","author":"D Catanzariti","year":"2013","unstructured":"Catanzariti, D. et al. Permanent His-bundle pacing maintains long-term ventricular synchrony and left ventricular performance, unlike conventional right ventricular apical pacing. Europace 15, 546\u2013553 (2013).","journal-title":"Europace"},{"key":"69388_CR22","doi-asserted-by":"publisher","first-page":"e483","DOI":"10.1161\/CIR.0000000000000629","volume":"140","author":"DJ Slotwiner","year":"2019","unstructured":"Slotwiner, D. J. et al. Impact of physiologic pacing versus right ventricular pacing among patients with left ventricular ejection fraction greater than 35%: A systematic review for the 2018 ACC\/AHA\/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation 140, e483\u2013e503 (2019).","journal-title":"Circulation"},{"key":"69388_CR23","doi-asserted-by":"publisher","first-page":"12200","DOI":"10.1038\/s41598-021-91610-8","volume":"11","author":"N Tokavanich","year":"2021","unstructured":"Tokavanich, N. et al. A network meta-analysis and systematic review of change in QRS duration after left bundle branch pacing, His bundle pacing, biventricular pacing, or right ventricular pacing in patients requiring permanent pacemaker. Sci. Rep. 11, 12200 (2021).","journal-title":"Sci. Rep."},{"key":"69388_CR24","doi-asserted-by":"publisher","first-page":"100070","DOI":"10.1016\/j.jacadv.2022.100070","volume":"1","author":"P Goyal","year":"2022","unstructured":"Goyal, P. et al. Geriatric cardiology: Coming of age. JACC Adv. 1, 100070 (2022).","journal-title":"JACC Adv."},{"key":"69388_CR25","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1136\/heartjnl-2022-321723","volume":"109","author":"SS Ponnusamy","year":"2023","unstructured":"Ponnusamy, S. S., Syed, T. & Vijayaraman, P. Pacing induced cardiomyopathy: Recognition and management. Heart 109, 1407\u20131415 (2023).","journal-title":"Heart"},{"key":"69388_CR26","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.hrthm.2017.12.022","volume":"15","author":"P Vijayaraman","year":"2018","unstructured":"Vijayaraman, P. et al. Permanent His-bundle pacing: Long-term lead performance and clinical outcomes. Heart Rhythm 15, 696\u2013702 (2018).","journal-title":"Heart Rhythm"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69388-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69388-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69388-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:05:32Z","timestamp":1723539932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69388-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["69388"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-69388-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"5 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18755"}}