{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T14:39:53Z","timestamp":1784471993180,"version":"3.55.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005632","name":"Narodowe Centrum Bada\u0144 i Rozwoju","doi-asserted-by":"publisher","award":["LIDER\/12\/0056\/L-10\/18\/NCBR\/2019"],"award-info":[{"award-number":["LIDER\/12\/0056\/L-10\/18\/NCBR\/2019"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-72591-w","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T03:13:49Z","timestamp":1726456429000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intracranial bypass for giant aneurysms treatment assessed by computational fluid dynamics (CFD) analysis"],"prefix":"10.1038","volume":"14","author":[{"given":"Karol","family":"Wi\u015bniewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Reorowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Tyfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fahlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Obidowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz J.","family":"Jask\u00f3lski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"J\u00f3\u017awik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wessels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vajkoczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios A.","family":"Adamides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"72591_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1474-4422(13)70263-1","volume":"13","author":"JP Greving","year":"2014","unstructured":"Greving, J. P. et al. Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: A pooled analysis of six prospective cohort studies. Lancet Neurol. 13, 59\u201366 (2014).","journal-title":"Lancet Neurol."},{"key":"72591_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","volume":"362","author":"DO Wiebers","year":"2003","unstructured":"Wiebers, D. O. et al. Unruptured intracranial aneurysms: Natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362, 103\u2013110 (2003).","journal-title":"Lancet"},{"issue":"1","key":"72591_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3171\/2019.8.JNS183078","volume":"134","author":"J Dengler","year":"2019","unstructured":"Dengler, J. et al. Giant intracranial aneurysm study group. giant intracranial aneurysms: Natural history and 1\u00a0year case fatality after endovascular or surgical treatment. J. Neurosurg. 134(1), 49\u201357. https:\/\/doi.org\/10.3171\/2019.8.JNS183078 (2019) (PMID: 31812141).","journal-title":"J. Neurosurg."},{"key":"72591_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-3-319-29887-0_8","volume":"123","author":"T Hara","year":"2016","unstructured":"Hara, T., Arai, S., Goto, Y., Takizawa, T. & Uchida, T. Bypass surgeries in the treatment of cerebral aneurysms. Acta Neurochir Suppl. 123, 57\u201364. https:\/\/doi.org\/10.1007\/978-3-319-29887-0_8 (2016) (PMID: 27637629).","journal-title":"Acta Neurochir Suppl."},{"key":"72591_CR5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10143-014-0571-5","volume":"38","author":"X Shi","year":"2015","unstructured":"Shi, X. et al. Management of complex intracranial aneurysms with bypass surgery: A technique application and experience in 93 patients. Neurosurg. Rev. 38, 109\u2013120 (2015).","journal-title":"Neurosurg. Rev."},{"key":"72591_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.1481","author":"DM Sforza","year":"2012","unstructured":"Sforza, D. M., Putman, C. M. & Cebral, J. R. Computational fluid dynamics in brain aneurysms. Int. J. Numer. Method Biomed. Eng. https:\/\/doi.org\/10.1002\/cnm.1481 (2012).","journal-title":"Int. J. Numer. Method Biomed. Eng."},{"key":"72591_CR7","doi-asserted-by":"publisher","first-page":"e282","DOI":"10.1016\/j.wneu.2020.12.050","volume":"147","author":"L Wessels","year":"2021","unstructured":"Wessels, L. et al. Complete or partial parent artery sacrifice: Effect of vessel-occlusion strategies on complete obliteration of complex aneurysms. World Neurosurg. 