{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:56:37Z","timestamp":1780494997796,"version":"3.54.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-73094-4","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T06:02:04Z","timestamp":1728453724000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genome-wide association study of subfoveal choroidal thickness in a longitudinal cohort of older adults"],"prefix":"10.1038","volume":"14","author":[{"given":"Hyeong Min","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsic","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Woong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sejoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Joon","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"73094_CR1","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.ophtha.2013.10.014","volume":"121","author":"D Ferrara","year":"2014","unstructured":"Ferrara, D. et al. En face enhanced-depth swept-source optical coherence tomography features of chronic central serous chorioretinopathy. Ophthalmology 121, 719\u2013726. https:\/\/doi.org\/10.1016\/j.ophtha.2013.10.014 (2014).","journal-title":"Ophthalmology"},{"key":"73094_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/IAE.0000000000000331","volume":"35","author":"CE Pang","year":"2015","unstructured":"Pang, C. E. & Freund, K. B. Pachychoroid neovasculopathy. Retina 35, 1\u20139. https:\/\/doi.org\/10.1097\/IAE.0000000000000331 (2015).","journal-title":"Retina"},{"key":"73094_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/s0002-9394(14)75989-6","volume":"109","author":"D Pauleikhoff","year":"1990","unstructured":"Pauleikhoff, D., Chen, J. C., Chisholm, I. H. & Bird, A. C. Choroidal perfusion abnormality with age-related Bruch\u2019s membrane change. Am. J. Ophthalmol. 109, 211\u2013217. https:\/\/doi.org\/10.1016\/s0002-9394(14)75989-6 (1990).","journal-title":"Am. J. Ophthalmol."},{"key":"73094_CR4","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1097\/IAE.0b013e3182953df4","volume":"33","author":"DJ Warrow","year":"2013","unstructured":"Warrow, D. J., Hoang, Q. V. & Freund, K. B. Pachychoroid pigment epitheliopathy. Retina 33, 1659\u20131672. https:\/\/doi.org\/10.1097\/IAE.0b013e3182953df4 (2013).","journal-title":"Retina"},{"key":"73094_CR5","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ajo.2008.12.008","volume":"147","author":"R Margolis","year":"2009","unstructured":"Margolis, R. & Spaide, R. F. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am. J. Ophthalmol. 147, 811\u2013815. https:\/\/doi.org\/10.1016\/j.ajo.2008.12.008 (2009).","journal-title":"Am. J. Ophthalmol."},{"key":"73094_CR6","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","volume":"146","author":"RF Spaide","year":"2008","unstructured":"Spaide, R. F., Koizumi, H. & Pozzoni, M. C. Enhanced depth imaging spectral-domain optical coherence tomography. Am. J. Ophthalmol. 146, 496\u2013500. https:\/\/doi.org\/10.1016\/j.ajo.2008.05.032 (2008).","journal-title":"Am. J. Ophthalmol."},{"key":"73094_CR7","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.ophtha.2010.09.012","volume":"118","author":"SE Chung","year":"2011","unstructured":"Chung, S. E., Kang, S. W., Lee, J. H. & Kim, Y. T. Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration. Ophthalmology 118, 840\u2013845. https:\/\/doi.org\/10.1016\/j.ophtha.2010.09.012 (2011).","journal-title":"Ophthalmology"},{"key":"73094_CR8","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/IAE.0000000000000742","volume":"36","author":"KK Dansingani","year":"2016","unstructured":"Dansingani, K. K., Balaratnasingam, C., Naysan, J. & Freund, K. B. En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography. Retina 36, 499\u2013516. https:\/\/doi.org\/10.1097\/IAE.0000000000000742 (2016).","journal-title":"Retina"},{"key":"73094_CR9","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1110189","volume":"308","author":"AO Edwards","year":"2005","unstructured":"Edwards, A. O. et al. Complement factor H polymorphism and age-related macular degeneration. Science 308, 421\u2013424. https:\/\/doi.org\/10.1126\/science.1110189 (2005).","journal-title":"Science"},{"key":"73094_CR10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1126\/science.1110359","volume":"308","author":"JL Haines","year":"2005","unstructured":"Haines, J. L. et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 308, 419\u2013421. https:\/\/doi.org\/10.1126\/science.1110359 (2005).","journal-title":"Science"},{"key":"73094_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1109557","volume":"308","author":"RJ Klein","year":"2005","unstructured":"Klein, R. J. et al. Complement factor H polymorphism in age-related macular degeneration. Science 308, 385\u2013389. https:\/\/doi.org\/10.1126\/science.1109557 (2005).","journal-title":"Science"},{"key":"73094_CR12","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/ng.938","volume":"43","author":"S Arakawa","year":"2011","unstructured":"Arakawa, S. et al. Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Nat. Genet. 43, 1001\u20131004. https:\/\/doi.org\/10.1038\/ng.938 (2011).","journal-title":"Nat. Genet."},{"key":"73094_CR13","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/01.APO.0000656976.47696.7d","volume":"9","author":"LJ Chen","year":"2020","unstructured":"Chen, L. J. Genetic association of age-related macular degeneration and polypoidal choroidal vasculopathy. Asia Pac. J. Ophthalmol. (Phila) 9, 104\u2013109. https:\/\/doi.org\/10.1097\/01.APO.0000656976.47696.7d (2020).","journal-title":"Asia Pac. J. Ophthalmol. (Phila)"},{"key":"73094_CR14","doi-asserted-by":"publisher","first-page":"7401","DOI":"10.1073\/pnas.0912702107","volume":"107","author":"W Chen","year":"2010","unstructured":"Chen, W. et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc. Natl. Acad. Sci. U S A 107, 7401\u20137406. https:\/\/doi.org\/10.1073\/pnas.0912702107 (2010).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"73094_CR15","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1126\/science.1133807","volume":"314","author":"A Dewan","year":"2006","unstructured":"Dewan, A. et al. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science 314, 989\u2013992. https:\/\/doi.org\/10.1126\/science.1133807 (2006).","journal-title":"Science"},{"key":"73094_CR16","doi-asserted-by":"publisher","first-page":"6261","DOI":"10.1073\/pnas.1802212115","volume":"115","author":"Y Hosoda","year":"2018","unstructured":"Hosoda, Y. et al. CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy. Proc. Natl. Acad. Sci. U S A 115, 6261\u20136266. https:\/\/doi.org\/10.1073\/pnas.1802212115 (2018).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"73094_CR17","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.ophtha.2022.04.018","volume":"129","author":"Y Mori","year":"2022","unstructured":"Mori, Y. et al. Genome-wide survival analysis for macular neovascularization development in central serous chorioretinopathy revealed shared genetic susceptibility with polypoidal choroidal vasculopathy. Ophthalmology 129, 1034\u20131042. https:\/\/doi.org\/10.1016\/j.ophtha.2022.04.018 (2022).","journal-title":"Ophthalmology"},{"key":"73094_CR18","doi-asserted-by":"publisher","first-page":"7395","DOI":"10.1073\/pnas.0912019107","volume":"107","author":"BM Neale","year":"2010","unstructured":"Neale, B. M. et al. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc. Natl. Acad. Sci. U S A 107, 7395\u20137400. https:\/\/doi.org\/10.1073\/pnas.0912019107 (2010).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"73094_CR19","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.ophtha.2022.02.026","volume":"129","author":"EF Thee","year":"2022","unstructured":"Thee, E. F. et al. The phenotypic course of age-related macular degeneration for ARMS2\/HTRA1: The EYE-RISK Consortium. Ophthalmology 129, 752\u2013764. https:\/\/doi.org\/10.1016\/j.ophtha.2022.02.026 (2022).","journal-title":"Ophthalmology"},{"key":"73094_CR20","doi-asserted-by":"publisher","first-page":"e0209276","DOI":"10.1371\/journal.pone.0209276","volume":"13","author":"NK Ryoo","year":"2018","unstructured":"Ryoo, N. K. et al. Thickness of retina and choroid in the elderly population and its association with complement factor H polymorphism: KLoSHA Eye study. PLoS ONE 13, e0209276. https:\/\/doi.org\/10.1371\/journal.pone.0209276 (2018).","journal-title":"PLoS ONE"},{"key":"73094_CR21","doi-asserted-by":"publisher","first-page":"767","DOI":"10.30773\/pi.2018.06.02","volume":"15","author":"JW Han","year":"2018","unstructured":"Han, J. W. et al. Overview of the Korean longitudinal study on cognitive aging and dementia. Psychiatry Investig. 15, 767\u2013774. https:\/\/doi.org\/10.30773\/pi.2018.06.02 (2018).","journal-title":"Psychiatry Investig."},{"key":"73094_CR22","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1001\/jamaophthalmol.2022.1563","volume":"140","author":"HM Kim","year":"2022","unstructured":"Kim, H. M. et al. Association between retinal layer thickness and cognitive decline in older adults. JAMA Ophthalmol. 140, 683\u2013690. https:\/\/doi.org\/10.1001\/jamaophthalmol.2022.1563 (2022).","journal-title":"JAMA Ophthalmol."},{"key":"73094_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ajo.2020.11.012","volume":"224","author":"K Joo","year":"2021","unstructured":"Joo, K., Mun, Y. S., Park, S. J., Park, K. H. & Woo, S. J. Ten-year progression from intermediate to exudative age-related macular degeneration and risk factors: Bundang AMD Cohort Study Report 1. Am. J. Ophthalmol. 