{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:25:52Z","timestamp":1788038752812,"version":"build-2784847793"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K02584"],"award-info":[{"award-number":["24K02584"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K02591"],"award-info":[{"award-number":["24K02591"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19cm0106502"],"award-info":[{"award-number":["JP19cm0106502"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-69796-4","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T15:05:03Z","timestamp":1723561503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Integrated genomic\/epigenomic analysis stratifies subtypes of clear cell ovarian carcinoma, highlighting their cellular origin"],"prefix":"10.1038","volume":"14","author":[{"given":"Akira","family":"Nishijima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosei","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Koso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genta","family":"Nagae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tatsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Tanikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenbun","family":"Sone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuyo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Ikemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Ushiku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Osuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Aburatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"69796_CR1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/diagnostics11020199","volume":"11","author":"G Santandrea","year":"2021","unstructured":"Santandrea, G. et al. Immunohistochemical biomarkers as a surrogate of molecular analysis in ovarian carcinomas: A review of the literature. Diagnostics (Basel) 11, 199 (2021).","journal-title":"Diagnostics (Basel)"},{"key":"69796_CR2","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nature10166","volume":"474","author":"Cancer Genome Atlas Research Network","year":"2011","unstructured":"Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474, 609\u2013615 (2011).","journal-title":"Nature"},{"issue":"Suppl 3","key":"69796_CR3","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1097\/IGC.0000000000000289","volume":"24","author":"A Okamoto","year":"2014","unstructured":"Okamoto, A. et al. Gynecologic cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the ovary. Int. J. Gynecol. Cancer 24(Suppl 3), S20\u2013S25 (2014).","journal-title":"Int. J. Gynecol. Cancer"},{"key":"69796_CR4","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ygyno.2018.09.001","volume":"151","author":"K Oda","year":"2018","unstructured":"Oda, K., Hamanishi, J., Matsuo, K. & Hasegawa, K. Genomics to immunotherapy of ovarian clear cell carcinoma: unique opportunities for management. Gynecol. Oncol. 151, 381\u2013389 (2018).","journal-title":"Gynecol. Oncol."},{"key":"69796_CR5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nature14410","volume":"521","author":"AM Patch","year":"2015","unstructured":"Patch, A. M. et al. Whole\u2013genome characterization of chemoresistant ovarian cancer. Nature 521, 489\u2013494 (2015).","journal-title":"Nature"},{"key":"69796_CR6","first-page":"1","volume":"6460","author":"BM Norquist","year":"2015","unstructured":"Norquist, B. M. et al. Inherited mutations in women with ovarian carcinoma. JAMA Oncol. 6460, 1\u20139 (2015).","journal-title":"JAMA Oncol."},{"key":"69796_CR7","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/ng.3849","volume":"49","author":"YK Wang","year":"2017","unstructured":"Wang, Y. K. et al. Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes. Nat. Genet. 49, 856\u2013865 (2017).","journal-title":"Nat. Genet."},{"key":"69796_CR8","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.1158\/1078-0432.CCR-21-3817","volume":"28","author":"KL Bolton","year":"2022","unstructured":"Bolton, K. L. et al. Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes. Clin. Cancer Res. 28, 4947\u20134956 (2022).","journal-title":"Clin. Cancer Res."},{"key":"69796_CR9","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1101\/gad.225680.113","volume":"27","author":"MC Jaramillo","year":"2013","unstructured":"Jaramillo, M. C. & Zhang, D. D. The emerging role of the Nrf2\u2013Keap1 signaling pathway in cancer. Genes Dev. 27, 2179\u20132191 (2013).","journal-title":"Genes Dev."