{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:27:40Z","timestamp":1781634460589,"version":"3.54.5"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-70343-4","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T13:45:32Z","timestamp":1724420732000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of classical music on light-plane anaesthesia and analgesia in dogs subjected to surgical nociceptive stimuli"],"prefix":"10.1038","volume":"14","author":[{"given":"S. G.","family":"Georgiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. L.","family":"Anagnostou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"Sideri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. G.","family":"Gouletsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. V.","family":"Athanasiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kazakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Tsioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Dermisiadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Galatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"70343_CR1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/00000542-199808000-00005","volume":"89","author":"ME Koch","year":"1998","unstructured":"Koch, M. E., Kain, Z. N., Ayoub, C. & Rosenbaum, S. H. The sedative and analgesic sparing effect of music. Anesthesiology 89, 300\u2013306306. https:\/\/doi.org\/10.1097\/00000542-199808000-00005 (1998).","journal-title":"Anesthesiology"},{"key":"70343_CR2","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/s0090-4295(02)02375-0","volume":"61","author":"E Yilmaz","year":"2003","unstructured":"Yilmaz, E. et al. Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy. Urology 61, 282\u2013286. https:\/\/doi.org\/10.1016\/s0090-4295(02)02375-0 (2003).","journal-title":"Urology"},{"key":"70343_CR3","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/j.1365-2044.2005.04299.x","volume":"60","author":"XW Zhang","year":"2005","unstructured":"Zhang, X. W., Fan, Y., Manyande, A., Tian, Y. K. & Yin, P. Effects of music on target-controlled infusion of propofol requirements during combined spinal-epidural anaesthesia. Anaesthesia 60, 990\u2013994. https:\/\/doi.org\/10.1111\/j.1365-2044.2005.04299.x (2005).","journal-title":"Anaesthesia"},{"key":"70343_CR4","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1097\/01.ccm.0000291648.99043.b9","volume":"35","author":"C Conrad","year":"2007","unstructured":"Conrad, C. et al. Overture for growth hormone: Requiem for interleukin-6?. Crit. Care Med. 35, 2709\u20132713. https:\/\/doi.org\/10.1097\/01.ccm.0000291648.99043.b9 (2007).","journal-title":"Crit. Care Med."},{"key":"70343_CR5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fpsyg.2011.00058","volume":"2","author":"S Koelsch","year":"2011","unstructured":"Koelsch, S. et al. Effects of music listening on cortisol levels and propofol consumption during spinal anesthesia. Front. Psychol. 2, 58. https:\/\/doi.org\/10.3389\/fpsyg.2011.00058 (2011).","journal-title":"Front. Psychol."},{"key":"70343_CR6","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1159\/000488319","volume":"27","author":"E Do\u011fan Bak\u0131","year":"2018","unstructured":"Do\u011fan Bak\u0131, E., Ulu, \u015e, Y\u00fcksek, A., Arican, H. & Sivaci, R. Does listening to music during tonsillectomy affect sevoflurane consumption?. Med. Princ. Pract. 27, 343\u2013349. https:\/\/doi.org\/10.1159\/000488319 (2018).","journal-title":"Med. Princ. Pract."},{"key":"70343_CR7","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.bjorl.2019.01.008","volume":"86","author":"E G\u00f6k\u00e7ek","year":"2020","unstructured":"G\u00f6k\u00e7ek, E. & Kaydu, A. The effects of music therapy in patients undergoing septorhinoplasty surgery under general anesthesia. Braz. J. Otorhinolaryngol. 