147, e282\u2013e292. https:\/\/doi.org\/10.1016\/j.wneu.2020.12.050 (2021).","journal-title":"World Neurosurg."},{"issue":"10","key":"72591_CR8","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.3390\/diagnostics11101866","volume":"11","author":"A Polanczyk","year":"2021","unstructured":"Polanczyk, A. et al. Computational fluid dynamic technique for assessment of how changing character of blood flow and different value of hct influence blood hemodynamic in dissected aorta. Diagnostics 11(10), 1866 (2021).","journal-title":"Diagnostics"},{"issue":"1","key":"72591_CR9","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bbe.2022.02.008","volume":"42","author":"P Reorowicz","year":"2022","unstructured":"Reorowicz, P. et al. Blood flow through the fusiform aneurysm treated with the flow diverter stent\u2013numerical investigations. Biocybern. Biomed. Eng. 42(1), 375\u2013390 (2022).","journal-title":"Biocybern. Biomed. Eng."},{"key":"72591_CR10","doi-asserted-by":"publisher","first-page":"632066","DOI":"10.3389\/fneur.2021.632066","volume":"12","author":"Y Liu","year":"2021","unstructured":"Liu, Y., Jiang, G., Wang, F. & An, X. Quantitative assessment of changes in hemodynamics after obliteration of large intracranial carotid aneurysms using computational fluid dynamics. Front. Neurol. 12, 632066 (2021).","journal-title":"Front. Neurol."},{"issue":"1","key":"72591_CR11","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1038\/s41598-024-55345-6","volume":"14","author":"K Wi\u015bniewski","year":"2024","unstructured":"Wi\u015bniewski, K. et al. Numerical flow experiment for assessing predictors for cerebrovascular accidents in patients with PHACES syndrome. Sci. Rep. 14(1), 5161 (2024).","journal-title":"Sci. Rep."},{"issue":"8","key":"72591_CR12","doi-asserted-by":"publisher","first-page":"e3630","DOI":"10.1002\/cnm.3630","volume":"38","author":"D Jodko","year":"2022","unstructured":"Jodko, D., Jeckowski, M. & Tyfa, Z. Fluid structure interaction versus rigid-wall approach in the study of the symptomatic stenosed carotid artery: Importance of wall compliance and resilience of loose connective tissue. Int. J. Numer. Methods Biomed. Eng. 38(8), e3630 (2022).","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"issue":"1","key":"72591_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-16213-3","volume":"12","author":"H Shahzad","year":"2022","unstructured":"Shahzad, H. et al. Fluid structure interaction study of non-Newtonian Casson fluid in a bifurcated channel having stenosis with elastic walls. Sci. Rep. 12(1), 1\u201313 (2022).","journal-title":"Sci. Rep."},{"issue":"11","key":"72591_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40430-022-03787-2","volume":"44","author":"PC Carvalho","year":"2022","unstructured":"Carvalho, P. C. & Bazani, M. A. Numerical analysis of a brain artery in ANSYS. J. Braz. Soc. Mech. Sci. Eng. 44(11), 1\u201314 (2022).","journal-title":"J. Braz. Soc. Mech. Sci. Eng."},{"issue":"3","key":"72591_CR15","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3233\/BME-181732","volume":"29","author":"M Jahed","year":"2018","unstructured":"Jahed, M., Ghalichi, F. & Farhoudi, M. Fluid-structure interaction of patient-specific Circle of Willis with aneurysm: Investigation of hemodynamic parameters. Bio-med. Mater. Eng. 29(3), 357\u2013368 (2018).","journal-title":"Bio-med. Mater. Eng."},{"issue":"11","key":"72591_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40430-022-03792-5","volume":"44","author":"N Kumar","year":"2022","unstructured":"Kumar, N., Pai, R., Abdul Khader, S. M., Khan, S. H. & Kyriacou, P. A. Influence of blood pressure and rheology on oscillatory shear index and wall shear stress in the carotid artery. J. Braz. Soc. Mech. Sci. Eng. 44(11), 1\u201316 (2022).","journal-title":"J. Braz. Soc. Mech. Sci. Eng."