{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:55:58Z","timestamp":1792036558713,"version":"4.4.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["819424"],"award-info":[{"award-number":["819424"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NWO VICI Grant","award":["VI.C.182.004"],"award-info":[{"award-number":["VI.C.182.004"]}]},{"name":"NWO","award":["OCENW.GROOT.20t9.O22"],"award-info":[{"award-number":["OCENW.GROOT.20t9.O22"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-70759-y","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T16:17:21Z","timestamp":1724861841000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cell spheroid viscoelasticity is deformation-dependent"],"prefix":"10.1038","volume":"14","author":[{"given":"Ruben C.","family":"Boot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"van der Net","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Gogou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimphna H.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijsje H.","family":"Koenderink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouyan E.","family":"Boukany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"70759_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nrm2596","volume":"10","author":"C Hahn","year":"2009","unstructured":"Hahn, C. & Schwartz, M. A. Mechanotransduction in vascular physiology and atherogenesis. Nat. Rev. Mol. Cell Biol. 10, 53\u201362. https:\/\/doi.org\/10.1038\/nrm2596 (2009).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"70759_CR2","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1242\/dev.024166","volume":"137","author":"T Mammoto","year":"2010","unstructured":"Mammoto, T. & Ingber, D. E. Mechanical control of tissue and organ development. Development 137, 1407\u20131420. https:\/\/doi.org\/10.1242\/dev.024166 (2010).","journal-title":"Development"},{"key":"70759_CR3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nphys3040.Forces","volume":"10","author":"A Brugu\u00e9s","year":"2014","unstructured":"Brugu\u00e9s, A. et al. Forces driving epithelial wound healing. Nat. Phys. 10, 683\u2013690. https:\/\/doi.org\/10.1038\/nphys3040.Forces (2014).","journal-title":"Nat. Phys."},{"key":"70759_CR4","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1126\/science.1171643","volume":"324","author":"DE Discher","year":"2009","unstructured":"Discher, D. E., Mooney, D. J. & Zandstra, P. W. Growth factors, matrices, and forces combine and control stem cells. Science 324, 1673\u20131677. https:\/\/doi.org\/10.1126\/science.1171643 (2009).","journal-title":"Science"},{"key":"70759_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41551-016-0004.Solid","volume":"1","author":"HT Nia","year":"2016","unstructured":"Nia, H. T. et al. Solid stress and elastic energy as measures of tumour mechanopathology. Nat. Biomed. Eng. 1, 1\u201325. https:\/\/doi.org\/10.1038\/s41551-016-0004.Solid (2016).","journal-title":"Nat. Biomed. Eng."},{"key":"70759_CR6","doi-asserted-by":"publisher","unstructured":"Nia, H.\u00a0T., Munn, L.\u00a0L. & Jain, R.\u00a0K. Physical traits of cancer. Science. 370, eaaz0868. https:\/\/doi.org\/10.1126\/SCIENCE.AAZ0868 (2020).","DOI":"10.1126\/SCIENCE.AAZ0868"},{"key":"70759_CR7","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1042\/BCJ20210806","volume":"479","author":"PA Galie","year":"2022","unstructured":"Galie, P. A., Georges, P. C. & Janmey, P. A. How do cells stiffen?. Biochem. J. 479, 1825\u20131842. https:\/\/doi.org\/10.1042\/BCJ20210806 (2022).","journal-title":"Biochem. J."},{"key":"70759_CR8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ceb.2010.10.015","volume":"23","author":"P Friedl","year":"2011","unstructured":"Friedl, P., Wolf, K. & Lammerding, J. Nuclear mechanics during cell migration. Curr. Opin. Cell Biol. 23, 55\u201364. https:\/\/doi.org\/10.1016\/j.ceb.2010.10.015 (2011).","journal-title":"Curr. Opin. Cell Biol."},{"key":"70759_CR9","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/jor.22880","volume":"33","author":"NR Schiele","year":"2015","unstructured":"Schiele, N. R. et al. Actin cytoskeleton contributes to the elastic modulus of embryonic tendon during early development. J. Orthop. Res. 33, 874\u2013881. https:\/\/doi.org\/10.1002\/jor.22880 (2015).","journal-title":"J. Orthop. Res."