},{"key":"69796_CR10","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1158\/1535-7163.MCT-15-0945","volume":"15","author":"M Choi","year":"2016","unstructured":"Choi, M., Kipps, T. & Kurzrock, R. ATM mutations in cancer: therapeutic implications. Mol. Cancer Ther. 15, 1781\u20131791 (2016).","journal-title":"Mol. Cancer Ther."},{"key":"69796_CR11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1158\/2159-8290.CD-16-0127","volume":"7","author":"Y Jeong","year":"2017","unstructured":"Jeong, Y. et al. Role of KEAP1\/NRF2 and TP53 mutations in lung squamous cell carcinoma development and radiation resistance. Cancer Discov. 7, 86\u2013101 (2017).","journal-title":"Cancer Discov."},{"key":"69796_CR12","doi-asserted-by":"publisher","first-page":"17808","DOI":"10.1038\/s41598-019-54116-y","volume":"9","author":"K Sugino","year":"2019","unstructured":"Sugino, K. et al. Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients. Sci. Rep. 9, 17808 (2019).","journal-title":"Sci. Rep."},{"key":"69796_CR13","doi-asserted-by":"publisher","first-page":"3962","DOI":"10.1158\/1078-0432.CCR-18-3691","volume":"25","author":"M Takenaka","year":"2019","unstructured":"Takenaka, M. et al. Survival following chemotherapy in ovarian clear cell carcinoma is not associated with pathological misclassification of tumor histotype. Clin. Cancer Res. 25, 3962\u20133973 (2019).","journal-title":"Clin. Cancer Res."},{"key":"69796_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2021.798173","volume":"11","author":"H Liu","year":"2022","unstructured":"Liu, H. et al. Next-generation sequencing reveals a very low prevalence of deleterious mutations of homologous recombination repair genes and homologous recombination deficiency in ovarian clear cell carcinoma. Front. Oncol. 11, 1\u20139 (2022).","journal-title":"Front. Oncol."},{"key":"69796_CR15","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1136\/ijgc-2019-000384","volume":"29","author":"T Enomoto","year":"2019","unstructured":"Enomoto, T. et al. The first Japanese nationwide multicenter study of BRCA mutation testing in ovarian cancer: CHARacterizing the cross-sectionaL approach to Ovarian cancer geneTic TEsting of BRCA (Charlotte). Int. J. Gynecol. Cancer 29, 1043\u20131049 (2019).","journal-title":"Int. J. Gynecol. Cancer"},{"key":"69796_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128066","volume":"10","author":"Y Uehara","year":"2015","unstructured":"Uehara, Y. et al. Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas. PLOS One 10, e0128066 (2015).","journal-title":"PLOS One"},{"key":"69796_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057724","volume":"8","author":"Y Yamashita","year":"2013","unstructured":"Yamashita, Y. et al. Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. PLOS one 8, e57724 (2013).","journal-title":"PLOS one"},{"key":"69796_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12935-015-0267-0","volume":"15","author":"S Matsuzaki","year":"2015","unstructured":"Matsuzaki, S. et al. Potential targets for ovarian clear cell carcinoma: a review of updates and future perspectives. Cancer Cell Int. 15, 117 (2015).","journal-title":"Cancer Cell Int."},{"key":"69796_CR19","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.ajpath.2015.11.011","volume":"186","author":"RJ Kurman","year":"2016","unstructured":"Kurman, R. J. & Shih, I. M. The dualistic model of ovarian carcinogenesis revisited, revised, and expanded. Am. J. Pathol. 186, 733\u2013747 (2016).","journal-title":"Am. J. Pathol."},{"key":"69796_CR20","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.ygyno.2011.01.005","volume":"121","author":"MS Anglesio","year":"2011","unstructured":"Anglesio, M. S. et al. Clear cell carcinoma of the ovary: A report from the first ovarian clear cell symposium, June 24th, 2010. Gynecol. Oncol. 121, 407\u2013415 (2011).","journal-title":"Gynecol. Oncol."},{"key":"69796_CR21","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1470-2045(11)70404-1","volume":"13","author":"CL Pearce","year":"2012","unstructured":"Pearce, C. L. et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: A pooled analysis of case-control studies. Lancet Oncol 13, 385\u2013394 (2012).","journal-title":"Lancet Oncol"},{"key":"69796_CR22","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1056\/NEJMoa1614814","volume":"376","author":"MS Anglesio","year":"2017","unstructured":"Anglesio, M. S. et al. Cancer-associated mutations in endometriosis without cancer. N. Engl. J. Med. 376, 1835\u20131848 (2017).","journal-title":"N. Engl. J. Med."