{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:58:05Z","timestamp":1793217485584,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Hebei Provincial Natural Science Foundation","award":["H2024206280"],"award-info":[{"award-number":["H2024206280"]}]},{"name":"the Hebei Provincial Natural Science Foundation","award":["H2024206245"],"award-info":[{"award-number":["H2024206245"]}]},{"name":"Foundation of XingHuo Project  of the First Hospital of Hebei Medical University","award":["XH202401"],"award-info":[{"award-number":["XH202401"]}]},{"name":"the Key Projects of Hebei Administration of Traditional Chinese Medicine","award":["Z2022015"],"award-info":[{"award-number":["Z2022015"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-70584-3","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T15:03:21Z","timestamp":1728918201000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["High glucose- or AGE-induced oxidative stress inhibits hippocampal neuronal mitophagy through the Keap1\u2013Nrf2\u2013PHB2 pathway in diabetic encephalopathy"],"prefix":"10.1038","volume":"14","author":[{"given":"Shan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunjiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"issue":"4","key":"70584_CR1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.cpm.2022.05.001","volume":"39","author":"LR Hjelm","year":"2022","unstructured":"Hjelm, L. R. Diabetes mellitus: An overview in relationship to Charcot Neuroarthropathy. Clin. Podiatr. Med. Surg. 39(4), 535\u2013542 (2022).","journal-title":"Clin. Podiatr. Med. Surg."},{"issue":"2","key":"70584_CR2","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s10571-022-01214-7","volume":"43","author":"H Zhou","year":"2023","unstructured":"Zhou, H., Rao, Z., Zhang, Z. & Zhou, J. Function of the GABAergic system in diabetic encephalopathy. Cell Mol. Neurobiol. 43(2), 605\u2013619 (2023).","journal-title":"Cell Mol. Neurobiol."},{"issue":"3\u20134","key":"70584_CR3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/BF01257917","volume":"1","author":"E Reske-Nielsen","year":"1966","unstructured":"Reske-Nielsen, E., Lundb\u00e6k, K. & Rafaelsen, O. J. Pathological changes in the central and peripheral nervous system of young long-term diabetics: I Diabetic encephalopathy. Diabetologia. 1(3\u20134), 233\u2013241 (1966).","journal-title":"Diabetologia."},{"issue":"2","key":"70584_CR4","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s10787-019-00665-7","volume":"28","author":"M Zeinivand","year":"2020","unstructured":"Zeinivand, M., Nahavandi, A. & Zare, M. Deferoxamine regulates neuroinflammation and oxidative stress in rats with diabetes-induced cognitive dysfunction. Inflammopharmacology. 28(2), 575\u2013583 (2020).","journal-title":"Inflammopharmacology."},{"issue":"4","key":"70584_CR5","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1007\/s12035-019-01858-5","volume":"57","author":"JC Shieh","year":"2020","unstructured":"Shieh, J. C., Huang, P. T. & Lin, Y. F. Alzheimer\u2019s disease and diabetes: Insulin signaling as the bridge linking two pathologies. Mol. Neurobiol. 57(4), 1966\u20131977 (2020).","journal-title":"Mol. Neurobiol."},{"key":"70584_CR6","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.pharmthera.2017.02.030","volume":"177","author":"K Byun","year":"2017","unstructured":"Byun, K. et al. Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases. Pharmacol. Ther. 177, 44\u201355 (2017).","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"70584_CR7","doi-asserted-by":"publisher","DOI":"10.2174\/1573399818666220513142030","volume":"19","author":"P Sarkar","year":"2023","unstructured":"Sarkar, P., Banu, S., Bhattacharya, S., Bala, A. & Sur, D. Pathophysiology associated with diabetes-induced Tauopathy and development of Alzheimer\u2019s disease. Curr. Diabetes Rev. 19(5), e130522204763 (2023).","journal-title":"Curr. Diabetes Rev."},{"issue":"3","key":"70584_CR8","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3400\/avd.ra.18-00070","volume":"11","author":"SI Yamagishi","year":"2018","unstructured":"Yamagishi, S. I. & Matsui, T. Role of hyperglycemia-induced advanced glycation end product (AGE) accumulation in atherosclerosis. Ann. Vasc. Dis. 11(3), 253\u2013258 (2018).","journal-title":"Ann. Vasc. Dis."},{"issue":"2","key":"70584_CR9","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3390\/nu12020441","volume":"12","author":"T van der Lugt","year":"2020","unstructured":"van der Lugt, T., Weseler, A. R., Vrolijk, M. F., Opperhuizen, A. & Bast, A. Dietary advanced glycation endproducts decrease glucocorticoid sensitivity in vitro. Nutrients. 12(2), 441 (2020).","journal-title":"Nutrients."},{"issue":"8","key":"70584_CR10","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3390\/cells12081211","volume":"12","author":"A Qi","year":"2023","unstructured":"Qi, A. et al. Essential protein PHB2 and its regulatory mechanisms in cancer. Cells. 12(8), 1211 (2023).","journal-title":"Cells."