{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:34:14Z","timestamp":1789774454110,"version":"4.0.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07121"],"award-info":[{"award-number":["22K07121"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K15609"],"award-info":[{"award-number":["22K15609"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08433"],"award-info":[{"award-number":["22K08433"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K08205"],"award-info":[{"award-number":["21K08205"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09245"],"award-info":[{"award-number":["20K09245"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02736"],"award-info":[{"award-number":["23H02736"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Naito Memorial Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-69987-z","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T14:05:30Z","timestamp":1724162730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Suppressive effect of the anesthetic propofol on the T cell function and T cell-dependent immune responses"],"prefix":"10.1038","volume":"14","author":[{"given":"Waichi","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Omori-Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amane","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Yorozuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"69987_CR1","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1097\/ALN.0b013e31819b5bdc","volume":"110","author":"G Li","year":"2009","unstructured":"Li, G., Warner, M., Lang, B. H., Huang, L. & Sun, L. S. Epidemiology of anesthesia-related mortality in the United States, 1999\u20132005. Anesthesiology 110, 759\u2013765 (2009).","journal-title":"Anesthesiology"},{"key":"69987_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2022. CA Cancer J. Clin. 72, 7\u201333 (2022).","journal-title":"CA Cancer J. Clin."},{"key":"69987_CR3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1067\/msy.2000.103498","volume":"127","author":"K Ogawa","year":"2000","unstructured":"Ogawa, K. et al. Suppression of cellular immunity by surgical stress. Surgery 127, 329\u2013336 (2000).","journal-title":"Surgery"},{"key":"69987_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12967-018-1389-7","volume":"16","author":"R Kim","year":"2018","unstructured":"Kim, R. Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence. J. Transl. Med. 16, 8 (2018).","journal-title":"J. Transl. Med."},{"key":"69987_CR5","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1007\/s11596-018-1970-6","volume":"38","author":"B Jiao","year":"2018","unstructured":"Jiao, B. et al. Relationship between volatile anesthetics and tumor progression: Unveiling the mystery. Curr. Med. Sci. 38, 962\u2013967 (2018).","journal-title":"Curr. Med. Sci."},{"key":"69987_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1055\/s-0043-119071","volume":"68","author":"MR Moradkhani","year":"2018","unstructured":"Moradkhani, M. R. & Karimi, A. Role of drug anesthesia and cancer. Drug Res. (Stuttg.) 68, 125\u2013131 (2018).","journal-title":"Drug Res. (Stuttg.)"},{"key":"69987_CR7","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s40263-017-0463-7","volume":"31","author":"J Brohan","year":"2017","unstructured":"Brohan, J. & Goudra, B. G. The role of GABA receptor agonists in anesthesia and sedation. CNS Drugs 31, 845\u2013856 (2017).","journal-title":"CNS Drugs"},{"key":"69987_CR8","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1111\/j.1476-5381.1995.tb16660.x","volume":"116","author":"BA Orser","year":"1995","unstructured":"Orser, B. A., Bertlik, M., Wang, L. Y. & MacDonald, J. F. Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. Br. J. Pharmacol. 116, 1761\u20131768 (1995).","journal-title":"Br. J. Pharmacol."},{"key":"69987_CR9","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.biopha.2010.03.006","volume":"64","author":"Y Miao","year":"2010","unstructured":"Miao, Y., Zhang, Y., Wan, H., Chen, L. & Wang, F. GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells. Biomed. Pharmacother. 