{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:15:58Z","timestamp":1793445358621,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018935","name":"Universit\u00e4tsklinikum Erlangen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018935","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) represents the standard treatment for therapy-refractory, malignant or complicated ulcerative colitis (UC) and can be performed as a 2-stage or 3-stage procedure. This study aimed to compare the short- and long-term outcomes after 2- and 3-stage IPAA in patients with UC in our department. A retrospective analysis of 176 patients with UC who received 2- or 3-stage restorative proctocolectomy with IPAA at our institution from 2001 to 2021 was performed. Outcomes for short-term (morbidity, longer hospital stay, readmission) and long-term (pouch failure and quality of life) parameters were compared between the 2- and 3-stage procedure. Regarding short-term outcomes for all patients, in-hospital morbidity and readmission rates after any surgical stage were observed in 69% and 24%, respectively. Morbidity and readmission did not differ significantly between the 2- and 3-stage procedure in uni- and multivariate analysis. Median length of hospital stay for all stages was 17\u00a0days. The 3-stage procedure was identified as an independent factor for longer hospital stay (OR 3.8 (CI 1.3\u201310.8), <jats:italic>p<\/jats:italic>\u2009=\u20090.014). Pouch failure and failure of improved quality of life during long-term follow-up occurred both in 10% of patients, with no significant differences between the 2- and 3-stage procedure in uni- and multivariate analysis. Our data suggest that both the 2- and 3-stage proctocolectomy with IPAA demonstrate favourable and comparable postoperative short- and long-term outcomes, with a high rate of improved quality of life in patients with UC.<\/jats:p>","DOI":"10.1038\/s41598-024-72466-0","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T11:01:44Z","timestamp":1727780504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["2-Stage and 3-stage restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis show comparable short- and long-term outcomes"],"prefix":"10.1038","volume":"14","author":[{"given":"Maximilian","family":"Brunner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Brandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Denz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Krautz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg F.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gr\u00fctzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"issue":"3","key":"72466_CR1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cgh.2017.06.016","volume":"16","author":"M Fumery","year":"2018","unstructured":"Fumery, M. et al. Natural history of adult ulcerative colitis in population-based cohorts: A systematic review. Clin. Gastroenterol. Hepatol. 16(3), 343-356.e3 (2018).","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"1","key":"72466_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/DCR.0000000000000030","volume":"57","author":"H Ross","year":"2014","unstructured":"Ross, H. et al. Standards practice task force of the American Society of Colon and Rectal Surgeons. Practice parameters for the surgical treatment of ulcerative colitis. Dis. Colon Rectum 57(1), 5\u201322 (2014).","journal-title":"Dis. Colon Rectum"},{"issue":"8","key":"72466_CR3","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1038\/ajg.2012.127","volume":"107","author":"LE Targownik","year":"2012","unstructured":"Targownik, L. E., Singh, H., Nugent, Z. & Bernstein, C. N. The epidemiology of colectomy in ulcerative colitis: Results from a population-based cohort. Am. J. Gastroenterol. 107(8), 1228\u20131235 (2012).","journal-title":"Am. J. Gastroenterol."},{"issue":"4","key":"72466_CR4","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.gtc.2020.09.001","volume":"49","author":"MJ Grieco","year":"2020","unstructured":"Grieco, M. J. & Remzi, F. H. Surgical management of ulcerative colitis. Gastroenterol. Clin. North Am. 49(4), 753\u2013768 (2020).","journal-title":"Gastroenterol. Clin. North Am."},{"issue":"8","key":"72466_CR5","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.1538","volume":"152","author":"AS Kulaylat","year":"2017","unstructured":"Kulaylat, A. S. et al. Association of preoperative anti-tumor necrosis factor therapy with adverse postoperative outcomes in patients undergoing abdominal surgery for ulcerative colitis. JAMA Surg. 152(8), e171538 (2017).","journal-title":"JAMA Surg."},{"issue":"7","key":"72466_CR6","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S2468-1253(22)00001-2","volume":"7","author":"PG Kotze","year":"2022","unstructured":"Kotze, P. G., Heuthorst, L., Lightner, A. L., Dami\u00e3o, A. O. M. C. & Bemelman, W. A. New insights on the surgical management of ulcerative colitis in the 21st century. Lancet Gastroenterol. Hepatol. 7(7), 679\u2013688 (2022).","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"9","key":"72466_CR7","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1097\/DCR.0000000000000418","volume":"58","author":"PB Murphy","year":"2015","unstructured":"Murphy, P. B., Khot, Z., Vogt, K. N., Ott, M. & Dubois, L. Quality of life after total proctocolectomy with ileostomy or IPAA: A systematic review. Dis. Colon. Rectum. 58(9), 899\u2013908 (2015).","journal-title":"Dis. Colon. 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This study was approved by the Ethics Committee of FAU Erlangen (22-222-Br).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human rights"}},{"value":"This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement on the welfare of animals"}},{"value":"The need for informed consent was waived by the Ethics Committee of FAU Erlangen (22-222-Br), as this study contains no information that would enable individual patient identity.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"22807"}}