{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:50:04Z","timestamp":1792785004848,"version":"4.5.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["No. 2021J01266"],"award-info":[{"award-number":["No. 2021J01266"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["No. 2021J01276"],"award-info":[{"award-number":["No. 2021J01276"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["No. 2022J01273"],"award-info":[{"award-number":["No. 2022J01273"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Quanzhou City Science and Technology Program of China","award":["No. 2023C008YR"],"award-info":[{"award-number":["No. 2023C008YR"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-70041-1","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T13:01:54Z","timestamp":1723813314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiple omics integrative analysis identifies GARS1 as a novel prognostic and immunological biomarker: from pan-cancer to bladder cancer"],"prefix":"10.1038","volume":"14","author":[{"given":"Weihui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingliu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyi","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"issue":"10","key":"70041_CR1","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.3390\/cancers16101835","volume":"16","author":"TK Sahin","year":"2024","unstructured":"Sahin, T. K., Rizzo, A., Aksoy, S. & Guven, D. C. Prognostic significance of the Royal Marsden Hospital (RMH) score in patients with cancer: A systematic review and meta-analysis. Cancers (Basel) 16(10), 1835 (2024).","journal-title":"Cancers (Basel)"},{"issue":"1","key":"70041_CR2","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.euf.2021.01.003","volume":"8","author":"A Rizzo","year":"2022","unstructured":"Rizzo, A., Mollica, V. & Massari, F. Expression of programmed cell death ligand 1 as a predictive biomarker in metastatic urothelial carcinoma patients treated with first-line immune checkpoint inhibitors versus chemotherapy: A systematic review and meta-analysis. Eur. Urol. Focus 8(1), 152\u2013159 (2022).","journal-title":"Eur. Urol. Focus"},{"issue":"12","key":"70041_CR3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s11864-018-0598-x","volume":"19","author":"RK Jain","year":"2018","unstructured":"Jain, R. K. et al. Immunotherapy advances in urothelial carcinoma. Curr. Treat. Options Oncol. 19(12), 79 (2018).","journal-title":"Curr. Treat. Options Oncol."},{"issue":"10031","key":"70041_CR4","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/S0140-6736(16)00561-4","volume":"387","author":"JE Rosenberg","year":"2016","unstructured":"Rosenberg, J. E. et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial. Lancet 387(10031), 1909\u20131920 (2016).","journal-title":"Lancet"},{"issue":"6","key":"70041_CR5","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1007\/s00262-023-03366-x","volume":"72","author":"A Rizzo","year":"2023","unstructured":"Rizzo, A. et al. Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: The MOUSEION-05 study. Cancer Immunol. Immunother. 72(6), 1381\u20131394 (2023).","journal-title":"Cancer Immunol. Immunother."},{"issue":"3","key":"70041_CR6","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2217\/imt-2020-0179","volume":"13","author":"FG Dall'Olio","year":"2021","unstructured":"Dall\u2019Olio, F. G. et al. Immortal time bias in the association between toxicity and response for immune checkpoint inhibitors: A meta-analysis. Immunotherapy 13(3), 257\u2013270 (2021).","journal-title":"Immunotherapy"},{"issue":"4","key":"70041_CR7","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1634\/theoncologist.2018-0084","volume":"24","author":"DL Suzman","year":"2019","unstructured":"Suzman, D. L. et al. FDA approval summary: Atezolizumab or pembrolizumab for the treatment of patients with advanced urothelial carcinoma ineligible for cisplatin-containing chemotherapy. Oncologist 24(4), 563\u2013569 (2019).","journal-title":"Oncologist"},{"issue":"9","key":"70041_CR8","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1007\/s00345-018-2538-6","volume":"37","author":"V St\u00fchler","year":"2019","unstructured":"St\u00fchler, V. et al. Molecular predictors of response to PD-1\/PD-L1 inhibition in urothelial cancer. World J. Urol. 37(9), 1773\u20131784 (2019).","journal-title":"World J. Urol."