86, 419\u2013426. https:\/\/doi.org\/10.1016\/j.bjorl.2019.01.008 (2020).","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"70343_CR8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1914.02560480063031","author":"EO Kane","year":"1914","unstructured":"Kane, E. O. Phonograph in operating-room. JAMA https:\/\/doi.org\/10.1001\/jama.1914.02560480063031 (1914).","journal-title":"JAMA"},{"key":"70343_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3390\/ani10010127","volume":"10","author":"AM Lindig","year":"2020","unstructured":"Lindig, A. M., McGreevy, P. D. & Crean, A. J. Musical dogs: A review of the influence of auditory enrichment on canine health and behavior. Animals 10, 127. https:\/\/doi.org\/10.3390\/ani10010127 (2020).","journal-title":"Animals"},{"key":"70343_CR10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/ani11010010","volume":"11","author":"V Amaya","year":"2021","unstructured":"Amaya, V., Descovich, K., Paterson, M. B. A. & Phillips, C. J. C. Effects of music pitch and tempo on the behaviour of kennelled dogs. Animals 11, 10. https:\/\/doi.org\/10.3390\/ani11010010 (2021).","journal-title":"Animals"},{"key":"70343_CR11","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1177\/1098612X15575778","volume":"18","author":"F Mira","year":"2016","unstructured":"Mira, F., Costa, A., Mendes, E., Azevedo, P. & Carreira, L. M. Influence of music and its genres on respiratory rate and pupil diameter variations in cats under general anaesthesia: Contribution to promoting patient safety. J. Feline Med. Surg. 18, 150\u2013159. https:\/\/doi.org\/10.1177\/1098612X15575778 (2016).","journal-title":"J. Feline Med. Surg."},{"key":"70343_CR12","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1177\/1098612X15588968","volume":"18","author":"F Mira","year":"2016","unstructured":"Mira, F., Costa, A., Mendes, E., Azevedo, P. & Carreira, L. M. A pilot study exploring the effects of musical genres on the depth of general anaesthesia assessed by haemodynamic responses. J. Feline Med. Surg. 18, 673\u2013678. https:\/\/doi.org\/10.1177\/1098612X15588968 (2016).","journal-title":"J. Feline Med. Surg."},{"key":"70343_CR13","doi-asserted-by":"publisher","first-page":"e3659","DOI":"10.7717\/peerj.3659","volume":"5","author":"JD Albright","year":"2017","unstructured":"Albright, J. D., Seddighi, R. M., Ng, Z., Sun, X. & Rezac, D. J. Effect of environmental noise and music on dexmedetomidine-induced sedation in dogs. Peer J. 5, e3659. https:\/\/doi.org\/10.7717\/peerj.3659 (2017).","journal-title":"Peer J."},{"key":"70343_CR14","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3390\/vetsci10070433","volume":"10","author":"SG Georgiou","year":"2023","unstructured":"Georgiou, S. G. et al. Effect of classical music on depth of sedation and induction propofol requirements in dogs. Vet. Sci. 10, 433. https:\/\/doi.org\/10.3390\/vetsci10070433 (2023).","journal-title":"Vet. Sci."},{"key":"70343_CR15","first-page":"51","volume":"8","author":"T Bilginer","year":"2018","unstructured":"Bilginer, T., Kisadere, \u0130 & D\u00f6nmez, N. Influence of music intervention on first wake up anesthesia period, some physiological and hematological parameters in dogs. MJAVL 8, 51\u201358 (2018).","journal-title":"MJAVL"},{"key":"70343_CR16","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/laban.162","volume":"42","author":"LC Alworth","year":"2013","unstructured":"Alworth, L. C. & Buerkle, S. C. The effects of music on animal physiology, behavior and welfare. Lab. Anim. 42, 54\u201361. https:\/\/doi.org\/10.1038\/laban.162 (2013).","journal-title":"Lab. Anim."},{"key":"70343_CR17","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.physbeh.2015.02.035","volume":"143","author":"A Bowman","year":"2015","unstructured":"Bowman, A., Scottish, S. P. C. A., Dowell, F. J. & Evans, N. P. \u201cFour seasons\u201d in an animal rescue centre; classical music reduces environmental stress in kennelled dogs. Physiol. Behav. 143, 70\u201382. https:\/\/doi.org\/10.1016\/j.physbeh.2015.02.035 (2015).","journal-title":"Physiol. Behav."