{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:55:25Z","timestamp":1787003725008,"version":"build-2736575974"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["219S349"],"award-info":[{"award-number":["219S349"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-71871-9","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T07:02:43Z","timestamp":1729666963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A unique and biocompatible corneal collagen crosslinking in vivo"],"prefix":"10.1038","volume":"14","author":[{"given":"Ayesha","family":"Gulzar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humeyra N","family":"Kaleli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcls\u00fcm D","family":"K\u00f6seo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Hasanreiso\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsun","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Kizilel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"71871_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jtos.2023.08.001","volume":"30","author":"S Kaur","year":"2023","unstructured":"Kaur, S. et al. Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery. Ocul. Surf. 30, 3\u201313 (2023).","journal-title":"Ocul. Surf."},{"issue":"1","key":"71871_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74383-4","volume":"10","author":"A Ramier","year":"2020","unstructured":"Ramier, A. et al. In vivo measurement of shear modulus of the human cornea using optical coherence elastography. Sci. Rep. UK 10(1), 17366 (2020).","journal-title":"Sci. Rep. UK"},{"key":"71871_CR3","doi-asserted-by":"crossref","unstructured":"MacAdam, A. J. et al. Low energy blue pulsed light-activated injectable materials for restoring thinning corneas, advanced functional materials (2023).","DOI":"10.1002\/adfm.202302721"},{"key":"71871_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12598-8","volume":"7","author":"R Sharif","year":"2017","unstructured":"Sharif, R., Hjortdal, J., Sejersen, H., Frank, G. & Karamichos, D. Human model reveals the effects of collagen cross-linking on keratoconus pathogenesis. Sci. Rep. UK 7, 12517 (2017).","journal-title":"Sci. Rep. UK"},{"issue":"1","key":"71871_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46572-3","volume":"9","author":"A Batista","year":"2019","unstructured":"Batista, A., Breunig, H. G., Hager, T., Seitz, B. & Konig, K. Early evaluation of corneal collagen crosslinking in ex-vivo human corneas using two-photon imaging. Sci. Rep. 9(1), 10241 (2019).","journal-title":"Sci. Rep."},{"key":"71871_CR6","doi-asserted-by":"publisher","first-page":"5652","DOI":"10.1038\/srep05652","volume":"4","author":"CY Tian","year":"2014","unstructured":"Tian, C. Y., Peng, X. J., Fan, Z. J., Zhang, X. & Zhou, F. H. Corneal collagen cross-linking in keratoconus: A systematic review and meta-analysis. Sci. Rep. UK 4, 5652 (2014).","journal-title":"Sci. Rep. UK"},{"issue":"8","key":"71871_CR7","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00417-018-3966-0","volume":"256","author":"SK Subasinghe","year":"2018","unstructured":"Subasinghe, S. K., Ogbuehi, K. C. & Dias, G. J. Current perspectives on corneal collagen crosslinking (CXL). Graefes Arch. Clin. Exp. Ophthalmol. 256(8), 1363\u20131384 (2018).","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"71871_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40662-015-0025-3","volume":"2","author":"XJ Chen","year":"2015","unstructured":"Chen, X. J., Stojanovic, A., Eidet, J. R. & Utheim, T. P. Corneal collagen cross-linking (CXL) in thin corneas. Eye Vis. 2, 15 (2015).","journal-title":"Eye Vis."},{"issue":"9","key":"71871_CR9","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/S0886-3350(03)00343-2","volume":"29","author":"G Wollensak","year":"2003","unstructured":"Wollensak, G., Spoerl, E., Wilsch, M. & Seiler, T. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J. Cataract Refract. Surg. 29(9), 1786\u20131790 (2003).","journal-title":"J. Cataract Refract. Surg."},{"issue":"1","key":"71871_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4103\/JCOS.JCOS_13_22","volume":"1","author":"S Basak","year":"2023","unstructured":"Basak, S., Basak, S. K. & Gupta, R. Acute focal corneal endothelial burn: A unique early and rare complication of corneal cross-linking in keratoconus. J. Cornea Ocul. Surf. 1(1), 61\u201363 (2023).","journal-title":"J. Cornea Ocul. Surf."