},{"key":"70041_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1039121","volume":"9","author":"DC Guven","year":"2022","unstructured":"Guven, D. C. et al. The association between albumin levels and survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis. Front. Mol. Biosci. 9, 1039121 (2022).","journal-title":"Front. Mol. Biosci."},{"issue":"4","key":"70041_CR10","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.eururo.2019.09.006","volume":"77","author":"A Kamoun","year":"2020","unstructured":"Kamoun, A. et al. A consensus molecular classification of muscle-invasive bladder cancer. Eur. Urol. 77(4), 420\u2013433 (2020).","journal-title":"Eur. Urol."},{"issue":"5572","key":"70041_CR11","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1126\/science.1069588","volume":"296","author":"G Srinivasan","year":"2002","unstructured":"Srinivasan, G., James, C. M. & Krzycki, J. A. Pyrrolysine encoded by UAG in Archaea: Charging of a UAG-decoding specialized tRNA. Science (New York, NY) 296(5572), 1459\u20131462 (2002).","journal-title":"Science (New York, NY)"},{"issue":"5717","key":"70041_CR12","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1126\/science.1108329","volume":"307","author":"A Sauerwald","year":"2005","unstructured":"Sauerwald, A. et al. RNA-dependent cysteine biosynthesis in archaea. Science (New York, NY) 307(5717), 1969\u20131972 (2005).","journal-title":"Science (New York, NY)"},{"issue":"6289","key":"70041_CR13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/347203a0","volume":"347","author":"G Eriani","year":"1990","unstructured":"Eriani, G., Delarue, M., Poch, O., Gangloff, J. & Moras, D. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature 347(6289), 203\u2013206 (1990).","journal-title":"Nature"},{"issue":"10","key":"70041_CR14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/bies.950151007","volume":"15","author":"M Delarue","year":"1993","unstructured":"Delarue, M. & Moras, D. The aminoacyl-tRNA synthetase family: Modules at work. BioEssays 15(10), 675\u2013687 (1993).","journal-title":"BioEssays"},{"issue":"9","key":"70041_CR15","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/nrm2956","volume":"11","author":"M Guo","year":"2010","unstructured":"Guo, M., Yang, X. L. & Schimmel, P. New functions of aminoacyl-tRNA synthetases beyond translation. Nat. Rev. Mol. Cell Biol. 11(9), 668\u2013674 (2010).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"70041_CR16","first-page":"343","volume":"377","author":"W Freist","year":"1996","unstructured":"Freist, W., Logan, D. T. & Gauss, D. H. Glycyl-tRNA synthetase. Biol. Chem. Hoppe-Seyler 377(6), 343\u2013356 (1996).","journal-title":"Biol. Chem. Hoppe-Seyler"},{"issue":"3","key":"70041_CR17","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/j.1432-1033.1996.00814.x","volume":"241","author":"MH Mazauric","year":"1996","unstructured":"Mazauric, M. H. et al. An example of non-conservation of oligomeric structure in prokaryotic aminoacyl-tRNA synthetases. Biochemical and structural properties of glycyl-tRNA synthetase from Thermus thermophilus. Eur. J. Biochem. 241(3), 814\u2013826 (1996).","journal-title":"Eur. J. Biochem."},{"issue":"4","key":"70041_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/nrc2824","volume":"10","author":"D Silvera","year":"2010","unstructured":"Silvera, D., Formenti, S. C. & Schneider, R. J. Translational control in cancer. Nat. Rev. Cancer 10(4), 254\u2013266 (2010).","journal-title":"Nat. Rev. Cancer"},{"issue":"10","key":"70041_CR19","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/nrc3124","volume":"11","author":"S Kim","year":"2011","unstructured":"Kim, S., You, S. & Hwang, D. Aminoacyl-tRNA synthetases and tumorigenesis: More than housekeeping. Nat. Rev. Cancer 11(10), 708\u2013718 (2011).","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"70041_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12029","volume":"10","author":"PC Goughnour","year":"2020","unstructured":"Goughnour, P. C. et al. Extracellular vesicles derived from macrophages display glycyl-tRNA synthetase 1 and exhibit anti-cancer activity. J. Extracell. Vesicles 10(1), e12029 (2020).","journal-title":"J. Extracell. Vesicles"},{"key":"70041_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.canlet.2016.01.043","volume":"387","author":"T Wu","year":"2017","unstructured":"Wu, T. & Dai, Y. Tumor microenvironment and therapeutic response. Cancer Lett. 387, 61\u201368 (2017).","journal-title":"Cancer Lett."