},{"key":"70343_CR18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.applanim.2015.11.008","volume":"174","author":"C Brayley","year":"2016","unstructured":"Brayley, C. & Montrose, V. T. The effects of audiobooks on the behaviour of dogs at a rehoming kennels. Appl. Anim. Behav. Sci. 174, 111\u2013115. https:\/\/doi.org\/10.1016\/j.applanim.2015.11.008 (2016).","journal-title":"Appl. Anim. Behav. Sci."},{"key":"70343_CR19","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.3390\/ani10081385","volume":"10","author":"V Amaya","year":"2020","unstructured":"Amaya, V., Paterson, M. B. A., Descovich, K. & Phillips, C. J. C. Effects of olfactory and auditory enrichment on heart rate variability in shelter dogs. Animals 10, 1385. https:\/\/doi.org\/10.3390\/ani10081385 (2020).","journal-title":"Animals"},{"key":"70343_CR20","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/ani10040581","volume":"10","author":"V Amaya","year":"2020","unstructured":"Amaya, V., Paterson, M. B. A. & Phillips, C. J. C. Effects of olfactory and auditory enrichment on the behaviour of shelter dogs. Animals 10, 581. https:\/\/doi.org\/10.3390\/ani10040581 (2020).","journal-title":"Animals"},{"key":"70343_CR21","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2460\/javma.251.2.195","volume":"251","author":"WJ Engler","year":"2017","unstructured":"Engler, W. J. & Bain, M. Effect of different types of classical music played at a veterinary hospital on dog behavior and owner satisfaction. JAVMA 251, 195\u2013200. https:\/\/doi.org\/10.2460\/javma.251.2.195 (2017).","journal-title":"JAVMA"},{"key":"70343_CR22","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/j.1399-6576.2005.00703.x","volume":"49","author":"MH Dueck","year":"2005","unstructured":"Dueck, M. H. et al. Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: A FMRI study. Acta Anaesthesiol. Scand. 49, 784\u2013791. https:\/\/doi.org\/10.1111\/j.1399-6576.2005.00703.x (2005).","journal-title":"Acta Anaesthesiol. Scand."},{"key":"70343_CR23","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1016\/j.clinph.2006.05.009","volume":"117","author":"S Koelsch","year":"2006","unstructured":"Koelsch, S., Heinke, W., Sammler, D. & Olthoff, D. Auditory processing during deep propofol sedation and recovery from unconsciousness. J. Clin. Neurophysiol. 117, 1746\u20131759. https:\/\/doi.org\/10.1016\/j.clinph.2006.05.009 (2006).","journal-title":"J. Clin. Neurophysiol."},{"key":"70343_CR24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/00000542-200507000-00006","volume":"103","author":"C Kerssens","year":"2005","unstructured":"Kerssens, C. et al. Attenuated brain response to auditory word stimulation with sevoflurane: A functional magnetic resonance imaging study in humans. Anesthesiology 103, 11\u201319. https:\/\/doi.org\/10.1097\/00000542-200507000-00006 (2005).","journal-title":"Anesthesiology"},{"key":"70343_CR25","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.heares.2005.01.013","volume":"206","author":"J Syka","year":"2005","unstructured":"Syka, J., Suta, D. & Popel\u00e1r, J. Responses to species-specific vocalizations in the auditory cortex of awake and anesthetized guinea pigs. Hear. Res. 206, 177\u2013184. https:\/\/doi.org\/10.1016\/j.heares.2005.01.013 (2005).","journal-title":"Hear. Res."},{"key":"70343_CR26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/00016480600740613","volume":"127","author":"Y Feng","year":"2007","unstructured":"Feng, Y., Wang, J. & Yin, S. General anesthesia changes gap-evoked auditory responses in guinea pigs. Acta Otolaryngol. 127, 143\u2013148. https:\/\/doi.org\/10.1080\/00016480600740613 (2007).","journal-title":"Acta Otolaryngol."},{"key":"70343_CR27","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/s0378-5955(01)00272-6","volume":"156","author":"SW Cheung","year":"2001","unstructured":"Cheung, S. W. et al. Auditory cortical neuron response differences under isoflurane versus pentobarbital anesthesia. Hear. Res. 156, 115\u2013127. https:\/\/doi.org\/10.1016\/s0378-5955(01)00272-6 (2001).","journal-title":"Hear. Res."