{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:56:55Z","timestamp":1790056615040,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004392"],"award-info":[{"award-number":["82004392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274544"],"award-info":[{"award-number":["82274544"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573996"],"award-info":[{"award-number":["81573996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the major project of \u201cDouble First-class\u201d and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine","award":["2021XK05"],"award-info":[{"award-number":["2021XK05"]}]},{"name":"the cultivated project of \u201cDouble First-class\u201d and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine","award":["2021XK41"],"award-info":[{"award-number":["2021XK41"]}]},{"name":"the cultivated project of \u201cDouble First-class\u201d and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine","award":["2021XK46"],"award-info":[{"award-number":["2021XK46"]}]},{"name":"Bijie Science and Technology Bureau 'the open competition project'","award":["no. BST Major Project No.1,2022"],"award-info":[{"award-number":["no. BST Major Project No.1,2022"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-71743-2","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T14:03:03Z","timestamp":1729605783000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma SQSTM1\/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head"],"prefix":"10.1038","volume":"14","author":[{"given":"Wenyuan","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianshun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mincong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"71743_CR1","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.23.04929-7","author":"H Xu","year":"2023","unstructured":"Xu, H., Zhao, J. & Shi, C. Current status of clinical research on the pathogenesis and treatment of femoral head necrosis. Panminerva Med. https:\/\/doi.org\/10.23736\/S0031-0808.23.04929-7 (2023).","journal-title":"Panminerva Med."},{"issue":"3","key":"71743_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1302\/2058-5241.4.180036","volume":"4","author":"D Petek","year":"2019","unstructured":"Petek, D., Hannouche, D. & Suva, D. Osteonecrosis of the femoral head: Pathophysiology and current concepts of treatment. EFORT Open Rev. 4(3), 85\u201397 (2019).","journal-title":"EFORT Open Rev."},{"issue":"5","key":"71743_CR3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s00198-018-04826-2","volume":"30","author":"J Bergman","year":"2019","unstructured":"Bergman, J., Nordstr\u00f6m, A. & Nordstr\u00f6m, P. Epidemiology of osteonecrosis among older adults in Sweden. Osteoporos. Int. 30(5), 965\u2013973 (2019).","journal-title":"Osteoporos. Int."},{"issue":"2","key":"71743_CR4","doi-asserted-by":"publisher","first-page":"e020680","DOI":"10.1136\/bmjopen-2017-020680","volume":"8","author":"A Dima","year":"2018","unstructured":"Dima, A., Pedersen, A. B., Pedersen, L., Baicus, C. & Thomsen, R. W. Association of common comorbidities with osteonecrosis: A nationwide population-based case-control study in Denmark. BMJ Open 8(2), e020680 (2018).","journal-title":"BMJ Open"},{"issue":"10","key":"71743_CR5","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1007\/s11999-010-1292-x","volume":"468","author":"W Fukushima","year":"2010","unstructured":"Fukushima, W. et al. Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head. Clin. Orthop. Relat. Res. 468(10), 2715\u20132724 (2010).","journal-title":"Clin. Orthop. Relat. Res."},{"key":"71743_CR6","first-page":"100","volume":"21","author":"D Zhao","year":"2020","unstructured":"Zhao, D. et al. Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). J. Orthop. Transl. 21, 100\u2013110 (2020).","journal-title":"J. Orthop. Transl."},{"issue":"4","key":"71743_CR7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.jos.2016.03.008","volume":"21","author":"T Kubo","year":"2016","unstructured":"Kubo, T. et al. Clinical and basic research on steroid-induced osteonecrosis of the femoral head in Japan. J. Orthop. Sci. 21(4), 407\u2013413 (2016).","journal-title":"J. Orthop. Sci."},{"issue":"7","key":"71743_CR8","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1007\/s00264-018-3994-8","volume":"42","author":"P Luo","year":"2018","unstructured":"Luo, P., Gao, F., Han, J., Sun, W. & Li, Z. The role of autophagy in steroid necrosis of the femoral head: A comprehensive research review. Int. Orthop. 42(7), 1747\u20131753 (2018).","journal-title":"Int. Orthop."},{"issue":"1","key":"71743_CR9","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/os.13584","volume":"15","author":"B Liu","year":"2023","unstructured":"Liu, B. et al. Denosumab can prevent collapse in patients with early-stage steroid-induced osteonecrosis of the femoral head by inhibiting osteoclasts and autophagy. Orthop. Surg. 15(1), 256\u2013265 (2023).","journal-title":"Orthop. Surg."