64, 583\u2013588 (2010).","journal-title":"Biomed. Pharmacother."},{"key":"69987_CR10","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biopha.2011.10.006","volume":"66","author":"Q Li","year":"2012","unstructured":"Li, Q., Zhang, L., Han, Y., Jiang, Z. & Wang, Q. Propofol reduces MMPs expression by inhibiting NF-\u03baB activity in human MDA-MB-231 cells. Biomed. Pharmacother. 66, 52\u201356 (2012).","journal-title":"Biomed. Pharmacother."},{"key":"69987_CR11","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3109\/1547691X.2012.712066","volume":"10","author":"T Inada","year":"2013","unstructured":"Inada, T., Ueshima, H. & Shingu, K. Intravenous anesthetic propofol suppresses leukotriene production in murine dendritic cells. J. Immunotoxicol. 10, 262\u2013269 (2013).","journal-title":"J. Immunotoxicol."},{"key":"69987_CR12","doi-asserted-by":"publisher","first-page":"1919538","DOI":"10.1155\/2019\/1919538","volume":"2019","author":"T Kochiyama","year":"2019","unstructured":"Kochiyama, T. et al. Effect of propofol on the production of inflammatory cytokines by human polarized macrophages. Mediat. Inflamm. 2019, 1919538 (2019).","journal-title":"Mediat. Inflamm."},{"key":"69987_CR13","doi-asserted-by":"publisher","first-page":"6511","DOI":"10.4049\/jimmunol.1202215","volume":"190","author":"SC Yang","year":"2013","unstructured":"Yang, S. C. et al. Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1. J. Immunol. 190, 6511\u20136519 (2013).","journal-title":"J. Immunol."},{"key":"69987_CR14","doi-asserted-by":"publisher","first-page":"428","DOI":"10.7150\/ijms.41899","volume":"17","author":"HJ Park","year":"2020","unstructured":"Park, H. J., Piao, L., Seo, E. H., Lee, S. H. & Kim, S. H. The effect of repetitive exposure to intravenous anesthetic agents on the immunity in mice. Int. J. Med. Sci. 17, 428\u2013436 (2020).","journal-title":"Int. J. Med. Sci."},{"key":"69987_CR15","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12865-022-00490-8","volume":"23","author":"C Cui","year":"2022","unstructured":"Cui, C. et al. Propofol maintains Th17\/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor. BMC Immunol. 23, 58 (2022).","journal-title":"BMC Immunol."},{"key":"69987_CR16","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/08923970701675085","volume":"29","author":"A Kushida","year":"2007","unstructured":"Kushida, A., Inada, T. & Shingu, K. Enhancement of antitumor immunity after propofol treatment in mice. Immunopharmacol. Immunotoxicol. 29, 477\u2013486 (2007).","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"69987_CR17","doi-asserted-by":"publisher","first-page":"5430","DOI":"10.21037\/jtd-21-878","volume":"13","author":"A Yamaguchi","year":"2021","unstructured":"Yamaguchi, A. et al. Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: A randomized controlled trial. J. Thorac. Dis. 13, 5430\u20135438 (2021).","journal-title":"J. Thorac. Dis."},{"key":"69987_CR18","doi-asserted-by":"publisher","first-page":"1242454","DOI":"10.1126\/science.1242454","volume":"342","author":"EL Pearce","year":"2013","unstructured":"Pearce, E. L., Poffenberger, M. C., Chang, C. H. & Jones, R. G. Fueling immunity: Insights into metabolism and lymphocyte function. Science 342, 1242454 (2013).","journal-title":"Science"},{"key":"69987_CR19","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1146\/annurev-immunol-032713-120236","volume":"32","author":"K Ganeshan","year":"2014","unstructured":"Ganeshan, K. & Chawla, A. Metabolic regulation of immune responses. Annu. Rev. Immunol. 32, 609\u2013634 (2014).","journal-title":"Annu. Rev. Immunol."},{"key":"69987_CR20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nri3701","volume":"14","author":"KN Pollizzi","year":"2014","unstructured":"Pollizzi, K. N. & Powell, J. D. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat. Rev. Immunol. 14, 435\u2013446 (2014).","journal-title":"Nat. Rev. Immunol."