{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:52:27Z","timestamp":1791219147243,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102726"],"award-info":[{"award-number":["82102726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-69833-2","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T12:02:12Z","timestamp":1723723332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Homotypic cell-in-cell structure as a novel prognostic predictor in non-small cell lung cancer and frequently localized at the invasive front"],"prefix":"10.1038","volume":"14","author":[{"given":"Xiaona","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2019nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"69833_CR1","first-page":"11","volume":"5","author":"J Eberth","year":"1864","unstructured":"Eberth, J. \u00dcber die feineren bau der darmschleithaut. Wurzb Nat Zeitschr 5, 11 (1864).","journal-title":"Wurzb Nat Zeitschr"},{"issue":"12","key":"69833_CR2","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/s41568-018-0073-9","volume":"18","author":"S Fais","year":"2018","unstructured":"Fais, S. & Overholtzer, M. Cell-in-cell phenomena in cancer. Nat. Rev. Cancer 18(12), 758\u2013766 (2018).","journal-title":"Nat. Rev. Cancer"},{"key":"69833_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/ar.1090310106","volume":"31","author":"WH Lewis","year":"1925","unstructured":"Lewis, W. H. The engulfment of living blood cells by others of the same type. Anat. Rec. 31, 43\u201349 (1925).","journal-title":"Anat. Rec."},{"issue":"10","key":"69833_CR4","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/nrm2504","volume":"9","author":"M Overholtzer","year":"2008","unstructured":"Overholtzer, M. & Brugge, J. S. The cell biology of cell-in-cell structures. Nat. Rev. Mol. Cell Biol. 9(10), 796\u2013809 (2008).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"40","key":"69833_CR5","doi-asserted-by":"publisher","first-page":"16735","DOI":"10.1073\/pnas.1112251108","volume":"108","author":"V Benseler","year":"2011","unstructured":"Benseler, V. et al. Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proc. Natl. Acad. Sci. USA 108(40), 16735\u201316740 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"69833_CR6","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1038\/s41418-021-00782-3","volume":"28","author":"Z Zhang","year":"2021","unstructured":"Zhang, Z. et al. SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination. Cell Death Differ. 28(9), 2765\u20132777 (2021).","journal-title":"Cell Death Differ."},{"issue":"11","key":"69833_CR7","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/cr.2015.119","volume":"25","author":"C Ni","year":"2015","unstructured":"Ni, C. et al. Implication of cell-in-cell structures in the transmission of HIV to epithelial cells. Cell Res. 25(11), 1265\u20131268 (2015).","journal-title":"Cell Res."},{"issue":"7","key":"69833_CR8","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/cr.2015.50","volume":"25","author":"C Ni","year":"2015","unstructured":"Ni, C. et al. In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures. Cell Res. 25(7), 785\u2013800 (2015).","journal-title":"Cell Res."},{"issue":"7847","key":"69833_CR9","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/s41586-021-03200-3","volume":"590","author":"E Hoijman","year":"2021","unstructured":"Hoijman, E. et al. Cooperative epithelial phagocytosis enables error correction in the early embryo. Nature 590(7847), 618\u2013623 (2021).","journal-title":"Nature"},{"issue":"5","key":"69833_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/jmcb\/mjab015","volume":"13","author":"Z Niu","year":"2021","unstructured":"Niu, Z., He, M. & Sun, Q. Molecular mechanisms underlying cell-in-cell formation: Core machineries and beyond. J. Mol. Cell Biol. 13(5), 329\u2013334 (2021).","journal-title":"J. Mol. Cell Biol."},{"key":"69833_CR11","doi-asserted-by":"publisher","first-page":"7608521","DOI":"10.1155\/2022\/7608521","volume":"2022","author":"Q Chen","year":"2022","unstructured":"Chen, Q., Wang, X. & He, M. Cell-in-cell: From cell biology to translational medicine. Biomed. Res. Int. 2022, 7608521 (2022).","journal-title":"Biomed. Res. Int."},{"issue":"5","key":"69833_CR12","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.cell.2007.10.040","volume":"131","author":"M Overholtzer","year":"2007","unstructured":"Overholtzer, M. et al. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 131(5), 966\u2013979 (2007).","journal-title":"Cell"},{"issue":"2","key":"69833_CR13","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1042\/BST20180618","volume":"47","author":"HL Mackay","year":"2019","unstructured":"Mackay, H. L. & Muller, P. A. J. Biological relevance of cell-in-cell in cancers. Biochem. Soc. Trans. 