{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:45:21Z","timestamp":1792413921756,"version":"4.4.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-73590-7","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T07:02:09Z","timestamp":1728025329000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pathophysiological dynamics of acute myocardial infarction rats under chronic psychological stress at different time points"],"prefix":"10.1038","volume":"14","author":[{"given":"Luying","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuerong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"73590_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9","author":"GBD 2019 Diseases and Injuries Collaborators","year":"2020","unstructured":"GBD 2019 Diseases and Injuries Collaborators. Global Burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: A. Lancet. 396 (10258), 1204\u20131222. https:\/\/doi.org\/10.1016\/S0140-6736(20)30925-9 (2020). systematic analysis for the global burden of disease study 2019."},{"key":"73590_CR2","unstructured":"World Health Organization. The Top 10 Causes of Death. Geneva. (2020). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death. Accessed May 26 2023."},{"issue":"8","key":"73590_CR3","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1093\/eurheartj\/ehab892","volume":"43","author":"A Timmis","year":"2022","unstructured":"Timmis, A. et al. European society of cardiology: Cardiovascular disease statistics 2021. Eur. Heart J.43(8), 716\u2013799. https:\/\/doi.org\/10.1093\/eurheartj\/ehab892 (2022).","journal-title":"Eur. Heart J."},{"issue":"15","key":"73590_CR4","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1161\/CIRCULATIONAHA.116.023142","volume":"134","author":"A Smyth","year":"2016","unstructured":"Smyth, A. et al. Physical activity and anger or emotional upset as triggers of acute myocardial infarction: The interheart study. Circulation. 134(15), 1059\u20131067 (2016).","journal-title":"Circulation"},{"issue":"9438","key":"73590_CR5","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","volume":"364","author":"S Yusuf","year":"2004","unstructured":"Yusuf, S. et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the Interheart Study): Case-control study. Lancet. 364(9438), 937\u2013952 (2004).","journal-title":"Lancet"},{"issue":"22","key":"73590_CR6","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1136\/hrt.2008.155796","volume":"95","author":"KK Teo","year":"2009","unstructured":"Teo, K. K. et al. Potentially modifiable risk factors associated with myocardial infarction in China: The interheart China study. Heart. 95(22), 1857\u20131864. https:\/\/doi.org\/10.1136\/hrt.2008.155796 (2009).","journal-title":"Heart"},{"key":"73590_CR7","doi-asserted-by":"publisher","first-page":"111141","DOI":"10.1016\/j.jpsychores.2022.111141","volume":"165","author":"PY Aw","year":"2023","unstructured":"Aw, P. Y. et al. Co-prevalence and incidence of myocardial infarction and\/or stroke in patients with depression and\/or anxiety: A systematic review and meta-analysis. J. Psychosom. Res.165, 111141. https:\/\/doi.org\/10.1016\/j.jpsychores.2022.111141 (2023).","journal-title":"J. Psychosom. Res."},{"issue":"11","key":"73590_CR8","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1093\/gerona\/glz228","volume":"75","author":"H Li","year":"2020","unstructured":"Li, H. et al. Longitudinal changes in depressive symptoms and risks of cardiovascular disease and all-cause mortality: A nationwide population-based cohort study. J. Gerontol. Biol. Sci. Med. Sci.75(11), 2200\u20132206. https:\/\/doi.org\/10.1093\/gerona\/glz228 (2020).","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"issue":"18","key":"73590_CR9","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1161\/CIRCULATIONAHA.116.025140","volume":"135","author":"KG Smolderen","year":"2017","unstructured":"Smolderen, K. G. et al. Depression treatment and 1-year mortality after acute myocardial infarction: Insights from the triumph registry (translational research investigating underlying disparities in acute myocardial infarction patients\u2019 health status). Circulation. 135(18), 1681\u20131689. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.025140 (2017).","journal-title":"Circulation"},{"issue":"5","key":"73590_CR10","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1192\/bjp.bp.116.194605","volume":"210","author":"J Sundb\u00f8ll","year":"2017","unstructured":"Sundb\u00f8ll, J. et al. Impact of pre-admission depression on mortality following myocardial infarction. Br. J. Psychiatry. 