224, 228\u2013237. https:\/\/doi.org\/10.1016\/j.ajo.2020.11.012 (2021).","journal-title":"Am. J. Ophthalmol."},{"key":"73094_CR24","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","volume":"8","author":"ZL Liu","year":"2023","unstructured":"Liu, Z. L., Chen, H. H., Zheng, L. L., Sun, L. P. & Shi, L. Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal. Transduct. Target. Ther. 8, 198. https:\/\/doi.org\/10.1038\/s41392-023-01460-1 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"73094_CR25","doi-asserted-by":"publisher","first-page":"7738","DOI":"10.1073\/pnas.0802857105","volume":"105","author":"S Wang","year":"2008","unstructured":"Wang, S. et al. Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc. Natl. Acad. Sci. U S A 105, 7738\u20137743. https:\/\/doi.org\/10.1073\/pnas.0802857105 (2008).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"73094_CR26","doi-asserted-by":"publisher","first-page":"a005959","DOI":"10.1101\/cshperspect.a005959","volume":"7","author":"P Devreotes","year":"2015","unstructured":"Devreotes, P. & Horwitz, A. R. Signaling networks that regulate cell migration. Cold Spring Harb. Perspect. Biol. 7, a005959. https:\/\/doi.org\/10.1101\/cshperspect.a005959 (2015).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"73094_CR27","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1167\/iovs.14-14059","volume":"55","author":"M Miyake","year":"2014","unstructured":"Miyake, M. et al. Choroidal neovascularization in eyes with choroidal vascular hyperpermeability. Invest. Ophthalmol. Vis. Sci. 55, 3223\u20133230. https:\/\/doi.org\/10.1167\/iovs.14-14059 (2014).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"73094_CR28","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1093\/hmg\/ddq351","volume":"19","author":"L Li","year":"2010","unstructured":"Li, L. et al. Estrogen and progesterone receptor status affect genome-wide DNA methylation profile in breast cancer. Hum. Mol. Genet. 19, 4273\u20134277. https:\/\/doi.org\/10.1093\/hmg\/ddq351 (2010).","journal-title":"Hum. Mol. Genet."},{"key":"73094_CR29","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/mp.2013.187","volume":"19","author":"V Boraska","year":"2014","unstructured":"Boraska, V. et al. A genome-wide association study of anorexia nervosa. Mol. Psychiatry 19, 1085\u20131094. https:\/\/doi.org\/10.1038\/mp.2013.187 (2014).","journal-title":"Mol. Psychiatry"},{"key":"73094_CR30","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3892\/ol.2021.13084","volume":"22","author":"Y Kuang","year":"2021","unstructured":"Kuang, Y., Wang, Y., Cao, X., Peng, C. & Gao, H. New prognostic factors and scoring system for patients with acute myeloid leukemia. Oncol. Lett. 22, 823. https:\/\/doi.org\/10.3892\/ol.2021.13084 (2021).","journal-title":"Oncol. Lett."},{"key":"73094_CR31","doi-asserted-by":"publisher","first-page":"e52640","DOI":"10.1371\/journal.pone.0052640","volume":"7","author":"T Batsukh","year":"2012","unstructured":"Batsukh, T. et al. Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex. PLoS ONE 7, e52640. https:\/\/doi.org\/10.1371\/journal.pone.0052640 (2012).","journal-title":"PLoS ONE"},{"key":"73094_CR32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nature13772","volume":"515","author":"S De Rubeis","year":"2014","unstructured":"De Rubeis, S. et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515, 209\u2013215. https:\/\/doi.org\/10.1038\/nature13772 (2014).","journal-title":"Nature"},{"key":"73094_CR33","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1038\/s41467-021-23123-x","volume":"12","author":"J Morandell","year":"2021","unstructured":"Morandell, J. et al. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. Nat. Commun. 12, 3058. https:\/\/doi.org\/10.1038\/s41467-021-23123-x (2021).","journal-title":"Nat. Commun."},{"key":"73094_CR34","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.15252\/emmm.201505444","volume":"7","author":"FR Schumacher","year":"2015","unstructured":"Schumacher, F. R. et al. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol. Med. 7, 1285\u20131306. https:\/\/doi.org\/10.15252\/emmm.201505444 (2015).","journal-title":"EMBO Mol. Med."},{"key":"73094_CR35","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1681\/ASN.2017121307","volume":"30","author":"W Abdel Khalek","year":"2019","unstructured":"Abdel Khalek, W. et al. Severe arterial hypertension from Cullin 3 mutations is caused by both renal and vascular effects. J. Am. Soc. Nephrol. 