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Estradiol Benzoate (EB) was utilized in a dose f (60 \u03bcg\/100 g, i.m) three times\/week for 4 weeks to induce cervical hyperkeratosis. VIN was administered alone in a dose of (10 mg\/kg\/day, orally) for 4 weeks and in the presence of EB. Levels of malondialdehyde (MDA), total nitrites (NOx), reduced glutathione (GSH), interleukin-18 (IL-18), IL-1\u03b2, tumor necrosis factor-alpha (TNF-\u03b1) were measured in cervical tissue. The expression of NLRP3\/GSDMD\/Caspase-1, and SIRT1\/Nrf2 was determined using ELISA. Cervical histopathological examination was also done. EB significantly raised MDA, NOx, TNF-\u03b1, IL-18, IL-1\u03b2, and GSDMD and up-regulated NLRP3\/Caspase-1 proteins. However, GSH, SIRT1, and Nrf2 levels were reduced in cervical tissue. VIN significantly alleviates all biochemical and histopathological abnormalities. 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