47(2), 725\u2013732 (2019).","journal-title":"Biochem. Soc. Trans."},{"issue":"7","key":"69833_CR14","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.1158\/0008-5472.CAN-05-3204","volume":"66","author":"L Lugini","year":"2006","unstructured":"Lugini, L. et al. Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells. Cancer Res. 66(7), 3629\u20133638 (2006).","journal-title":"Cancer Res."},{"key":"69833_CR15","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3389\/fonc.2019.00895","volume":"9","author":"X Zhang","year":"2019","unstructured":"Zhang, X. et al. Subtype-based prognostic analysis of cell-in-cell structures in early breast cancer. Front. Oncol. 9, 895 (2019).","journal-title":"Front. Oncol."},{"key":"69833_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.541878","volume":"10","author":"J Fan","year":"2020","unstructured":"Fan, J. et al. Role of heterotypic neutrophil-in-tumor structure in the prognosis of patients with buccal mucosa squamous cell carcinoma. Front. Oncol. 10, 541878 (2020).","journal-title":"Front. Oncol."},{"issue":"1","key":"69833_CR17","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41392-020-00346-w","volume":"5","author":"H Huang","year":"2020","unstructured":"Huang, H. et al. Identification and validation of heterotypic cell-in-cell structure as an adverse prognostic predictor for young patients of resectable pancreatic ductal adenocarcinoma. Signal Transduct. Target Ther. 5(1), 246 (2020).","journal-title":"Signal Transduct. Target Ther."},{"issue":"3","key":"69833_CR18","first-page":"1091","volume":"13","author":"Y Wei","year":"2023","unstructured":"Wei, Y. et al. Subtype-based analysis of cell-in-cell structures in non-small cell lung cancer. Am. J. Cancer Res. 13(3), 1091\u20131102 (2023).","journal-title":"Am. J. Cancer Res."},{"issue":"1","key":"69833_CR19","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.celrep.2017.06.037","volume":"20","author":"JC Hamann","year":"2017","unstructured":"Hamann, J. C. et al. Entosis is induced by glucose starvation. Cell Rep. 20(1), 201\u2013210 (2017).","journal-title":"Cell Rep."},{"issue":"23","key":"69833_CR20","doi-asserted-by":"publisher","first-page":"3736","DOI":"10.1091\/mbc.e13-07-0408","volume":"24","author":"M Krajcovic","year":"2013","unstructured":"Krajcovic, M., Krishna, S., Akkari, L., Joyce, J. A. & Overholtzer, M. mTOR regulates phagosome and entotic vacuole fission. Mol. Biol. Cell 24(23), 3736\u20133745 (2013).","journal-title":"Mol. Biol. Cell"},{"issue":"11","key":"69833_CR21","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/cr.2014.138","volume":"24","author":"Q Sun","year":"2014","unstructured":"Sun, Q. et al. Competition between human cells by entosis. Cell Res. 24(11), 1299\u20131310 (2014).","journal-title":"Cell Res."},{"issue":"4","key":"69833_CR22","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2014.1002707","volume":"2","author":"Q Sun","year":"2015","unstructured":"Sun, Q., Huang, H. & Overholtzer, M. Cell-in-cell structures are involved in the competition between cells in human tumors. Mol. Cell Oncol. 2(4), e1002707 (2015).","journal-title":"Mol. Cell Oncol."},{"issue":"1","key":"69833_CR23","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1038\/s41467-018-05368-1","volume":"9","author":"HL Mackay","year":"2018","unstructured":"Mackay, H. L. et al. Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nat. Commun. 9(1), 3070 (2018).","journal-title":"Nat. Commun."},{"issue":"5","key":"69833_CR24","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/S0025-6196(11)60735-0","volume":"83","author":"JR Molina","year":"2008","unstructured":"Molina, J. R., Yang, P., Cassivi, S. D., Schild, S. E. & Adjei, A. A. Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clin. Proc. 83(5), 584\u2013594 (2008).","journal-title":"Mayo Clin. Proc."},{"issue":"10","key":"69833_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers16101835","volume":"16","author":"TK Sahin","year":"2024","unstructured":"Sahin, T. K., Rizzo, A., Aksoy, S. & Guven, D. C. Prognostic significance of the royal marsden hospital (RMH) score in patients with cancer: A systematic review and meta-analysis. Cancers (Basel) 16(10), 1 (2024).","journal-title":"Cancers (Basel)"},{"key":"69833_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.103119","volume":"156","author":"G Lamberti","year":"2020","unstructured":"Lamberti, G. et al. Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma. Crit. Rev. Oncol. Hematol. 