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The aetiology cannot be clarified in every case. However, tumour-related gastric ulcers are observed repeatedly. This study reports clinical, laboratory and pathological findings in six alpacas, three each with adenocarcinoma- and squamous cell carcinoma-associated gastric ulcers. Clinically they were presented with general symptoms like emaciation, anorexia and recumbency. Laboratory findings of these animals were non-specific. All animals were at least nine years old. The adenocarcinomas as well as the squamous cell carcinomas were metastasised in various organs, especially in the lymph nodes. Two adenocarcinoma-associated gastric ulcers were perforated. In summary, squamous cell carcinomas and adenocarcinomas can lead to ulcerative lesions in the gastrointestinal tract. Although neoplasms are rare overall, they should be considered as a possible differential diagnosis in the case of non-specific symptoms. 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