{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:16:11Z","timestamp":1782850571403,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jiangsu Provincial Research Hospital","award":["YJXYY202204"],"award-info":[{"award-number":["YJXYY202204"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370253"],"award-info":[{"award-number":["82370253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Team Project of Affiliated Hospital of Nantong University","award":["XNBHCX31773"],"award-info":[{"award-number":["XNBHCX31773"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-71473-5","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T15:02:44Z","timestamp":1725289364000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A composite patch loaded with 2-Deoxy Glucose facilitates cardiac recovery after myocardial infarction via attenuating local inflammatory response"],"prefix":"10.1038","volume":"14","author":[{"given":"Weizhang","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahai","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"issue":"6","key":"71473_CR1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/s41569-022-00823-5","volume":"20","author":"J Yap","year":"2023","unstructured":"Yap, J. et al. Macrophages in cardiac remodelling after myocardial infarction. Nat. Rev. Cardiol. 20(6), 373\u2013385 (2023).","journal-title":"Nat. Rev. Cardiol."},{"issue":"8","key":"71473_CR2","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","volume":"147","author":"CW Tsao","year":"2023","unstructured":"Tsao, C. W. et al. Heart disease and stroke statistics-2023 update: A report from the American Heart Association. Circulation 147(8), e93\u2013e621 (2023).","journal-title":"Circulation"},{"issue":"10065","key":"71473_CR3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","volume":"389","author":"GW Reed","year":"2017","unstructured":"Reed, G. W., Rossi, J. E. & Cannon, C. P. Acute myocardial infarction. Lancet 389(10065), 197\u2013210 (2017).","journal-title":"Lancet"},{"issue":"3","key":"71473_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/eurheartj\/ehy904","volume":"40","author":"P Widimsky","year":"2019","unstructured":"Widimsky, P., Crea, F., Binder, R. K. & L\u00fcscher, T. F. The year in cardiology 2018: acute coronary syndromes. Eur. Heart J. 40(3), 271\u2013282 (2019).","journal-title":"Eur. Heart J."},{"issue":"2","key":"71473_CR5","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jjcc.2022.07.003","volume":"81","author":"Y Saito","year":"2023","unstructured":"Saito, Y., Oyama, K., Tsujita, K., Yasuda, S. & Kobayashi, Y. Treatment strategies of acute myocardial infarction: Updates on revascularization, pharmacological therapy, and beyond. J. Cardiol. 81(2), 168\u2013178 (2023).","journal-title":"J. Cardiol."},{"key":"71473_CR6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI167079","author":"D Weissman","year":"2023","unstructured":"Weissman, D. & Maack, C. Mitochondrial function in macrophages controls cardiac repair after myocardial infarction. J. Clin. Invest. https:\/\/doi.org\/10.1172\/JCI167079 (2023).","journal-title":"J. Clin. Invest."},{"issue":"2","key":"71473_CR7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","volume":"45","author":"MA Matter","year":"2024","unstructured":"Matter, M. A. et al. Inflammation in acute myocardial infarction: The good, the bad and the ugly. Eur. Heart J. 45(2), 89\u2013103 (2024).","journal-title":"Eur. Heart J."},{"issue":"6","key":"71473_CR8","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1161\/CIRCRESAHA.115.307516","volume":"118","author":"X Hu","year":"2016","unstructured":"Hu, X. et al. A large-scale investigation of hypoxia-preconditioned allogeneic mesenchymal stem cells for myocardial repair in nonhuman primates: Paracrine activity without remuscularization. Circ. Res. 118(6), 970\u2013983 (2016).","journal-title":"Circ. Res."},{"issue":"6","key":"71473_CR9","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/cvr\/cvz336","volume":"116","author":"C Peet","year":"2020","unstructured":"Peet, C., Ivetic, A., Bromage, D. I. & Shah, A. M. Cardiac monocytes and macrophages after myocardial infarction. Cardiovasc. Res. 116(6), 1101\u20131112 (2020).","journal-title":"Cardiovasc. Res."},{"key":"71473_CR10","doi-asserted-by":"publisher","first-page":"599511","DOI":"10.3389\/fimmu.2020.599511","volume":"11","author":"M Silvis","year":"2020","unstructured":"Silvis, M. et al. Damage-associated molecular patterns in myocardial infarction and heart transplantation: The road to translational success. Front. Immunol. 11, 599511 (2020).","journal-title":"Front. Immunol."},{"issue":"9","key":"71473_CR11","doi-asserted-by":"publisher","first-page":"e232","DOI":"10.1161\/CIRCRESAHA.120.317200","volume":"127","author":"E Vafadarnejad","year":"2020","unstructured":"Vafadarnejad, E. et al. Dynamics of cardiac neutrophil diversity in murine myocardial infarction. Circ. Res. 127(9), e232\u2013e249 (2020).","journal-title":"Circ. Res."