},{"key":"71871_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jtos.2023.02.003","volume":"28","author":"C Donovan","year":"2023","unstructured":"Donovan, C. et al. Genipin increases extracellular matrix synthesis preventing corneal perforation. Ocul. Surf. 28, 115\u2013123 (2023).","journal-title":"Ocul. Surf."},{"issue":"9","key":"71871_CR12","first-page":"S824","volume":"25","author":"F Raiskup","year":"2009","unstructured":"Raiskup, F., Hoyer, A. & Spoerl, E. Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. J. Refract. Surg. 25(9), S824\u2013S828 (2009).","journal-title":"J. Refract. Surg."},{"issue":"7","key":"71871_CR13","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/sj.eye.6700751","volume":"18","author":"G Wollensak","year":"2004","unstructured":"Wollensak, G., Spoerl, E., Reber, F. & Seiler, T. Keratocyte cytotoxicity of riboflavin\/UVA-treatment. Eye 18(7), 718\u2013722 (2004).","journal-title":"Eye"},{"issue":"6","key":"71871_CR14","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.ajo.2012.06.005","volume":"154","author":"A Sharma","year":"2012","unstructured":"Sharma, A. et al. Persistent corneal edema after collagen cross-linking for keratoconus. Am. J. Ophthalmol. 154(6), 922-926 e1 (2012).","journal-title":"Am. J. Ophthalmol."},{"issue":"3","key":"71871_CR15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1097\/ICO.0000000000002144","volume":"39","author":"PL Muller","year":"2020","unstructured":"Muller, P. L. et al. Histological corneal alterations in keratoconus after crosslinking-expansion of findings. Cornea 39(3), 333\u2013341 (2020).","journal-title":"Cornea"},{"issue":"6","key":"71871_CR16","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1097\/ICO.0000000000001912","volume":"38","author":"RS Rubinfeld","year":"2019","unstructured":"Rubinfeld, R. S., Caruso, C. & Ostacolo, C. Corneal cross-linking: The science beyond the myths and misconceptions. Cornea 38(6), 780\u2013790 (2019).","journal-title":"Cornea"},{"issue":"1","key":"71871_CR17","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1097\/ICO.0000000000000299","volume":"34","author":"U Elbaz","year":"2015","unstructured":"Elbaz, U. et al. Accelerated (9 mW\/cm2) corneal collagen crosslinking for keratoconus\u2014A 1-year follow-up. Cornea 34(1), e1-2 (2015).","journal-title":"Cornea"},{"issue":"1","key":"71871_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.4103\/sjopt.sjopt_49_22","volume":"36","author":"W Aldairi","year":"2022","unstructured":"Aldairi, W. et al. Accelerated versus conventional corneal collagen crosslinking: Short-term clinical outcomes in stabilizing keratoconus. Saudi J. Ophthalmol. 36(1), 47\u201352 (2022).","journal-title":"Saudi J. Ophthalmol."},{"issue":"3","key":"71871_CR19","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3928\/1081597X-20160204-03","volume":"32","author":"A Peyman","year":"2016","unstructured":"Peyman, A., Nouralishahi, A., Hafezi, F., Kling, S. & Peyman, M. Stromal demarcation line in pulsed versus continuous light accelerated corneal cross-linking for keratoconus. J. Refract. Surg. 32(3), 206\u2013208 (2016).","journal-title":"J. Refract. Surg."},{"issue":"2","key":"71871_CR20","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1097\/ICO.0000000000002092","volume":"39","author":"H Kobashi","year":"2020","unstructured":"Kobashi, H. & Tsubota, K. Accelerated versus standard corneal cross-linking for progressive keratoconus: A meta-analysis of randomized controlled trials. Cornea 39(2), 172\u2013180 (2020).","journal-title":"Cornea"},{"issue":"4","key":"71871_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3928\/1081597X-20200302-01","volume":"36","author":"SA Turhan","year":"2020","unstructured":"Turhan, S. A., Yargi, B. & Toker, E. Efficacy of conventional versus accelerated corneal cross-linking in pediatric keratoconus: Two-year outcomes. J. Refract. Surg. 36(4), 265\u2013269 (2020).","journal-title":"J. Refract. Surg."},{"key":"71871_CR22","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ajo.2020.11.001","volume":"223","author":"TG Seiler","year":"2021","unstructured":"Seiler, T. G. et al. Oxygen kinetics during corneal cross-linking with and without supplementary oxygen. Am. J. Ophthalmol. 223, 368\u2013376 (2021).","journal-title":"Am. J. Ophthalmol."