},{"key":"70343_CR28","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1111\/ejn.13007","volume":"42","author":"T Noda","year":"2015","unstructured":"Noda, T. & Takahashi, H. Anesthetic effects of isoflurane on the tonotopic map and neuronal population activity in the rat auditory cortex. Eur. J. Neurosci. 42, 2298\u20132311. https:\/\/doi.org\/10.1111\/ejn.13007 (2015).","journal-title":"Eur. J. Neurosci."},{"key":"70343_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuroscience.2015.05.004","volume":"300","author":"H Takahashi","year":"2015","unstructured":"Takahashi, H., Tokushige, H., Shiramatsu, T. I., Noda, T. & Kanzaki, R. Covariation of pupillary and auditory cortical activity in rats under isoflurane anesthesia. Neurosci. J. 300, 29\u201338. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.05.004 (2015).","journal-title":"Neurosci. J."},{"key":"70343_CR30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cvfa.2012.11.002","volume":"29","author":"JF Coetzee","year":"2013","unstructured":"Coetzee, J. F. Assessment and management of pain associated with castration in cattle. Vet. Clin. North Am. Food Anim. 29, 75\u2013101. https:\/\/doi.org\/10.1016\/j.cvfa.2012.11.002 (2013).","journal-title":"Vet. Clin. North Am. Food Anim."},{"key":"70343_CR31","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00441-018-2922-y","volume":"375","author":"W Zieglg\u00e4nsberger","year":"2019","unstructured":"Zieglg\u00e4nsberger, W. Substance P and pain chronicity. Cell Tissue Res. 375, 227\u2013241. https:\/\/doi.org\/10.1007\/s00441-018-2922-y (2019).","journal-title":"Cell Tissue Res."},{"key":"70343_CR32","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1097\/01.don.0000158237.63383.d8","volume":"31","author":"J Caviedes-Bucheli","year":"2005","unstructured":"Caviedes-Bucheli, J. et al. The effect of cavity preparation on substance P expression in human dental pulp. J. Endod. 31, 857\u2013859. https:\/\/doi.org\/10.1097\/01.don.0000158237.63383.d8 (2005).","journal-title":"J. Endod."},{"key":"70343_CR33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1080\/00016350701810658","volume":"66","author":"NL Avell\u00e1n","year":"2008","unstructured":"Avell\u00e1n, N. L., Sorsa, T., Tervahartiala, T., Forster, C. & Kemppainen, P. Experimental tooth pain elevates substance P and matrix metalloproteinase-8 levels in human gingival crevice fluid. Acta Odontol. Scand. 66, 18\u201322. https:\/\/doi.org\/10.1080\/00016350701810658 (2008).","journal-title":"Acta Odontol. Scand."},{"key":"70343_CR34","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/1471-2474-15-92","volume":"15","author":"H Wang","year":"2014","unstructured":"Wang, H. et al. Increasing substance P levels in serum and synovial tissues from patients with developmental dysplasia of the hip (DDH). BMC Musculoskelet. Disord. 15, 92. https:\/\/doi.org\/10.1186\/1471-2474-15-92 (2014).","journal-title":"BMC Musculoskelet. Disord."},{"key":"70343_CR35","doi-asserted-by":"publisher","first-page":"e0146400","DOI":"10.1371\/journal.pone.0146400","volume":"11","author":"B Lisowska","year":"2016","unstructured":"Lisowska, B., Siewruk, K. & Lisowski, A. Substance P and acute pain in patients undergoing orthopedic surgery. PLoS\u00a0One 11, e0146400. https:\/\/doi.org\/10.1371\/journal.pone.0146400 (2016).","journal-title":"PLoS\u00a0One"},{"key":"70343_CR36","doi-asserted-by":"publisher","first-page":"e59234","DOI":"10.1371\/journal.pone.0059234","volume":"8","author":"MM Zhang","year":"2013","unstructured":"Zhang, M. M. et al. Acute colitis induces neurokinin 1 receptor internalization in the rat lumbosacral spinal cord. PLoS\u00a0One 8, e59234. https:\/\/doi.org\/10.1371\/journal.pone.0059234 (2013).","journal-title":"PLoS\u00a0One"},{"key":"70343_CR37","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1016\/j.pain.2014.07.017","volume":"155","author":"P Rialland","year":"2014","unstructured":"Rialland, P. et