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HITHION YH-15, the extract of Torula yeast (\n                    <jats:italic>Cyberlindnera jadinii<\/jats:italic>\n                    ), is rich in cysteine-containing peptides such as reduced and oxidized glutathione (GSH and GSSG), \u03b3-glutamylcysteine (\u03b3-Glu-Cys), and cysteinylglycine (Cys-Gly). These four constituents are termed cysteine peptides. In this study, we investigated the protective effects of cysteine peptides against UV-B in a randomized, placebo-controlled, double-blind, parallel-group study. A total of 90 healthy males and females aged 30\u201359\u00a0years were enrolled and randomized into two groups of 45 individuals each (cysteine peptides (48\u00a0mg\/day) and placebo). Changes in UV-B-induced erythema and pigmentation were compared between groups after 5\u00a0weeks of test food intake. The minimal erythema dose (MED) significantly increased (*\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019) in the cysteine peptides group compared to that in the placebo group, indicating suppression of UV-B-induced erythema. \u0394L* value significantly increased (***\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) in the cysteine peptides group compared to that in the placebo, indicating pigmentation suppression. We demonstrated that oral administration of cysteine peptides suppresses UV-B-induced erythema and pigmentation through multiple mechanisms. Thus, cysteine peptides may find use as nutricosmetics for maintaining skin health and well-being.\n                  <\/jats:p>\n                  <jats:p>UMIN Clinical Trials Registry ID: UMIN 000050157.<\/jats:p>","DOI":"10.1038\/s41598-024-73447-z","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T10:03:42Z","timestamp":1727431422000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral administration of cysteine peptides attenuates UV-B-induced skin erythema and pigmentation in humans"],"prefix":"10.1038","volume":"14","author":[{"given":"Ayako","family":"Sakuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimitsu","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"73447_CR1","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1111\/j.1751-1097.2012.01115.x","volume":"88","author":"DN Syed","year":"2012","unstructured":"Syed, D. 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