},{"issue":"10","key":"71871_CR23","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/eye.2014.163","volume":"28","author":"C Mazzotta","year":"2014","unstructured":"Mazzotta, C., Traversi, C., Caragiuli, S. & Rechichi, M. Pulsed vs continuous light accelerated corneal collagen crosslinking: In vivo qualitative investigation by confocal microscopy and corneal OCT. Eye (Lond) 28(10), 1179\u20131183 (2014).","journal-title":"Eye (Lond)"},{"issue":"5","key":"71871_CR24","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/s41433-018-0323-9","volume":"33","author":"DSJ Ting","year":"2019","unstructured":"Ting, D. S. J. et al. Effectiveness and safety of accelerated (9\u00a0mW\/cm2) corneal collagen cross-linking for progressive keratoconus: A 24-month follow-up. Eye 33(5), 812\u2013818 (2019).","journal-title":"Eye"},{"key":"71871_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/srep14425","volume":"5","author":"VWS Chow","year":"2015","unstructured":"Chow, V. W. S., Chan, T. C. Y., Yu, M., Wong, V. W. Y. & Jhanji, V. One-year outcomes of conventional and accelerated collagen crosslinking in progressive keratoconus. Sci. Rep. 5, 14425 (2015).","journal-title":"Sci. Rep."},{"key":"71871_CR26","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.actbio.2022.05.040","volume":"147","author":"A Gulzar","year":"2022","unstructured":"Gulzar, A. et al. Ruthenium-induced corneal collagen crosslinking under visible light. Acta Biomater. 147, 198\u2013208 (2022).","journal-title":"Acta Biomater."},{"key":"71871_CR27","doi-asserted-by":"crossref","unstructured":"Vashi, A. V., Werkmeister, J. A., Vuocolo, T., Elvin, C. M. & Ramshaw, J. A. M. Stabilization of collagen tissues by photocrosslinking. J. Biomed. Mater. Res. Part A. 100A, 2239\u20132243 (2012).","DOI":"10.1002\/jbm.a.34164"},{"issue":"10","key":"71871_CR28","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1016\/j.biomaterials.2010.12.010","volume":"32","author":"JW Bjork","year":"2011","unstructured":"Bjork, J. W., Johnson, S. L. & Tranquillo, R. T. Ruthenium-catalyzed photo cross-linking of fibrin-based engineered tissue. Biomaterials 32(10), 2479\u20132488 (2011).","journal-title":"Biomaterials"},{"key":"71871_CR29","doi-asserted-by":"crossref","unstructured":"Fancy, D. A. & Kodadek, T. Chemistry for the analysis of protein-protein interactions: Rapid and efficient cross-linking triggered by long wavelength light (vol 96, pg 6020, 1999). Proc. Natl. Acad. Sci. USA 97(3), 1317\u20131317 (2000).","DOI":"10.1073\/pnas.96.11.6020"},{"issue":"10","key":"71871_CR30","volume":"12","author":"T Inomata","year":"2017","unstructured":"Inomata, T., Mashaghi, A., Hong, J. X., Nakao, T. & Dana, R. Scaling and maintenance of corneal thickness during aging. PLoS\u00a0One 12(10), e185694 (2017).","journal-title":"PLoS\u00a0One"},{"issue":"11","key":"71871_CR31","doi-asserted-by":"publisher","first-page":"618","DOI":"10.5483\/BMBRep.2015.48.11.041","volume":"48","author":"DW Kim","year":"2015","unstructured":"Kim, D. W. et al. PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury. BMB Rep. 48(11), 618\u2013623 (2015).","journal-title":"BMB Rep."},{"key":"71871_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.639500","volume":"8","author":"YH Song","year":"2021","unstructured":"Song, Y. H. et al. Application of collagen I and IV in bioengineering transparent ocular tissues. Front. Surg. 8, 639500 (2021).","journal-title":"Front. Surg."},{"issue":"6","key":"71871_CR33","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0042-6989(03)00005-1","volume":"43","author":"D Schulz","year":"2003","unstructured":"Schulz, D., Iliev, M. E., Frueh, B. E. & Goldblum, D. In vivo pachymetry in normal eyes of rats, mice and rabbits with the optical low coherence reflectometer. Vis. Res. 43(6), 723\u2013728 (2003).","journal-title":"Vis. Res."},{"issue":"11","key":"71871_CR34","doi-asserted-by":"publisher","first-page":"6581","DOI":"10.1167\/iovs.15-17426","volume":"56","author":"A Hammer","year":"2015","unstructured":"Hammer, A. et al. Establishing corneal cross-linking with riboflavin and UV-A in the mouse cornea in vivo: Biomechanical analysis. Investig. Ophthalmol. Vis. Sci. 56(11), 6581\u20136590 (2015).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1","key":"71871_CR35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/tvst.6.1.7","volume":"6","author":"S Kling","year":"2017","unstructured":"Kling, S., Hammer, A., Conti, A. & Hafezi, F. Corneal cross-linking with riboflavin and UV-A in the mouse cornea in vivo: Morphological, biochemical, and physiological analysis. Transl. Vis. Sci. Technol. 