{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:13:17Z","timestamp":1777486397238,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["No. NRF-2021R1A2C1007718"],"award-info":[{"award-number":["No. NRF-2021R1A2C1007718"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NTX 121267"],"award-info":[{"award-number":["NTX 121267"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-71832-2","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T11:02:18Z","timestamp":1725620538000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inner retinal layer thickness alterations in adult and pediatric patients with neurofibromatosis 1"],"prefix":"10.1038","volume":"14","author":[{"given":"So Young","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Ji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seul Gi","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Ah","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei Yeul","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"71832_CR1","doi-asserted-by":"publisher","first-page":"17004","DOI":"10.1038\/nrdp.2017.4","volume":"3","author":"DH Gutmann","year":"2017","unstructured":"Gutmann, D. H. et al. Neurofibromatosis type 1. Nat. Rev. Dis. Prim. 3, 17004. https:\/\/doi.org\/10.1038\/nrdp.2017.4 (2017).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"71832_CR2","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.survophthal.2017.10.007","volume":"63","author":"M Kinori","year":"2018","unstructured":"Kinori, M., Hodgson, N. & Zeid, J. L. Ophthalmic manifestations in neurofibromatosis type 1. Surv. Ophthalmol. 63, 518\u2013533. https:\/\/doi.org\/10.1016\/j.survophthal.2017.10.007 (2018).","journal-title":"Surv. Ophthalmol."},{"key":"71832_CR3","doi-asserted-by":"publisher","first-page":"8112","DOI":"10.1167\/iovs.13-13093","volume":"54","author":"R Parrozzani","year":"2013","unstructured":"Parrozzani, R. et al. Optical coherence tomography in the diagnosis of optic pathway gliomas. Investig. Ophthalmol. Vis. Sci. 54, 8112\u20138118. https:\/\/doi.org\/10.1167\/iovs.13-13093 (2013).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"71832_CR4","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.ajo.2010.08.046","volume":"151","author":"RA Avery","year":"2011","unstructured":"Avery, R. A. et al. Retinal nerve fiber layer thickness in children with optic pathway gliomas. Am. J. Ophthalmol. 151, 542-549.e542. https:\/\/doi.org\/10.1016\/j.ajo.2010.08.046 (2011).","journal-title":"Am. J. Ophthalmol."},{"key":"71832_CR5","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jaapos.2010.08.014","volume":"14","author":"L Chang","year":"2010","unstructured":"Chang, L. et al. Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas. J. AAPOS 14, 511\u2013517. https:\/\/doi.org\/10.1016\/j.jaapos.2010.08.014 (2010).","journal-title":"J. AAPOS"},{"key":"71832_CR6","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1136\/bjophthalmol-2018-313002","volume":"103","author":"A Moramarco","year":"2019","unstructured":"Moramarco, A. et al. Retinal microvascular abnormalities in neurofibromatosis type 1. Br. J. Ophthalmol. 103, 1590\u20131594. https:\/\/doi.org\/10.1136\/bjophthalmol-2018-313002 (2019).","journal-title":"Br. J. Ophthalmol."},{"key":"71832_CR7","doi-asserted-by":"publisher","first-page":"8503859","DOI":"10.1155\/2016\/8503859","volume":"2016","author":"M Satue","year":"2016","unstructured":"Satue, M. et al. Optical coherence tomography as a biomarker for diagnosis, progression, and prognosis of neurodegenerative diseases. J. Ophthalmol. 2016, 8503859. https:\/\/doi.org\/10.1155\/2016\/8503859 (2016).","journal-title":"J. Ophthalmol."},{"key":"71832_CR8","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.ophtha.2009.12.036","volume":"117","author":"XR Duan","year":"2010","unstructured":"Duan, X. R. et al. Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: The Handan Eye Study. Ophthalmology 117, 1585\u20131594. https:\/\/doi.org\/10.1016\/j.ophtha.2009.12.036 (2010).","journal-title":"Ophthalmology"},{"key":"71832_CR9","doi-asserted-by":"publisher","first-page":"8769","DOI":"10.1167\/iovs.11-8388","volume":"52","author":"S Ooto","year":"2011","unstructured":"Ooto, S. et al. Effects of age, sex, and axial length on the three-dimensional profile of normal macular layer structures. Investig. Ophthalmol. Vis. Sci. 52, 8769\u20138779. https:\/\/doi.org\/10.1167\/iovs.11-8388 (2011).