},{"issue":"1","key":"72591_CR17","doi-asserted-by":"publisher","first-page":"7283","DOI":"10.1038\/s41598-022-11321-6","volume":"12","author":"S Muraoka","year":"2022","unstructured":"Muraoka, S. et al. Blood flow stagnation after treatment of a giant internal carotid artery aneurysm: A computed fluid dynamics analysis. Sci. Rep. 12(1), 7283 (2022).","journal-title":"Sci. Rep."},{"key":"72591_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.913457","author":"Y Zhu","year":"2022","unstructured":"Zhu, Y., Mirsadraee, S., Rosendahl, U., Pepper, J. & Xu, X. Y. Fluid-structure interaction simulations of repaired type A aortic dissection: A comprehensive comparison with rigid wall models. Front. Phys. https:\/\/doi.org\/10.3389\/fphys.2022.913457 (2022).","journal-title":"Front. Phys."},{"key":"72591_CR19","doi-asserted-by":"crossref","unstructured":"V. Carvalho, N. Rodrigues, R. A. Lima and S. Teixeira, \u201cNumerical simulation of blood pulsatile flow in stenotic coronary arteries: The effect of turbulence modeling and non-Newtonian assumptions,\u201d 2020 24th International Conference on Circuits, Systems, Communications and Computers (CSCC), Chania, Greece, pp. 112\u2013116, (2020)","DOI":"10.1109\/CSCC49995.2020.00027"},{"key":"72591_CR20","doi-asserted-by":"crossref","unstructured":"R. Tabe, F. Ghalichi, S. Hossainpour and K. Ghasemzadeh, \u201cNumerical simulation of transitional blood flow in large arteries,\u201d 2011 18th Iranian Conference of Biomedical Engineering (ICBME), Tehran, Iran, pp. 68-71, (2011).","DOI":"10.1109\/ICBME.2011.6168588"},{"key":"72591_CR21","doi-asserted-by":"publisher","DOI":"10.2478\/ama-2024-0002","author":"Z Tyfa","year":"2024","unstructured":"Tyfa, Z., Reorowicz, P., Obidowski, D. & J\u00f3\u017awik, K. Influence of fluid rheology on blood flow haemodynamics in patient-specific arterial networks of varied complexity\u2013in-silico studies. Acta Mech. Automatica https:\/\/doi.org\/10.2478\/ama-2024-0002 (2024).","journal-title":"Acta Mech. Automatica"},{"key":"72591_CR22","doi-asserted-by":"publisher","DOI":"10.37190\/ABB-01571-2020-02","author":"DM Jodko","year":"2020","unstructured":"Jodko, D. M., Obidowski, D. S., Reorowicz, P. & J\u00f3\u017awik, K. A two-stage model of an arteriovenous fistula maturation process. Acta Bioeng. Biomech. https:\/\/doi.org\/10.37190\/ABB-01571-2020-02 (2020).","journal-title":"Acta Bioeng. Biomech."},{"key":"72591_CR23","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1177\/0391398818790204","volume":"41","author":"D Obidowski","year":"2018","unstructured":"Obidowski, D., Reorowicz, P., Witkowski, D., Sobczak, K. & J\u00f3\u017awik, K. Methods for determination of stagnation in pneumatic ventricular assist devices. Artif. Organs. 41, 653\u2013663 (2018).","journal-title":"Artif. Organs."},{"issue":"8","key":"72591_CR24","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1177\/0271678X16676826","volume":"37","author":"CY Xing","year":"2017","unstructured":"Xing, C. Y. et al. Distribution of cardiac output to the brain across the adult lifespan. J. Cereb. Blood Flow Metab. 37(8), 2848\u20132856 (2017).","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"4","key":"72591_CR25","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1113\/jphysiol.2010.204776","volume":"589","author":"CK Willie","year":"2011","unstructured":"Willie, C. K. & Smith, K. J. Fuelling the exercising brain: A regulatory quagmire for lactate metabolism. J. physiol. 589(4), 779 (2011).","journal-title":"J. physiol."},{"issue":"5","key":"72591_CR26","doi-asserted-by":"publisher","first-page":"903","DOI":"10.2214\/ajr.137.5.903","volume":"137","author":"BM Lantz","year":"1981","unstructured":"Lantz, B. M., Foerster, J. M., Link, D. P. & Holcroft, J. W. Regional distribution of cardiac output: normal values in man determined by video dilution technique. Am. J. Roentgenol. 