6(1), 7 (2017).","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"5","key":"71871_CR36","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3928\/1081597X-20160225-04","volume":"32","author":"C Mazzotta","year":"2016","unstructured":"Mazzotta, C., Jacob, S., Agarwal, A. & Kumar, D. A. In vivo confocal microscopy after contact lens-assisted corneal collagen cross-linking for thin keratoconic corneas. J. Refract. Surg. 32(5), 326\u2013331 (2016).","journal-title":"J. Refract. Surg."},{"key":"71871_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101705","volume":"28","author":"A Tillmann","year":"2022","unstructured":"Tillmann, A. et al. Acute corneal melt and perforation\u2014A possible complication after riboflavin\/UV-A crosslinking (CXL) in keratoconus. Am. J. Ophthalmol. Case Rep. 28, 101705 (2022).","journal-title":"Am. J. Ophthalmol. Case Rep."},{"issue":"2","key":"71871_CR38","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/ICO.0b013e3181e16d93","volume":"30","author":"M Hovakimyan","year":"2011","unstructured":"Hovakimyan, M. et al. Short-term corneal response to cross-linking in rabbit eyes assessed by in vivo confocal laser scanning microscopy and histology. Cornea 30(2), 196\u2013203 (2011).","journal-title":"Cornea"},{"key":"71871_CR39","unstructured":"Kizilel, S., \u015eahin, A., Ta\u015f, A. Y., Nazeer, M. A., Gulzar, A. & Yildiz, E. A method and a pharmaceutical composition for visible light-induced corneal crosslinking with ruthenium compounds for the treatment of eye disorders. In WO\/2024\/054165. https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2024054165&_cid=P21-LWEMZJ-87892-1 (2024)."},{"key":"71871_CR40","doi-asserted-by":"crossref","unstructured":"Elvin, C. M. et al. The development of photochemically crosslinked native fibrinogen as a rapidly formed and mechanically strong surgical tissue sealant. Biomaterials 30(11), 2059\u20132065 (2009).","DOI":"10.1016\/j.biomaterials.2008.12.059"},{"key":"71871_CR41","doi-asserted-by":"crossref","unstructured":"Elvin, C. M. et al. Evaluation of photo-crosslinked fibrinogen as a rapid and strong tissue adhesive. J. Biomed. Mater. Res. A. 93a(2), 687\u2013695 (2010).","DOI":"10.1002\/jbm.a.32572"},{"key":"71871_CR57","doi-asserted-by":"crossref","unstructured":"Sando, L. et al. Photochemically crosslinked matrices of gelatin and fibrinogen promote rapid cell proliferation. J. Tissue Eng. Regen. M. 5(5), 337\u2013346 (2011).","DOI":"10.1002\/term.318"},{"issue":"3","key":"71871_CR42","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/ICO.0000000000001134","volume":"36","author":"R Hollhumer","year":"2017","unstructured":"Hollhumer, R., Watson, S. & Beckingsale, P. Persistent epithelial defects and corneal opacity after collagen cross-linking with substitution of dextran (T-500) with dextran sulfate in compounded topical riboflavin. Cornea 36(3), 382\u2013385 (2017).","journal-title":"Cornea"},{"issue":"8","key":"71871_CR43","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/sj.eye.6700559","volume":"17","author":"WM Bourne","year":"2003","unstructured":"Bourne, W. M. Biology of the corneal endothelium in health and disease. Eye 17(8), 912\u2013918 (2003).","journal-title":"Eye"},{"key":"71871_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2022.112568","volume":"235","author":"GJ Jiang","year":"2022","unstructured":"Jiang, G. J., You, X. G. & Fan, T. J. Ultraviolet B irradiation induces senescence of human corneal endothelial cells in vitro by DNA damage response and oxidative stress. J. Photochem. Photobiol. B 235, 112568 (2022).","journal-title":"J. Photochem. Photobiol. B"},{"issue":"1","key":"71871_CR45","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s43246-021-00123-4","volume":"2","author":"M Han","year":"2021","unstructured":"Han, M. et al. Photovoltaic neurointerface based on aluminum antimonide nanocrystals. Commun. Mater. 2(1), 19 (2021).","journal-title":"Commun. Mater."},{"issue":"4","key":"71871_CR46","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ajo.2008.05.042","volume":"146","author":"C Mazzotta","year":"2008","unstructured":"Mazzotta, C. et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: Early and late modifications. Am. J. Ophthalmol. 