{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:17:23Z","timestamp":1785867443147,"version":"3.56.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Henan Province Key Research and Development and Promotion (Science and Technology) Project","award":["222102310651"],"award-info":[{"award-number":["222102310651"]}]},{"name":"Henan Province Medical Science and Technology Research Program Joint Construction Project","award":["LHGJ20220476"],"award-info":[{"award-number":["LHGJ20220476"]}]},{"name":"Key Scientific Research Project of Henan Provincial Education Department","award":["24B320029"],"award-info":[{"award-number":["24B320029"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-73601-7","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T11:04:19Z","timestamp":1729249459000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2"],"prefix":"10.1038","volume":"14","author":[{"given":"Yilin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"issue":"3","key":"73601_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71 (3), 209\u2013249 (2021).","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"73601_CR2","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1016\/S2214-109X(22)00501-0","volume":"11","author":"D Singh","year":"2023","unstructured":"Singh, D. et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO global cervical cancer elimination initiative. Lancet Glob. Health 11 (2), e197\u2013e206 (2023).","journal-title":"Lancet Global Health"},{"issue":"3","key":"73601_CR3","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/ijc.30695","volume":"141","author":"AK Mezei","year":"2017","unstructured":"Mezei, A. K. et al. Cost-effectiveness of cervical cancer screening methods in low- and middle-income countries: a systematic review. Int. J. Cancer 141 (3), 437\u2013446 (2017).","journal-title":"Int. J. Cancer"},{"key":"73601_CR4","doi-asserted-by":"publisher","first-page":"103178","DOI":"10.1016\/j.critrevonc.2020.103178","volume":"157","author":"D Adiga","year":"2021","unstructured":"Adiga, D., Eswaran, S., Pandey, D., Sharan, K. & Kabekkodu, S. P. Molecular landscape of recurrent cervical cancer. Crit. Rev. Oncol. Hematol. 157, 103178 (2021).","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"10167","key":"73601_CR5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","volume":"393","author":"PA Cohen","year":"2019","unstructured":"Cohen, P. A., Jhingran, A., Oaknin, A. & Denny, L. Cervical cancer. Lancet 393 (10167), 169\u2013182 (2019).","journal-title":"Lancet"},{"issue":"1","key":"73601_CR6","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12943-019-1109-9","volume":"18","author":"L He","year":"2019","unstructured":"He, L. et al. Functions of N6-methyladenosine and its role in cancer. Mol. Cancer 18 (1), 176 (2019).","journal-title":"Mol. Cancer"},{"issue":"1","key":"73601_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12943-020-01204-7","volume":"19","author":"T Wang","year":"2020","unstructured":"Wang, T., Kong, S., Tao, M. & Ju, S. The potential role of RNA N6-methyladenosine in Cancer progression. Mol. Cancer 19 (1), 88 (2020).","journal-title":"Mol. Cancer"},{"issue":"1","key":"73601_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12943-022-01522-y","volume":"21","author":"Y Hu","year":"2022","unstructured":"Hu, Y. et al. Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification. Mol. Cancer 21 (1), 34 (2022).","journal-title":"Mol. Cancer"},{"issue":"6","key":"73601_CR9","first-page":"1631","volume":"10","author":"S Liu","year":"2020","unstructured":"Liu, S. et al. METTL3 plays multiple functions in biological processes. Am. J. cancer Res. 10 (6), 1631\u20131646 (2020).","journal-title":"Am. J. cancer Res."},{"issue":"6","key":"73601_CR10","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1002\/hep.29683","volume":"67","author":"M Chen","year":"2018","unstructured":"Chen, M. et al. RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. Hepatology 67 (6), 2254\u20132270 (2018).","journal-title":"Hepatol. (Baltimore Md)"},{"issue":"1","key":"73601_CR11","first-page":"17","volume":"23","author":"NK Panchal","year":"2023","unstructured":"Panchal, N. K. & Evan Prince, S. The NEK family of serine\/threonine kinases as a biomarker for cancer. Clin. Exp. Med. 23 (1), 17\u201330 (2023).","journal-title":"Clin. Experimental Med."},{"key":"73601_CR12","doi-asserted-by":"publisher","first-page":"215917","DOI":"10.1016\/j.canlet.2022.215917","volume":"549","author":"YR Zhang","year":"2022","unstructured":"Zhang, Y. R. & Zheng, P. S. NEK2 inactivates the Hippo pathway to advance the proliferation of cervical cancer cells by cooperating with STRIPAK complexes. Cancer Lett. 549, 215917 (2022).","journal-title":"Cancer Lett."},{"issue":"4","key":"73601_CR13","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (4), 402\u2013408 (2001).","journal-title":"Methods"},{"issue":"5","key":"73601_CR14","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1002\/ddr.21942","volume":"83","author":"M Wu","year":"2022","unstructured":"Wu, M., Chen, G., Liao, X., Xiao, L. & Zheng, J. YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1. Drug Dev. Res. 83 (5), 1190\u20131200 (2022).","journal-title":"Drug Dev. Res."