{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:01:30Z","timestamp":1790758890004,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6\u20102021\u20100096"],"award-info":[{"award-number":["6\u20102021\u20100096"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI22C0154"],"award-info":[{"award-number":["HI22C0154"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-73400-0","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T07:02:09Z","timestamp":1728025329000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical impacts of concomitant left atrial appendage occlusion during mitral valve surgery in patients with mitral regurgitation"],"prefix":"10.1038","volume":"14","author":[{"given":"Jiwon","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iksung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sak","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geu-Ru","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Won","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Young","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"issue":"7","key":"73400_CR1","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.jacc.2019.06.032","volume":"74","author":"B Essayagh","year":"2019","unstructured":"Essayagh, B. et al. Prognostic implications of left atrial enlargement in degenerative mitral regurgitation. J. Am. Coll. Cardiol.74(7), 858\u2013870 (2019).","journal-title":"J. Am. Coll. Cardiol."},{"key":"73400_CR2","doi-asserted-by":"crossref","unstructured":"Thomas, K. L. et al. Prevalence, characteristics, and outcomes of Valvular Heart Disease in patients with Atrial Fibrillation: Insights from the ORBIT-AF (outcomes Registry for Better Informed Treatment for Atrial Fibrillation). J. Am. Heart Assoc.6(12). (2017).","DOI":"10.1161\/JAHA.117.006475"},{"issue":"1","key":"73400_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/heartjnl-2020-317659","volume":"108","author":"R Melduni","year":"2022","unstructured":"Melduni, R. et al. Risk of left atrial appendage thrombus and stroke in patients with atrial fibrillation and mitral regurgitation. Heart. 108(1), 29\u201336 (2022).","journal-title":"Heart"},{"issue":"1","key":"73400_CR4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.36628\/ijhf.2021.0043","volume":"4","author":"HD Kim","year":"2022","unstructured":"Kim, H. D. et al. Left atrial dysfunction, fibrosis and the risk of thromboembolism in patients with paroxysmal and persistent Atrial Fibrillation. Int. J. Heart Fail.4(1), 42\u201353 (2022).","journal-title":"Int. J. Heart Fail."},{"issue":"22","key":"73400_CR5","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1056\/NEJMoa2101897","volume":"384","author":"RP Whitlock","year":"2021","unstructured":"Whitlock, R. P. et al. Left atrial appendage occlusion during cardiac surgery to prevent stroke. N Engl. J. Med.384(22), 2081\u20132091 (2021).","journal-title":"N Engl. J. Med."},{"issue":"1","key":"73400_CR6","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","volume":"149","author":"JA Joglar","year":"2024","unstructured":"Joglar, J. A. et al. 2023 ACC\/AHA\/ACCP\/HRS Guideline for the diagnosis and management of Atrial Fibrillation: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice guidelines. Circulation. 149(1), e1\u2013e156 (2024).","journal-title":"Circulation"},{"issue":"3","key":"73400_CR7","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/ejhf.1677","volume":"22","author":"RM Inciardi","year":"2020","unstructured":"Inciardi, R. M. et al. Mitral regurgitation, left atrial structural and functional remodelling and the effect on pulmonary haemodynamics. Eur. J. Heart Fail.22(3), 499\u2013506 (2020).","journal-title":"Eur. J. Heart Fail."},{"issue":"1","key":"73400_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2018.06.004","volume":"32","author":"C Mitchell","year":"2019","unstructured":"Mitchell, C. et al. Guidelines for performing a comprehensive transthoracic echocardiographic examination in adults: Recommendations from the American Society of Echocardiography. J. Am. Soc. Echocardiogr. 32(1), 1\u201364 (2019).","journal-title":"J. Am. Soc. Echocardiogr"},{"issue":"6","key":"73400_CR9","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jacc.2012.04.032","volume":"60","author":"L Di Biase","year":"2012","unstructured":"Di Biase, L. et al. Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. J. Am. Coll. Cardiol.60(6), 531\u2013538 (2012).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"73400_CR10","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1055\/s-0038-1651587","volume":"69","author":"FR Rosendaal","year":"1993","unstructured":"Rosendaal, F. R., Cannegieter, S. C., van der Meer, F. J. & Briet, E. A method to determine the optimal intensity of oral anticoagulant therapy. Thromb. Haemost. 69(3), 236\u2013239 (1993).","journal-title":"Thromb. Haemost"},{"issue":"1","key":"73400_CR11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.21037\/atm.2016.08.57","volume":"5","author":"Z Zhang","year":"2017","unstructured":"Zhang, Z. Propensity score method: A non-parametric technique to reduce model dependence. Ann. Transl Med.5(1), 7 (2017).","journal-title":"Ann. Transl Med."},{"issue":"7","key":"73400_CR12","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/S0735-1097(03)00954-9","volume":"42","author":"MA Garcia-Fernandez","year":"2003","unstructured":"Garcia-Fernandez, M. A. et al. Role of left atrial appendage obliteration in stroke reduction in patients with mitral valve prosthesis: A transesophageal echocardiographic study. J. Am. Coll. Cardiol.42(7), 1253\u20131258 (2003).