{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:38Z","timestamp":1768521638630,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Key Research and Development Program of Hebei Province-Biomedical Innovation Project","award":["23377705D"],"award-info":[{"award-number":["23377705D"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-72291-5","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:05:05Z","timestamp":1726502705000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combined DeRitis ratio and alkaline phosphatase on the prediction of portal vein tumor thrombosis in patients with hepatocellular carcinoma"],"prefix":"10.1038","volume":"14","author":[{"given":"Tong-Guo","family":"Miao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Min","family":"Nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"issue":"11","key":"72291_CR1","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.3390\/cancers14112798","volume":"14","author":"E Chakraborty","year":"2022","unstructured":"Chakraborty, E. & Sarkar, D. Emerging therapies for hepatocellular carcinoma (HCC). Cancers (Basel) 14(11), 2798 (2022).","journal-title":"Cancers (Basel)"},{"issue":"4","key":"72291_CR2","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1001\/jamasurg.2022.7989","volume":"158","author":"ZJ Brown","year":"2023","unstructured":"Brown, Z. J. et al. Management of hepatocellular carcinoma: A review. JAMA Surg. 158(4), 410\u2013420 (2023).","journal-title":"JAMA Surg."},{"key":"72291_CR3","first-page":"288","volume":"60","author":"National Health Commission Office","year":"2022","unstructured":"National Health Commission Office. Guidelines for the diagnosis and treatment of primary liver cancer (2022 edition). J. Clin. Hepatol. 60, 288\u2013303 (2022).","journal-title":"J. Clin. Hepatol."},{"issue":"3","key":"72291_CR4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.5582\/bst.2021.01083","volume":"15","author":"D Liu","year":"2021","unstructured":"Liu, D. & Song, T. Changes in and challenges regarding the surgical treatment of hepatocellular carcinoma in China. Biosci. Trends 15(3), 142\u2013147 (2021).","journal-title":"Biosci. Trends"},{"issue":"10360","key":"72291_CR5","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","volume":"400","author":"A Vogel","year":"2022","unstructured":"Vogel, A., Meyer, T., Sapisochin, G., Salem, R. & Saborowski, A. Hepatocellular carcinoma. Lancet 400(10360), 1345\u20131362 (2022).","journal-title":"Lancet"},{"issue":"4","key":"72291_CR6","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s12029-020-00488-8","volume":"51","author":"C Aydin","year":"2020","unstructured":"Aydin, C. & Yilmaz, S. Is macroscopic portal vein tumor thrombosis of HCC really an exclusion for liver transplantation?. J. Gastrointest. Cancer 51(4), 1137\u20131140 (2020).","journal-title":"J. Gastrointest. Cancer"},{"issue":"2","key":"72291_CR7","first-page":"169","volume":"5","author":"J Yin","year":"2017","unstructured":"Yin, J. et al. New evidence and perspectives on the management of hepatocellular carcinoma with portal vein tumor thrombus. J. Clin. Transl. Hepatol. 5(2), 169\u2013176 (2017).","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"2","key":"72291_CR8","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.hbpd.2021.12.004","volume":"21","author":"ZW Tao","year":"2022","unstructured":"Tao, Z. W., Cheng, B. Q., Zhou, T. & Gao, Y. J. Management of hepatocellular carcinoma patients with portal vein tumor thrombosis: A narrative review. Hepatobiliary Pancreat. Dis. Int. 21(2), 134\u2013144 (2022).","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"72291_CR9","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.2147\/JHC.S318070","volume":"8","author":"AR Khan","year":"2021","unstructured":"Khan, A. R., Wei, X. & Xu, X. Portal vein tumor thrombosis and hepatocellular carcinoma\u2014The changing tides. J. Hepatocell. Carcinoma 8, 1089\u20131115 (2021).","journal-title":"J. Hepatocell. Carcinoma"},{"issue":"43","key":"72291_CR10","doi-asserted-by":"publisher","first-page":"7735","DOI":"10.3748\/wjg.v23.i43.7735","volume":"23","author":"Z Zhang","year":"2017","unstructured":"Zhang, Z. et al. Combined endovascular brachytherapy, sorafenib, and transarterial chemobolization therapy for hepatocellular carcinoma patients with portal vein tumor thrombus. World J. Gastroenterol. 