},{"issue":"18","key":"71473_CR12","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1016\/j.jacc.2018.08.2149","volume":"72","author":"KJ Lavine","year":"2018","unstructured":"Lavine, K. J. et al. The macrophage in cardiac homeostasis and disease: JACC macrophage in CVD series (Part 4). J. Am. Coll. Cardiol. 72(18), 2213\u20132230 (2018).","journal-title":"J. Am. Coll. Cardiol."},{"key":"71473_CR13","doi-asserted-by":"publisher","first-page":"664457","DOI":"10.3389\/fimmu.2021.664457","volume":"12","author":"I Kologrivova","year":"2021","unstructured":"Kologrivova, I., Shtatolkina, M., Suslova, T. & Ryabov, V. Cells of the immune system in cardiac remodeling: Main players in resolution of inflammation and repair after myocardial infarction. Front. Immunol. 12, 664457 (2021).","journal-title":"Front. Immunol."},{"issue":"2","key":"71473_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","volume":"167","author":"EL Mills","year":"2016","unstructured":"Mills, E. L. et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell 167(2), 457-470.e13 (2016).","journal-title":"Cell"},{"issue":"3","key":"71473_CR15","doi-asserted-by":"publisher","first-page":"e10471","DOI":"10.1002\/btm2.10471","volume":"8","author":"W Xiao","year":"2023","unstructured":"Xiao, W. et al. An immunometabolic patch facilitates mesenchymal stromal\/stem cell therapy for myocardial infarction through a macrophage-dependent mechanism. Bioeng. Transl. Med. 8(3), e10471 (2023).","journal-title":"Bioeng. Transl. Med."},{"key":"71473_CR16","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.celrep.2016.09.008","volume":"17","author":"J Van den Bossche","year":"2016","unstructured":"Van den Bossche, J. et al. Mitochondrial dysfunction prevents repolarization of inflammatory macrophages. Cell Rep. 17, 684\u2013696 (2016).","journal-title":"Cell Rep."},{"issue":"49","key":"71473_CR17","doi-asserted-by":"publisher","first-page":"19725","DOI":"10.1073\/pnas.1108586108","volume":"108","author":"E Mezzaroma","year":"2011","unstructured":"Mezzaroma, E. et al. The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc. Natl. Acad. Sci. U. S. A. 108(49), 19725\u201319730 (2011).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"71473_CR18","doi-asserted-by":"publisher","first-page":"6614009","DOI":"10.1155\/2021\/6614009","volume":"2021","author":"M Xiang","year":"2021","unstructured":"Xiang, M. et al. Role of oxidative stress in reperfusion following myocardial ischemia and its treatments. Oxid. Med. Cell Longev. 2021, 6614009 (2021).","journal-title":"Oxid. Med. Cell Longev."},{"issue":"13","key":"71473_CR19","doi-asserted-by":"publisher","first-page":"e2209041","DOI":"10.1002\/adma.202209041","volume":"35","author":"W Chen","year":"2023","unstructured":"Chen, W. et al. A matrix-metalloproteinase-responsive hydrogel system for modulating the immune microenvironment in myocardial infarction. Adv. Mater. 35(13), e2209041 (2023).","journal-title":"Adv. Mater."},{"issue":"10","key":"71473_CR20","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1016\/j.immuni.2023.07.019","volume":"56","author":"W Wang","year":"2023","unstructured":"Wang, W. et al. Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair. Immunity 56(10), 2342-2357.e10 (2023).","journal-title":"Immunity"},{"issue":"1","key":"71473_CR21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","volume":"119","author":"SD Prabhu","year":"2016","unstructured":"Prabhu, S. D. & Frangogiannis, N. G. The biological basis for cardiac repair after myocardial infarction: From inflammation to fibrosis. Circ. Res. 119(1), 91\u2013112 (2016).","journal-title":"Circ. Res."},{"issue":"6","key":"71473_CR22","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","volume":"117","author":"NG Frangogiannis","year":"2021","unstructured":"Frangogiannis, N. G. Cardiac fibrosis. Cardiovasc. Res. 117(6), 1450\u20131488 (2021).","journal-title":"Cardiovasc. Res."},{"key":"71473_CR23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146926","author":"C Humeres","year":"2022","unstructured":"Humeres, C. et al. Smad7 effects on TGF-\u03b2 and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure. J. Clin. Investig. https:\/\/doi.org\/10.1172\/JCI146926 (2022).","journal-title":"J. Clin. Investig."},{"key":"71473_CR24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","volume":"186","author":"SB Ong","year":"2018","unstructured":"Ong, S. B. et al. Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities. Pharmacol. Ther. 186, 73\u201387 (2018).","journal-title":"Pharmacol. Ther."