},{"issue":"4","key":"70041_CR22","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"G Bindea","year":"2013","unstructured":"Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39(4), 782\u2013795 (2013).","journal-title":"Immunity"},{"issue":"1","key":"70041_CR23","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1186\/s12885-018-4832-5","volume":"18","author":"KH Lee","year":"2018","unstructured":"Lee, K. H. et al. The prognostic and predictive value of tumor-infiltrating lymphocytes and hematologic parameters in patients with breast cancer. BMC Cancer 18(1), 938 (2018).","journal-title":"BMC Cancer"},{"issue":"2","key":"70041_CR24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.pathol.2015.12.006","volume":"48","author":"N Lee","year":"2016","unstructured":"Lee, N., Zakka, L. R., Mihm, M. C. Jr. & Schatton, T. Tumour-infiltrating lymphocytes in melanoma prognosis and cancer immunotherapy. Pathology 48(2), 177\u2013187 (2016).","journal-title":"Pathology"},{"issue":"4","key":"70041_CR25","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.ccell.2015.03.001","volume":"27","author":"SL Topalian","year":"2015","unstructured":"Topalian, S. L., Drake, C. G. & Pardoll, D. M. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 27(4), 450\u2013461 (2015).","journal-title":"Cancer Cell"},{"issue":"7655","key":"70041_CR26","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nature22396","volume":"545","author":"SR Gordon","year":"2017","unstructured":"Gordon, S. R. et al. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature 545(7655), 495\u2013499 (2017).","journal-title":"Nature"},{"issue":"1","key":"70041_CR27","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1172\/JCI123391","volume":"129","author":"CS Pai","year":"2019","unstructured":"Pai, C. S. et al. Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity. J. Clin. Investig. 129(1), 349\u2013363 (2019).","journal-title":"J. Clin. Investig."},{"issue":"3","key":"70041_CR28","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nri.2017.108","volume":"18","author":"AH Sharpe","year":"2018","unstructured":"Sharpe, A. H. & Pauken, K. E. The diverse functions of the PD1 inhibitory pathway. Nat. Rev. Immunol. 18(3), 153\u2013167 (2018).","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"70041_CR29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","volume":"18","author":"RS Riley","year":"2019","unstructured":"Riley, R. S., June, C. H., Langer, R. & Mitchell, M. J. Delivery technologies for cancer immunotherapy. Nat. Rev. Drug Discov. 18(3), 175\u2013196 (2019).","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1a","key":"70041_CR30","first-page":"A68","volume":"19","author":"K Tomczak","year":"2015","unstructured":"Tomczak, K., Czerwi\u0144ska, P. & Wiznerowicz, M. The Cancer Genome Atlas (TCGA): An immeasurable source of knowledge. Contemp. Oncol. (Poznan, Poland) 19(1a), A68-77 (2015).","journal-title":"Contemp. Oncol. (Poznan, Poland)"},{"issue":"6","key":"70041_CR31","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","volume":"45","author":"GTEx Consortium","year":"2013","unstructured":"GTEx Consortium. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45(6), 580\u2013585 (2013).","journal-title":"Nat. Genet."},{"issue":"7391","key":"70041_CR32","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nature11003","volume":"483","author":"J Barretina","year":"2012","unstructured":"Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483(7391), 603\u2013607 (2012).","journal-title":"Nature"},{"issue":"W1","key":"70041_CR33","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Z Tang","year":"2019","unstructured":"Tang, Z., Kang, B., Li, C., Chen, T. & Zhang, Z. GEPIA2: An enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 47(W1), W556\u2013W560 (2019).","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"70041_CR34","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cell.2019.12.023","volume":"180","author":"DP Nusinow","year":"2020","unstructured":"Nusinow, D. P. et al. Quantitative proteomics of the cancer