},{"key":"69796_CR23","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature12477","volume":"500","author":"LB Alexandrov","year":"2013","unstructured":"Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415\u2013421 (2013).","journal-title":"Nature"},{"key":"69796_CR24","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nrg3729","volume":"15","author":"T Helleday","year":"2014","unstructured":"Helleday, T., Eshtad, S. & Nik-Zainal, S. Mechanisms underlying mutational signatures in human cancers. Nat. Rev. Genet. 15, 585\u2013598 (2014).","journal-title":"Nat. Rev. Genet."},{"key":"69796_CR25","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature26000","volume":"555","author":"D Capper","year":"2018","unstructured":"Capper, D. et al. DNA methylation-based classification of central nervous system tumours. Nature 555, 469\u2013474 (2018).","journal-title":"Nature"},{"key":"69796_CR26","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/nan.12590","volume":"46","author":"MY Deng","year":"2020","unstructured":"Deng, M. Y. et al. Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) \u2013 a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14. Neuropathol. Appl. Neurobiol. 46, 422\u2013430 (2020).","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"69796_CR27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1443","volume":"41","author":"M Costello","year":"2013","unstructured":"Costello, M. et al. Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation. Nucleic Acids Res. 41, e67 (2013).","journal-title":"Nucleic Acids Res."},{"key":"69796_CR28","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/s41467-021-21254-9","volume":"12","author":"Z Zhang","year":"2021","unstructured":"Zhang, Z. et al. Uniform genomic data analysis in the NCI genomic data commons. Nat. Commun. 12, 1226 (2021).","journal-title":"Nat. Commun."},{"key":"69796_CR29","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/ng.2984","volume":"46","author":"M Kakiuchi","year":"2014","unstructured":"Kakiuchi, M. et al. Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat. Genet. 46, 583\u2013587 (2014).","journal-title":"Nat. Genet."},{"key":"69796_CR30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).","journal-title":"Nucleic Acids Res."},{"key":"69796_CR31","volume":"44","author":"R D\u2019Aurizio","year":"2016","unstructured":"D\u2019Aurizio, R. et al. Enhanced copy number variants detection from whole-exome sequencing data using EXCAVATOR2. Nucleic Acids Res. 44, e154 (2016).","journal-title":"Nucleic Acids Res."},{"key":"69796_CR32","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ng.3547","volume":"48","author":"A Fujimoto","year":"2016","unstructured":"Fujimoto, A. et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat. Genet. 48, 500\u2013509 (2016).","journal-title":"Nat. Genet."},{"key":"69796_CR33","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.bbrc.2005.06.040","volume":"333","author":"S Ishikawa","year":"2005","unstructured":"Ishikawa, S. et al. Allelic dosage analysis with genotyping microarrays. Biochem. Biophys. Res. Commun. 333, 1309\u20131314 (2005).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"69796_CR34","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.celrep.2012.12.008","volume":"3","author":"LB Alexandrov","year":"2013","unstructured":"Alexandrov, L. B., Nik-Zainal, S., Wedge, D. C., Campbell, P. J. & Stratton, M. R. Deciphering signatures of mutational processes operative in human cancer. Cell. Rep. 3, 246\u2013259 (2013).","journal-title":"Cell. Rep."},{"key":"69796_CR35","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/bioinformatics\/bts680","volume":"29","author":"AE Teschendorff","year":"2013","unstructured":"Teschendorff, A. E. et al. A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics 29, 189\u2013196 (2013).","journal-title":"Bioinformatics"},{"key":"69796_CR36","doi-asserted-by":"publisher","first-page":"4164","DOI":"10.1073\/pnas.0308531101","volume":"101","author":"JP Brunet","year":"2004","unstructured":"Brunet, J. P., Tamayo, P., Golub, T. R. & Mesirov, J. P. Metagenes and molecular pattern discovery using matrix factorization. Proc. Natl Acad. Sci. USA. 101, 4164\u20134169 (2004).","journal-title":"Proc. Natl Acad. Sci. USA."