},{"key":"70759_CR10","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.cell.2013.05.008","volume":"153","author":"CP Heisenberg","year":"2013","unstructured":"Heisenberg, C. P. & Bella\u00efche, Y. Forces in tissue morphogenesis and patterning. Cell 153, 948\u2013962. https:\/\/doi.org\/10.1016\/j.cell.2013.05.008 (2013).","journal-title":"Cell"},{"key":"70759_CR11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41567-019-0680-8","volume":"16","author":"YL Han","year":"2020","unstructured":"Han, Y. L. et al. Cell swelling, softening and invasion in a three-dimensional breast cancer model. Nat. Phys. 16, 101\u2013108. https:\/\/doi.org\/10.1038\/s41567-019-0680-8 (2020).","journal-title":"Nat. Phys."},{"key":"70759_CR12","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1002\/dvdy.21684","volume":"237","author":"K Jakab","year":"2008","unstructured":"Jakab, K. et al. Relating cell and tissue mechanics: Implications and applications. Develop. Dynam. 237, 2438\u20132449. https:\/\/doi.org\/10.1002\/dvdy.21684 (2008).","journal-title":"Develop. Dynam."},{"key":"70759_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-69540-8","volume":"10","author":"NV Kosheleva","year":"2020","unstructured":"Kosheleva, N. V. et al. Cell spheroid fusion: Beyond liquid drops model. Sci. Rep. 10, 1\u201315. https:\/\/doi.org\/10.1038\/s41598-020-69540-8 (2020).","journal-title":"Sci. Rep."},{"key":"70759_CR14","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevX.11.011033","volume":"11","author":"S Grosser","year":"2021","unstructured":"Grosser, S. et al. Cell and nucleus shape as an indicator of tissue fluidity in carcinoma. Phys. Rev. X 11, 011033. https:\/\/doi.org\/10.1103\/PhysRevX.11.011033 (2021).","journal-title":"Phys. Rev. X"},{"key":"70759_CR15","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1126\/science.1226418","volume":"82","author":"D Gonzalez-Rodriguez","year":"2012","unstructured":"Gonzalez-Rodriguez, D., Guevorkian, K., Douezan, S. & Brochard-Wyart, F. Soft matter models of developing. Science 82, 910\u2013917 (2012).","journal-title":"Science"},{"key":"70759_CR16","doi-asserted-by":"publisher","first-page":"1978316","DOI":"10.1080\/23746149.2021.1978316","volume":"6","author":"RC Boot","year":"2021","unstructured":"Boot, R. C., Koenderink, G. H. & Boukany, P. E. Spheroid mechanics and implications for cell invasion. Adv. Phys. X 6, 1978316. https:\/\/doi.org\/10.1080\/23746149.2021.1978316 (2021).","journal-title":"Adv. Phys. X"},{"key":"70759_CR17","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1242\/dev.122.5.1611","volume":"122","author":"RA Foty","year":"1996","unstructured":"Foty, R. A., Pfleger, C. M., Forgacs, G. & Steinberg, M. S. Surface tensions of embryonic tissues predict their mutual envelopment behavior. Development 122, 1611\u20131620 (1996).","journal-title":"Development"},{"key":"70759_CR18","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1073\/pnas.071615398","volume":"98","author":"PL Ryan","year":"2001","unstructured":"Ryan, P. L., Foty, R. A., Kohn, J. & Steinberg, M. S. Tissue spreading on implantable substrates is a competitive outcome of cell-cell vs. cell-substratum adhesivity. Proc. Natl. Acad. Sci. USA 98, 4323\u20134327. https:\/\/doi.org\/10.1073\/pnas.071615398 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"70759_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2976\/1.2834817","volume":"2","author":"EM Sch\u00f6tz","year":"2008","unstructured":"Sch\u00f6tz, E. M. et al. Quantitative differences in tissue surface tension influence zebrafish germ layer positioning. HFSP J. 2, 42\u201356. https:\/\/doi.org\/10.2976\/1.2834817 (2008).","journal-title":"HFSP J."},{"key":"70759_CR20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ydbio.2004.11.012","volume":"278","author":"RA Foty","year":"2005","unstructured":"Foty, R. A. & Steinberg, M. S. The differential adhesion hypothesis: A direct evaluation. Develop. Biol. 278, 255\u2013263. https:\/\/doi.org\/10.1016\/j.ydbio.2004.11.012 (2005).","journal-title":"Develop. Biol."},{"key":"70759_CR21","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1115\/1.1449491","volume":"124","author":"GW Brodland","year":"2002","unstructured":"Brodland, G. W. The Differential Interfacial Tension Hypothesis (DITH): A comprehensive theory for the self-rearrangement of embryonic cells and tissues. J. Biomech. Eng. 124, 188\u2013197. https:\/\/doi.org\/10.1115\/1.1449491 (2002).","journal-title":"J. Biomech. Eng."},{"key":"70759_CR22","doi-asserted-by":"publisher","first-page":"12517","DOI":"10.1073\/pnas.1003743107","volume":"107","author":"ML Manning","year":"2010","unstructured":"Manning, M. L., Foty, R. A., Steinberg, M. S. & Schoetz, E. M. Coaction of intercellular adhesion and cortical tension specifies tissue surface tension. Proc. Natl. Acad. Sci. USA 107, 12517\u201312522. https:\/\/doi.org\/10.1073\/pnas.1003743107 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"70759_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1103\/PhysRevLett.104.218101","volume":"104","author":"K Guevorkian","year":"2010","unstructured":"Guevorkian, K., Colbert, M.