{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:59:14Z","timestamp":1793411954170,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["21K17324"],"award-info":[{"award-number":["21K17324"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-72318-x","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T13:03:20Z","timestamp":1726232600000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Roles of HMGB1 on life-threatening traumatic brain injury and sequential peripheral organ damage"],"prefix":"10.1038","volume":"14","author":[{"given":"Chihiro","family":"Kawai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Miyao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirozo","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Abiru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nishitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"72318_CR1","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.chest.2021.01.016","volume":"160","author":"V Krishnamoorthy","year":"2021","unstructured":"Krishnamoorthy, V., Komisarow, J. M., Laskowitz, D. T. & Vavilala, M. S. Multiorgan dysfunction after severe traumatic brain injury: Epidemiology, mechanisms, and clinical management. Chest 160, 956\u2013964 (2021).","journal-title":"Chest"},{"key":"72318_CR2","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1097\/01.CCM.0000155911.01844.54","volume":"33","author":"DA Zygun","year":"2005","unstructured":"Zygun, D. A., Kortbeek, J. B., Fick, G. H., Laupland, K. B. & Doig, C. J. Non-neurologic organ dysfunction in severe traumatic brain injury. Crit. Care Med. 33, 654\u2013660 (2005).","journal-title":"Crit. Care Med."},{"key":"72318_CR3","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1089\/neu.2019.6885","volume":"37","author":"SJ McDonald","year":"2020","unstructured":"McDonald, S. J. et al. Beyond the brain: Peripheral interactions after traumatic brain injury. J. Neurotrauma 37, 770\u2013781 (2020).","journal-title":"J. Neurotrauma"},{"key":"72318_CR4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143777","volume":"131","author":"M Hanscom","year":"2021","unstructured":"Hanscom, M., Loane, D. J. & Shea-Donohue, T. Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury. J. Clin. Invest. 131, e143777 (2021).","journal-title":"J. Clin. Invest."},{"key":"72318_CR5","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.tins.2020.12.004","volume":"44","author":"AI Faden","year":"2021","unstructured":"Faden, A. I., Barrett, J. P., Stoica, B. A. & Henry, R. J. Bidirectional brain-systemic interactions and outcomes after TBI. Trends Neurosci. 44, 406\u2013418 (2021).","journal-title":"Trends Neurosci."},{"key":"72318_CR6","doi-asserted-by":"publisher","first-page":"40112","DOI":"10.1038\/srep40112","volume":"7","author":"D Nizamutdinov","year":"2017","unstructured":"Nizamutdinov, D. et al. Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury. Sci. Rep. 7, 40112 (2017).","journal-title":"Sci. Rep."},{"key":"72318_CR7","doi-asserted-by":"publisher","first-page":"e937","DOI":"10.1097\/CCM.0000000000003270","volume":"46","author":"DC Humphries","year":"2018","unstructured":"Humphries, D. C. et al. Cerebral concussion primes the lungs for subsequent neutrophil-mediated injury. Crit. Care Med. 46, e937\u2013e944 (2018).","journal-title":"Crit. Care Med."},{"key":"72318_CR8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12974-020-02067-x","volume":"18","author":"M Hanscom","year":"2021","unstructured":"Hanscom, M. et al. Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits. J. Neuroinflammation 18, 24 (2021).","journal-title":"J. Neuroinflammation"},{"key":"72318_CR9","doi-asserted-by":"publisher","first-page":"e2301360120","DOI":"10.1073\/pnas.2301360120","volume":"120","author":"Y Dai","year":"2023","unstructured":"Dai, Y. et al. Enhancement of the liver\u2019s neuroprotective role ameliorates traumatic brain injury pathology. Proc. Natl. Acad. Sci. USA 120, e2301360120 (2023).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"72318_CR10","doi-asserted-by":"publisher","first-page":"eaax8847","DOI":"10.1126\/sciadv.aax8847","volume":"6","author":"K Vaibhav","year":"2020","unstructured":"Vaibhav, K. et al. Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury. Sci. Adv. 6, eaax8847 (2020).","journal-title":"Sci. Adv."},{"key":"72318_CR11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nrn3407","volume":"14","author":"Y Xiong","year":"2013","unstructured":"Xiong, Y., Mahmood, A. & Chopp, M. Animal models of traumatic brain injury. Nat. Rev. Neurosci. 