},{"key":"69987_CR21","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1146\/annurev-immunol-032712-095956","volume":"31","author":"NJ MacIver","year":"2013","unstructured":"MacIver, N. J., Michalek, R. D. & Rathmell, J. C. Metabolic regulation of T lymphocytes. Annu. Rev. Immunol. 31, 259\u2013283 (2013).","journal-title":"Annu. Rev. Immunol."},{"key":"69987_CR22","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S1097-2765(00)00066-6","volume":"6","author":"JC Rathmell","year":"2000","unstructured":"Rathmell, J. C., Vander Heiden, M. G., Harris, M. H., Frauwirth, K. A. & Thompson, C. B. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6, 683\u2013692 (2000).","journal-title":"Mol. Cell"},{"key":"69987_CR23","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1084\/jem.20151159","volume":"212","author":"MD Buck","year":"2015","unstructured":"Buck, M. D., O\u2019Sullivan, D. & Pearce, E. L. T cell metabolism drives immunity. J. Exp. Med. 212, 1345\u20131360 (2015).","journal-title":"J. Exp. Med."},{"key":"69987_CR24","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.immuni.2011.09.021","volume":"35","author":"R Wang","year":"2011","unstructured":"Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871\u2013882 (2011).","journal-title":"Immunity"},{"key":"69987_CR25","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1172\/JCI83005","volume":"126","author":"N Assmann","year":"2016","unstructured":"Assmann, N. & Finlay, D. K. Metabolic regulation of immune responses: Therapeutic opportunities. J. Clin. Invest. 126, 2031\u20132039 (2016).","journal-title":"J. Clin. Invest."},{"key":"69987_CR26","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.tem.2023.03.006","volume":"34","author":"S Liu","year":"2023","unstructured":"Liu, S., Liao, S., Liang, L., Deng, J. & Zhou, Y. The relationship between CD4. Trends Endocrinol. Metab. 34, 345\u2013360 (2023).","journal-title":"Trends Endocrinol. Metab."},{"key":"69987_CR27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41419-023-05937-3","volume":"14","author":"J Cao","year":"2023","unstructured":"Cao, J. et al. Effects of altered glycolysis levels on CD8. Cell Death Dis. 14, 407 (2023).","journal-title":"Cell Death Dis."},{"key":"69987_CR28","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41401-019-0308-7","volume":"41","author":"SL L\u00fc","year":"2020","unstructured":"L\u00fc, S. L. et al. Shikonin attenuates hyperhomocysteinemia-induced CD4. Acta Pharmacol. Sin. 41, 47\u201355 (2020).","journal-title":"Acta Pharmacol. Sin."},{"key":"69987_CR29","doi-asserted-by":"publisher","first-page":"L300","DOI":"10.1152\/ajplung.00221.2011","volume":"302","author":"M Ostroukhova","year":"2012","unstructured":"Ostroukhova, M. et al. The role of low-level lactate production in airway inflammation in asthma. Am. J. Physiol. Lung Cell Mol. Physiol. 302, L300-307 (2012).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"69987_CR30","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1002\/art.41420","volume":"72","author":"MM Souto-Carneiro","year":"2020","unstructured":"Souto-Carneiro, M. M. et al. Effect of increased lactate dehydrogenase A activity and aerobic glycolysis on the proinflammatory profile of autoimmune CD8+ T cells in rheumatoid arthritis. Arthritis Rheumatol. 72, 2050\u20132064 (2020).","journal-title":"Arthritis Rheumatol."},{"key":"69987_CR31","first-page":"2960","volume":"16","author":"HJ Wan","year":"2018","unstructured":"Wan, H. J., Wang, Y., Si, J. Q. & Li, L. Propofol-induced vasodilation of mesenteric arterioles via BK. Exp. Ther. Med. 16, 2960\u20132968 (2018).","journal-title":"Exp. Ther. Med."