al. Association between sensitisation and pain-related behaviours in an experimental canine model of osteoarthritis. Pain 155, 2071\u20132079. https:\/\/doi.org\/10.1016\/j.pain.2014.07.017 (2014).","journal-title":"Pain"},{"key":"70343_CR38","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/jvim.12080","volume":"27","author":"MJ Schmidt","year":"2013","unstructured":"Schmidt, M. J., Roth, J., Ondreka, N., Kramer, M. & Rummel, C. A potential role for substance P and interleukin-6 in the cerebrospinal fluid of Cavalier King Charles Spaniels with neuropathic pain. J. Vet. Intern. Med. 27, 530\u2013535. https:\/\/doi.org\/10.1111\/jvim.12080 (2013).","journal-title":"J. Vet. Intern. Med."},{"key":"70343_CR39","first-page":"289","volume":"20","author":"JS Yoon","year":"2019","unstructured":"Yoon, J. S., Park, J., Song, R. & Yu, D. Substance P as a potential biomarker of pain assessment in dogs. Iran. J. Vet. Res. 20, 289\u2013292 (2019).","journal-title":"Iran. J. Vet. Res."},{"key":"70343_CR40","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/ALN.0b013e31829996b6","volume":"119","author":"T Takasusuki","year":"2013","unstructured":"Takasusuki, T., Yamaguchi, S., Hamaguchi, S. & Yaksh, T. L. Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn. Anesthesiology 119, 433\u2013442. https:\/\/doi.org\/10.1097\/ALN.0b013e31829996b6 (2013).","journal-title":"Anesthesiology"},{"key":"70343_CR41","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1467-2995.2011.00646.x","volume":"38","author":"E De Mattos-Junior","year":"2011","unstructured":"De Mattos-Junior, E. et al. Bispectral monitoring in dogs subjected to ovariohysterectomy and anesthetized with halothane, isoflurane or sevoflurane. Vet. Anaesth. Analg. 38, 475\u2013483. https:\/\/doi.org\/10.1111\/j.1467-2995.2011.00646.x (2011).","journal-title":"Vet. Anaesth. Analg."},{"key":"70343_CR42","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1177\/155005949903000204","volume":"30","author":"JR Hughes","year":"1999","unstructured":"Hughes, J. R., Fino, J. J. & Melyn, M. A. Is there a chronic change of the \u201cMozart effect\u201d on epileptiform activity? A case study. . Clin. Electroencephalogr. 30, 44\u201345. https:\/\/doi.org\/10.1177\/155005949903000204 (1999).","journal-title":". Clin. Electroencephalogr."},{"key":"70343_CR43","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.yebeh.2010.12.044","volume":"20","author":"LC Lin","year":"2011","unstructured":"Lin, L. C. et al. Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy. Epilepsy Behav. 20, 490\u2013493. https:\/\/doi.org\/10.1016\/j.yebeh.2010.12.044 (2011).","journal-title":"Epilepsy Behav."},{"key":"70343_CR44","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.yebeh.2011.05.015","volume":"21","author":"LC Lin","year":"2011","unstructured":"Lin, L. C. et al. The long-term effect of listening to Mozart K.448 decreases epileptiform discharges in children with epilepsy. Epilepsy Behav. 21, 420\u2013424. https:\/\/doi.org\/10.1016\/j.yebeh.2011.05.015 (2011).","journal-title":"Epilepsy Behav."},{"key":"70343_CR45","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/01616412.1998.11740543","volume":"20","author":"FH Rauscher","year":"1998","unstructured":"Rauscher, F. H., Robinson, K. D. & Jens, J. J. Improved maze learning through early music exposure in rats. Neurol. Res. 20, 427\u2013432. https:\/\/doi.org\/10.1080\/01616412.1998.11740543 (1998).","journal-title":"Neurol. Res."},{"key":"70343_CR46","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.eplepsyres.2012.11.005","volume":"104","author":"LC Lin","year":"2013","unstructured":"Lin, L. C. et al. Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats. Epilepsy Res. 104, 234\u2013240. https:\/\/doi.org\/10.1016\/j.eplepsyres.2012.11.005 (2013).","journal-title":"Epilepsy Res."