{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:15:48Z","timestamp":1784747748463,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-70620-2","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T11:01:38Z","timestamp":1728126098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of the conceivable inhibitory activity of pathogenic microorganisms extracted from seaweed using phytochemicals, antioxidants, and in-silico molecular dynamic simulation"],"prefix":"10.1038","volume":"14","author":[{"given":"Eman A.","family":"Alwaleed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahaa M.","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah Tegeldein","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashaill A.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa S.","family":"Abdelgaliel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"issue":"12","key":"70620_CR1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3844\/ajassp.2019.346.354","volume":"16","author":"AA Eman","year":"2019","unstructured":"Eman, A. A. Biochemical composition and nutraceutical perspectives Red Sea seaweeds. Am. J. Appl. Sci 16(12), 346\u2013354 (2019).","journal-title":"Am. J. Appl. Sci"},{"key":"70620_CR2","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3390\/md20060342","volume":"20","author":"SEB Hossam","year":"2022","unstructured":"Hossam, S. E. B. et al. phytochemical and potential properties of seaweeds and their recent applications: A review. J. Mar. Drugs 20, 342. https:\/\/doi.org\/10.3390\/md20060342 (2022).","journal-title":"J. Mar. Drugs"},{"issue":"1","key":"70620_CR25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/biology10010067","volume":"10","author":"ON Ayrapetyan","year":"2021","unstructured":"Ayrapetyan, O. N. et al. Antibacterial properties of fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea. Biology (Basel). 10(1), 67. https:\/\/doi.org\/10.3390\/biology10010067 (2021).","journal-title":"Biology (Basel)."},{"issue":"3","key":"70620_CR3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/md14030052","volume":"14","author":"P Mar\u00eda Jos\u00e9","year":"2016","unstructured":"Mar\u00eda Jos\u00e9, P., Elena, F. & Herminia, D. Antimicrobial action of compounds from marine seaweed. Mar. Drugs 14(3), 52. https:\/\/doi.org\/10.3390\/md14030052 (2016).","journal-title":"Mar. Drugs"},{"key":"70620_CR22","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3390\/agronomy11030545","volume":"11","author":"AHA Arafat","year":"2021","unstructured":"Arafat, A. H. A., Zaid, A. & Eman, A. A. Influences of priming on selected physiological attributes and protein pattern responses of salinized wheat with extracts of Hormophysa cuneiformis and Actinotrichia fragilis. Agronomy 11, 545. https:\/\/doi.org\/10.3390\/agronomy11030545 (2021).","journal-title":"Agronomy"},{"key":"70620_CR4","first-page":"99","volume":"2","author":"AA Aleem","year":"1978","unstructured":"Aleem, A. A. Contributions to the study of the marine algae of the Red Sea. Marine algae from Obhor, in the vicinity of Jeddah Saudi Arabia. Bull. Fac. Sci. KAUJ 2, 99\u2013118 (1978).","journal-title":"Bull. Fac. Sci. KAUJ"},{"key":"70620_CR5","first-page":"1","volume":"5","author":"AA Aleem","year":"1981","unstructured":"Aleem, A. A. Contributions to the study of the marine algae of the Red Sea. New or little-known algae from the west coast of Saudi Arabia. Bull. Fac. Sci. KAUJ 5, 1\u201349 (1981).","journal-title":"Bull. Fac. Sci. KAUJ"},{"key":"70620_CR6","volume-title":"Marine Algae of California Stanford","author":"LA Abbott","year":"1976","unstructured":"Abbott, L. A. & Hollenberg, L. G. Marine Algae of California Stanford (University Press, 1976)."},{"key":"70620_CR7","doi-asserted-by":"publisher","first-page":"10537","DOI":"10.1038\/s41598-017-07692-w","volume":"7","author":"AAH Abdel Latef","year":"2017","unstructured":"Abdel Latef, A. A. H. et al. Sargassum muticum and Jania rubens regulate amino acid metabolism to improve growth and alleviate salinity in chickpea. Sci. Rep. 7, 10537. https:\/\/doi.org\/10.1038\/s41598-017-07692-w (2017).","journal-title":"Sci. Rep."