},{"key":"69796_CR37","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576\u2013589 (2010).","journal-title":"Mol. Cell"},{"key":"69796_CR38","unstructured":"Roadmap Epigenomics Consortium et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317\u2013330. (2015)."},{"key":"69796_CR39","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nbt.1630","volume":"28","author":"CY McLean","year":"2010","unstructured":"McLean, C. Y. et al. GREAT improves functional interpretation of cis-regulatory regions. Nat. Biotechnol. 28, 495\u2013501 (2010).","journal-title":"Nat. Biotechnol."},{"key":"69796_CR40","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.chom.2015.11.002","volume":"18","author":"S Tripathi","year":"2015","unstructured":"Tripathi, S. et al. Meta- and orthogonal integration of influenza \u201cOMICs\u201d data defines a role for UBR4 in virus budding. Cell Host Microbe 18, 723\u2013735 (2015).","journal-title":"Cell Host Microbe"},{"key":"69796_CR41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.lungcan.2011.05.028","volume":"75","author":"T Fujiwara","year":"2012","unstructured":"Fujiwara, T. et al. ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis. Lung Cancer 75, 119\u2013125 (2012).","journal-title":"Lung Cancer"},{"key":"69796_CR42","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA. 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl Acad. Sci. USA."},{"key":"69796_CR43","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/S1470-2045(16)30297-2","volume":"17","author":"S Moran","year":"2016","unstructured":"Moran, S. et al. Epigenetic profiling to classify cancer of unknown primary: A multicentre, retrospective analysis. Lancet Oncol. 17, 1386\u20131395 (2016).","journal-title":"Lancet Oncol."},{"key":"69796_CR44","doi-asserted-by":"publisher","first-page":"14648","DOI":"10.1038\/ncomms14648","volume":"8","author":"BH Alver","year":"2017","unstructured":"Alver, B. H. et al. The SWI\/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers. Nat. Commun. 8, 14648 (2017).","journal-title":"Nat. Commun."},{"key":"69796_CR45","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1038\/ng.2701","volume":"45","author":"MB Burns","year":"2013","unstructured":"Burns, M. B., Temiz, N. A. & Harris, R. S. Evidence for APOBEC3B mutagenesis in multiple human cancers. Nat. Genet. 45, 977\u2013983 (2013).","journal-title":"Nat. Genet."},{"key":"69796_CR46","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1126\/science.aag0299","volume":"354","author":"LB Alexandrov","year":"2016","unstructured":"Alexandrov, L. B. et al. Mutational signatures associated with tobacco smoking in human cancer. Science 354, 618\u2013622 (2016).","journal-title":"Science"},{"key":"69796_CR47","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1016\/j.celrep.2014.05.012","volume":"7","author":"S Henderson","year":"2014","unstructured":"Henderson, S., Chakravarthy, A., Su, X., Boshoff, C. & Fenton, T. R. APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development. Cell Rep. 7, 1833\u20131841 (2014).","journal-title":"Cell Rep."},{"key":"69796_CR48","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1006\/gyno.2000.6071","volume":"80","author":"PJ Paley","year":"2001","unstructured":"Paley, P. J. et al. Occult cancer of the fallopian tube in BRCA-1 germline mutation carriers at prophylactic oophorectomy: A case for recommending hysterectomy at surgical prophylaxis. Gynecol. Oncol. 80, 176\u2013180 (2001).","journal-title":"Gynecol. Oncol."},{"key":"69796_CR49","doi-asserted-by":"publisher","first-page":"6310","DOI":"10.1158\/1078-0432.CCR-20-0270","volume":"26","author":"TR Pisanic","year":"2020","unstructured":"Pisanic, T. R. et al. Methylomic landscapes of ovarian cancer precursor lesions. Clin. Cancer Res. 26, 6310\u20136320 (2020).","journal-title":"Clin. Cancer Res."},{"key":"69796_CR50","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1097\/PAS.0b013e318164edf7","volume":"32","author":"G Han","year":"2008","unstructured":"Han, G. et al. Mixed ovarian epithelial carcinomas with clear cell and serous components are variants of high-grade serous carcinoma: An interobserver correlative 5 immunohistochemical study of 32 cases. Am. J. Surg. Pathol. 32, 955\u2013964 (2008).","journal-title":"Am. J. Surg. Pathol."