30, 811\u2013823. https:\/\/doi.org\/10.1681\/ASN.2017121307 (2019).","journal-title":"J. Am. Soc. Nephrol."},{"key":"73094_CR36","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/j.ophtha.2013.03.009","volume":"120","author":"J Xu","year":"2013","unstructured":"Xu, J. et al. Subfoveal choroidal thickness in diabetes and diabetic retinopathy. Ophthalmology 120, 2023\u20132028. https:\/\/doi.org\/10.1016\/j.ophtha.2013.03.009 (2013).","journal-title":"Ophthalmology"},{"key":"73094_CR37","doi-asserted-by":"publisher","first-page":"6017","DOI":"10.1167\/iovs.12-9692","volume":"53","author":"G Querques","year":"2012","unstructured":"Querques, G. et al. Enhanced depth imaging optical coherence tomography in type 2 diabetes. Invest. Ophthalmol. Vis. Sci. 53, 6017\u20136024. https:\/\/doi.org\/10.1167\/iovs.12-9692 (2012).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"73094_CR38","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/IAE.0b013e31822f5678","volume":"32","author":"CV Regatieri","year":"2012","unstructured":"Regatieri, C. V., Branchini, L., Carmody, J., Fujimoto, J. G. & Duker, J. S. Choroidal thickness in patients with diabetic retinopathy analyzed by spectral-domain optical coherence tomography. Retina 32, 563\u2013568. https:\/\/doi.org\/10.1097\/IAE.0b013e31822f5678 (2012).","journal-title":"Retina"},{"key":"73094_CR39","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1097\/IAE.0b013e31825db73d","volume":"32","author":"S Vujosevic","year":"2012","unstructured":"Vujosevic, S., Martini, F., Cavarzeran, F., Pilotto, E. & Midena, E. Macular and peripapillary choroidal thickness in diabetic patients. Retina 32, 1781\u20131790. https:\/\/doi.org\/10.1097\/IAE.0b013e31825db73d (2012).","journal-title":"Retina"},{"key":"73094_CR40","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1167\/iovs.18-26488","volume":"60","author":"L Arnould","year":"2019","unstructured":"Arnould, L. et al. Subfoveal choroidal thickness, cardiovascular history, and risk factors in the elderly: The Montrachet study. Invest. Ophthalmol. Vis. Sci. 60, 2431\u20132437. https:\/\/doi.org\/10.1167\/iovs.18-26488 (2019).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"73094_CR41","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.ajo.2012.11.001","volume":"155","author":"JH Kim","year":"2013","unstructured":"Kim, J. H., Kim, J. R., Kang, S. W., Kim, S. J. & Ha, H. S. Thinner choroid and greater drusen extent in retinal angiomatous proliferation than in typical exudative age-related macular degeneration. Am. J. Ophthalmol. 155, 743\u2013749. https:\/\/doi.org\/10.1016\/j.ajo.2012.11.001 (2013).","journal-title":"Am. J. Ophthalmol."},{"key":"73094_CR42","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.ajo.2011.03.008","volume":"152","author":"V Manjunath","year":"2011","unstructured":"Manjunath, V., Goren, J., Fujimoto, J. G. & Duker, J. S. Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography. Am. J. Ophthalmol. 152, 663\u2013668. https:\/\/doi.org\/10.1016\/j.ajo.2011.03.008 (2011).","journal-title":"Am. J. Ophthalmol."},{"key":"73094_CR43","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.ophtha.2012.02.022","volume":"119","author":"T Yamazaki","year":"2012","unstructured":"Yamazaki, T., Koizumi, H., Yamagishi, T. & Kinoshita, S. Subfoveal choroidal thickness after ranibizumab therapy for neovascular age-related macular degeneration: 12-month results. Ophthalmology 119, 1621\u20131627. https:\/\/doi.org\/10.1016\/j.ophtha.2012.02.022 (2012).","journal-title":"Ophthalmology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73094-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73094-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73094-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T09:02:29Z","timestamp":1728723749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73094-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["73094"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-73094-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4134234\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"20 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"I attest that the research included in this report was conducted in a manner consistent with the principles of research ethics, including those described in the Declaration of Helsinki and the Belmont Report. This research was conducted with the voluntary informed consent of all research participants, free of coercion or coercive circumstances, and received Institutional Review Board (IRB) approval consistent with the principles of research ethics and the legal requirements of the lead authors\u2019 jurisdiction(s).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"23545"}}