cell line encyclopedia. Cell 180(2), 387-402.e16 (2020).","journal-title":"Cell"},{"issue":"7","key":"70041_CR35","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nmeth.1607","volume":"8","author":"K Colwill","year":"2011","unstructured":"Colwill, K. & Gr\u00e4slund, S. A roadmap to generate renewable protein binders to the human proteome. Nat. Methods 8(7), 551\u2013558 (2011).","journal-title":"Nat. Methods"},{"issue":"8","key":"70041_CR36","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","volume":"19","author":"DS Chandrashekar","year":"2017","unstructured":"Chandrashekar, D. S. et al. UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia (New York, NY) 19(8), 649\u2013658 (2017).","journal-title":"Neoplasia (New York, NY)"},{"issue":"2","key":"70041_CR37","first-page":"527","volume":"38","author":"S Wang","year":"2021","unstructured":"Wang, S. et al. UCSCXenaShiny: An R\/CRAN package for interactive analysis of UCSC Xena data. Bioinformatics (Oxford, England) 38(2), 527\u2013529 (2021).","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"269","key":"70041_CR38","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao, J. et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal. 6(269), pl1 (2013).","journal-title":"Sci. Signal."},{"issue":"3","key":"70041_CR39","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2217\/epi-2017-0118","volume":"10","author":"V Modhukur","year":"2018","unstructured":"Modhukur, V. et al. MethSurv: A web tool to perform multivariable survival analysis using DNA methylation data. Epigenomics 10(3), 277\u2013288 (2018).","journal-title":"Epigenomics"},{"issue":"11","key":"70041_CR40","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1245\/s10434-019-07431-7","volume":"26","author":"Y Fan","year":"2019","unstructured":"Fan, Y. et al. Exosomal PD-L1 retains immunosuppressive activity and is associated with gastric cancer prognosis. Ann. Surg. Oncol. 26(11), 3745\u20133755 (2019).","journal-title":"Ann. Surg. Oncol."},{"issue":"D1","key":"70041_CR41","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","volume":"45","author":"M Kanehisa","year":"2017","unstructured":"Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y. & Morishima, K. KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45(D1), D353\u2013D361 (2017).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"70041_CR42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28(1), 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"70041_CR43","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28(11), 1947\u20131951 (2019).","journal-title":"Protein Sci."},{"issue":"D1","key":"70041_CR44","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51(D1), D587\u2013D592 (2023).","journal-title":"Nucleic Acids Res."},{"issue":"43","key":"70041_CR45","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102(43), 15545\u201315550 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"70041_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann, S., Castelo, R. & Guinney, J. GSVA: Gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 14, 7 (2013).","journal-title":"BMC Bioinform."},{"issue":"W1","key":"70041_CR47","doi-asserted-by":"publisher","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","volume":"48","author":"T Li","year":"2020","unstructured":"Li, T. et al. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 48(W1), W509\u2013W514 (2020).","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"70041_CR48","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1055\/s-2008-1062264","volume":"28","author":"A Jani-Acsadi","year":"2008","unstructured":"Jani-Acsadi, A., Krajewski, K. & Shy, M. E. Charcot\u2013Marie\u2013Tooth neuropathies: Diagnosis and management. Semin. Neurol. 28(2), 185\u2013194 (2008).","journal-title":"Semin. Neurol."},{"issue":"1","key":"70041_CR49","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0022-510X(98)00264-0","volume":"161","author":"N Sambuughin","year":"1998","unstructured":"Sambuughin, N. et al. Autosomal dominant distal spinal muscular atrophy type V (dSMA-V) and Charcot\u2013Marie\u2013Tooth disease type 2D (CMT2D) segregate within a single large kindred and map to a refined region on chromosome 7p15. J. Neurol. Sci. 161(1), 23\u201328 (1998).","journal-title":"J. Neurol. Sci."