-J., Durth, M., Dufour, S. & Brochard-Wyart, F. Aspiration of biological viscoelastic drops. Phys. Rev. Lett. 104, 1\u20134. https:\/\/doi.org\/10.1103\/PhysRevLett.104.218101 (2010).","journal-title":"Phys. Rev. Lett."},{"key":"70759_CR24","doi-asserted-by":"publisher","first-page":"48103","DOI":"10.1103\/physrevlett.128.048103","volume":"128","author":"MS Yousafzai","year":"2022","unstructured":"Yousafzai, M. S. et al. Active regulation of pressure and volume defines an energetic constraint on the size of cell aggregates. Phys. Rev. Lett. 128, 48103. https:\/\/doi.org\/10.1103\/physrevlett.128.048103 (2022).","journal-title":"Phys. Rev. Lett."},{"key":"70759_CR25","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1039\/d2lc01060g","volume":"23","author":"RC Boot","year":"2023","unstructured":"Boot, R. C. et al. High-throughput mechanophenotyping of multicellular spheroids using a microfluidic micropipette aspiration chip. Lab Chip 23, 1768\u20131778. https:\/\/doi.org\/10.1039\/d2lc01060g (2023).","journal-title":"Lab Chip"},{"key":"70759_CR26","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1039\/c9lc00444k","volume":"19","author":"PM Davidson","year":"2019","unstructured":"Davidson, P. M. et al. High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells. Lab Chip 19, 3652\u20133663. https:\/\/doi.org\/10.1039\/c9lc00444k (2019).","journal-title":"Lab Chip"},{"key":"70759_CR27","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.polymer.2006.11.048","volume":"48","author":"Y Son","year":"2007","unstructured":"Son, Y. Determination of shear viscosity and shear rate from pressure drop and flow rate relationship in a rectangular channel. Polymer 48, 632\u2013637. https:\/\/doi.org\/10.1016\/j.polymer.2006.11.048 (2007).","journal-title":"Polymer"},{"key":"70759_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-820310-1.00008-2","volume-title":"Flow Dynamics of 3D Multicellular Systems into Capillaries","author":"K Guevorkian","year":"2021","unstructured":"Guevorkian, K., Brochard-Wyart, F. & Gonzalez-Rodriguez, D. Flow Dynamics of 3D Multicellular Systems into Capillaries (Academic Press, 2021)."},{"key":"70759_CR29","doi-asserted-by":"publisher","first-page":"13387","DOI":"10.1073\/pnas.1105741108","volume":"108","author":"K Guevorkian","year":"2011","unstructured":"Guevorkian, K., Gonzalez-rodriguez, D., Carlier, C., Dufour, S. & Brochard-Wyart, F. Mechanosensitive shivering of model tissues under controlled aspiration. PNAS 108, 13387\u201313392. https:\/\/doi.org\/10.1073\/pnas.1105741108 (2011).","journal-title":"PNAS"},{"key":"70759_CR30","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1177\/0022034512467352","volume":"92","author":"CS Scanlon","year":"2013","unstructured":"Scanlon, C. S., Van Tubergen, E. A., Inglehart, R. C. & D\u2019Silva, N. J. Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J. Dental Res. 92, 114\u2013121. https:\/\/doi.org\/10.1177\/0022034512467352 (2013).","journal-title":"J. Dental Res."},{"key":"70759_CR31","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1091\/mbc.12.9.2730","volume":"12","author":"B Hinz","year":"2001","unstructured":"Hinz, B., Celetta, G., Tomasek, J. J., Gabbiani, G. & Chaponnier, C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol. Biol. Cell 12, 2730\u20132741. https:\/\/doi.org\/10.1091\/mbc.12.9.2730 (2001).","journal-title":"Mol. Biol. Cell"},{"key":"70759_CR32","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1158\/0008-5472.CAN-07-2017","volume":"68","author":"D Sarri\u00f3","year":"2008","unstructured":"Sarri\u00f3, D. et al. Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res. 68, 989\u2013997. https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-2017 (2008).","journal-title":"Cancer Res."},{"key":"70759_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1091\/mbc.E20-08-0536","volume":"32","author":"MT Doolin","year":"2021","unstructured":"Doolin, M. T., Smith, I. M. & Stroka, K. M. Fibroblast to myofibroblast transition is enhanced by increased cell density. Mol. Biol. Cell 32, 1\u20139. https:\/\/doi.org\/10.1091\/mbc.E20-08-0536 (2021).","journal-title":"Mol. Biol. Cell"},{"key":"70759_CR34","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1016\/j.bpj.2018.04.025","volume":"114","author":"M Yu","year":"2018","unstructured":"Yu, M. et al. Coherent timescales and mechanical structure of multicellular aggregates. Biophys. J. 114, 2703\u20132716. https:\/\/doi.org\/10.1016\/j.bpj.2018.04.025 (2018).","journal-title":"Biophys. J."