},{"key":"70343_CR47","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/medicina57020132","volume":"57","author":"AF Rogobete","year":"2021","unstructured":"Rogobete, A. F. et al. Multiparametric monitoring of hypnosis and nociception-antinociception balance during general anesthesia-A new era in patient safety standards and healthcare management. Medicina 57, 132. https:\/\/doi.org\/10.3390\/medicina57020132 (2021).","journal-title":"Medicina"},{"key":"70343_CR48","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/anae.12168","volume":"68","author":"A Aranake","year":"2013","unstructured":"Aranake, A., Mashour, G. A. & Avidan, M. S. Minimum alveolar concentration: Ongoing relevance and clinical utility. Anaesthesia 68, 512\u2013522. https:\/\/doi.org\/10.1111\/anae.12168 (2013).","journal-title":"Anaesthesia"},{"key":"70343_CR49","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1177\/15500594221131680","volume":"54","author":"MCJ N\u00e6vra","year":"2023","unstructured":"N\u00e6vra, M. C. J., Romundstad, L., Aasheim, A. & Larsson, P. G. Monitoring the awake and anesthetized unconscious states using bispectral index and electroencephalographic connectivity measures. Clin. EEG Neurosci. 54, 273\u2013280. https:\/\/doi.org\/10.1177\/15500594221131680 (2023).","journal-title":"Clin. EEG Neurosci."},{"key":"70343_CR50","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.bjane.2015.09.001","volume":"67","author":"CR Oliveira","year":"2017","unstructured":"Oliveira, C. R., Bernardo, W. M. & Nunes, V. M. Benefit of general anesthesia monitored by bispectral index compared with monitoring guided only by clinical parameters. Systematic review and meta-analysis. Braz. J. Anesthesiol. 67, 72\u201384. https:\/\/doi.org\/10.1016\/j.bjane.2015.09.001 (2017).","journal-title":"Braz. J. Anesthesiol."},{"key":"70343_CR51","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.2460\/ajvr.2004.65.1128","volume":"65","author":"MS Carrasco-Jim\u00e9nez","year":"2004","unstructured":"Carrasco-Jim\u00e9nez, M. S. et al. Relationships between a proprietary index, bispectral index, and hemodynamic variables as a means for evaluating depth of anesthesia in dogs anesthetized with sevoflurane. Am. J. Vet. Res. 65, 1128\u20131135. https:\/\/doi.org\/10.2460\/ajvr.2004.65.1128 (2004).","journal-title":"Am. J. Vet. Res."},{"key":"70343_CR52","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/j.1467-2995.2011.00651.x","volume":"38","author":"EH Bleijenberg","year":"2011","unstructured":"Bleijenberg, E. H., van Oostrom, H., Akkerdaas, L. C., Doornenbal, A. & Hellebrekers, L. J. Bispectral index and the clinically evaluated anaesthetic depth in dogs. Vet. Anaesth. Analg. 38, 536\u2013543. https:\/\/doi.org\/10.1111\/j.1467-2995.2011.00651.x (2011).","journal-title":"Vet. Anaesth. Analg."},{"key":"70343_CR53","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1213\/ane.0b013e3181733e16","volume":"107","author":"P Szmuk","year":"2008","unstructured":"Szmuk, P. et al. Listening to music during anesthesia does not reduce the sevoflurane concentration needed to maintain a constant bispectral index. Anesth. Analg. 107, 77\u201380. https:\/\/doi.org\/10.1213\/ane.0b013e3181733e16 (2008).","journal-title":"Anesth. Analg."},{"key":"70343_CR54","doi-asserted-by":"publisher","first-page":"580","DOI":"10.4103\/1687-7934.172744","volume":"8","author":"NP Kalyani","year":"2015","unstructured":"Kalyani, N. P., Poonam, G. G. & Shalini, K. T. Impact of intraoperative music therapy on the anesthetic requirement and stress response in laparoscopic surgeries under general anesthesia. Ain Shams J. Anaesthesiol. 8, 580\u2013584. https:\/\/doi.org\/10.4103\/1687-7934.172744 (2015).","journal-title":"Ain Shams J. Anaesthesiol."},{"key":"70343_CR55","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1097\/00000539-200111000-00022","volume":"93","author":"DW Kim","year":"2001","unstructured":"Kim, D. W., Kil, H. Y. & White, P. F. The effect of noise on the bispectral index during propofol sedation. Anesth. Analg. 93, 1170\u20131173. https:\/\/doi.org\/10.1097\/00000539-200111000-00022 (2001).","journal-title":"Anesth. Analg."