137(5), 903\u2013907 (1981).","journal-title":"Am. J. Roentgenol."},{"issue":"6","key":"72591_CR27","doi-asserted-by":"publisher","first-page":"e02176","DOI":"10.1002\/brb3.2176","volume":"11","author":"A Ovsenik","year":"2021","unstructured":"Ovsenik, A., Podbregar, M. & Fabjan, A. Cerebral blood flow impairment and cognitive decline in heart failure. Brain Behav. 11(6), e02176 (2021).","journal-title":"Brain Behav."},{"key":"72591_CR28","doi-asserted-by":"crossref","unstructured":"Holland, Watton, and Ventikos, \u201c5.17 - Biological Fluid Mechanics: Integrative and Multiscale Computational Modeling,\u201d in Comprehensive Biotechnology (Second Edition), Second Edi., Moo-Young, Ed. Academic Press, pp. 203\u2013216 (2011)","DOI":"10.1016\/B978-0-08-088504-9.00529-8"},{"issue":"6","key":"72591_CR29","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.ijheatfluidflow.2010.07.003","volume":"31","author":"P Zuleger","year":"2010","unstructured":"Zuleger, P. Valavanis, and Kollias, \u201cCombining magnetic resonance measurements with numerical simulations\u2014Extracting blood flow physiology information relevant to the investigation of intracranial aneurysms in the circle of Willis\u201d. Int. J. Heat Fluid Flow 31(6), 1032\u20131039 (2010).","journal-title":"Int. J. Heat Fluid Flow"},{"key":"72591_CR30","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.medengphy.2018.12.023","volume":"65","author":"AL DiCarlo","year":"2019","unstructured":"DiCarlo, A. L., Holdsworth, D. W. & Poepping, T. L. Study of the effect of stenosis severity and non-Newtonian viscosity on multidirectional wall shear stress and flow disturbances in the carotid artery using particle image velocimetry. Med. Eng. Phys. 65, 8\u201323 (2019).","journal-title":"Med. Eng. Phys."},{"key":"72591_CR31","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ijmecsci.2018.10.046","volume":"150","author":"J Moradicheghamahi","year":"2019","unstructured":"Moradicheghamahi, J., Sadeghiseraji, J. & Jahangiri, M. Numerical solution of the Pulsatile, non-Newtonian and turbulent blood flow in a patient specific elastic carotid artery. Int. J. Mech. Sci. 150, 393\u2013403 (2019).","journal-title":"Int. J. Mech. Sci."},{"issue":"7","key":"72591_CR32","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.3390\/jcm10071348","volume":"10","author":"T Wisniewski","year":"2021","unstructured":"Wisniewski, T. Tyfa, reorowicz, and bobeff, \u201cporous media computational fluid dynamics and the role of the first coil in the embolization of ruptured intracranial aneurysms\u201d. J. Clin. Med. 10(7), 1348 (2021).","journal-title":"J. Clin. Med."},{"issue":"7","key":"72591_CR33","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s00701-015-2448-y","volume":"157","author":"N Maldaner","year":"2015","unstructured":"Maldaner, N. et al. Giant intracranial aneurysms treated by surgical strategies other than direct clipping. Acta Neurochir. (Wien). 157(7), 1117\u20131123. https:\/\/doi.org\/10.1007\/s00701-015-2448-y (2015).","journal-title":"Acta Neurochir. (Wien)."},{"issue":"1","key":"72591_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3171\/2019.8.JNS183078","volume":"134","author":"J Dengler","year":"2019","unstructured":"Dengler, J. et al. Giant intracranial aneurysm study group giant intracranial aneurysms: Natural history and 1\u00a0year case fatality after endovascular or surgical treatment. J. Neurosurg. 134(1), 49\u201357. https:\/\/doi.org\/10.3171\/2019.8.JNS183078 (2019).","journal-title":"J. Neurosurg."},{"key":"72591_CR35","doi-asserted-by":"publisher","first-page":"e721","DOI":"10.1016\/j.wneu.2018.07.026","volume":"118","author":"J Wang","year":"2018","unstructured":"Wang, J., Liu, J., Zhao, C., Yang, X. & Li, M. Hemodynamics in ruptured intracranial aneurysms with known rupture points. World Neurosurg. 