},{"issue":"20","key":"71473_CR25","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1161\/CIRCULATIONAHA.121.057549","volume":"145","author":"D Jia","year":"2022","unstructured":"Jia, D. et al. Cardiac resident macrophage-derived legumain improves cardiac repair by promoting clearance and degradation of apoptotic cardiomyocytes after myocardial infarction. Circulation 145(20), 1542\u20131556 (2022).","journal-title":"Circulation"},{"issue":"4","key":"71473_CR26","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1111\/jcmm.14972","volume":"24","author":"P Zhao","year":"2020","unstructured":"Zhao, P. et al. Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice. J. Cell. Mol. Med. 24(4), 2593\u20132609 (2020).","journal-title":"J. Cell. Mol. Med."},{"issue":"4","key":"71473_CR27","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.1002\/jcp.27261","volume":"234","author":"WJ Zhong","year":"2019","unstructured":"Zhong, W. J. et al. Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model. J. Cell. Physiol. 234(4), 4641\u20134654 (2019).","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"71473_CR28","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","volume":"7","author":"Q Zhang","year":"2022","unstructured":"Zhang, Q. et al. Signaling pathways and targeted therapy for myocardial infarction. Signal Transduct. Target Ther. 7(1), 78 (2022).","journal-title":"Signal Transduct. Target Ther."},{"issue":"9","key":"71473_CR29","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1161\/CIRCRESAHA.120.315937","volume":"126","author":"A Abbate","year":"2020","unstructured":"Abbate, A. et al. Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease. Circ. Res. 126(9), 1260\u20131280 (2020).","journal-title":"Circ. Res."},{"key":"71473_CR30","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12983","author":"IA Derkachev","year":"2024","unstructured":"Derkachev, I. A. et al. Angiotensin 1\u20137 increases cardiac tolerance to ischemia\/reperfusion and mitigates adverse remodeling of the heart-The signaling mechanism. Fundam. Clin. Pharmacol. https:\/\/doi.org\/10.1111\/fcp.12983 (2024).","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"2","key":"71473_CR31","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00280-012-2045-1","volume":"71","author":"LE Raez","year":"2013","unstructured":"Raez, L. E. et al. A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother. Pharmacol. 71(2), 523\u2013530 (2013).","journal-title":"Cancer Chemother. Pharmacol."},{"key":"71473_CR32","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1038\/ncomms4563","volume":"5","author":"S Weimer","year":"2014","unstructured":"Weimer, S. et al. D-Glucosamine supplementation extends life span of nematodes and of ageing mice. Nat. Commun. 5, 3563 (2014).","journal-title":"Nat. Commun."},{"key":"71473_CR33","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.cmet.2016.11.005","volume":"25","author":"T Li","year":"2017","unstructured":"Li, T. et al. Defective branched-chain amino acid catabolism disrupts glucose metabolism and sensitizes the heart to ischemia-reperfusion injury. Cell Metab. 25, 374\u2013385 (2017).","journal-title":"Cell Metab."},{"key":"71473_CR34","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1161\/CIRCULATIONAHA.119.045033","volume":"141","author":"S Selvaraj","year":"2020","unstructured":"Selvaraj, S., Kelly, D. P. & Margulies, K. B. Implications of altered ketone metabolism and therapeutic ketosis in heart failure. Circulation 141, 1800\u20131812 (2020).","journal-title":"Circulation"},{"key":"71473_CR35","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","volume":"25","author":"P Puchalska","year":"2017","unstructured":"Puchalska, P. & Crawford, P. A. Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell Metab. 25, 262\u2013284 (2017).","journal-title":"Cell Metab."},{"issue":"5","key":"71473_CR36","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/CIRCULATIONAHA.118.036044","volume":"139","author":"Q Fan","year":"2019","unstructured":"Fan, Q. et al. Dectin-1 contributes to myocardial ischemia\/reperfusion injury by regulating macrophage polarization and neutrophil infiltration. Circulation 139(5), 663\u2013678 (2019).","journal-title":"Circulation"},{"issue":"5","key":"71473_CR37","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1016\/j.ajpath.2011.01.041","volume":"178","author":"W Chen","year":"2011","unstructured":"Chen, W. et al. Protein phosphatase 2A catalytic subunit \u03b1 (PP2Ac\u03b1) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway. Am. J. Pathol. 178(5), 2333\u20132343 (2011).","journal-title":"Am. J. Pathol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71473-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71473-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71473-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T15:14:24Z","timestamp":1725290064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71473-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["71473"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-71473-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"8 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20368"}}