},{"key":"70620_CR8","doi-asserted-by":"publisher","first-page":"100237","DOI":"10.1016\/j.bcdf.2020.100237","volume":"24","author":"AA Eman","year":"2020","unstructured":"Eman, A. A., Asmaa, J., Naglaa, R. A. K. & Hamdy, G. Evaluation of the pancreatoprotective effect of algal extracts on Alloxan-induced diabetic rat. J. Bioactive Carbohyd. Dietary Fibre 24, 100237. https:\/\/doi.org\/10.1016\/j.bcdf.2020.100237 (2020).","journal-title":"J. Bioactive Carbohyd. Dietary Fibre"},{"issue":"25","key":"70620_CR9","first-page":"6055","volume":"5","author":"AM Khan","year":"2011","unstructured":"Khan, A. M. et al. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings. J. Med. Plants Res. 5(25), 6055\u20136060 (2011).","journal-title":"J. Med. Plants Res."},{"key":"70620_CR10","unstructured":"Mtolera, M.S.P. & Semesi, A.K. Antimicrobial Activity of Extracts from Six Green Algae from Tanzania, in Current Trends in Marine Botanical Research East African Region, (eds Borg, M., Semesi, A., Pederson, M. & Bergman, B.) Sidal SAREC Uppsala (1996)."},{"issue":"1","key":"70620_CR11","first-page":"106","volume":"2","author":"ME Zain","year":"2012","unstructured":"Zain, M. E., Awaad, A. S., Al-Outhman, M. R. & El-Meligy, R. M. Antimicrobial activities of Saudi Arabian desert plants. Phytopharmacol. 2(1), 106\u2013113 (2012).","journal-title":"Phytopharmacol."},{"key":"70620_CR12","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1038\/1811199a0","volume":"26","author":"MS Blois","year":"1958","unstructured":"Blois, M. S. Antioxidant determinations by the use of a stable free radical. Nature 26, 1199\u20131200 (1958).","journal-title":"Nature"},{"issue":"12","key":"70620_CR23","doi-asserted-by":"publisher","first-page":"3284","DOI":"10.1021\/ci500467k","volume":"54","author":"G Franco","year":"2014","unstructured":"Franco, G. et al. iLOGP: a simple, robust, and efficient description of n-octanol\/water partition coefficient for drug design using the GB\/SA approach. J. Chem. Inf. Model. 54(12), 3284\u20133301 (2014).","journal-title":"J. Chem. Inf. Model."},{"key":"70620_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1145974","author":"A Imad","year":"2023","unstructured":"Imad, A. et al. Computational pharmacology and computational chemistry of 4-hydroxyisoleucine: Physicochemical, pharmacokinetic, and DFT-based approaches. Front. Chem. https:\/\/doi.org\/10.3389\/fchem.2023.1145974 (2023).","journal-title":"Front. Chem."},{"key":"70620_CR13","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"D Antoine","year":"2017","unstructured":"Antoine, D., Olivier, M. & Vincent, Z. Swiss ADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. J. Sci. Rep. 7, 42717. https:\/\/doi.org\/10.1038\/srep42717 (2017).","journal-title":"J. Sci. Rep."},{"key":"70620_CR14","doi-asserted-by":"publisher","first-page":"31578","DOI":"10.1039\/D3RA06831E","volume":"13","author":"VS Conrad","year":"2023","unstructured":"Conrad, V. S. et al. Challenges in natural product-based drug discovery assisted with in silico-based methods. RSC Adv. 13, 31578\u201331594 (2023).","journal-title":"RSC Adv."},{"issue":"1\u20132","key":"70620_CR15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0169-4332(00)00040-4","volume":"161","author":"N Barreau","year":"2000","unstructured":"Barreau, N., Marsillac, S., Bernede, J. C. & Barreau, A. Investigation of \u03b2-In2S3 growth on different transparent conductive oxides. Appl. Sur. Sci. 161(1\u20132), 20\u201326 (2000).","journal-title":"Appl. Sur. Sci."},{"issue":"23","key":"70620_CR26","doi-asserted-by":"publisher","first-page":"7717","DOI":"10.3390\/molecules28237717","volume":"28","author":"OO Olaokun","year":"2023","unstructured":"Olaokun, O. O. & Zubair, M. S. Antidiabetic Activity, Molecular Docking, and ADMET properties of compounds isolated from bioactive ethyl acetate fraction of ficus iutea leaf extract. Molecules. 28(23), 7717. https:\/\/doi.org\/10.3390\/molecules28237717 (2023).","journal-title":"Molecules."