},{"key":"69987_CR32","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/biom12040570","volume":"12","author":"M Shimizu","year":"2022","unstructured":"Shimizu, M. et al. Propofol, an anesthetic agent, inhibits HCN channels through the allosteric modulation of the cAMP-dependent gating mechanism. Biomolecules 12, 4 (2022).","journal-title":"Biomolecules"},{"key":"69987_CR33","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/j.1476-5381.1994.tb14865.x","volume":"111","author":"H Takahashi","year":"1994","unstructured":"Takahashi, H., Puttick, R. M. & Terrar, D. A. The effects of propofol and enflurane on single calcium channel currents of guinea-pig isolated ventricular myocytes. Br. J. Pharmacol. 111, 1147\u20131153 (1994).","journal-title":"Br. J. Pharmacol."},{"key":"69987_CR34","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.neulet.2016.01.058","volume":"616","author":"YZ Zhang","year":"2016","unstructured":"Zhang, Y. Z., Zhang, R., Zeng, X. Z. & Song, C. Y. The inhibitory effect of propofol on Kv2.1 potassium channel in rat parietal cortical neurons. Neurosci. Lett. 616, 93\u201397 (2016).","journal-title":"Neurosci. Lett."},{"key":"69987_CR35","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1097\/00000542-199603000-00018","volume":"84","author":"CY Yang","year":"1996","unstructured":"Yang, C. Y., Wong, C. S., Yu, C. C., Luk, H. N. & Lin, C. I. Propofol inhibits cardiac L-type calcium current in guinea pig ventricular myocytes. Anesthesiology 84, 626\u2013635 (1996).","journal-title":"Anesthesiology"},{"key":"69987_CR36","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1177\/0091270010373098","volume":"51","author":"J Fassl","year":"2011","unstructured":"Fassl, J., High, K. M., Stephenson, E. R., Yarotskyy, V. & Elmslie, K. S. The intravenous anesthetic propofol inhibits human L-type calcium channels by enhancing voltage-dependent inactivation. J. Clin. Pharmacol. 51, 719\u2013730 (2011).","journal-title":"J. Clin. Pharmacol."},{"key":"69987_CR37","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3389\/fimmu.2013.00324","volume":"4","author":"KM Fracchia","year":"2013","unstructured":"Fracchia, K. M., Pai, C. Y. & Walsh, C. M. Modulation of T cell metabolism and function through calcium signaling. Front. Immunol. 4, 324 (2013).","journal-title":"Front. Immunol."},{"key":"69987_CR38","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/s42003-020-01122-w","volume":"3","author":"K Toriyama","year":"2020","unstructured":"Toriyama, K. et al. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun. Biol. 3, 394 (2020).","journal-title":"Commun. Biol."},{"key":"69987_CR39","doi-asserted-by":"publisher","first-page":"798S","DOI":"10.3945\/an.115.011221","volume":"7","author":"EA Ananieva","year":"2016","unstructured":"Ananieva, E. A., Powell, J. D. & Hutson, S. M. Leucine metabolism in T cell activation: mTOR signaling and beyond. Adv. Nutr. 7, 798S-805S (2016).","journal-title":"Adv. Nutr."},{"key":"69987_CR40","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s001010050595","volume":"47","author":"M Bauer","year":"1998","unstructured":"Bauer, M., Rensing, H. & Ziegenfuss, T. Anesthesia and perioperative immune function. Anaesthesist 47, 538\u2013556 (1998).","journal-title":"Anaesthesist"},{"key":"69987_CR41","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1213\/ANE.0000000000005237","volume":"132","author":"CY Chang","year":"2021","unstructured":"Chang, C. Y. et al. Anesthesia and long-term oncological outcomes: A systematic review and meta-analysis. Anesth. Analg 132, 623\u2013634 (2021).","journal-title":"Anesth. Analg"},{"key":"69987_CR42","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/EJA.0000000000000921","volume":"36","author":"V Russotto","year":"2019","unstructured":"Russotto, V., Sabat\u00e9, S. & Canet, J. Development of a prediction model for postoperative pneumonia: A multicentre prospective observational study. Eur. J. Anaesthesiol. 36, 93\u2013104 (2019).","journal-title":"Eur. J. Anaesthesiol."},{"key":"69987_CR43","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/00000658-199908000-00016","volume":"230","author":"TC Collins","year":"1999","unstructured":"Collins, T. C., Daley, J., Henderson, W. H. & Khuri, S. F. Risk factors for prolonged length of stay after major elective surgery. Ann. Surg. 230, 251\u2013259 (1999).","journal-title":"Ann. Surg."