{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:28:21Z","timestamp":1792790901448,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"\"Yi-Fang\" Graduate Innovation Project of Hunan University of Chinese Medicine","award":["2023YF10"],"award-info":[{"award-number":["2023YF10"]}],"id":[{"id":"https:\/\/ror.org\/01tsmvz08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Graduate Research Innovation Project of Hunan Province","award":["QL20230197"],"award-info":[{"award-number":["QL20230197"]}]},{"name":"Graduate Research Innovation Project of Hunan Province","award":["CX20230832"],"award-info":[{"award-number":["CX20230832"]}]},{"name":"Key Scientific Research Project of Hunan Province","award":["2022SK2012"],"award-info":[{"award-number":["2022SK2012"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174343"],"award-info":[{"award-number":["82174343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673955"],"award-info":[{"award-number":["81673955"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-72011-z","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T04:05:51Z","timestamp":1725595551000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Integrating bioinformatics and ferroptosis to reveal the protective mechanism of Astragaloside IV on chronic heart failure rats"],"prefix":"10.1038","volume":"14","author":[{"given":"Hui","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"issue":"18","key":"72011_CR1","first-page":"e876","volume":"145","author":"PA Heidenreich","year":"2022","unstructured":"Heidenreich, P. A. et al. 2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145(18), e876\u2013e894 (2022).","journal-title":"Circulation"},{"issue":"1","key":"72011_CR2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","volume":"7","author":"Y Yu","year":"2021","unstructured":"Yu, Y. et al. Ferroptosis: A cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discov. 7(1), 193 (2021).","journal-title":"Cell Death Discov."},{"key":"72011_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1269451","volume":"14","author":"XD Zhang","year":"2023","unstructured":"Zhang, X. D. et al. Mechanisms and regulations of ferroptosis. Front. Immunol. 14, 1269451 (2023).","journal-title":"Front. Immunol."},{"key":"72011_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.yjmcc.2022.10.004","volume":"173","author":"X Yang","year":"2022","unstructured":"Yang, X. et al. Ferroptosis in heart failure. J. Mol. Cell. Cardiol. 173, 141\u2013153 (2022).","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"72011_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1142\/S0192415X23500015","volume":"51","author":"L Dong","year":"2023","unstructured":"Dong, L. et al. Research progress of Chinese medicine in the treatment of myocardial ischemia\u2013reperfusion injury. Am. J. Chin. Med. 51(1), 1\u201317 (2023).","journal-title":"Am. J. Chin. Med."},{"key":"72011_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110012","volume":"126","author":"Y Zang","year":"2020","unstructured":"Zang, Y. et al. An updated role of astragaloside IV in heart failure. Biomed. Pharmacother. 126, 110012 (2020).","journal-title":"Biomed. Pharmacother."},{"issue":"D1","key":"72011_CR7","doi-asserted-by":"publisher","first-page":"D571","DOI":"10.1093\/nar\/gkac935","volume":"51","author":"N Zhou","year":"2023","unstructured":"Zhou, N. et al. FerrDb V2: Update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations. Nucleic Acids Res. 51(D1), D571\u2013D582 (2023).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"72011_CR8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2105-15-293","volume":"15","author":"P Bardou","year":"2014","unstructured":"Bardou, P. et al. jvenn: An interactive Venn diagram viewer. BMC Bioinform. 15(1), 293 (2014).","journal-title":"BMC Bioinform."},{"issue":"1","key":"72011_CR9","first-page":"57","volume":"17","author":"MF Sanner","year":"1999","unstructured":"Sanner, M. F. Python: A programming language for software integration and development. J. Mol. Graph. Model. 17(1), 57\u201361 (1999).","journal-title":"J. Mol. Graph. Model."},{"issue":"2","key":"72011_CR10","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott, O. & Olson, A. J. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem. 31(2), 455\u2013461 (2010).","journal-title":"J. Comput. Chem."},{"issue":"16","key":"72011_CR11","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/jcc.20291","volume":"26","author":"D van der Spoel","year":"2005","unstructured":"van der Spoel, D. et al. GROMACS: Fast, flexible, and free. J. Comput. Chem. 26(16), 1701\u20131718 (2005).","journal-title":"J. Comput. Chem."},{"key":"72011_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","volume":"1\u20132","author":"MJ Abraham","year":"2015","unstructured":"Abraham, M. J. et al. GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX 1\u20132, 19\u201325 (2015).","journal-title":"SoftwareX"},{"issue":"5","key":"72011_CR13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.21315\/mjms2017.24.5.11","volume":"24","author":"WN Arifin","year":"2017","unstructured":"Arifin, W. N. & Zahiruddin, W. M. Sample size calculation in animal studies using resource equation approach. Malays. J. Med. Sci. 24(5), 101\u2013105 (2017).","journal-title":"Malays. J. Med. Sci."