14, 128\u2013142 (2013).","journal-title":"Nat. Rev. Neurosci."},{"key":"72318_CR12","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1038\/nprot.2009.148","volume":"4","author":"MA Flierl","year":"2009","unstructured":"Flierl, M. A. et al. Mouse closed head injury model induced by a weight-drop device. Nat. Protoc. 4, 1328\u20131337 (2009).","journal-title":"Nat. Protoc."},{"key":"72318_CR13","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nri2215","volume":"8","author":"H Kono","year":"2008","unstructured":"Kono, H. & Rock, K. L. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8, 279\u2013289 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"72318_CR14","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1016\/j.bbadis.2017.05.020","volume":"1863","author":"M Braun","year":"2017","unstructured":"Braun, M. et al. White matter damage after traumatic brain injury: A role for damage associated molecular patterns. Biochim. Biophys. Acta Mol. Basis Dis. 1863, 2614\u20132626 (2017).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"72318_CR15","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","volume":"464","author":"Q Zhang","year":"2010","unstructured":"Zhang, Q. et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464, 104\u2013107 (2010).","journal-title":"Nature"},{"key":"72318_CR16","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.arr.2015.03.003","volume":"24","author":"JW Kang","year":"2015","unstructured":"Kang, J. W., Kim, S. J., Cho, H. I. & Lee, S. M. DAMPs activating innate immune responses in sepsis. Ageing Res. Rev. 24, 54\u201365 (2015).","journal-title":"Ageing Res. Rev."},{"key":"72318_CR17","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.ajpath.2015.11.025","volume":"186","author":"C Kawai","year":"2016","unstructured":"Kawai, C. et al. Circulating extracellular histones are clinically relevant mediators of multiple organ injury. Am. J. Pathol. 186, 829\u2013843 (2016).","journal-title":"Am. J. Pathol."},{"key":"72318_CR18","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.3390\/cells11121919","volume":"11","author":"H Block","year":"2022","unstructured":"Block, H., Rossaint, J. & Zarbock, A. The fatal circle of NETs and NET-associated DAMPs contributing to organ dysfunction. Cells 11, 1919 (2022).","journal-title":"Cells"},{"key":"72318_CR19","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/s41577-023-00894-6","volume":"23","author":"D Tang","year":"2023","unstructured":"Tang, D., Kang, R., Zeh, H. J. & Lotze, M. T. The multifunctional protein HMGB1: 50 years of discovery. Nat. Rev. Immunol. 23, 824\u2013841 (2023).","journal-title":"Nat. Rev. Immunol."},{"key":"72318_CR20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s12975-010-0052-2","volume":"2","author":"K Murakami","year":"2011","unstructured":"Murakami, K. et al. Subarachnoid hemorrhage induces gliosis and increased expression of the pro-inflammatory cytokine high mobility group box 1 protein. Transl. Stroke Res. 2, 72\u201379 (2011).","journal-title":"Transl. Stroke Res."},{"key":"72318_CR21","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1742-2094-11-106","volume":"11","author":"Q Sun","year":"2014","unstructured":"Sun, Q. et al. Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro. J. Neuroinflammation 11, 106 (2014).","journal-title":"J. Neuroinflammation"},{"key":"72318_CR22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/ana.23602","volume":"72","author":"Y Okuma","year":"2012","unstructured":"Okuma, Y. et al. Anti-high mobility group box-1 antibody therapy for traumatic brain injury. Ann. Neurol. 72, 373\u2013384 (2012).","journal-title":"Ann. Neurol."},{"key":"72318_CR23","doi-asserted-by":"publisher","first-page":"e864","DOI":"10.1016\/j.wneu.2018.10.164","volume":"122","author":"Y Okuma","year":"2019","unstructured":"Okuma, Y. et al. Anti-high mobility group box 1 antibody therapy may prevent cognitive dysfunction after traumatic brain injury. World Neurosurg. 122, e864\u2013e871 (2019).","journal-title":"World Neurosurg."},{"key":"72318_CR24","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1089\/ars.2015.6299","volume":"23","author":"DJ Weber","year":"2015","unstructured":"Weber, D. J., Allette, Y. M., Wilkes, D. S. & White, F. A. The HMGB1-RAGE inflammatory pathway: Implications for brain injury-induced pulmonary dysfunction. Antioxid. Redox Signal. 23, 1316\u20131328 (2015).","journal-title":"Antioxid. Redox Signal."