23(43), 7735\u20137745 (2017).","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"72291_CR11","first-page":"504","volume":"14","author":"CH Pan","year":"2022","unstructured":"Pan, C. H. et al. Overview of CT perfusion imaging and treatment methods for hepatocellular carcinoma with portal vein tumor thrombosis. Chin. J. Oncol. Surg. 14(5), 504\u2013508 (2022).","journal-title":"Chin. J. Oncol. Surg."},{"issue":"12","key":"72291_CR12","first-page":"101","volume":"20","author":"H Li","year":"2022","unstructured":"Li, H. et al. Value of CT portal venography three-dimensional reconstruction in diagnosing portal vein tumor thrombus. Chin. J. CT MRI 20(12), 101\u2013102 (2022).","journal-title":"Chin. J. CT MRI"},{"issue":"1","key":"72291_CR13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1055\/s-0038-1676806","volume":"39","author":"YM Yang","year":"2019","unstructured":"Yang, Y. M., Kim, S. Y. & Seki, E. Inflammation and liver cancer: Molecular mechanisms and therapeutic targets. Semin. Liver Dis. 39(1), 26\u201342 (2019).","journal-title":"Semin. Liver Dis."},{"issue":"10","key":"72291_CR14","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.3390\/v14102275","volume":"14","author":"G Yang","year":"2022","unstructured":"Yang, G. et al. Innate immunity, inflammation, and intervention in HBV infection. Viruses 14(10), 2275 (2022).","journal-title":"Viruses"},{"issue":"11","key":"72291_CR15","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3390\/diagnostics10110973","volume":"10","author":"O Knittelfelder","year":"2020","unstructured":"Knittelfelder, O. et al. The AST\/ALT (De Ritis) ratio predicts survival in patients with oral and oropharyngeal cancer. Diagnostics (Basel) 10(11), 973 (2020).","journal-title":"Diagnostics (Basel)"},{"key":"72291_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1049804","volume":"10","author":"W Xie","year":"2022","unstructured":"Xie, W. et al. Low aspartate aminotransferase\/alanine aminotransferase (DeRitis) ratio assists in predicting diabetes in Chinese population. Front. Public Health 10, 1049804 (2022).","journal-title":"Front. Public Health"},{"issue":"7","key":"72291_CR17","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/hed.26673","volume":"43","author":"A Sansa","year":"2021","unstructured":"Sansa, A. et al. The aspartate aminotransaminase\/alanine aminotransaminase (DeRitis) ratio predicts sensitivity to radiotherapy in head and neck carcinoma patients. Head Neck 43(7), 2091\u20132100 (2021).","journal-title":"Head Neck"},{"issue":"7490","key":"72291_CR18","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/nature13062","volume":"507","author":"SB Coffelt","year":"2014","unstructured":"Coffelt, S. B. & de Visser, K. E. Cancer: Inflammation lights the way to metastasis. Nature. 507(7490), 48\u201349 (2014).","journal-title":"Nature."},{"issue":"3","key":"72291_CR19","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1002\/hep.29565","volume":"67","author":"JD Riordan","year":"2018","unstructured":"Riordan, J. D. et al. Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice. Hepatology 67(3), 924\u2013939 (2018).","journal-title":"Hepatology"},{"issue":"4","key":"72291_CR20","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3390\/jpm12040518","volume":"12","author":"CW Huang","year":"2022","unstructured":"Huang, C. W. et al. Reappraisal of the role of alkaline phosphatase in hepatocellular carcinoma. J. Pers. Med. 12(4), 518 (2022).","journal-title":"J. Pers. Med."