},{"key":"72011_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152949","volume":"62","author":"Z Zeng","year":"2019","unstructured":"Zeng, Z. et al. Qishen granule attenuates cardiac fibrosis by regulating TGF-\u03b2\/Smad3 and GSK-3\u03b2 pathway. Phytomedicine 62, 152949 (2019).","journal-title":"Phytomedicine"},{"issue":"6","key":"72011_CR15","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1152\/japplphysiol.00033.2007","volume":"102","author":"J Takagawa","year":"2007","unstructured":"Takagawa, J. et al. Myocardial infarct size measurement in the mouse chronic infarction model: Comparison of area- and length-based approaches. J. Appl. Physiol. 102(6), 2104\u20132111 (2007).","journal-title":"J. Appl. Physiol."},{"issue":"4","key":"72011_CR16","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3390\/foods13040612","volume":"13","author":"Y Pan","year":"2024","unstructured":"Pan, Y. et al. Screening of active substances regulating Alzheimer\u2019s disease in ginger and visualization of the effectiveness on 6-gingerol pathway targets. Foods 13(4), 612 (2024).","journal-title":"Foods"},{"issue":"8","key":"72011_CR17","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1002\/ejhf.1858","volume":"22","author":"A Groenewegen","year":"2020","unstructured":"Groenewegen, A. et al. Epidemiology of heart failure. Eur. J. Heart Fail. 22(8), 1342\u20131356 (2020).","journal-title":"Eur. J. Heart Fail."},{"key":"72011_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108185","volume":"238","author":"H Tsutsui","year":"2022","unstructured":"Tsutsui, H. Recent advances in the pharmacological therapy of chronic heart failure: Evidence and guidelines. Pharmacol. Ther. 238, 108185 (2022).","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"72011_CR19","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1093\/bib\/bbx144","volume":"20","author":"G G\u00f3mez-L\u00f3pez","year":"2019","unstructured":"G\u00f3mez-L\u00f3pez, G. et al. Precision medicine needs pioneering clinical bioinformaticians. Brief. Bioinform. 20(3), 752\u2013766 (2019).","journal-title":"Brief. Bioinform."},{"issue":"14","key":"72011_CR20","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell, B. R. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell 185(14), 2401\u20132421 (2022).","journal-title":"Cell"},{"issue":"1","key":"72011_CR21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/imr.13235","volume":"321","author":"D Tang","year":"2024","unstructured":"Tang, D., Kroemer, G. & Kang, R. Ferroptosis in immunostimulation and immunosuppression. Immunol. Rev. 321(1), 199\u2013210 (2024).","journal-title":"Immunol. Rev."},{"issue":"2","key":"72011_CR22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li, J. et al. Ferroptosis: Past, present and future. Cell Death Dis. 11(2), 88 (2020).","journal-title":"Cell Death Dis."},{"issue":"6","key":"72011_CR23","doi-asserted-by":"publisher","first-page":"368","DOI":"10.21037\/atm-21-6942","volume":"10","author":"M Liu","year":"2022","unstructured":"Liu, M. et al. The critical role and molecular mechanisms of ferroptosis in antioxidant systems: A narrative review. Ann. Transl. Med. 10(6), 368 (2022).","journal-title":"Ann. Transl. Med."},{"key":"72011_CR24","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2018.05.074","volume":"133","author":"R Kang","year":"2019","unstructured":"Kang, R., Kroemer, G. & Tang, D. The tumor suppressor protein p53 and the ferroptosis network. Free Radic. Biol. Med. 133, 162\u2013168 (2019).","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"72011_CR25","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3390\/biom12030390","volume":"12","author":"Y Guo","year":"2022","unstructured":"Guo, Y. et al. Ferroptosis in cardiovascular diseases: Current status, challenges, and future perspectives. Biomolecules 12(3), 390 (2022).","journal-title":"Biomolecules"},{"issue":"18","key":"72011_CR26","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.3390\/cells11182842","volume":"11","author":"Q Li","year":"2022","unstructured":"Li, Q. et al. Ferroptosis: The potential target in heart failure with preserved ejection fraction. Cells 11(18), 2842 (2022).","journal-title":"Cells"},{"issue":"6","key":"72011_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2023.119480","volume":"1870","author":"L Xie","year":"2023","unstructured":"Xie, L., Fang, B. & Zhang, C. The role of ferroptosis in metabolic diseases. Biochim. Biophys. Acta Mol. Cell Res. 1870(6), 119480 (2023).","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"8","key":"72011_CR28","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/s41419-023-06045-y","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu, Y. et al. The diversified role of mitochondria in ferroptosis in cancer. Cell Death Dis. 14(8), 519 (2023).","journal-title":"Cell Death Dis."},{"issue":"4","key":"72011_CR29","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang, X., Stockwell, B. R. & Conrad, M. Ferroptosis: Mechanisms, biology and role in disease. Nat. Rev. Mol. Cell Biol. 22(4), 266\u2013282 (2021).