},{"key":"72318_CR25","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1523\/JNEUROSCI.2439-14.2015","volume":"35","author":"A Liesz","year":"2015","unstructured":"Liesz, A. et al. DAMP signaling is a key pathway inducing immune modulation after brain injury. J. Neurosci. 35, 583\u2013598 (2015).","journal-title":"J. Neurosci."},{"key":"72318_CR26","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.3390\/ijms21093344","volume":"21","author":"A Cash","year":"2020","unstructured":"Cash, A. & Theus, M. H. Mechanisms of blood-brain barrier dysfunction in traumatic brain injury. Int. J. Mol. Sci. 21, 3344 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"72318_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.etp.2010.07.007","volume":"64","author":"MJ Mirzayan","year":"2012","unstructured":"Mirzayan, M. J. et al. Histopathological features of the brain, liver, kidney and spleen following an innovative polytrauma model of the mouse. Exp. Toxicol. Pathol. 64, 133\u2013139 (2012).","journal-title":"Exp. Toxicol. Pathol."},{"key":"72318_CR28","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","volume":"233","author":"A Shapouri-Moghaddam","year":"2018","unstructured":"Shapouri-Moghaddam, A. et al. Macrophage plasticity, polarization, and function in health and disease. J. Cell. Physiol. 233, 6425\u20136440 (2018).","journal-title":"J. Cell. Physiol."},{"key":"72318_CR29","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cytogfr.2022.07.007","volume":"69","author":"W Zhang","year":"2023","unstructured":"Zhang, W. et al. MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets. Cytokine Growth Factor Rev. 69, 90\u2013103 (2023).","journal-title":"Cytokine Growth Factor Rev."},{"key":"72318_CR30","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/jcbfm.2010.142","volume":"31","author":"A Helmy","year":"2011","unstructured":"Helmy, A., Carpenter, K. L., Menon, D. K., Pickard, J. D. & Hutchinson, P. J. The cytokine response to human traumatic brain injury: Temporal profiles and evidence for cerebral parenchymal production. J. Cereb. Blood Flow Metab. 31, 658\u2013670 (2011).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"72318_CR31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fnmol.2012.00006","volume":"5","author":"CL Dalgard","year":"2012","unstructured":"Dalgard, C. L. et al. The cytokine temporal profile in rat cortex after controlled cortical impact. Front. Mol. Neurosci. 5, 6 (2012).","journal-title":"Front. Mol. Neurosci."},{"key":"72318_CR32","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","volume":"32","author":"MV Sofroniew","year":"2009","unstructured":"Sofroniew, M. V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32, 638\u2013647 (2009).","journal-title":"Trends Neurosci."},{"key":"72318_CR33","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1078\/0940-2993-00247","volume":"54","author":"M van Griensven","year":"2002","unstructured":"van Griensven, M. et al. Polymicrobial sepsis induces organ changes due to granulocyte adhesion in a murine two hit model of trauma. Exp. Toxicol. Pathol. 54, 203\u2013209 (2002).","journal-title":"Exp. Toxicol. Pathol."},{"key":"72318_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146871","volume":"11","author":"T Ishida","year":"2016","unstructured":"Ishida, T. et al. Renal impairment with sublethal tubular cell injury in a chronic liver disease mouse model. PLoS One 11, e0146871 (2016).","journal-title":"PLoS One"},{"key":"72318_CR35","first-page":"49","volume":"27","author":"C Dacho","year":"2013","unstructured":"Dacho, C. et al. Catecholamines reduce dose-dependent oedema formation and inflammatory reaction in an isolated rat lung model. In Vivo 27, 49\u201356 (2013).","journal-title":"In Vivo"},{"key":"72318_CR36","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1042\/CS20200553","volume":"134","author":"Y Tian","year":"2020","unstructured":"Tian, Y. et al. HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson\u2019s disease model. Clin. Sci. 134, 2075\u20132090 (2020).","journal-title":"Clin. Sci."},{"key":"72318_CR37","doi-asserted-by":"publisher","first-page":"252ra124","DOI":"10.1126\/scitranslmed.3009443","volume":"6","author":"DJ Weber","year":"2014","unstructured":"Weber, D. J. et al. The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation. Sci. Transl. Med. 6, 252ra124 (2014).","journal-title":"Sci. Transl. Med."