},{"issue":"1","key":"72291_CR21","doi-asserted-by":"publisher","first-page":"146045822098420","DOI":"10.1177\/1460458220984205","volume":"27","author":"D Chicco","year":"2021","unstructured":"Chicco, D. & Oneto, L. Computational intelligence identifies alkaline phosphatase (ALP), alpha-fetoprotein (AFP), and hemoglobin levels as most predictive survival factors for hepatocellular carcinoma. Health Inform. J. 27(1), 1460458220984205 (2021).","journal-title":"Health Inform. J."},{"issue":"6","key":"72291_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100360","volume":"3","author":"N Wetzstein","year":"2021","unstructured":"Wetzstein, N. et al. Hepatic sarcoidosis: Clinical characteristics and outcome. JHEP Rep. 3(6), 100360 (2021).","journal-title":"JHEP Rep."},{"issue":"9","key":"72291_CR23","doi-asserted-by":"publisher","first-page":"7815","DOI":"10.1007\/s11033-023-08666-0","volume":"50","author":"SS Tamber","year":"2023","unstructured":"Tamber, S. S., Bansal, P., Sharma, S., Singh, R. B. & Sharma, R. Biomarkers of liver diseases. Mol. Biol. Rep. 50(9), 7815\u20137823 (2023).","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"72291_CR24","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1186\/s12883-022-02989-4","volume":"22","author":"MA Ahmadabad","year":"2022","unstructured":"Ahmadabad, M. A. et al. Evaluation of DeRitis (AST\/ALT), ALP\/ALT, and AST\/ALP ratios as prognostic factors in patients with acute ischemic stroke. BMC Neurol. 22(1), 450 (2022).","journal-title":"BMC Neurol."},{"issue":"1","key":"72291_CR25","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1186\/s12885-019-6011-8","volume":"19","author":"LX Zhang","year":"2019","unstructured":"Zhang, L. X. et al. The prognostic significance of serum gamma-glutamyltransferase levels and AST\/ALT in primary hepatic carcinoma. BMC Cancer 19(1), 841 (2019).","journal-title":"BMC Cancer"},{"issue":"11","key":"72291_CR26","first-page":"965","volume":"30","author":"F Chen","year":"2021","unstructured":"Chen, F. et al. Prognostic value of preoperative prognostic nutritional index and albumin\/alkaline phosphatase ratio in patients with renal cell carcinoma. J. Reg. Surg. 30(11), 965\u2013970 (2021).","journal-title":"J. Reg. Surg."},{"issue":"2","key":"72291_CR27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000370212","volume":"91","author":"K Piras-Straub","year":"2015","unstructured":"Piras-Straub, K. et al. Glutamate dehydrogenase and alkaline phosphatase as very early predictors of hepatocellular carcinoma recurrence after liver transplantation. Digestion 91(2), 117\u2013127 (2015).","journal-title":"Digestion"},{"issue":"11","key":"72291_CR28","first-page":"508","volume":"69","author":"CD Witjes","year":"2011","unstructured":"Witjes, C. D. et al. Quantitative HBV DNA and AST are strong predictors for survival after HCC detection in chronic HBV patients. Neth. J. Med. 69(11), 508\u2013513 (2011).","journal-title":"Neth. J. Med."},{"issue":"4","key":"72291_CR29","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s12029-021-00740-9","volume":"52","author":"BI Carr","year":"2021","unstructured":"Carr, B. I. et al. A combination of blood lymphocytes and AST levels distinguishes patients with small hepatocellular carcinomas from non-cancer patients. J. Gastrointest. Cancer 52(4), 1211\u20131216 (2021).","journal-title":"J. Gastrointest. Cancer"},{"issue":"7","key":"72291_CR30","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1111\/j.1478-3231.2008.01733.x","volume":"28","author":"FM Sanai","year":"2008","unstructured":"Sanai, F. M. et al. Is serum alanine transaminase level a reliable marker of histological disease in chronic hepatitis C infection?. Liver Int. 28(7), 1011\u20131018 (2008).","journal-title":"Liver Int."},{"issue":"1","key":"72291_CR31","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12876-023-02719-1","volume":"23","author":"F Wang","year":"2023","unstructured":"Wang, F. et al. The prognostic role of the AST\/ALT ratio in hepatocellular carcinoma patients receiving thermal ablation combined with simultaneous TACE. BMC Gastroenterol. 