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"72011_CR30","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon, S. J. et al. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell 149(5), 1060\u20131072 (2012).","journal-title":"Cell"},{"issue":"8","key":"72011_CR31","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1080\/1061186X.2023.2250574","volume":"31","author":"M Zhang","year":"2023","unstructured":"Zhang, M. et al. Relationship between ferroptosis and mitophagy in renal fibrosis: A systematic review. J. Drug Target. 31(8), 858\u2013866 (2023).","journal-title":"J. Drug Target."},{"issue":"1","key":"72011_CR32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41420-023-01517-8","volume":"9","author":"R Xu","year":"2023","unstructured":"Xu, R., Wang, W. & Zhang, W. Ferroptosis and the bidirectional regulatory factor p53. Cell Death Discov. 9(1), 197 (2023).","journal-title":"Cell Death Discov."},{"issue":"7545","key":"72011_CR33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14344","volume":"520","author":"L Jiang","year":"2015","unstructured":"Jiang, L. et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520(7545), 57\u201362 (2015).","journal-title":"Nature"},{"issue":"3","key":"72011_CR34","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3892\/etm.2023.11812","volume":"25","author":"S Xu","year":"2023","unstructured":"Xu, S., Li, X. & Wang, Y. Regulation of the p53-mediated ferroptosis signaling pathway in cerebral ischemia stroke (Review). Exp. Ther. Med. 25(3), 113 (2023).","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"72011_CR35","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","volume":"99","author":"DP del Re","year":"2019","unstructured":"del Re, D. P. et al. Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol. Rev. 99(4), 1765\u20131817 (2019).","journal-title":"Physiol. Rev."},{"issue":"1","key":"72011_CR36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bbrc.2019.06.015","volume":"516","author":"X Chen","year":"2019","unstructured":"Chen, X. et al. Role of TLR4\/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure. Biochem. Biophys. Res. Commun. 516(1), 37\u201343 (2019).","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"72011_CR37","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/s41419-020-02777-3","volume":"11","author":"J Wang","year":"2020","unstructured":"Wang, J. et al. Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. Cell Death Dis. 11(7), 574 (2020).","journal-title":"Cell Death Dis."},{"key":"72011_CR38","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.freeradbiomed.2023.07.025","volume":"207","author":"Y Chen","year":"2023","unstructured":"Chen, Y. et al. Ferroptosis contributes to catecholamine-induced cardiotoxicity and pathological remodeling. Free Radic. Biol. Med. 207, 227\u2013238 (2023).","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"72011_CR39","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/CIRCRESAHA.120.316509","volume":"127","author":"X Fang","year":"2020","unstructured":"Fang, X. et al. Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circ. Res. 127(4), 486\u2013501 (2020).","journal-title":"Circ. Res."},{"issue":"3","key":"72011_CR40","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s11655-019-3032-8","volume":"27","author":"CH Zhang","year":"2021","unstructured":"Zhang, C. H. et al. Ethnopharmacology, phytochemistry, pharmacology, toxicology and clinical applications of radix astragali. Chin. J. Integr. Med. 27(3), 229\u2013240 (2021).","journal-title":"Chin. J. Integr. Med."},{"issue":"34","key":"72011_CR41","first-page":"5115","volume":"23","author":"Y Wang","year":"2017","unstructured":"Wang, Y. et al. A review of Chinese herbal medicine for the treatment of chronic heart failure. Curr. Pharm. Des. 23(34), 5115\u20135124 (2017).","journal-title":"Curr. Pharm. Des."},{"key":"72011_CR42","doi-asserted-by":"publisher","first-page":"1187910","DOI":"10.3389\/fphar.2023.1187910","volume":"14","author":"C Yang","year":"2023","unstructured":"Yang, C. et al. Review on the protective mechanism of astragaloside IV against cardiovascular diseases. Front. Pharmacol. 14, 1187910 (2023).","journal-title":"Front. Pharmacol."},{"issue":"16","key":"72011_CR43","doi-asserted-by":"publisher","first-page":"6118","DOI":"10.3390\/molecules28166118","volume":"28","author":"Y Liang","year":"2023","unstructured":"Liang, Y. et al. Pharmacological effects of astragaloside IV: A review. Molecules 28(16), 6118 (2023).","journal-title":"Molecules"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72011-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72011-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72011-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T04:10:36Z","timestamp":1725595836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72011-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["72011"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-72011-z","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"30 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20787"}}