},{"issue":"1","key":"71743_CR10","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12943-024-01934-y","volume":"23","author":"J Liu","year":"2024","unstructured":"Liu, J. et al. Selective autophagy in cancer: Mechanisms, therapeutic implications, and future perspectives. Mol. Cancer 23(1), 22 (2024).","journal-title":"Mol. Cancer"},{"issue":"8","key":"71743_CR11","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","volume":"24","author":"J Debnath","year":"2023","unstructured":"Debnath, J., Gammoh, N. & Ryan, K. M. Autophagy and autophagy-related pathways in cancer. Nat. Rev. Mol. Cell Biol. 24(8), 560\u2013575 (2023).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"71743_CR12","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/s41418-020-0497-0","volume":"27","author":"EA Allen","year":"2020","unstructured":"Allen, E. A. & Baehrecke, E. H. Autophagy in animal development. Cell Death Differ. 27(3), 903\u2013918 (2020).","journal-title":"Cell Death Differ."},{"key":"71743_CR13","doi-asserted-by":"publisher","first-page":"116054","DOI":"10.1016\/j.ejmech.2023.116054","volume":"265","author":"X Li","year":"2024","unstructured":"Li, X. et al. Dual target PARP1\/EZH2 inhibitors inducing excessive autophagy and producing synthetic lethality for triple-negative breast cancer therapy. Eur. J. Med. Chem. 265, 116054 (2024).","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"71743_CR14","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/s41418-019-0286-9","volume":"26","author":"S Miyamoto","year":"2019","unstructured":"Miyamoto, S. Autophagy and cardiac aging. Cell Death Differ. 26(4), 653\u2013664 (2019).","journal-title":"Cell Death Differ."},{"key":"71743_CR15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/ijms21238974","volume":"21","author":"T Ichimiya","year":"2020","unstructured":"Ichimiya, T. et al. Autophagy and autophagy-related diseases: A review. Int. J. Mol. Sci. 21, 23 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"71743_CR16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.molcel.2019.09.005","volume":"76","author":"V Kirkin","year":"2019","unstructured":"Kirkin, V. & Rogov, V. V. A diversity of selective autophagy receptors determines the specificity of the autophagy pathway. Mol. Cell 76(2), 268\u2013285 (2019).","journal-title":"Mol. Cell"},{"key":"71743_CR17","doi-asserted-by":"publisher","first-page":"101538","DOI":"10.1016\/j.arr.2021.101538","volume":"73","author":"X Fan","year":"2022","unstructured":"Fan, X. et al. p62 works as a hub modulation in the ageing process. Age. Res. Rev. 73, 101538 (2022).","journal-title":"Age. Res. Rev."},{"issue":"4","key":"71743_CR18","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/febs.16317","volume":"290","author":"CT Tan","year":"2023","unstructured":"Tan, C. T., Soh, N. J. H., Chang, H. C. & Yu, V. C. p62\/SQSTM1 in liver diseases: The usual suspect with multifarious identities. FEBS J. 290(4), 892\u2013912 (2023).","journal-title":"FEBS J."},{"issue":"6","key":"71743_CR19","doi-asserted-by":"publisher","first-page":"6805","DOI":"10.3934\/mbe.2019340","volume":"16","author":"BJ Wang","year":"2019","unstructured":"Wang, B. J., Tang, Y. D., Yu, B. Y., Gui, D. & Xu, H. Expression of autophagy-related factor p62 for lung cancer diagnosis and prognosis: A systematic review and meta-analysis. Math. Biosci. Eng. 16(6), 6805\u20136821 (2019).","journal-title":"Math. Biosci. Eng."},{"issue":"1","key":"71743_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.arth.2018.09.005","volume":"34","author":"BH Yoon","year":"2019","unstructured":"Yoon, B. H. et al. Etiologic classification criteria of ARCO on femoral head osteonecrosis part 1: Glucocorticoid-associated osteonecrosis. J. Arthroplasty 34(1), 163\u2013168 (2019).","journal-title":"J. Arthroplasty"},{"key":"71743_CR21","doi-asserted-by":"publisher","first-page":"111711","DOI":"10.1016\/j.biopha.2021.111711","volume":"139","author":"Z Huang","year":"2021","unstructured":"Huang, Z., Wang, Q., Zhang, T., Fu, Y. & Wang, W. Hyper-activated platelet lysates prevent glucocorticoid-associated femoral head necrosis by regulating autophagy. Biomed. Pharmacother. 139, 111711 (2021).","journal-title":"Biomed. Pharmacother."},{"key":"71743_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/ijms22115891","volume":"22","author":"D Sbardella","year":"2021","unstructured":"Sbardella, D., Tundo, G. R., Coletta, M., Manni, G. & Oddone, F. Dexamethasone downregulates autophagy through accelerated turn-over of the Ulk-1 complex in a trabecular meshwork cells strain: Insights on steroid-induced glaucoma pathogenesis. Int. J. Mol. Sci. 22, 11 (2021).","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"71743_CR23","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/s41418-018-0267-4","volume":"26","author":"J Kriel","year":"2019","unstructured":"Kriel, J. & Loos, B. The good, the bad and the autophagosome: Exploring unanswered questions of autophagy-dependent cell death. Cell Death Differ. 