},{"key":"70584_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.714228","volume":"12","author":"M Belser","year":"2021","unstructured":"Belser, M. & Walker, D. W. Role of prohibitins in aging and therapeutic potential against age-related diseases. Front. Genet. 12, 714228 (2021).","journal-title":"Front. Genet."},{"issue":"12","key":"70584_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102704","volume":"298","author":"S Sun","year":"2022","unstructured":"Sun, S. et al. The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy. J. Biol. Chem. 298(12), 102704 (2022).","journal-title":"J. Biol. Chem."},{"issue":"8","key":"70584_CR13","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3390\/pathogens9080621","volume":"9","author":"F De Falco","year":"2020","unstructured":"De Falco, F. et al. Prohibitin 2 is involved in parkin-mediated Mitophagy in Urothelial cells of cattle infected with bovine papillomavirus. Pathogens. 9(8), 621 (2020).","journal-title":"Pathogens."},{"issue":"3","key":"70584_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/jnc.14472","volume":"146","author":"CJ Anderson","year":"2018","unstructured":"Anderson, C. J. et al. Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress. J. Neurochem. 146(3), 235\u2013250 (2018).","journal-title":"J. Neurochem."},{"issue":"10","key":"70584_CR15","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.2337\/db13-0152","volume":"62","author":"S Supale","year":"2013","unstructured":"Supale, S. et al. Loss of prohibitin induces mitochondrial damages altering \u03b2-cell function and survival and is responsible for gradual diabetes development. Diabetes. 62(10), 3488\u20133499 (2013).","journal-title":"Diabetes."},{"issue":"4","key":"70584_CR16","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3233\/JAD-215301","volume":"85","author":"Z Gao","year":"2022","unstructured":"Gao, Z. et al. Administration of miR-195 inhibitor enhances memory function through improving synaptic degradation and mitochondrial dysfunction of the hippocampal neurons in SAMP8 mice. J. Alzheimers Dis. 85(4), 1495\u20131509 (2022).","journal-title":"J. Alzheimers Dis."},{"key":"70584_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112330","volume":"248","author":"J Zheng","year":"2020","unstructured":"Zheng, J. et al. BuZangTongLuo decoction improved hindlimb ischemia by activating angiogenesis and regulating gut microbiota in diabetic mice. J. Ethnopharmacol. 248, 112330 (2020).","journal-title":"J. Ethnopharmacol."},{"key":"70584_CR18","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.brainresbull.2022.08.007","volume":"188","author":"L Jiang","year":"2022","unstructured":"Jiang, L. et al. Advanced glycation end products induce A\u03b21-42 deposition and cognitive decline through H19\/miR-15b\/BACE1 axis in diabetic encephalopathy. Brain Res. Bull. 188, 187\u2013196 (2022).","journal-title":"Brain Res. Bull."},{"issue":"2","key":"70584_CR19","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3390\/ijms24021196","volume":"24","author":"E Falvo","year":"2023","unstructured":"Falvo, E. et al. Diabetic encephalopathy in a preclinical experimental model of type 1 diabetes mellitus: Observations in adult female rat. Int. J. Mol. Sci. 24(2), 1196 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"70584_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109930","volume":"118","author":"X Zhang","year":"2023","unstructured":"Zhang, X. et al. Lipin2 ameliorates diabetic encephalopathy via suppressing JNK\/ERK-mediated NLRP3 inflammasome overactivation. Int. Immunopharmacol. 118, 109930 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"70584_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101799","volume":"37","author":"Q Kang","year":"2020","unstructured":"Kang, Q. & Yang, C. Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications. Redox Biol. 37, 101799 (2020).","journal-title":"Redox Biol."},{"key":"70584_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.883057","volume":"13","author":"X Yi","year":"2022","unstructured":"Yi, X. et al. Erythropoietin mitigates diabetic nephropathy by restoring PINK1\/Parkin-mediated mitophagy. Front. Pharmacol. 13, 883057 (2022).","journal-title":"Front. Pharmacol."},{"key":"70584_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.897046","volume":"13","author":"T Zheng","year":"2022","unstructured":"Zheng, T. et al. Src activation aggravates podocyte injury in diabetic nephropathy via suppression of FUNDC1-mediated mitophagy. Front. Pharmacol. 13, 897046 (2022).","journal-title":"Front. Pharmacol."},{"key":"70584_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108640","volume":"209","author":"J Xie","year":"2021","unstructured":"Xie, J. et al. VDAC1 regulates mitophagy in NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions. Exp. Eye Res. 209, 108640 (2021).","journal-title":"Exp. Eye Res."},{"key":"70584_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109015","volume":"218","author":"L Huang","year":"2022","unstructured":"Huang, L. et al. Effect of Sirt3 on retinal pigment epithelial cells in high glucose through Foxo3a\/ PINK1-Parkin pathway mediated mitophagy. Exp. Eye Res. 218, 109015 (2022).","journal-title":"Exp. Eye Res."