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"71832_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/iae.0000000000000650","volume":"36","author":"S Abdolrahimzadeh","year":"2016","unstructured":"Abdolrahimzadeh, S. et al. Spectral domain optical coherence tomography evidence of retinal nerve fiber layer and ganglion cell loss in adult patients with neurofibromatosis Type 1. Retina 36, 75\u201381. https:\/\/doi.org\/10.1097\/iae.0000000000000650 (2016).","journal-title":"Retina"},{"key":"71832_CR11","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s10384-014-0308-6","volume":"58","author":"P Topcu-Yilmaz","year":"2014","unstructured":"Topcu-Yilmaz, P., Kasim, B. & Kiratli, H. Investigation of retinal nerve fiber layer thickness in patients with neurofibromatosis-1. Jpn. J. Ophthalmol. 58, 172\u2013176. https:\/\/doi.org\/10.1007\/s10384-014-0308-6 (2014).","journal-title":"Jpn. J. Ophthalmol."},{"key":"71832_CR12","doi-asserted-by":"publisher","first-page":"851","DOI":"10.2147\/opth.s102830","volume":"10","author":"B Abdolrahimzadeh","year":"2016","unstructured":"Abdolrahimzadeh, B., Piraino, D. C., Albanese, G., Cruciani, F. & Rahimi, S. Neurofibromatosis: An update of ophthalmic characteristics and applications of optical coherence tomography. Clin. Ophthalmol. 10, 851\u2013860. https:\/\/doi.org\/10.2147\/opth.s102830 (2016).","journal-title":"Clin. Ophthalmol."},{"key":"71832_CR13","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/ICU.0b013e3283570127","volume":"23","author":"RE Schnur","year":"2012","unstructured":"Schnur, R. E. Type I neurofibromatosis: A geno-oculo-dermatologic update. Curr. Opin. Ophthalmol. 23, 364\u2013372. https:\/\/doi.org\/10.1097\/ICU.0b013e3283570127 (2012).","journal-title":"Curr. Opin. Ophthalmol."},{"key":"71832_CR14","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/j.1468-3083.2004.00915.x","volume":"18","author":"A Richetta","year":"2004","unstructured":"Richetta, A. et al. Lisch nodules of the iris in neurofibromatosis type 1. J. Eur. Acad. Dermatol. Venereol. 18, 342\u2013344. https:\/\/doi.org\/10.1111\/j.1468-3083.2004.00915.x (2004).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"71832_CR15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2147\/opth.s56327","volume":"8","author":"S Makino","year":"2014","unstructured":"Makino, S., Tampo, H., Arai, Y. & Obata, H. Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1. Clin. Ophthalmol. 8, 165\u2013168. https:\/\/doi.org\/10.2147\/opth.s56327 (2014).","journal-title":"Clin. Ophthalmol."},{"key":"71832_CR16","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.ophtha.2007.01.023","volume":"114","author":"RS Parikh","year":"2007","unstructured":"Parikh, R. S. et al. Normal age-related decay of retinal nerve fiber layer thickness. Ophthalmology 114, 921\u2013926. https:\/\/doi.org\/10.1016\/j.ophtha.2007.01.023 (2007).","journal-title":"Ophthalmology"},{"key":"71832_CR17","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1001\/archopht.1980.01020040905024","volume":"98","author":"CL Dolman","year":"1980","unstructured":"Dolman, C. L., McCormick, A. Q. & Drance, S. M. Aging of the optic nerve. Arch. Ophthalmol. 98, 2053\u20132058. https:\/\/doi.org\/10.1001\/archopht.1980.01020040905024 (1980).","journal-title":"Arch. Ophthalmol."},{"key":"71832_CR18","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/0002-9394(84)90509-9","volume":"97","author":"AG Balazsi","year":"1984","unstructured":"Balazsi, A. G., Rootman, J., Drance, S. M., Schulzer, M. & Douglas, G. R. The effect of age on the nerve fiber population of the human optic nerve. Am. J. Ophthalmol. 97, 760\u2013766. https:\/\/doi.org\/10.1016\/0002-9394(84)90509-9 (1984).","journal-title":"Am. J. Ophthalmol."},{"key":"71832_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/s0161-6420(89)32928-9","volume":"96","author":"MX Repka","year":"1989","unstructured":"Repka, M. X. & Quigley, H. A. The effect of age on normal human optic nerve fiber number and diameter. Ophthalmology 96, 26\u201332. https:\/\/doi.org\/10.1016\/s0161-6420(89)32928-9 (1989).","journal-title":"Ophthalmology"},{"key":"71832_CR20","unstructured":"Kissel, P., Andr\u00e9, J. M. & Jacquier, A. The Neurocristopathies 223\u2013232 (Masson, 1981)."},{"key":"71832_CR21","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1136\/bjophthalmol-2014-306062","volume":"99","author":"S Abdolrahimzadeh","year":"2015","unstructured":"Abdolrahimzadeh, S. et al. Morphologic and vasculature features of the choroid and associated choroid-retinal thickness alterations in neurofibromatosis type 1. Br. J. Ophthalmol. 