210(5), 356\u2013361. https:\/\/doi.org\/10.1192\/bjp.bp.116.194605 (2017).","journal-title":"Br. J. Psychiatry"},{"issue":"6","key":"73590_CR11","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1002\/clc.23605","volume":"44","author":"Y Wen","year":"2021","unstructured":"Wen, Y., Yang, Y., Shen, J. & Luo, S. Anxiety and prognosis of patients with myocardial infarction: A meta-analysis. Clin. Cardiol.44(6), 761\u2013770. https:\/\/doi.org\/10.1002\/clc.23605 (2021).","journal-title":"Clin. Cardiol."},{"issue":"17","key":"73590_CR12","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1161\/CIRCULATIONAHA.119.041914","volume":"140","author":"GN Levine","year":"2019","unstructured":"Levine, G. N. The mind-heart-body connection. Circulation. 140(17), 1363\u20131365. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.041914 (2019).","journal-title":"Circulation"},{"key":"73590_CR13","doi-asserted-by":"publisher","first-page":"1328048","DOI":"10.3389\/fpsyt.2024.1328048","volume":"15","author":"L Xu","year":"2024","unstructured":"Xu, L., Zhai, X., Shi, D. & Zhang, Y. Depression and coronary heart disease: Mechanisms, interventions, and treatments. Front. Psychiatry. 15, 1328048. https:\/\/doi.org\/10.3389\/fpsyt.2024.1328048 (2024).","journal-title":"Front. Psychiatry"},{"key":"73590_CR14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","volume":"99","author":"S Antoniuk","year":"2019","unstructured":"Antoniuk, S., Bijata, M., Ponimaskin, E. & Wlodarczyk, J. Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability. Neurosci. Biobehav Rev.99, 101\u2013116. https:\/\/doi.org\/10.1016\/j.neubiorev.2018.12.002 (2019).","journal-title":"Neurosci. Biobehav Rev."},{"issue":"4","key":"73590_CR15","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.biopsych.2005.07.010","volume":"59","author":"AJ Grippo","year":"2006","unstructured":"Grippo, A. J., Beltz, T. G., Weiss, R. M. & Johnson, A. K. The effects of chronic fluoxetine treatment on chronic mild stress-induced cardiovascular changes and anhedonia. Biol. Psychiatry. 59(4), 309\u2013316 (2006).","journal-title":"Biol. Psychiatry"},{"key":"73590_CR16","doi-asserted-by":"publisher","first-page":"561817","DOI":"10.3389\/fphar.2020.561817","volume":"11","author":"Y Hu","year":"2020","unstructured":"Hu, Y. et al. Behavioral and biochemical effects of kxs on postmyocardial infarction depression. Front. Pharmacol.11, 561817. https:\/\/doi.org\/10.3389\/fphar.2020.561817 (2020).","journal-title":"Front. Pharmacol."},{"key":"73590_CR17","doi-asserted-by":"publisher","unstructured":"Zhang, L. et al. Ginkgo biloba extract reduces cardiac and brain inflammation in rats fed a Hfd and exposed to chronic mental stress through Nf-\u039ab inhibition. Med. Inflamm. (2022). https:\/\/doi.org\/10.1155\/2022\/2408598","DOI":"10.1155\/2022\/2408598"},{"issue":"01","key":"73590_CR18","first-page":"70","volume":"26","author":"X Jin","year":"2010","unstructured":"Jin, X., Liu, J. G. & Shi, D. Z. Influence of chronic stress on vasoactive substances and inflammatory factor in rat model with acute myocardial infarction by factorial analysis. Chin. J. Pathoph. 26(01), 70\u201374 (2010).","journal-title":"Chin. J. Pathoph"},{"issue":"01","key":"73590_CR19","first-page":"8","volume":"18","author":"X Jin","year":"2008","unstructured":"Jin, X., Liu, J. G., Li, J. & Shi, D. Z. Effects of chronic stress on the hemorrheology in rat model with acute myocardial infarction. Chin. J. Hemorh. 18 (01), 8\u201311 (2008).","journal-title":"Chin. J. Hemorh"},{"issue":"12","key":"73590_CR20","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1161\/CIRCRESAHA.110.223925","volume":"107","author":"E Gao","year":"2010","unstructured":"Gao, E. et al. A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ. Res.107(12), 1445\u20131453. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.223925 (2010).","journal-title":"Circ. Res."},{"key":"73590_CR21","doi-asserted-by":"publisher","first-page":"102458","DOI":"10.1016\/j.jtherbio.2019.102458","volume":"87","author":"H Nakagawa","year":"2020","unstructured":"Nakagawa, H., Matsunaga, D. & Ishiwata, T. Effect of heat acclimation on anxiety-like behavior of rats in an open field. J. Therm. Biol.87, 102458. https:\/\/doi.org\/10.1016\/j.jtherbio.2019.102458 (2020).","journal-title":"J. Therm. Biol."