},{"key":"70584_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.917135","volume":"9","author":"J Lin","year":"2022","unstructured":"Lin, J. et al. Mitochondrial dynamics and Mitophagy in Cardiometabolic disease. Front. Cardiovasc. Med. 9, 917135 (2022).","journal-title":"Front. Cardiovasc. Med."},{"key":"70584_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.750382","volume":"9","author":"H Zheng","year":"2021","unstructured":"Zheng, H. et al. Mitophagy in diabetic cardiomyopathy: roles and mechanisms. Front. Cell Dev. Biol. 9, 750382 (2021).","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"70584_CR28","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang, E. F. et al. Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease. Nat. Neurosci. 22(3), 401\u2013412 (2019).","journal-title":"Nat. Neurosci."},{"issue":"2","key":"70584_CR29","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/s41419-017-0228-8","volume":"9","author":"Y Xiao","year":"2018","unstructured":"Xiao, Y., Zhou, Y., Lu, Y., Zhou, K. & Cai, W. PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver. Cell Death Dis. 9(2), 160 (2018).","journal-title":"Cell Death Dis."},{"issue":"2","key":"70584_CR30","doi-asserted-by":"publisher","first-page":"F396","DOI":"10.1152\/ajprenal.00420.2018","volume":"316","author":"Y Xu","year":"2019","unstructured":"Xu, Y., Wang, J., Xu, W., Ding, F. & Ding, W. Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation. Am. J. Physiol. Renal. Physiol. 316(2), F396\u2013F407 (2019).","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"70584_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102260","volume":"50","author":"L Liu","year":"2022","unstructured":"Liu, L. et al. Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy. Redox Biol. 50, 102260 (2022).","journal-title":"Redox Biol."},{"key":"70584_CR32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12986-019-0338-7","volume":"16","author":"J Yang","year":"2019","unstructured":"Yang, J. et al. Resveratrol attenuates oxidative injury in human umbilical vein endothelial cells through regulating mitochondrial fusion via TyrRS-PARP1 pathway. Nutr. Metab. (Lond). 16, 9 (2019).","journal-title":"Nutr. Metab. (Lond)."},{"issue":"8","key":"70584_CR33","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1073\/pnas.1318951111","volume":"111","author":"A Hoshino","year":"2014","unstructured":"Hoshino, A. et al. Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic \u03b2-cell function in diabetes. Proc. Natl. Acad. Sci. U.S.A. 111(8), 3116\u20133121 (2014).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"70584_CR34","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ejphar.2008.06.067","volume":"591","author":"JA Rubiolo","year":"2008","unstructured":"Rubiolo, J. A., Mithieux, G. & Vega, F. V. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur. J. Pharmacol. 591, 66\u201372 (2008).","journal-title":"Eur. J. Pharmacol."},{"key":"70584_CR35","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/biom10020320","volume":"10","author":"S Kasai","year":"2020","unstructured":"Kasai, S. et al. Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology. Biomolecules 10, 320 (2020).","journal-title":"Biomolecules"},{"issue":"4","key":"70584_CR36","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1161\/STROKEAHA.118.021590","volume":"50","author":"T Zhang","year":"2019","unstructured":"Zhang, T. et al. Mitophagy reduces oxidative stress via Keap1 (Kelch-like epichlorohydrin-associated protein 1)\/Nrf2 (Nuclear Factor-E2-Related Factor 2)\/PHB2 (Prohibitin 2) pathway after subarachnoid hemorrhage in rats. Stroke. 50(4), 978\u2013988 (2019).","journal-title":"Stroke."},{"key":"70584_CR37","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","volume":"11","author":"L Xiao","year":"2016","unstructured":"Xiao, L. et al. The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1. Redox Biol. 11, 297\u2013311 (2016).","journal-title":"Redox Biol."},{"key":"70584_CR38","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.pneurobio.2016.06.006","volume":"157","author":"PB Ham 3rd","year":"2017","unstructured":"Ham, P. B. 3rd. & Raju, R. Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog. Neurobiol. 157, 92\u2013116 (2017).","journal-title":"Prog. Neurobiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70584-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70584-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70584-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:03:52Z","timestamp":1729155832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70584-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["70584"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-70584-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"15 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24044"}}