99, 789\u2013793. https:\/\/doi.org\/10.1136\/bjophthalmol-2014-306062 (2015).","journal-title":"Br. J. Ophthalmol."},{"key":"71832_CR22","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ophtha.2011.07.046","volume":"119","author":"F Viola","year":"2012","unstructured":"Viola, F. et al. Choroidal abnormalities detected by near-infrared reflectance imaging as a new diagnostic criterion for neurofibromatosis 1. Ophthalmology 119, 369\u2013375. https:\/\/doi.org\/10.1016\/j.ophtha.2011.07.046 (2012).","journal-title":"Ophthalmology"},{"key":"71832_CR23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000027287","volume":"212","author":"C Rescaldani","year":"1998","unstructured":"Rescaldani, C., Nicolini, P., Fatigati, G. & Bottoni, F. G. Clinical application of digital indocyanine green angiography in choroidal neurofibromatosis. Ophthalmologica 212, 99\u2013104. https:\/\/doi.org\/10.1159\/000027287 (1998).","journal-title":"Ophthalmologica"},{"key":"71832_CR24","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/j.1442-9071.2008.001742.x","volume":"36","author":"A Ayata","year":"2008","unstructured":"Ayata, A., Unal, M., Ersanli, D. & Tatlipinar, S. Near infrared fluorescence and OCT features of choroidal abnormalities in type 1 neurofibromatosis. Clin. Exp. Ophthalmol. 36, 390\u2013392. https:\/\/doi.org\/10.1111\/j.1442-9071.2008.001742.x (2008).","journal-title":"Clin. Exp. Ophthalmol."},{"key":"71832_CR25","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1136\/jnnp.2010.206532","volume":"10","author":"RE Ferner","year":"2010","unstructured":"Ferner, R. E. The neurofibromatoses. Pract. Neurol. 10, 82\u201393. https:\/\/doi.org\/10.1136\/jnnp.2010.206532 (2010).","journal-title":"Pract. Neurol."},{"key":"71832_CR26","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1017\/s0012162206002131","volume":"48","author":"SL Hyman","year":"2006","unstructured":"Hyman, S. L., Arthur Shores, E. & North, K. N. Learning disabilities in children with neurofibromatosis type 1: Subtypes, cognitive profile, and attention-deficit-hyperactivity disorder. Dev. Med. Child Neurol. 48, 973\u2013977. https:\/\/doi.org\/10.1017\/s0012162206002131 (2006).","journal-title":"Dev. Med. Child Neurol."},{"key":"71832_CR27","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1212\/01.wnl.0000179303.72345.ce","volume":"65","author":"SL Hyman","year":"2005","unstructured":"Hyman, S. L., Shores, A. & North, K. N. The nature and frequency of cognitive deficits in children with neurofibromatosis type 1. Neurology 65, 1037\u20131044. https:\/\/doi.org\/10.1212\/01.wnl.0000179303.72345.ce (2005).","journal-title":"Neurology"},{"key":"71832_CR28","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1017\/s0012162201001876","volume":"44","author":"VF Mautner","year":"2002","unstructured":"Mautner, V. F., Kluwe, L., Thakker, S. D. & Leark, R. A. Treatment of ADHD in neurofibromatosis type 1. Dev. Med. Child Neurol. 44, 164\u2013170. https:\/\/doi.org\/10.1017\/s0012162201001876 (2002).","journal-title":"Dev. Med. Child Neurol."},{"key":"71832_CR29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/00004703-198606000-00009","volume":"7","author":"MJ Eliason","year":"1986","unstructured":"Eliason, M. J. Neurofibromatosis: Implications for learning and behavior. J. Dev. Behav. Pediatr. 7, 175\u2013179 (1986).","journal-title":"J. Dev. Behav. Pediatr."},{"key":"71832_CR30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<45::AID-AJMG9>3.0.CO;2-J","volume":"89","author":"S Ozonoff","year":"1999","unstructured":"Ozonoff, S. Cognitive impairment in neurofibromatosis type 1. Am. J. Med. Genet. 89, 45\u201352 (1999).","journal-title":"Am. J. Med. Genet."},{"key":"71832_CR31","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.stem.2007.07.008","volume":"1","author":"B Hegedus","year":"2007","unstructured":"Hegedus, B. et al. Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell 1, 443\u2013457. https:\/\/doi.org\/10.1016\/j.stem.2007.07.008 (2007).","journal-title":"Cell Stem Cell"},{"key":"71832_CR32","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.cell.2008.09.060","volume":"135","author":"Y Cui","year":"2008","unstructured":"Cui, Y. et al. Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell 135, 549\u2013560. https:\/\/doi.org\/10.1016\/j.cell.2008.09.060 (2008).","journal-title":"Cell"},{"key":"71832_CR33","doi-asserted-by":"publisher","first-page":"5579","DOI":"10.1523\/jneurosci.3994-09.2010","volume":"30","author":"JA Brown","year":"2010","unstructured":"Brown, J. A., Gianino, S. M. & Gutmann, D. H. Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity. J. Neurosci. 30, 5579\u20135589. https:\/\/doi.org\/10.1523\/jneurosci.3994-09.2010 (2010).","journal-title":"J. Neurosci."},{"key":"71832_CR34","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/s1350-9462(03)00039-9","volume":"22","author":"RE Marc","year":"2003","unstructured":"Marc, R. E., Jones, B. W., Watt, C. B. & Strettoi, E. Neural remodeling in retinal degeneration. Prog. Retin. Eye Res. 22, 607\u2013655. https:\/\/doi.org\/10.1016\/s1350-9462(03)00039-9 (2003).","journal-title":"Prog. Retin. Eye Res."},{"key":"71832_CR35","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1177\/1352458516679035","volume":"23","author":"O Al-Louzi","year":"2017","unstructured":"Al-Louzi, O., Button, J., Newsome, S. D., Calabresi, P. A. & Saidha, S. Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: A case series. Mult. Scler. 23, 1035\u20131039. https:\/\/doi.org\/10.1177\/1352458516679035 (2017).","journal-title":"Mult. Scler."},{"key":"71832_CR36","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1080\/08820538.2019.1648688","volume":"34","author":"NO Aksoy","year":"2019","unstructured":"Aksoy, N. O., Cakir, B., Dogan, E. & Alagoz, G. CORRELATIONS between functional and structural tests measured by spectral domain optical coherence tomography in severe glaucoma. Semin. Ophthalmol. 34, 446\u2013450. https:\/\/doi.org\/10.1080\/08820538.2019.1648688 (2019).","journal-title":"Semin. Ophthalmol."},{"key":"71832_CR37","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40662-021-00260-4","volume":"8","author":"J Li","year":"2021","unstructured":"Li, J. et al. Visual acuity is correlated with ischemia and neurodegeneration in patients with early stages of diabetic retinopathy. Eye Vis. (Lond.) 8, 38. https:\/\/doi.org\/10.1186\/s40662-021-00260-4 (2021).","journal-title":"Eye Vis. (Lond.)"},{"key":"71832_CR38","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/s0895-4356(00)00314-0","volume":"54","author":"R Bender","year":"2001","unstructured":"Bender, R. & Lange, S. Adjusting for multiple testing\u2013when and how?. J. Clin. Epidemiol. 54, 343\u2013349. https:\/\/doi.org\/10.1016\/s0895-4356(00)00314-0 (2001).","journal-title":"J. Clin. Epidemiol."},{"key":"71832_CR39","doi-asserted-by":"crossref","unstructured":"Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch. Neurol. 45, 575\u2013578 (1988).","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"71832_CR40","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1364\/BOE.4.001133","volume":"4","author":"A Lang","year":"2013","unstructured":"Lang, A. et al. Retinal layer segmentation of macular OCT images using boundary classification. Biomed. Opt. Express 4, 1133\u20131152. https:\/\/doi.org\/10.1364\/BOE.4.001133 (2013).","journal-title":"Biomed. Opt. Express"},{"key":"71832_CR41","doi-asserted-by":"publisher","DOI":"10.1212\/nxi.0000000000000449","volume":"5","author":"T Oberwahrenbrock","year":"2018","unstructured":"Oberwahrenbrock, T. et al. Multicenter reliability of semiautomatic retinal layer segmentation using OCT. Neurol. Neuroimmunol. Neuroinflamm. 5, e449. https:\/\/doi.org\/10.1212\/nxi.0000000000000449 (2018).","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"71832_CR42","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1167\/iovs.08-3093","volume":"50","author":"ML Monteiro","year":"2009","unstructured":"Monteiro, M. L., Cunha, L. P., Costa-Cunha, L. V., Maia, O. O. Jr. & Oyamada, M. K. Relationship between optical coherence tomography, pattern electroretinogram and automated perimetry in eyes with temporal hemianopia from chiasmal compression. Investig. Ophthalmol. Vis. Sci. 50, 3535\u20133541. https:\/\/doi.org\/10.1167\/iovs.08-3093 (2009).","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71832-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71832-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71832-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T11:13:55Z","timestamp":1725621235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71832-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["71832"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-71832-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"13 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20829"}}