26(4), 640\u2013652 (2019).","journal-title":"Cell Death Differ."},{"key":"71743_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/ijms21093289","volume":"21","author":"HR Yun","year":"2020","unstructured":"Yun, H. R. et al. Roles of autophagy in oxidative stress. Int. J. Mol. Sci. 21, 9 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"71743_CR25","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","volume":"14","author":"S Liu","year":"2023","unstructured":"Liu, S., Yao, S., Yang, H., Liu, S. & Wang, Y. Autophagy: Regulator of cell death. Cell Death Dis. 14(10), 648 (2023).","journal-title":"Cell Death Dis."},{"issue":"10","key":"71743_CR26","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1096\/fj.11-182519","volume":"25","author":"J Jia","year":"2011","unstructured":"Jia, J. et al. Glucocorticoid dose determines osteocyte cell fate. FASEB J. 25(10), 3366\u20133376 (2011).","journal-title":"FASEB J."},{"issue":"6","key":"71743_CR27","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.joen.2012.02.023","volume":"38","author":"EH Lai","year":"2012","unstructured":"Lai, E. H. et al. Simvastatin alleviates the progression of periapical lesions by modulating autophagy and apoptosis in osteoblasts. J. Endod. 38(6), 757\u2013763 (2012).","journal-title":"J. Endod."},{"issue":"4","key":"71743_CR28","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1002\/jcp.27335","volume":"234","author":"L Wang","year":"2019","unstructured":"Wang, L., Heckmann, B. L., Yang, X. & Long, H. Osteoblast autophagy in glucocorticoid-induced osteoporosis. J. Cell. Physiol. 234(4), 3207\u20133215 (2019).","journal-title":"J. Cell. Physiol."},{"key":"71743_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s11658-016-0031-z","volume":"21","author":"WJ Liu","year":"2016","unstructured":"Liu, W. J. et al. p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation. Cell. Mol. Biol. Lett. 21, 29 (2016).","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"6","key":"71743_CR30","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1089\/ars.2018.7649","volume":"31","author":"SJ Jeong","year":"2019","unstructured":"Jeong, S. J., Zhang, X., Rodriguez-Velez, A., Evans, T. D. & Razani, B. p62\/SQSTM1 and selective autophagy in cardiometabolic diseases. Antioxid. Redox Signal. 31(6), 458\u2013471 (2019).","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"71743_CR31","first-page":"2028","volume":"41","author":"W Liu","year":"2018","unstructured":"Liu, W. et al. Dexamethasone-induced production of reactive oxygen species promotes apoptosis via endoplasmic reticulum stress and autophagy in MC3T3-E1 cells. Int. J. Mol. Med. 41(4), 2028\u20132036 (2018).","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"71743_CR32","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1080\/21691401.2020.1774596","volume":"48","author":"MC He","year":"2020","unstructured":"He, M. C. et al. Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head. Artif. Cells Nanomed. Biotechnol. 48(1), 1036\u20131046 (2020).","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"71743_CR33","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/cells11132104","volume":"11","author":"J Ma","year":"2022","unstructured":"Ma, J. et al. Extracellular vesicles from BMSCs prevent glucocorticoid-induced BMECs injury by regulating autophagy via the PI3K\/Akt\/mTOR pathway. Cells 11, 13 (2022).","journal-title":"Cells"},{"issue":"1","key":"71743_CR34","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/2211-5463.13037","volume":"11","author":"P Peng","year":"2021","unstructured":"Peng, P., Nie, Z., Sun, F. & Peng, H. Glucocorticoids induce femoral head necrosis in rats through the ROS\/JNK\/c-Jun pathway. FEBS Open Bio 11(1), 312\u2013321 (2021).","journal-title":"FEBS Open Bio"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71743-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71743-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71743-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T14:04:25Z","timestamp":1729605865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71743-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["71743"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-71743-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4265724\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"14 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study adhered to the Declaration of Helsinki, and patients provided written informed consent before participation, which was approved by the Ethics Committee of the Third Affiliated Hospital of Guangzhou University of Chinese Medicine (GYH202101-04).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"24932"}}