},{"key":"69987_CR44","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1001\/jama.2009.1754","volume":"302","author":"JL Vincent","year":"2009","unstructured":"Vincent, J. L. et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA 302, 2323\u20132329 (2009).","journal-title":"JAMA"},{"key":"69987_CR45","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/ijms232314905","volume":"23","author":"B Oronsky","year":"2022","unstructured":"Oronsky, B., Caroen, S. & Reid, T. What exactly is inflammation (and what is it not?). Int. J. Mol. Sci. 23, 23 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"69987_CR46","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.immuni.2022.03.016","volume":"55","author":"C Nathan","year":"2022","unstructured":"Nathan, C. Nonresolving inflammation redux. Immunity 55, 592\u2013605 (2022).","journal-title":"Immunity"},{"key":"69987_CR47","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","volume":"129","author":"S Amor","year":"2010","unstructured":"Amor, S., Puentes, F., Baker, D. & van der Valk, P. Inflammation in neurodegenerative diseases. Immunology 129, 154\u2013169 (2010).","journal-title":"Immunology"},{"key":"69987_CR48","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1097\/WCO.0b013e32813ba151","volume":"20","author":"KW Muir","year":"2007","unstructured":"Muir, K. W., Tyrrell, P., Sattar, N. & Warburton, E. Inflammation and ischaemic stroke. Curr. Opin. Neurol. 20, 334\u2013342 (2007).","journal-title":"Curr. Opin. Neurol."},{"key":"69987_CR49","doi-asserted-by":"publisher","first-page":"e1655","DOI":"10.1212\/WNL.0000000000207066","volume":"100","author":"D Campbell","year":"2023","unstructured":"Campbell, D., Butler, E., Campbell, R. B., Ho, J. & Barber, P. A. General anesthesia compared with non-GA in endovascular thrombectomy for ischemic stroke: A systematic review and meta-analysis of randomized controlled trials. Neurology 100, e1655\u2013e1663 (2023).","journal-title":"Neurology"},{"key":"69987_CR50","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/ANA.0000000000000639","volume":"33","author":"WK Diprose","year":"2021","unstructured":"Diprose, W. K. et al. Intravenous propofol versus volatile anesthetics for stroke endovascular thrombectomy. J. Neurosurg. Anesthesiol. 33, 39\u201343 (2021).","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"69987_CR51","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/ni.2362","volume":"13","author":"M Kuwahara","year":"2012","unstructured":"Kuwahara, M. et al. The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-\u03b2 and suppresses T(H)2 differentiation. Nat. Immunol. 13, 778\u2013786 (2012).","journal-title":"Nat. Immunol."},{"key":"69987_CR52","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1016\/j.celrep.2015.08.035","volume":"12","author":"N Hermann-Kleiter","year":"2015","unstructured":"Hermann-Kleiter, N. et al. The nuclear orphan receptor NR2F6 is a central checkpoint for cancer immune surveillance. Cell Rep. 12, 2072\u20132085 (2015).","journal-title":"Cell Rep."},{"key":"69987_CR53","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.4049\/jimmunol.2001160","volume":"207","author":"T Inoue","year":"2021","unstructured":"Inoue, T. et al. The loss of H3K27 histone demethylase Utx in T cells aggravates allergic contact dermatitis. J. Immunol. 207, 2223\u20132234 (2021).","journal-title":"J. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69987-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69987-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69987-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T15:06:26Z","timestamp":1724166386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-69987-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["69987"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-69987-z","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]},"assertion":[{"value":"27 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19337"}}