23(1), 80 (2023).","journal-title":"BMC Gastroenterol."},{"issue":"45","key":"72291_CR32","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008512","volume":"96","author":"C Liu","year":"2017","unstructured":"Liu, C. et al. Neutrophil-to-lymphocyte and aspartate-to-alanine aminotransferase ratios predict hepatocellular carcinoma prognosis after transarterial embolization. Medicine (Baltimore) 96(45), e8512 (2017).","journal-title":"Medicine (Baltimore)"},{"key":"72291_CR33","doi-asserted-by":"publisher","unstructured":"Prognostic Value of Aspartate Transaminase\/Alanine Transaminase Ratio in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma Undergoing Hepatectomy. Front. Oncol. 12. https:\/\/doi.org\/10.3389\/fonc.2022.876900 (2022).","DOI":"10.3389\/fonc.2022.876900"},{"key":"72291_CR34","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1477-7819-11-40","volume":"11","author":"JM Kim","year":"2013","unstructured":"Kim, J. M. et al. The effect of alkaline phosphatase and intrahepatic metastases in large hepatocellular carcinoma. World J. Surg. Oncol. 11, 40 (2013).","journal-title":"World J. Surg. Oncol."},{"key":"72291_CR35","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.ejca.2008.12.025","volume":"45","author":"CH Chen","year":"2009","unstructured":"Chen, C. H. et al. Applicability of staging systems for patients with hepatocellular carcinoma is dependent on treatment method-analysis of 2,010 Taiwanese patients. Eur. J. Cancer 45, 1630\u20131639 (2009).","journal-title":"Eur. J. Cancer"},{"key":"72291_CR36","doi-asserted-by":"publisher","first-page":"e63","DOI":"10.1097\/MCG.0b013e3181b4b68b","volume":"44","author":"MJ Tong","year":"2010","unstructured":"Tong, M. J. et al. Survival in Asian Americans after treatments for hepatocellular carcinoma: A seven-year experience at UCLA. J. Clin. Gastroenterol. 44, e63\u2013e70 (2010).","journal-title":"J. Clin. Gastroenterol."},{"issue":"7","key":"72291_CR37","first-page":"4600","volume":"15","author":"M Li","year":"2023","unstructured":"Li, M. et al. A novel prognostic scoring system to predict portal vein tumor thrombosis in patients with hepatitis B virus-associated hepatocellular carcinoma. Am. J. Transl. Res. 15(7), 4600\u20134609 (2023).","journal-title":"Am. J. Transl. Res."},{"issue":"2","key":"72291_CR38","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3350\/cmh.2022.0212","volume":"29","author":"DY Kim","year":"2023","unstructured":"Kim, D. Y. et al. Utility of combining PIVKA-II and AFP in the surveillance and monitoring of hepatocellular carcinoma in the Asia-Pacific region. Clin. Mol. Hepatol. 29(2), 277\u2013292 (2023).","journal-title":"Clin. Mol. Hepatol."},{"issue":"1","key":"72291_CR39","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1186\/s13104-023-06600-y","volume":"16","author":"VT Tran","year":"2023","unstructured":"Tran, V. T. et al. The diagnostic performance of AFP and PIVKA-II models for non-B non-C hepatocellular carcinoma. BMC Res. Notes 16(1), 317 (2023).","journal-title":"BMC Res. Notes"},{"issue":"1","key":"72291_CR40","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.1038\/s41598-023-32879-9","volume":"13","author":"F Villalba-L\u00f3pez","year":"2023","unstructured":"Villalba-L\u00f3pez, F. et al. Usefulness of PIVKA-II for monitoring after liver transplantation in patients with hepatocellular carcinoma. Sci. Rep. 13(1), 5621 (2023).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72291-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72291-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72291-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:26:23Z","timestamp":1726503983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72291-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["72291"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-72291-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"23 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21614"}}