},{"key":"73590_CR22","doi-asserted-by":"publisher","unstructured":"Fioranelli, M. et al. Stress and inflammation in coronary artery disease: A review psychoneuroendocrineimmunology-based. Front. Immunol.9, 2031. (2018). https:\/\/doi.org\/10.3389\/fimmu.2018.02031","DOI":"10.3389\/fimmu.2018.02031"},{"key":"73590_CR23","doi-asserted-by":"publisher","first-page":"1225794","DOI":"10.3389\/fpsyt.2023.1225794","volume":"14","author":"E Garrels","year":"2023","unstructured":"Garrels, E. et al. Pathophysiological mechanisms of post-myocardial infarction depression: A narrative review. Front. Psychiatry. 14, 1225794. https:\/\/doi.org\/10.3389\/fpsyt.2023.1225794 (2023).","journal-title":"Front. Psychiatry"},{"key":"73590_CR24","doi-asserted-by":"publisher","unstructured":"Kumar, M. & Nayak, P. K. Psychological sequelae of myocardial infarction. Biomed. Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.109 (2017).","DOI":"10.1016\/j.biopha.2017.08.109"},{"issue":"2","key":"73590_CR25","doi-asserted-by":"publisher","first-page":"H488","DOI":"10.1152\/ajpheart.00244.2020","volume":"319","author":"LD Sher","year":"2020","unstructured":"Sher, L. D. et al. Chronic stress and endothelial dysfunction: Mechanisms, experimental challenges, and the way ahead. Am. J. Physiol. Heart Circ. Physiol.319(2), H488\u2013H506. https:\/\/doi.org\/10.1152\/ajpheart.00244.2020 (2020).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"73590_CR26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.pneurobio.2018.06.002","volume":"173","author":"M Ghasemi","year":"2019","unstructured":"Ghasemi, M., Claunch, J. & Niu, K. Pathologic role of nitrergic neurotransmission in mood disorders. Prog Neurobiol.173, 54\u201387. https:\/\/doi.org\/10.1016\/j.pneurobio.2018.06.002 (2019).","journal-title":"Prog Neurobiol."},{"issue":"10","key":"73590_CR27","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1358\/mf.2008.30.10.1316822","volume":"30","author":"G Mercanoglu","year":"2008","unstructured":"Mercanoglu, G., Safran, N., Uzun, H. & Eroglu, L. Chronic emotional stress exposure increases infarct size in rats: The role of oxidative and nitrosative damage in response to sympathetic hyperactivity. Methods Find. Exp. Clin. Pharmacol.30(10), 745\u2013752. https:\/\/doi.org\/10.1358\/mf.2008.30.10.1316822 (2008).","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"issue":"1","key":"73590_CR28","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/med.21599","volume":"40","author":"MA Cinelli","year":"2020","unstructured":"Cinelli, M. A., Do, H. T., Miley, G. P. & Silverman, R. B. Inducible nitric oxide synthase: Regulation, structure, and inhibition. Med. Res. Rev.40(1), 158\u2013189. https:\/\/doi.org\/10.1002\/med.21599 (2020).","journal-title":"Med. Res. Rev."},{"key":"73590_CR29","doi-asserted-by":"publisher","unstructured":"Fox, B. M. et al. Acute pressor response to psychosocial stress is dependent on endothelium-derived endothelin-1. J. Am. Heart Assoc.7(4). https:\/\/doi.org\/10.1161\/JAHA.117.007863 (2018).","DOI":"10.1161\/JAHA.117.007863"},{"key":"73590_CR30","doi-asserted-by":"publisher","first-page":"117062","DOI":"10.1016\/j.lfs.2019.117062","volume":"239","author":"P Lekkas","year":"2019","unstructured":"Lekkas, P. et al. Endothelin receptors in the brain modulate autonomic responses and arrhythmogenesis during acute myocardial infarction in rats. Life Sci.239, 117062. https:\/\/doi.org\/10.1016\/j.lfs.2019.117062 (2019).","journal-title":"Life Sci."},{"key":"73590_CR31","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.jad.2023.03.046","volume":"331","author":"J Lin","year":"2023","unstructured":"Lin, J. et al. The mediation effects of metabolic and immune-inflammation factors on the depression-premature coronary heart disease association. J. Affect. Disord. 331, 434\u2013441. https:\/\/doi.org\/10.1016\/j.jad.2023.03.046 (2023).","journal-title":"J. Affect. Disord"},{"issue":"7","key":"73590_CR32","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1038\/s41380-019-0395-3","volume":"25","author":"GM Khandaker","year":"2020","unstructured":"Khandaker, G. M. et al. Shared mechanisms between coronary heart disease and depression: Findings from a large Uk general population-based cohort. Mol. Psychiatry. 