},{"key":"69796_CR51","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1158\/1541-7786.MCR-16-0097","volume":"14","author":"D Klinkebiel","year":"2016","unstructured":"Klinkebiel, D., Zhang, W., Akers, S. N., Odunsi, K. & Karpf, A. R. DNA Methylome analyses implicate Fallopian tube epithelia as the origin for high-grade serous ovarian cancer. Mol. Cancer Res. 14, 787\u2013794 (2016).","journal-title":"Mol. Cancer Res."},{"key":"69796_CR52","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S0015-0282(99)00211-3","volume":"72","author":"DB Redwine","year":"1999","unstructured":"Redwine, D. B. Ovarian endometriosis: A marker for more extensive pelvic and intestinal disease. Fertil. Steril. 72, 310\u2013315 (1999).","journal-title":"Fertil. Steril."},{"key":"69796_CR53","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/S0015-0282(16)53571-7","volume":"53","author":"M Nisolle","year":"1990","unstructured":"Nisolle, M. et al. Histologic study of peritoneal endometriosis in infertile women. Fertil. Steril. 53, 984\u2013988 (1990).","journal-title":"Fertil. Steril."},{"key":"69796_CR54","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1093\/oxfordjournals.humrep.a138421","volume":"9","author":"JLH Evers","year":"1994","unstructured":"Evers, J. L. H. Endometriosis does not exist; all women have endometriosis. Hum. Reprod. 9, 2206\u20132209 (1994).","journal-title":"Hum. Reprod."},{"key":"69796_CR55","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0015-0282(97)00191-X","volume":"68","author":"M Nisolle","year":"1997","unstructured":"Nisolle, M. & Donnez, J. Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertil. Steril. 68, 585\u2013596 (1997).","journal-title":"Fertil. Steril."},{"key":"69796_CR56","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/00004347-200104000-00006","volume":"20","author":"J Scurry","year":"2001","unstructured":"Scurry, J., Whitehead, J. & Healey, M. Classification of ovarian endometriotic cysts. Int. J. Gynecol. Pathol. 20, 147\u2013154 (2001).","journal-title":"Int. J. Gynecol. Pathol."},{"key":"69796_CR57","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.cell.2018.05.048","volume":"174","author":"JA Pulikkan","year":"2018","unstructured":"Pulikkan, J. A. et al. CBF\u03b2-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia. Cell 174, 172-186.e21 (2018).","journal-title":"Cell"},{"key":"69796_CR58","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.molcel.2018.06.040","volume":"71","author":"GJ Sandoval","year":"2018","unstructured":"Sandoval, G. J. et al. Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis. Mol. Cell 71, 554-566.e7 (2018).","journal-title":"Mol. Cell"},{"key":"69796_CR59","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1038\/onc.2009.470","volume":"29","author":"K Yamaguchi","year":"2010","unstructured":"Yamaguchi, K. et al. Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes. Oncogene 29, 1741\u20131752 (2010).","journal-title":"Oncogene"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69796-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69796-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69796-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T15:22:28Z","timestamp":1723562548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69796-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["69796"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-69796-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"12 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"K.O. reports grants from Konica Minolta received during the conduct of the study; grants and personal fees from AstraZeneca, personal fees from Chugai, grants from Takeda, outside the submitted work; K.H. reports grants and personal fees from Daiichi-Sankyo, grants from Yakult Honsha, grants from Pfizer, personal fees from Chugai, personal fees from AstraZeneca, outside the submitted work; K.F. reports grants and personal fees from Chugai-Roche, Astra Zeneca, Pfizer, Eisai, MSD, Taiho, Zeria, and Chugai, grants from Kaken, Shionogi, GSK, Lilly, Immunogen, and Oncotherapy, personal fees from Nihon Kayaku, Novartis, Kyowahakko Kirin, Janssen, Daiichi Sankyo, and Mochida, outside the submitted work. K.T. and H.A. report grants from Konica Minolta, outside the submitted work. All other authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18797"}}