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However, high amounts can change food flavor and odor. Thus, ZnO nanoparticles (NPs) as a supplementary antimicrobial agent are added to gelatin film with CIN. The CIN\/ZnO interactions are the main topic of this investigation. FTIR-Attenuated Total Reflection (ATR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were utilized to investigate CIN\/ZnO@gelatin films. Transmission electron microscope (TEM) images revealed nanospheres morphology of ZnO NPs, with particle sizes ranging from 12 to 22\u00a0nm. ZnO NPs integration increased the overall activation energy of CIN\/ZnO@gelatin by 11.94%. The incorporation of ZnO NPs into the CIN@gelatin film significantly reduced water vapour permeability (WVP) of the CIN\/ZnO@gelatin film by 12.07% and the oxygen permeability (OP) by 86.86%. The water sorption isotherms of CIN\/ZnO@gelatin were described using Guggenheim-Anderson-de Boer (GAB) model. The incorporation of ZnO NPs into the CIN@gelatin film reduced monolayer moisture content (<jats:italic>M<\/jats:italic><jats:sub>0<\/jats:sub>) by 35.79% and significantly decreased the solubility of CIN\/ZnO@gelatin by 15.15%. The inclusion of ZnO into CIN@gelatin film significantly decreased tensile strength of CIN\/ZnO@gelatin by 13.32% and Young`s modulus by 18.33% and enhanced elongation at break by 11.27%. The incorporation of ZnO NPs into the CIN@gelatin film caused a significant decrease of antioxidant activity of CIN\/ZnO@gelatin film by 9.09%. The most susceptible organisms to the CIN\/ZnO@gelatin film included <jats:italic>Candida albicans<\/jats:italic>, <jats:italic>Helicobacter pylori<\/jats:italic>, and <jats:italic>Micrococcus leutus<\/jats:italic>. The inhibition zone produced by the CIN\/ZnO@gelatin film versus <jats:italic>Micrococcus leutus<\/jats:italic> was 25.0\u00a0mm, which was comparable to the inhibition zone created by antibacterial gentamicin (23.33\u00a0mm) and cell viability assessment revealed that ZnO\/CIN@gelatin (96.8\u2009\u00b1\u20090.1%) showed great performance as potent biocompatible active packaging material.<\/jats:p>","DOI":"10.1038\/s41598-024-72009-7","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T12:01:56Z","timestamp":1727524916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Antimicrobial gelatin-based films with cinnamaldehyde and ZnO nanoparticles for sustainable food packaging"],"prefix":"10.1038","volume":"14","author":[{"given":"Maha","family":"Sultan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam Mohammed","family":"El-Masry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef R.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"72009_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/su152015086","author":"O Zinina","year":"2023","unstructured":"Zinina, O., Merenkova, S. & Galimov, D. 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