},{"key":"70620_CR24","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s11626-013-9603-7","volume":"49","author":"M Kavitha","year":"2013","unstructured":"Kavitha, M. & Vidhya, V. I. Differential growth inhibition of cancer cell lines and antioxidant activity of extracts of red, brown, and green marine algae In Vitro Cell. Dev. Biol. Animal 49, 324\u2013334. https:\/\/doi.org\/10.1007\/s11626-013-9603-7 (2013).","journal-title":"Dev. Biol. Animal"},{"issue":"4","key":"70620_CR16","first-page":"277","volume":"40","author":"C Lee Ventola","year":"2015","unstructured":"Lee Ventola, C. The antibiotic resistance crisis. P T 40(4), 277\u2013283 (2015).","journal-title":"P T"},{"key":"70620_CR17","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.3390\/microorganisms11061407","volume":"11","author":"M Harris","year":"2023","unstructured":"Harris, M., Tracy, F., Diana, I., Nicole, J. & Davis, N. B. Genetic factors that contribute to antibiotic resistance through intrinsic and acquired bacterial genes in urinary tract infections. Microorganisms 11, 1407. https:\/\/doi.org\/10.3390\/microorganisms11061407 (2023).","journal-title":"Microorganisms"},{"key":"70620_CR27","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.3390\/pr11082248","volume":"11","author":"I Gulcin","year":"2023","unstructured":"Gulcin, I. & Alwasel, S.H. DPPH radical scavenging assay. Processes 11, 2248. https:\/\/doi.org\/10.3390\/pr11082248 (2023).","journal-title":"Processes"},{"issue":"1","key":"70620_CR28","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1080\/01652176.2022.2061744","volume":"42","author":"I Michalak","year":"2022","unstructured":"Michalak, I. et al. Antioxidant effects of seaweeds and their active compounds on animal health and production - a review. Vet Q. 42(1), 48\u201367. https:\/\/doi.org\/10.1080\/01652176.2022.2061744 (2022).","journal-title":"Vet Q."},{"issue":"7","key":"70620_CR18","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.3390\/ijms22073380","volume":"22","author":"GM Irina","year":"2021","unstructured":"Irina, G. M. & Constantin, A. Analytical methods used in determining antioxidant activity: A review. Int. J. Mol. Sci. 22(7), 3380. https:\/\/doi.org\/10.3390\/ijms22073380 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"70620_CR20","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/pharmaceutics11080411","volume":"11","author":"D David","year":"2019","unstructured":"David, D. & Hans, L. Intestinal permeability and drug absorption: predictive experimental computational and in vivo. Approaches. Pharmaceutics 11, 411. https:\/\/doi.org\/10.3390\/pharmaceutics11080411 (2019).","journal-title":"Approaches. Pharmaceutics"},{"issue":"3","key":"70620_CR21","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3934\/microbiol.2018.3.482","volume":"4","author":"CR Wanda","year":"2018","unstructured":"Wanda, C. R. An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiol. 4(3), 482\u2013501 (2018).","journal-title":"AIMS Microbiol."},{"key":"70620_CR29","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S0076-6879(09)04617-5","volume":"459","author":"JE Cronan","year":"2023","unstructured":"Cronan, J. E. & Thomas, J. Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways. Methods Enzymol. 459 395\u2013433. https:\/\/doi.org\/10.1016\/S0076-6879(09)04617-5 (2009).","journal-title":"Methods Enzymol."}],"updated-by":[{"DOI":"10.1038\/s41598-024-77714-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70620-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70620-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70620-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T14:03:43Z","timestamp":1731074623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70620-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,5]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["70620"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-70620-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,5]]},"assertion":[{"value":"27 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-024-77714-x","URL":"https:\/\/doi.org\/10.1038\/s41598-024-77714-x","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23200"}}