{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T01:48:58Z","timestamp":1749692938160,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Guangxi Zhuang Autonomous Region Health Committee self-funded scientific research","award":["Z20190841","20210968"],"award-info":[{"award-number":["Z20190841","20210968"]}]},{"name":"The project of improving the basic ability of scientific research of young and middle-aged teachers in Guangxi universities","award":["2022KY0083"],"award-info":[{"award-number":["2022KY0083"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-73422-8","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T08:01:30Z","timestamp":1727596890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development and validation of a novel liquid-liquid phase separation gene signature for bladder cancer"],"prefix":"10.1038","volume":"14","author":[{"given":"Sufan","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qisheng","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-3246","authenticated-orcid":false,"given":"Wuning","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"73422_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/jmri.27361","volume":"55","author":"V Panebianco","year":"2022","unstructured":"Panebianco, V. et al. VI-RADS for bladder cancer: Current applications and future developments. J. Magn. Reson. Imaging JMRI. 55, 23\u201336 (2022).","journal-title":"J. Magn. Reson. Imaging JMRI"},{"key":"73422_CR2","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3322\/caac.21631","volume":"70","author":"VG Patel","year":"2020","unstructured":"Patel, V. G., Oh, W. K. & Galsky, M. D. Treatment of muscle-invasive and advanced bladder cancer in 2020. CA Cancer J. Clin.70, 404\u2013423 (2020).","journal-title":"CA Cancer J. Clin."},{"key":"73422_CR3","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1001\/jama.2020.17598","volume":"324","author":"AT Lenis","year":"2020","unstructured":"Lenis, A. T., Lec, P. M., Chamie, K. & Mshs, M. D. Bladder cancer: A review. JAMA324, 1980\u20131991 (2020).","journal-title":"JAMA"},{"key":"73422_CR4","unstructured":"Identification and Quantification of Iron Metabolism Landscape on Therapy and Prognosis in Bladder Cancer. - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/35265613\/."},{"key":"73422_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1177\/0391560319899011","volume":"87","author":"S Siracusano","year":"2020","unstructured":"Siracusano, S., Rizzetto, R. & Porcaro, A. B. Bladder cancer genomics. Urologia. 87, 49\u201356 (2020).","journal-title":"Urologia"},{"key":"73422_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41568-022-00444-7","volume":"22","author":"S Mehta","year":"2022","unstructured":"Mehta, S. & Zhang, J. Liquid-liquid phase separation drives cellular function and dysfunction in cancer. Nat. Rev. Cancer. 22, 239\u2013252 (2022).","journal-title":"Nat. Rev. Cancer"},{"key":"73422_CR7","unstructured":"Liquid-Liquid Phase Separation (LLPS) in Cellular Physiology and Tumor Biology - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/34522448\/."},{"key":"73422_CR8","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev-genet-112618-043527","volume":"53","author":"S Alberti","year":"2019","unstructured":"Alberti, S. & Dormann, D. Liquid-liquid phase separation in disease. Annu. Rev. Genet.53, 171\u2013194 (2019).","journal-title":"Annu. Rev. Genet."},{"key":"73422_CR9","unstructured":"Liquid Phase Condensation in Cell Physiology and Disease - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/28935776\/."},{"key":"73422_CR10","unstructured":"RNA and Liquid-Liquid Phase Separation - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/33997539\/."},{"key":"73422_CR11","unstructured":"RPS: A Comprehensive Database of RNAs Involved in Liquid-Liquid Phase Separation - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/34718734\/."},{"key":"73422_CR12","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1109\/TCBB.2020.2975173","volume":"18","author":"C-Y Wang","year":"2021","unstructured":"Wang, C.-Y. et al. Dual hyper-graph regularized supervised NMF for selecting differentially expressed genes and tumor classification. IEEE\/ACM Trans. Comput. Biol. Bioinform.18, 2375\u20132383 (2021).","journal-title":"IEEE\/ACM Trans. Comput. Biol. Bioinform."},{"key":"73422_CR13","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.3389\/fgene.2019.01054","volume":"10","author":"C-Y Wang","year":"2019","unstructured":"Wang, C-Y., Liu, J-X., Yu, N. & Zheng, C-H. Sparse graph regularization non-negative matrix factorization based on Huber loss model for cancer data analysis. Front. Genet.10, 1054 (2019).","journal-title":"Front. Genet."},{"key":"73422_CR14","unstructured":"A Flexible R Package for Nonnegative Matrix Factorization - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/20598126\/."},{"key":"73422_CR15","unstructured":"Identification of Molecular Subtypes and Prognostic Signature for Hepatocellular Carcinoma Based on Genes Associated with Homologous Recombination Deficiency - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/34912005\/."},{"key":"73422_CR16","unstructured":"Head and Neck Squamous Cell Carcinoma Subtypes Based on Immunologic and Hallmark Gene Sets in Tumor and Non.-tumor Tissues - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/35187059\/."},{"key":"73422_CR17","unstructured":"GSEA-InContext: Identifying Novel and Common Patterns in Expression Experiments - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/29950010\/."},{"key":"73422_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/jcmm.14767","volume":"24","author":"R Cao","year":"2020","unstructured":"Cao, R. et al. An EMT-related gene signature for the prognosis of human bladder cancer. J. Cell. Mol. Med.24, 605\u2013617 (2020).","journal-title":"J. Cell. Mol. Med."},{"key":"73422_CR19","doi-asserted-by":"publisher","first-page":"BSR20194337","DOI":"10.1042\/BSR20194337","volume":"40","author":"J Lv","year":"2020","unstructured":"Lv, J., Zhu, Y., Ji, A., Zhang, Q. & Liao, G. Mining TCGA database for tumor mutation burden and their clinical significance in bladder cancer. Biosci. Rep.40, BSR20194337 (2020).","journal-title":"Biosci. Rep."},{"key":"73422_CR20","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.cell.2018.07.036","volume":"174","author":"AG Robertson","year":"2018","unstructured":"Robertson, A. G. et al. Comprehensive molecular characterization of muscle-invasive bladder Cancer. Cell. 174, 1033 (2018).","journal-title":"Cell"},{"key":"73422_CR21","unstructured":"Liquid-Liquid Phase Separation in Biology: Mechanisms, Physiological Functions and Human Diseases - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/32548680\/."},{"key":"73422_CR22","unstructured":"Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/31401334\/."},{"key":"73422_CR23","unstructured":"P4HB: A Novel Diagnostic and Prognostic Biomarker for Bladder Carcinoma - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/33376528\/."},{"key":"73422_CR24","unstructured":"OAS3 is a Co-immune Biomarker Associated with Tumour Microenvironment Disease Staging, Prognosis, and Treatment Response in Multiple Cancer Types - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/35592250\/."},{"key":"73422_CR25","unstructured":"AHNAK Contributes to Hepatocellular Carcinoma Growth by Interacting with IGF-1R - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/36557813\/."},{"key":"73422_CR26","unstructured":"Comprehensive Analysis of Prognostic Value and Immune Infiltration of the NT5DC Family in Hepatocellular Carcinoma. - PubMed, accessed 25 Apr 2023; https:\/\/pubmed.ncbi.nlm.nih.gov\/35047040\/."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73422-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73422-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73422-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T08:02:17Z","timestamp":1727596937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73422-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,29]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["73422"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-73422-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2024,9,29]]},"assertion":[{"value":"13 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All data are sourced from public databases, with ethics approval obtained by the data providers.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"22552"}}