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"73400_CR13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00059-015-4350-z","volume":"41","author":"XP Min","year":"2016","unstructured":"Min, X. P., Zhu, T. Y., Han, J., Li, Y. & Meng, X. Left atrial appendage obliteration in atrial fibrillation patients undergoing bioprosthetic mitral valve replacement. Herz. 41(1), 87\u201394 (2016).","journal-title":"Herz"},{"issue":"4","key":"73400_CR14","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1540-8167.2006.00755.x","volume":"18","author":"ST Almahameed","year":"2007","unstructured":"Almahameed, S. T. et al. Left atrial appendage exclusion and the risk of thromboembolic events following mitral valve surgery. J. Cardiovasc. Electrophysiol.18(4), 364\u2013366 (2007).","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"23","key":"73400_CR15","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1136\/heartjnl-2019-316387","volume":"106","author":"WK Kim","year":"2020","unstructured":"Kim, W. K. et al. Exclusion versus preservation of the left atrial appendage in rheumatic mitral valve surgery. Heart. 106(23), 1839\u20131846 (2020).","journal-title":"Heart"},{"issue":"2","key":"73400_CR16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.echo.2021.08.008","volume":"35","author":"A Singh","year":"2022","unstructured":"Singh, A. et al. Normal values of left atrial size and function and the impact of age: Results of the World Alliance societies of Echocardiography Study. J. Am. Soc. Echocardiogr. 35(2), 154\u2013164 (2022). e3.","journal-title":"J. Am. Soc. Echocardiogr"},{"issue":"3","key":"73400_CR17","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4250\/jcvi.2020.0043","volume":"28","author":"BJ Sun","year":"2020","unstructured":"Sun, B. J. et al. Normal reference values for left atrial strain and its determinants from a large Korean Multicenter Registry. J. Cardiovasc. Imaging. 28(3), 186\u2013198 (2020).","journal-title":"J. Cardiovasc. Imaging"},{"key":"73400_CR18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.amjcard.2021.01.006","volume":"145","author":"SL Van Laer","year":"2021","unstructured":"Van Laer, S. L. et al. Effect of mitral regurgitation on thrombotic risk in patients with nonrheumatic atrial fibrillation: A New CHA(2)DS(2)-VASc score risk modifier? Am. J. Cardiol.145, 69\u201376 (2021).","journal-title":"Am. J. Cardiol."},{"issue":"11 Pt 2","key":"73400_CR19","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1111\/j.1540-8159.2000.tb07039.x","volume":"23","author":"A Kranidis","year":"2000","unstructured":"Kranidis, A. et al. Mitral regurgitation protects from left atrial thrombogenesis in patients with mitral valve disease and atrial fibrillation. Pacing Clin. Electrophysiol.23(11 Pt 2), 1863\u20131866 (2000).","journal-title":"Pacing Clin. Electrophysiol."},{"issue":"11","key":"73400_CR20","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1067\/mje.2001.114395","volume":"14","author":"JW Ha","year":"2001","unstructured":"Ha, J. W. et al. Assessment of left atrial appendage filling pattern by using intravenous administration of microbubbles: Comparison between mitral stenosis and mitral regurgitation. J. Am. Soc. Echocardiogr. 14(11), 1100\u20131106 (2001).","journal-title":"J. Am. Soc. Echocardiogr"},{"issue":"1","key":"73400_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.echo.2022.08.010","volume":"36","author":"H Sato","year":"2023","unstructured":"Sato, H. et al. Significance of spontaneous echocardiographic contrast in transcatheter edge-to-edge repair for mitral regurgitation. J. Am. Soc. Echocardiogr. 36(1), 87\u201395 (2023).","journal-title":"J. Am. Soc. Echocardiogr"},{"key":"73400_CR22","doi-asserted-by":"publisher","first-page":"940560","DOI":"10.3389\/fcvm.2022.940560","volume":"9","author":"M Belli","year":"2022","unstructured":"Belli, M. et al. Combined MitraClip and left atrial appendage occlusion: Is it still a Utopia? Front. Cardiovasc. Med.9, 940560 (2022).","journal-title":"Front. Cardiovasc. Med."},{"issue":"16","key":"73400_CR23","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.4244\/EIJ-D-16-00784","volume":"12","author":"S Kuwata","year":"2017","unstructured":"Kuwata, S. et al. Feasibility of concomitant MitraClip and left atrial appendage occlusion. EuroIntervention. 12(16), 1940\u20131945 (2017).","journal-title":"EuroIntervention"},{"key":"73400_CR24","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ijcard.2016.06.170","volume":"220","author":"T Tichelbacker","year":"2016","unstructured":"Tichelbacker, T. et al. MitraClip(R) and amplatzer(R) cardiac plug implantation in a single procedure: A reasonable approach? Int. J. Cardiol.220, 107\u2013111 (2016).","journal-title":"Int. J. Cardiol."},{"issue":"8","key":"73400_CR25","doi-asserted-by":"publisher","first-page":"566","DOI":"10.4070\/kcj.2023.0038","volume":"53","author":"K Song","year":"2023","unstructured":"Song, K., Jang, W. S., Park, N., Kim, Y. S. & Kim, J. B. Is it safe to preserve left atrial appendage during maze procedure? Korean Circ. J.53(8), 566\u2013577 (2023).","journal-title":"Korean Circ. J."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73400-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73400-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73400-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T07:03:52Z","timestamp":1728025432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73400-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["73400"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-73400-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,4]]},"assertion":[{"value":"25 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23063"}}