},{"key":"70759_CR35","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.tibs.2004.05.003","volume":"29","author":"PA Janmey","year":"2004","unstructured":"Janmey, P. A. & Weitz, D. A. Dealing with mechanics: Mechanisms of force transduction in cells. Trends Biochem. Sci. 29, 364\u2013370. https:\/\/doi.org\/10.1016\/j.tibs.2004.05.003 (2004).","journal-title":"Trends Biochem. Sci."},{"key":"70759_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2018.00824","volume":"9","author":"F Martino","year":"2018","unstructured":"Martino, F., Perestrelo, A. R., Vinarsk\u00fd, V., Pagliari, S. & Forte, G. Cellular mechanotransduction: From tension to function. Front. Physiol. 9, 1\u201321. https:\/\/doi.org\/10.3389\/fphys.2018.00824 (2018).","journal-title":"Front. Physiol."},{"key":"70759_CR37","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1152\/ajpcell.00014.2008","volume":"295","author":"F Sbrana","year":"2008","unstructured":"Sbrana, F. et al. Role for stress fiber contraction in surface tension development and stretch-activated channel regulation in C2C12 myoblasts. Am. J. Physiol. Cell Physiol. 295, 160\u2013172. https:\/\/doi.org\/10.1152\/ajpcell.00014.2008 (2008).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"70759_CR38","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1073\/pnas.0304297101","volume":"101","author":"H Delanoe-Ayari","year":"2004","unstructured":"Delanoe-Ayari, H., Kurdi, R. A., Vallade, M., Gulino-Debrac, D. & Riveline, D. Membrane and acto-myosin tension promote clustering of adhesion proteins. PNAS 101, 2229\u20132234. https:\/\/doi.org\/10.1073\/pnas.0304297101 (2004).","journal-title":"PNAS"},{"key":"70759_CR39","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1096\/fj.05-5424rev","volume":"20","author":"DE Ingber","year":"2006","unstructured":"Ingber, D. E. Cellular mechanotransduction: Putting all the pieces together again. FASEB J. 20, 811\u2013827. https:\/\/doi.org\/10.1096\/fj.05-5424rev (2006).","journal-title":"FASEB J."},{"key":"70759_CR40","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s12195-011-0175-x","volume":"4","author":"R Kaunas","year":"2011","unstructured":"Kaunas, R. & Deguchi, S. Multiple roles for Myosin II in tensional homeostasis under mechanical loading. Cell. Mol. Bioeng. 4, 182\u2013191. https:\/\/doi.org\/10.1007\/s12195-011-0175-x (2011).","journal-title":"Cell. Mol. Bioeng."},{"key":"70759_CR41","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1387\/ijdb.041810rf","volume":"48","author":"RA Foty","year":"2004","unstructured":"Foty, R. A. & Steinberg, M. S. Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy. Int. J. Dev. Biol. 48, 397\u2013409 (2004).","journal-title":"Int. J. Dev. Biol."},{"key":"70759_CR42","doi-asserted-by":"publisher","DOI":"10.1088\/1367-2630\/17\/8\/083049","volume":"17","author":"S Pawlizak","year":"2015","unstructured":"Pawlizak, S. et al. Testing the differential adhesion hypothesis across the epithelial-mesenchymal transition. N. J. Phys. 17, 083049. https:\/\/doi.org\/10.1088\/1367-2630\/17\/8\/083049 (2015).","journal-title":"N. J. Phys."},{"key":"70759_CR43","doi-asserted-by":"publisher","first-page":"17271","DOI":"10.1073\/pnas.0902085106","volume":"106","author":"P Marmottant","year":"2009","unstructured":"Marmottant, P. et al. The role of fluctuations and stress on the effective viscosity of cell aggregates. PNAS 106, 17271\u201317275. https:\/\/doi.org\/10.1073\/pnas.0902085106 (2009).","journal-title":"PNAS"},{"key":"70759_CR44","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1242\/dev.104315","volume":"141","author":"R David","year":"2014","unstructured":"David, R. et al. Tissue cohesion and the mechanics of cell rearrangement. Development 141, 3672\u20133682. https:\/\/doi.org\/10.1242\/dev.104315 (2014).","journal-title":"Development"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70759-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70759-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70759-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T16:18:07Z","timestamp":1724861887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-70759-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["70759"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-70759-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4294324\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]},"assertion":[{"value":"19 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20013"}}