},{"key":"72318_CR38","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.3171\/2021.11.FOCUS21586","volume":"52","author":"EA Sribnick","year":"2022","unstructured":"Sribnick, E. A., Popovich, P. G. & Hall, M. W. Central nervous system injury-induced immune suppression. Neurosurg. Focus 52, E10 (2022).","journal-title":"Neurosurg. Focus"},{"key":"72318_CR39","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nrn1765","volume":"6","author":"C Meisel","year":"2005","unstructured":"Meisel, C., Schwab, J. M., Prass, K., Meisel, A. & Dirnagl, U. Central nervous system injury-induced immune deficiency syndrome. Nat. Rev. Neurosci. 6, 775\u2013786 (2005).","journal-title":"Nat. Rev. Neurosci."},{"key":"72318_CR40","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fneur.2015.00235","volume":"6","author":"J Hazeldine","year":"2015","unstructured":"Hazeldine, J., Lord, J. M. & Belli, A. Traumatic brain injury and peripheral immune suppression: Primer and prospectus. Front. Neurol. 6, 235 (2015).","journal-title":"Front. Neurol."},{"key":"72318_CR41","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41590-017-0022-x","volume":"19","author":"F Veglia","year":"2018","unstructured":"Veglia, F., Perego, M. & Gabrilovich, D. Myeloid-derived suppressor cells coming of age. Nat. Immunol. 19, 108\u2013119 (2018).","journal-title":"Nat. Immunol."},{"key":"72318_CR42","doi-asserted-by":"publisher","first-page":"5326","DOI":"10.3390\/jcm11185326","volume":"11","author":"N Bizymi","year":"2022","unstructured":"Bizymi, N. et al. New perspectives on myeloid-derived suppressor cells and their emerging role in haematology. J. Clin. Med. 11, 5326 (2022).","journal-title":"J. Clin. Med."},{"key":"72318_CR43","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1089\/neu.2018.5664","volume":"36","author":"RK Aneja","year":"2019","unstructured":"Aneja, R. K. et al. Lack of benefit on brain oedema, blood-brain barrier permeability, or cognitive outcome in global inducible high mobility group box 1 knockout mice despite tissue sparing after experimental traumatic brain injury. J. Neurotrauma 36, 360\u2013369 (2019).","journal-title":"J. Neurotrauma"},{"key":"72318_CR44","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s12264-022-00890-1","volume":"38","author":"J Shi","year":"2022","unstructured":"Shi, J. et al. HMGB1 from astrocytes promotes EAE by influencing the immune cell infiltration-associated functions of BMECs in mice. Neurosci. Bull. 38, 1303\u20131314 (2022).","journal-title":"Neurosci. Bull."},{"key":"72318_CR45","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/glia.20638","volume":"56","author":"Y Nadler","year":"2008","unstructured":"Nadler, Y. et al. Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury. Glia 56, 552\u2013567 (2008).","journal-title":"Glia"},{"key":"72318_CR46","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1538\/expanim.60.481","volume":"60","author":"S Kawai","year":"2011","unstructured":"Kawai, S., Takagi, Y., Kaneko, S. & Kurosawa, T. Effect of three types of mixed anesthetic agents alternate to ketamine in mice. Exp. Anim. 60, 481\u2013487 (2011).","journal-title":"Exp. Anim."},{"issue":"7","key":"72318_CR47","doi-asserted-by":"publisher","first-page":"e3000411","DOI":"10.1371\/journal.pbio.3000411","volume":"18","author":"NP Du Sert","year":"2020","unstructured":"Du Sert, N. P. et al. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS biology 18(7), e3000411 (2020).","journal-title":"PLoS biology"},{"key":"72318_CR48","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/BF01700662","volume":"21","author":"H Moriuchi","year":"1995","unstructured":"Moriuchi, H., Arai, I. & Yuizono, T. Tranexamic acid attenuates oleic-acid-induced pulmonary extravasation. Intensive Care Med. 21, 1003\u20131008 (1995).","journal-title":"Intensive Care Med."},{"key":"72318_CR49","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","volume":"44","author":"G Matute-Bello","year":"2011","unstructured":"Matute-Bello, G. et al. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am. J. Respir. Cell Mol. Biol. 44, 725\u2013738 (2011).","journal-title":"Am. J. Respir. Cell Mol. Biol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72318-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72318-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72318-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T14:16:55Z","timestamp":1726237015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72318-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["72318"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-72318-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]},"assertion":[{"value":"12 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21421"}}