},{"key":"70343_CR56","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.rvsc.2018.01.004","volume":"117","author":"R Reed","year":"2018","unstructured":"Reed, R. & Doherty, T. Minimum alveolar concentration: Key concepts and a review of its pharmacological reduction in dogs. Part 1. Res. Vet. Sci. 117, 266\u2013270. https:\/\/doi.org\/10.1016\/j.rvsc.2018.01.004 (2018).","journal-title":"Res. Vet. Sci."},{"key":"70343_CR57","doi-asserted-by":"publisher","first-page":"957","DOI":"10.2460\/ajvr.2003.64.957","volume":"64","author":"A Valverde","year":"2003","unstructured":"Valverde, A., Morey, T. E., Hern\u00e1ndez, J. & Davies, W. Validation of several types of noxious stimuli for use in determining the minimum alveolar concentration for inhalation anesthetics in dogs and rabbits. Am. J. Vet. Res. 64, 957\u2013962. https:\/\/doi.org\/10.2460\/ajvr.2003.64.957 (2003).","journal-title":"Am. J. Vet. Res."},{"key":"70343_CR58","first-page":"21","volume":"79","author":"PG Binns-Turner","year":"2011","unstructured":"Binns-Turner, P. G., Wilson, L. L., Pryor, E. R., Boyd, G. L. & Prickett, C. A. Perioperative music and its effects on anxiety, hemodynamics, and pain in women undergoing mastectomy. AANA J. 79, 21\u201327 (2011).","journal-title":"AANA J."},{"key":"70343_CR59","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1213\/ANE.0b013e31823dc5fb","volume":"114","author":"A Buvanendran","year":"2012","unstructured":"Buvanendran, A., Kroin, J. S., Della Valle, C. J., Moric, M. & Tuman, K. J. Cerebrospinal fluid neurotransmitter changes during the perioperative period in patients undergoing total knee replacement: A randomized trial. Anesth. Analg. 114, 434\u2013441. https:\/\/doi.org\/10.1213\/ANE.0b013e31823dc5fb (2012).","journal-title":"Anesth. Analg."},{"key":"70343_CR60","doi-asserted-by":"publisher","first-page":"7670","DOI":"10.1523\/JNEUROSCI.19-17-07670.1999","volume":"19","author":"P Honor","year":"1999","unstructured":"Honor, P. et al. Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states. J. Neurosci. 19, 7670\u20137678. https:\/\/doi.org\/10.1523\/JNEUROSCI.19-17-07670.1999 (1999).","journal-title":"J. Neurosci."},{"key":"70343_CR61","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1038\/jcbfm.2009.63","volume":"29","author":"JJ Donkin","year":"2009","unstructured":"Donkin, J. J., Nimmo, A. J., Cernak, I., Blumbergs, P. C. & Vink, R. Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. J. Cereb. Blood Flow Metab. 29, 1388\u20131398. https:\/\/doi.org\/10.1038\/jcbfm.2009.63 (2009).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"70343_CR62","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1213\/01.ane.0000167269.62966.af","volume":"101","author":"AA Dahaba","year":"2005","unstructured":"Dahaba, A. A. Different conditions that could result in the bispectral index indicating an incorrect hypnotic state. Anesth. Analg. 101, 765\u2013773. https:\/\/doi.org\/10.1213\/01.ane.0000167269.62966.af (2005).","journal-title":"Anesth. Analg."},{"key":"70343_CR63","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ics.2005.06.050","volume":"1283","author":"Y Morimoto","year":"2005","unstructured":"Morimoto, Y., Hirata, T. & Sakabe, T. Clinical monitoring for depth of anesthesia: Bispectral index (BIS). Int. Cong. Ser. 1283, 235\u2013238. https:\/\/doi.org\/10.1016\/j.ics.2005.06.050 (2005).","journal-title":"Int. Cong. Ser."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70343-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70343-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70343-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T13:53:17Z","timestamp":1724421197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70343-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["70343"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-70343-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"29 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19511"}}