},{"issue":"11","key":"70041_CR50","doi-asserted-by":"publisher","first-page":"E640","DOI":"10.1073\/pnas.1200194109","volume":"109","author":"MC Park","year":"2012","unstructured":"Park, M. C. et al. Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. Proc. Natl. Acad. Sci. USA 109(11), E640\u2013E647 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"70041_CR51","doi-asserted-by":"publisher","first-page":"632","DOI":"10.4161\/cbt.9.8.11265","volume":"9","author":"RE Schwarz","year":"2010","unstructured":"Schwarz, R. E. et al. Antitumor effects of EMAP II against pancreatic cancer through inhibition of fibronectin-dependent proliferation. Cancer Biol. Ther. 9(8), 632\u2013639 (2010).","journal-title":"Cancer Biol. Ther."},{"issue":"3","key":"70041_CR52","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00280-010-1514-7","volume":"68","author":"N Awasthi","year":"2011","unstructured":"Awasthi, N., Schwarz, M. A. & Schwarz, R. E. Enhancing cytotoxic agent activity in experimental pancreatic cancer through EMAP II combination therapy. Cancer Chemother. Pharmacol. 68(3), 571\u2013582 (2011).","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"4","key":"70041_CR53","first-page":"267","volume":"29","author":"AG Reznikov","year":"2007","unstructured":"Reznikov, A. G., Chaykovskaya, L. V., Polyakova, L. I. & Kornelyuk, A. I. Antitumor effect of endothelial monocyte-activating polypeptide-II on human prostate adenocarcinoma in mouse xenograft model. Exp. Oncol. 29(4), 267\u2013271 (2007).","journal-title":"Exp. Oncol."},{"issue":"1","key":"70041_CR54","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000381","volume":"8","author":"X Bai","year":"2020","unstructured":"Bai, X. et al. Development and validation of a genomic mutation signature to predict response to PD-1 inhibitors in non-squamous NSCLC: A multicohort study. J. Immunother. Cancer 8(1), e000381 (2020).","journal-title":"J. Immunother. Cancer"},{"issue":"18","key":"70041_CR55","doi-asserted-by":"publisher","first-page":"6694","DOI":"10.1002\/cam4.3324","volume":"9","author":"L Guo","year":"2020","unstructured":"Guo, L. et al. TOX correlates with prognosis, immune infiltration, and T cells exhaustion in lung adenocarcinoma. Cancer Med. 9(18), 6694\u20136709 (2020).","journal-title":"Cancer Med."},{"issue":"3","key":"70041_CR56","first-page":"223","volume":"8","author":"P Kidd","year":"2003","unstructured":"Kidd, P. Th1\/Th2 balance: The hypothesis, its limitations, and implications for health and disease. Altern. Med. Rev. 8(3), 223\u2013246 (2003).","journal-title":"Altern. Med. Rev."},{"issue":"4","key":"70041_CR57","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s12350-014-9908-2","volume":"21","author":"B George","year":"2014","unstructured":"George, B., Seals, S. & Aban, I. Survival analysis and regression models. J. Nucl. Cardiol. 21(4), 686\u2013694 (2014).","journal-title":"J. Nucl. Cardiol."},{"issue":"8","key":"70041_CR58","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1200\/JCO.2007.12.9791","volume":"26","author":"A Iasonos","year":"2008","unstructured":"Iasonos, A., Schrag, D., Raj, G. V. & Panageas, K. S. How to build and interpret a nomogram for cancer prognosis. J. Clin. Oncol. 26(8), 1364\u20131370 (2008).","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"70041_CR59","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/ni.2035","volume":"12","author":"EJ Wherry","year":"2011","unstructured":"Wherry, E. J. T cell exhaustion. Nat. Immunol. 12(6), 492\u2013499 (2011).","journal-title":"Nat. Immunol."}],"updated-by":[{"DOI":"10.1038\/s41598-024-76904-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70041-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70041-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70041-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T12:06:57Z","timestamp":1729771617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70041-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["70041"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-70041-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]},"assertion":[{"value":"6 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-024-76904-x","URL":"https:\/\/doi.org\/10.1038\/s41598-024-76904-x","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19025"}}