156, 103119 (2020).","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"8","key":"69833_CR27","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1038\/s41416-022-01929-w","volume":"127","author":"A Rizzo","year":"2022","unstructured":"Rizzo, A. Identifying optimal first-line treatment for advanced non-small cell lung carcinoma with high PD-L1 expression: A matter of debate. Br. J. Cancer 127(8), 1381\u20131382 (2022).","journal-title":"Br. J. Cancer"},{"issue":"6","key":"69833_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers14061404","volume":"14","author":"A Rizzo","year":"2022","unstructured":"Rizzo, A. et al. Impact of proton pump inhibitors and histamine-2-receptor antagonists on non-small cell lung cancer immunotherapy: A systematic review and meta-analysis. Cancers (Basel) 14(6), 1 (2022).","journal-title":"Cancers (Basel)"},{"key":"69833_CR29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejca.2022.09.031","volume":"177","author":"G Viscardi","year":"2022","unstructured":"Viscardi, G. et al. Comparative assessment of early mortality risk upon immune checkpoint inhibitors alone or in combination with other agents across solid malignancies: A systematic review and meta-analysis. Eur. J. Cancer 177, 175\u2013185 (2022).","journal-title":"Eur. J. Cancer"},{"issue":"8","key":"69833_CR30","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.1007\/s10238-023-01159-1","volume":"23","author":"V Mollica","year":"2023","unstructured":"Mollica, V. et al. The impact of ECOG performance status on efficacy of immunotherapy and immune-based combinations in cancer patients: The MOUSEION-06 study. Clin. Exp. Med. 23(8), 5039\u20135049 (2023).","journal-title":"Clin. Exp. Med."},{"key":"69833_CR31","doi-asserted-by":"publisher","first-page":"1039121","DOI":"10.3389\/fmolb.2022.1039121","volume":"9","author":"DC Guven","year":"2022","unstructured":"Guven, D. C. et al. The association between albumin levels and survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis. Front. Mol. Biosci. 9, 1039121 (2022).","journal-title":"Front. Mol. Biosci."},{"issue":"3","key":"69833_CR32","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2217\/imt-2020-0179","volume":"13","author":"FG Dall'Olio","year":"2021","unstructured":"Dall\u2019Olio, F. G. et al. Immortal time bias in the association between toxicity and response for immune checkpoint inhibitors: A meta-analysis. Immunotherapy 13(3), 257\u2013270 (2021).","journal-title":"Immunotherapy"},{"issue":"12","key":"69833_CR33","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1080\/17425255.2021.2029405","volume":"17","author":"A Rizzo","year":"2021","unstructured":"Rizzo, A. et al. Peripheral neuropathy and headache in cancer patients treated with immunotherapy and immuno-oncology combinations: The MOUSEION-02 study. Expert Opin. Drug Metab. Toxicol. 17(12), 1455\u20131466 (2021).","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"3","key":"69833_CR34","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.mcna.2018.12.006","volume":"103","author":"F Nasim","year":"2019","unstructured":"Nasim, F., Sabath, B. F. & Eapen, G. A. Lung cancer. Med. Clin. N. Am. 103(3), 463\u2013473 (2019).","journal-title":"Med. Clin. N. Am."},{"key":"69833_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.27134","volume":"6","author":"J Durgan","year":"2017","unstructured":"Durgan, J. et al. Mitosis can drive cell cannibalism through entosis. Elife 6, 1 (2017).","journal-title":"Elife"},{"issue":"7","key":"69833_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms24076819","volume":"24","author":"I Dziuba","year":"2023","unstructured":"Dziuba, I. et al. Homotypic entosis as a potential novel diagnostic marker in breast cancer. Int. J. Mol. Sci. 24(7), 1 (2023).","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"69833_CR37","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/s41418-020-00645-3","volume":"28","author":"J Liang","year":"2021","unstructured":"Liang, J. et al. p53-dependent elimination of aneuploid mitotic offspring by entosis. Cell Death Differ. 28(2), 799\u2013813 (2021).","journal-title":"Cell Death Differ."},{"key":"69833_CR38","doi-asserted-by":"crossref","unstructured":"Rami-Porta, R., Bolejack, V., Crowley, J., Ball, D., Kim, J., Lyons, G., Rice, T., Suzuki, K., Thomas, C. F., Travis, W. D. et al. The IASLC lung cancer staging project: proposals for the revisions of the T descriptors in the forthcoming eighth edition of the TNM classification for lung cancer. J. Thorac. Oncol. 10(7), 1 (2015).","DOI":"10.1097\/JTO.0000000000000559"},{"issue":"2","key":"69833_CR39","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.1601-0825.1998.tb00260.x","volume":"4","author":"M Bryne","year":"1998","unstructured":"Bryne, M. Is the invasive front of an oral carcinoma the most important area for prognostication?. Oral. Dis. 4(2), 70\u201377 (1998).","journal-title":"Oral. Dis."