118, e721\u2013e726 (2018).","journal-title":"World Neurosurg."},{"key":"72591_CR36","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1161\/STROKEAHA.110.592923","volume":"42","author":"J Xiang","year":"2011","unstructured":"Xiang, J. et al. Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke 42, 144\u2013152 (2011).","journal-title":"Stroke"},{"issue":"5","key":"72591_CR37","doi-asserted-by":"publisher","first-page":"H1916","DOI":"10.1152\/ajpheart.00897.2003","volume":"286","author":"HA Himburg","year":"2004","unstructured":"Himburg, H. A. et al. Friedman Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability Am. J. Physiol. Circ. Physiol. 286(5), H1916\u2013H1922 (2004).","journal-title":"J. Physiol. Circ. Physiol."},{"key":"72591_CR38","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3389\/fnins.2019.00233","volume":"13","author":"Q Liu","year":"2019","unstructured":"Liu, Q., Jiang, P., Wu, J., Gao, B. & Wang, S. The morphological and hemodynamic characteristics of the intraoperative ruptured aneurysm. Front. Neurosci. 13, 233. https:\/\/doi.org\/10.3389\/fnins.2019.00233 (2019).","journal-title":"Front. Neurosci."},{"key":"72591_CR39","doi-asserted-by":"publisher","first-page":"e2821","DOI":"10.1002\/cnm.2821","volume":"33","author":"LJ Kelsey","year":"2017","unstructured":"Kelsey, L. J., Powell, J. T., Norman, P. E., Miller, K. & Doyle, B. J. A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm. Int. J. Numer. Method Biomed. Eng. 33, e2821. https:\/\/doi.org\/10.1002\/cnm.2821 (2017).","journal-title":"Int. J. Numer. Method Biomed. Eng."},{"key":"72591_CR40","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jbiomech.2019.01.019","volume":"85","author":"C Ong","year":"2019","unstructured":"Ong, C. et al. Hemodynamic analysis of a novel stent graft design with slit perforations in thoracic aortic aneurysm. J. Biomech. 85, 210\u2013217. https:\/\/doi.org\/10.1016\/j.jbiomech.2019.01.019 (2019).","journal-title":"J. Biomech."},{"key":"72591_CR41","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-015-2448-y","author":"N Maldaner","year":"2015","unstructured":"Maldaner, N. et al. Giant intracranial aneurysm study group changes in volume of giant intracranial aneurysms treated by surgical strategies other than direct clipping. Acta Neurochir. (Wien). https:\/\/doi.org\/10.1007\/s00701-015-2448-y (2015).","journal-title":"Acta Neurochir. (Wien)."},{"key":"72591_CR42","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-319-02411-0_1","volume":"119","author":"G Esposito","year":"2014","unstructured":"Esposito, G. & Regli, L. Surgical decision-making for managing complex intracranial aneurysms. Acta Neurochir. Suppl. 119, 3\u201311 (2014).","journal-title":"Acta Neurochir. Suppl."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72591-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72591-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72591-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T15:06:30Z","timestamp":1726844790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-72591-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["72591"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-72591-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"18 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the local Bioethical Committee at the Medical University of Lodz, application number RNN\/119\/15\/KE. All experiments were performed in accordance with relevant guidelines and regulations. The study was designed in accordance with the Good Clinical Practice (GCP) guidelines and was conducted according to the principles of the Declaration of Helsinki. Informed consent was obtained from the participant prior to inclusion.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"21548"}}