25(7), 1477\u20131486. https:\/\/doi.org\/10.1038\/s41380-019-0395-3 (2020).","journal-title":"Mol. Psychiatry"},{"key":"73590_CR33","doi-asserted-by":"publisher","unstructured":"Baysak, E. et al. The possible role of Nlrp3 inflammasome in depression and myocardial infarction comorbidity. J. Pers. Med.13(9). https:\/\/doi.org\/10.3390\/jpm13091295 (2023).","DOI":"10.3390\/jpm13091295"},{"issue":"2","key":"73590_CR34","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nri3800","volume":"15","author":"S Epelman","year":"2015","unstructured":"Epelman, S., Liu, P. P. & Mann, D. L. Role of innate and adaptive immune mechanisms in cardiac injury and repair. Nat. Rev. Immunol.15(2), 117\u2013129. https:\/\/doi.org\/10.1038\/nri3800 (2015).","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"73590_CR35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41398-022-02297-y","volume":"13","author":"B Guo","year":"2023","unstructured":"Guo, B. et al. Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression. Transl Psychiatry. 13(1), 5. https:\/\/doi.org\/10.1038\/s41398-022-02297-y (2023).","journal-title":"Transl Psychiatry"},{"key":"73590_CR36","doi-asserted-by":"publisher","unstructured":"Wang, X., Guo, Z., Ding, Z. & Mehta, J. L. Inflammation, autophagy, and apoptosis after myocardial infarction. J. Am. Heart Assoc.7(9). https:\/\/doi.org\/10.1161\/JAHA.117.008024 (2018).","DOI":"10.1161\/JAHA.117.008024"},{"key":"73590_CR37","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","volume":"186","author":"S-B Ong","year":"2018","unstructured":"Ong, S-B. et al. Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities. Pharmacol. Ther.186, 73\u201387. https:\/\/doi.org\/10.1016\/j.pharmthera.2018.01.001 (2018).","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"73590_CR38","doi-asserted-by":"publisher","first-page":"e21391","DOI":"10.1096\/fj.202000764R","volume":"35","author":"CW Kim","year":"2021","unstructured":"Kim, C. W., Oh, E-T. & Park, H. J. A strategy to prevent atherosclerosis via TNF receptor regulation. FASEB J.35(3), e21391. https:\/\/doi.org\/10.1096\/fj.202000764R (2021).","journal-title":"FASEB J."},{"issue":"6","key":"73590_CR39","doi-asserted-by":"publisher","first-page":"e24404","DOI":"10.1002\/jcla.24404","volume":"36","author":"H Lu","year":"2022","unstructured":"Lu, H., Yang, Q. & Zhang, Y. The relation of common inflammatory cytokines with anxiety and depression and their values in estimating cardiovascular outcomes in coronary heart disease patients. J. Clin. Lab. Anal.36(6), e24404. https:\/\/doi.org\/10.1002\/jcla.24404 (2022).","journal-title":"J. Clin. Lab. Anal."},{"key":"73590_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01024-y","author":"V Vaccarino","year":"2024","unstructured":"Vaccarino, V. & Bremner, J. D. Stress and cardiovascular disease: An update. Nat. Rev. Cardiol.https:\/\/doi.org\/10.1038\/s41569-024-01024-y (2024).","journal-title":"Nat. Rev. Cardiol."},{"key":"73590_CR41","doi-asserted-by":"publisher","unstructured":"Zhang, H. & Dhalla, N. S. The role of pro-inflammatory cytokines in the pathogenesis of cardiovascular disease. Int. J. Mol. Sci.25(2). https:\/\/doi.org\/10.3390\/ijms25021082 (2024).","DOI":"10.3390\/ijms25021082"},{"issue":"2","key":"73590_CR42","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jphs.2021.12.005","volume":"148","author":"S Kitaoka","year":"2022","unstructured":"Kitaoka, S. Inflammation in the brain and periphery found in animal models of depression and its behavioral relevance. J. Pharmacol. Sci.148(2), 262\u2013266. https:\/\/doi.org\/10.1016\/j.jphs.2021.12.005 (2022).","journal-title":"J. Pharmacol. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73590-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73590-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73590-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T07:03:57Z","timestamp":1728025437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73590-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["73590"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-73590-7","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,4]]},"assertion":[{"value":"16 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study has been approved by the Ethics Committee of Xiyuan Hospital, China Academy of Chinese Medical Sciences (Approval No.: 2021XLC039-2).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"23062"}}