},{"issue":"5","key":"69833_CR40","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/j.1365-2303.2006.00326.x","volume":"17","author":"WT Abodief","year":"2006","unstructured":"Abodief, W. T., Dey, P. & Al-Hattab, O. Cell cannibalism in ductal carcinoma of breast. Cytopathology 17(5), 304\u2013305 (2006).","journal-title":"Cytopathology"},{"issue":"3","key":"69833_CR41","first-page":"277","volume":"25","author":"IS Hong","year":"1981","unstructured":"Hong, I. S. The exfoliative cytology of endometrial stromal sarcoma in peritoneal fluid. Acta Cytol. 25(3), 277\u2013281 (1981).","journal-title":"Acta Cytol."},{"issue":"9","key":"69833_CR42","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1002\/emmm.201201255","volume":"4","author":"CE Cano","year":"2012","unstructured":"Cano, C. E. et al. Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer. EMBO Mol. Med. 4(9), 964\u2013979 (2012).","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"69833_CR43","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.canlet.2007.09.014","volume":"258","author":"S Fais","year":"2007","unstructured":"Fais, S. Cannibalism: A way to feed on metastatic tumors. Cancer Lett. 258(2), 155\u2013164 (2007).","journal-title":"Cancer Lett."},{"issue":"2","key":"69833_CR44","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1016\/j.oraloncology.2011.08.013","volume":"48","author":"GS Sarode","year":"2012","unstructured":"Sarode, G. S., Sarode, S. C. & Karmarkar, S. Complex cannibalism: An unusual finding in oral squamous cell carcinoma. Oral. Oncol. 48(2), e4\u2013e6 (2012).","journal-title":"Oral. Oncol."},{"issue":"11","key":"69833_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1083\/jcb.202010030","volume":"220","author":"E Bozkurt","year":"2021","unstructured":"Bozkurt, E. et al. TRAIL signaling promotes entosis in colorectal cancer. J. Cell Biol. 220(11), 1 (2021).","journal-title":"J. Cell Biol."},{"key":"69833_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.670051","volume":"11","author":"Y Wang","year":"2021","unstructured":"Wang, Y. et al. Subtype-based analysis of cell-in-cell structures in esophageal squamous cell carcinoma. Front. Oncol. 11, 670051 (2021).","journal-title":"Front. Oncol."},{"key":"69833_CR47","doi-asserted-by":"publisher","first-page":"1007305","DOI":"10.3389\/fonc.2022.1007305","volume":"12","author":"R Wang","year":"2022","unstructured":"Wang, R. et al. Homotypic cell-in-cell structures as an adverse prognostic predictor of hepatocellular carcinoma. Front. Oncol. 12, 1007305 (2022).","journal-title":"Front. Oncol."},{"issue":"1","key":"69833_CR48","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41567-019-0680-8","volume":"16","author":"YL Han","year":"2020","unstructured":"Han, Y. L. et al. Cell swelling, softening and invasion in a three-dimensional breast cancer model. Nat. Phys. 16(1), 101\u2013108 (2020).","journal-title":"Nat. Phys."},{"key":"69833_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.02786","volume":"3","author":"V Purvanov","year":"2014","unstructured":"Purvanov, V., Holst, M., Khan, J., Baarlink, C. & Grosse, R. G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion. Elife 3, 1 (2014).","journal-title":"Elife"},{"issue":"3","key":"69833_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtcvs.2019.04.084","volume":"158","author":"KG Mitchell","year":"2019","unstructured":"Mitchell, K. G. et al. Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non-small cell lung cancer. J. Thorac. Cardiovasc. Surg. 158(3), 1 (2019).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"4","key":"69833_CR51","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s12672-018-0336-7","volume":"9","author":"L Grant","year":"2018","unstructured":"Grant, L. et al. Androgen receptor and Ki67 expression and survival outcomes in non-small cell lung cancer. Horm. Cancer 9(4), 288\u2013294 (2018).","journal-title":"Horm. Cancer"},{"issue":"10","key":"69833_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells10102569","volume":"10","author":"K Borensztejn","year":"2021","unstructured":"Borensztejn, K. et al. Classification of cell-in-cell structures: Different phenomena with similar appearance. Cells 10(10), 1 (2021).","journal-title":"Cells"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69833-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69833-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69833-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T13:02:36Z","timestamp":1723726956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69833-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,15]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["69833"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-69833-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,15]]},"assertion":[{"value":"11 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18952"}}