},{"issue":"5","key":"73601_CR15","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1002\/cncr.34617","volume":"129","author":"SE Podwika","year":"2023","unstructured":"Podwika, S. E. & Duska, L. R. Top advances of the year: cervical cancer. Cancer 129 (5), 657\u2013663 (2023).","journal-title":"Cancer"},{"issue":"3","key":"73601_CR16","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1136\/ijgc-2022-003758","volume":"33","author":"JF Grau","year":"2023","unstructured":"Grau, J. F., Farinas-Madrid, L., Garcia-Duran, C., Garcia-Illescas, D. & Oaknin, A. Advances in immunotherapy in cervical cancer. Int. J. Gynecol. Cancer 33 (3), 403\u2013413 (2023).","journal-title":"Int. J. Gynecol. Cancer"},{"key":"73601_CR17","doi-asserted-by":"publisher","first-page":"102546","DOI":"10.1016\/j.ctrv.2023.102546","volume":"116","author":"A Tolcher","year":"2023","unstructured":"Tolcher, A., Hamilton, E. & Coleman, R. L. The evolving landscape of antibody-drug conjugates in gynecologic cancers. Cancer Treat. Rev. 116, 102546 (2023).","journal-title":"Cancer Treat. Rev."},{"issue":"5","key":"73601_CR18","doi-asserted-by":"publisher","first-page":"100579","DOI":"10.1016\/j.esmoop.2022.100579","volume":"7","author":"C Gennigens","year":"2022","unstructured":"Gennigens, C. et al. Recurrent or primary metastatic cervical cancer: current and future treatments. ESMO Open 7 (5), 100579 (2022).","journal-title":"ESMO open."},{"key":"73601_CR19","doi-asserted-by":"publisher","first-page":"778582","DOI":"10.3389\/fcell.2021.778582","volume":"9","author":"DH Chen","year":"2021","unstructured":"Chen, D. H., Zhang, J. G., Wu, C. X. & Li, Q. Non-coding RNA m6A modification in Cancer: mechanisms and therapeutic targets. Front. Cell. Dev. Biol. 9, 778582 (2021).","journal-title":"Front. Cell. Dev. Biol."},{"issue":"1","key":"73601_CR20","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12943-023-01810-1","volume":"22","author":"Y Wang","year":"2023","unstructured":"Wang, Y. et al. Epigenetic modification of m(6)a regulator proteins in cancer. Mol. Cancer 22 (1), 102 (2023).","journal-title":"Mol. Cancer"},{"issue":"11","key":"73601_CR21","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41419-023-06265-2","volume":"14","author":"Z Mao","year":"2023","unstructured":"Mao, Z., Wang, B., Zhang, T. & Cui, B. The roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications. Cell. Death Dis. 14 (11), 734 (2023).","journal-title":"Cell. Death Dis."},{"issue":"7","key":"73601_CR22","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1111\/febs.16681","volume":"290","author":"H Du","year":"2023","unstructured":"Du, H., Zou, N. Y., Zuo, H. L., Zhang, X. Y. & Zhu, S. C. YTHDF3 mediates HNF1\u03b1 regulation of cervical cancer radio-resistance by promoting RAD51D translation in an m6A-dependent manner. FEBS J. 290 (7), 1920\u20131935 (2023).","journal-title":"FEBS J."},{"issue":"5","key":"73601_CR23","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/1440-1681.13754","volume":"50","author":"L Zhen","year":"2023","unstructured":"Zhen, L. & Pan, W. ALKBH5 inhibits the SIRT3\/ACC1 axis to regulate fatty acid metabolism via an m6A-IGF2BP1-dependent manner in cervical squamous cell carcinoma. Clin. Exp. Pharmacol. Physiol. 50 (5), 380\u2013392 (2023).","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"73601_CR24","doi-asserted-by":"publisher","first-page":"650383","DOI":"10.3389\/fonc.2021.650383","volume":"11","author":"H Wang","year":"2021","unstructured":"Wang, H. et al. YTHDF1 aggravates the progression of cervical cancer through m(6)A-mediated up-regulation of RANBP2. Front. Oncol. 11, 650383 (2021).","journal-title":"Front. Oncol."},{"issue":"10","key":"73601_CR25","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/s41419-020-03071-y","volume":"11","author":"Q Wang","year":"2020","unstructured":"Wang, Q. et al. N(6)-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1\/HK2 modification. Cell. Death Dis. 11 (10), 911 (2020).","journal-title":"Cell. Death Dis."},{"key":"73601_CR26","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.omto.2021.07.004","volume":"22","author":"F Ji","year":"2021","unstructured":"Ji, F. et al. M(6)a methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer. Mol. Therapy Oncolytics 22, 574\u2013581 (2021).","journal-title":"Mol. Therapy Oncolytics"},{"issue":"7","key":"73601_CR27","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1080\/15384101.2016.1152430","volume":"15","author":"Y Fang","year":"2016","unstructured":"Fang, Y. & Zhang, X. Targeting NEK2 as a promising therapeutic approach for cancer treatment. Cell. Cycle 15 (7), 895\u2013907 (2016).","journal-title":"Cell. Cycle"},{"issue":"1","key":"73601_CR28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s13046-020-01659-y","volume":"39","author":"T Xu","year":"2020","unstructured":"Xu, T. et al. Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1\/\u03b2-catenin signaling pathway in cervical cancer. J. Exp. Clin. Cancer Res. 39 (1), 183 (2020).","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"73601_CR29","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.ymthe.2022.01.019","volume":"30","author":"J Li","year":"2022","unstructured":"Li, J. et al. RNA m(6)a methylation regulates dissemination of cancer cells by modulating expression and membrane localization of \u03b2-catenin. Mol. Ther. 30 (4), 1578\u20131596 (2022).","journal-title":"Mol. Ther."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73601-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73601-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73601-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:05:59Z","timestamp":1729616759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73601-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["73601"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-73601-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,18]]},"assertion":[{"value":"21 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24469"}}