146(4), 527\u2013533 (2008).","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"71871_CR47","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/ICO.0b013e31824d701b","volume":"32","author":"EM Messmer","year":"2013","unstructured":"Messmer, E. M. et al. Morphological and immunohistochemical changes after corneal cross-linking. Cornea 32(2), 111\u2013117 (2013).","journal-title":"Cornea"},{"issue":"1","key":"71871_CR48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00003226-200401000-00008","volume":"23","author":"G Wollensak","year":"2004","unstructured":"Wollensak, G., Spoerl, E., Wilsch, M. & Seiler, T. Keratocyte apoptosis after corneal collagen cross-linking using riboflavin\/UVA treatment. Cornea 23(1), 43\u201349 (2004).","journal-title":"Cornea"},{"issue":"1","key":"71871_CR49","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/sj.eye.6700065","volume":"16","author":"K Bilgihan","year":"2002","unstructured":"Bilgihan, K. et al. Keratocyte apoptosis and corneal antioxidant enzyme activities after refractive corneal surgery. Eye 16(1), 63\u201368 (2002).","journal-title":"Eye"},{"issue":"10","key":"71871_CR50","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.biocel.2006.03.010","volume":"38","author":"JA West-Mays","year":"2006","unstructured":"West-Mays, J. A. & Dwivedi, D. J. The keratocyte: Corneal stromal cell with variable repair phenotypes. Int. J. Biochem. Cell B 38(10), 1625\u20131631 (2006).","journal-title":"Int. J. Biochem. Cell B"},{"issue":"8","key":"71871_CR51","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1167\/iovs.17-23036","volume":"59","author":"YR Zhu","year":"2018","unstructured":"Zhu, Y. R. et al. Corneal collagen cross-linking with riboflavin and UVA regulates hemangiogenesis and lymphangiogenesis in rats. Investig. Ophthalmol. Vis. Sci. 59(8), 3702\u20133712 (2018).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"71871_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108137","volume":"198","author":"EM Espana","year":"2020","unstructured":"Espana, E. M. & Birk, D. E. Composition, structure and function of the corneal stroma. Exp. Eye Res. 198, 108137 (2020).","journal-title":"Exp. Eye Res."},{"issue":"12","key":"71871_CR53","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/j.jcrs.2010.06.067","volume":"36","author":"SA Greenstein","year":"2010","unstructured":"Greenstein, S. A., Fry, K. L., Bhatt, J. & Hersh, P. S. Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis. J. Cataract Refract. Surg. 36(12), 2105\u20132114 (2010).","journal-title":"J. Cataract Refract. Surg."},{"issue":"1","key":"71871_CR54","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/ICO.0b013e31818225c3","volume":"28","author":"JS Dhaliwal","year":"2009","unstructured":"Dhaliwal, J. S. & Kaufman, S. C. Corneal collagen cross-linking: A confocal, electron, and light microscopy study of eye bank corneas. Cornea 28(1), 62\u201367 (2009).","journal-title":"Cornea"},{"issue":"1","key":"71871_CR55","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/ICO.0000000000000017","volume":"33","author":"Y Xia","year":"2014","unstructured":"Xia, Y., Liu, B. C., Fan, Z. J. & Peng, X. J. Corneal collagen fibril changes after ultraviolet A\/riboflavin corneal crosslinking. Cornea 33(1), 56\u201359 (2014).","journal-title":"Cornea"},{"issue":"3","key":"71871_CR56","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jcrs.2003.11.032","volume":"30","author":"G Wollensak","year":"2004","unstructured":"Wollensak, G. & Spoerl, E. Collagen crosslinking of human and porcine sclera. J. Cataract Refract. Surg. 30(3), 689\u2013695 (2004).","journal-title":"J. Cataract Refract. Surg."}],"updated-by":[{"DOI":"10.1038\/s41598-025-01649-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71871-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71871-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71871-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T11:07:36Z","timestamp":1748603256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-71871-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["71871"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-71871-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4449359\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]},"assertion":[{"value":"20 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-025-01649-0","URL":"https:\/\/doi.org\/10.1038\/s41598-025-01649-0","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors S.K., A.\u015e., A.Y., and A.G. are inventors and have filled a patent through the Koc University (A METHOD AND A PHARMACEUTICAL COMPOSITION FOR VISIBLE LIGHT-INDUCED CORNEAL CROSSLINKING WITH RUTHENIUM COMPOUNDS FOR THE TREATMENT OF EYE DISORDERS, application number PCT\/TR2022\/050954, in process) for the use of ruthenium for corneal collagen crosslinking. All the remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25042"}}