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Measurements of PCT were done in unstimulated plasma of microbiologically and clinically confirmed TBLN and TBPE patients registered for anti-TB treatment at a tertiary care hospital in Lahore, Pakistan. Plasma levels of PCT were found to be raised in 89% of the patients at baseline with a median of 1.5\u00a0ng\/ml. Levels were higher (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) in TBLN as compared to TBPE (2.69, 0.96\u00a0ng\/ml). PCT levels were not related to the bacterial burden depicted by culture positivity in these patients. PCT showed a negative correlation with the severity of constitutional symptoms (rho\u2009= \u2212\u00a00.238, <jats:italic>p<\/jats:italic>\u2009=\u20090.034), and inflammatory biomarkers; ferritin (rho\u2009=\u2009\u2212\u00a00.43,<jats:italic> p<\/jats:italic>\u2009&lt;\u20090.001), INF-\u03b3 (rho\u2009=\u2009\u2212\u00a00.314,<jats:italic> p<\/jats:italic>\u2009=\u20090.003), TNF-\u03b1 (rho\u2009=\u2009\u2212\u00a00.220,<jats:italic> p<\/jats:italic>\u2009=\u20090.039), IL-6 (rho\u2009=\u2009\u2212\u00a00.224,<jats:italic> p<\/jats:italic>\u2009=\u20090.035), and several chemokines of CCL and CCXL group. Raised plasma levels of PCT did not decrease with anti-TB treatment, indicating it is not a good biomarker to monitor treatment response in TBLN and TBPE patients. More studies with a larger number of confirmed EPTB cases are needed to define the role of PCT and its interaction with other biomarkers in EPTB.<\/jats:p>","DOI":"10.1038\/s41598-024-71627-5","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T17:08:01Z","timestamp":1727629681000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistently high plasma procalcitonin levels despite successful treatment of tuberculous pleuritis and tuberculous lymphadenitis patients"],"prefix":"10.1038","volume":"14","author":[{"given":"Zaib","family":"un Nisa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atiqa","family":"Ambreen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tehmina","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"71627_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1432-1033.1975.tb02176.x","volume":"55","author":"F Moya","year":"1975","unstructured":"Moya, F., Nieto, A. & R-Candela, J. 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