{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:16:10Z","timestamp":1781763370114,"version":"3.54.5"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["NMUB20210055"],"award-info":[{"award-number":["NMUB20210055"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changzhou Clinical Medical Center","award":["CMCM202203"],"award-info":[{"award-number":["CMCM202203"]}]},{"name":"Changzhou Municipal Health Commission","award":["2022CZBJ090"],"award-info":[{"award-number":["2022CZBJ090"]}]},{"name":"Changzhou Science and Technology Bureau","award":["CJ20230077"],"award-info":[{"award-number":["CJ20230077"]}]},{"name":"China Reproductive Public Welfare Fund","award":["SZ202412"],"award-info":[{"award-number":["SZ202412"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-73828-4","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T07:02:19Z","timestamp":1728111739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The senolytic drug ABT-263 accelerates ovarian aging in older female mice"],"prefix":"10.1038","volume":"14","author":[{"given":"Xiyang","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuliang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"key":"73828_CR1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ejogrb.2018.09.030","volume":"230","author":"D Garcia","year":"2018","unstructured":"Garcia, D., Brazal, S., Rodriguez, A., Prat, A. & Vassena, R. Knowledge of age-related fertility decline in women: A systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol. 230, 109\u2013118 (2018).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"73828_CR2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/ijgo.12156","volume":"138","author":"YM O\u2019Brien","year":"2017","unstructured":"O\u2019Brien, Y. M., Ryan, M., Martyn, F. & Wingfield, M. B. A retrospective study of the effect of increasing age on success rates of assisted reproductive technology. Int. J. Gynaecol. Obstet. 138, 42\u201346 (2017).","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"73828_CR3","doi-asserted-by":"crossref","unstructured":"Vollenhoven, B. & Hunt, S. Ovarian ageing and the impact on female fertility. F1000Res 7 (2018).","DOI":"10.12688\/f1000research.16509.1"},{"key":"73828_CR4","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s43587-023-00532-9","volume":"4","author":"Q Yang","year":"2024","unstructured":"Yang, Q. et al. NADase CD38 is a key determinant of ovarian aging. Nat. Aging 4, 110\u2013128 (2024).","journal-title":"Nat. Aging"},{"key":"73828_CR5","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1093\/humrep\/deaa188","volume":"35","author":"MW Christensen","year":"2020","unstructured":"Christensen, M. W., Kesmodel, U. S., Christensen, K., Kirkegaard, K. & Ingerslev, H. J. Early ovarian ageing: Is a low number of oocytes harvested in young women associated with an earlier and increased risk of age-related diseases? Hum. Reprod. 35, 2375\u20132390 (2020).","journal-title":"Hum. Reprod."},{"key":"73828_CR6","doi-asserted-by":"publisher","first-page":"e8772","DOI":"10.1371\/journal.pone.0008772","volume":"5","author":"WH Wallace","year":"2010","unstructured":"Wallace, W. H. & Kelsey, T. W. Human ovarian reserve from conception to the menopause. PLoS ONE 5, e8772 (2010).","journal-title":"PLoS ONE"},{"key":"73828_CR7","first-page":"105","volume":"26","author":"ARE Moghadam","year":"2022","unstructured":"Moghadam, A. R. E., Moghadam, M. T., Hemadi, M. & Saki, G. Oocyte quality and aging. JBRA Assist. Reprod. 26, 105\u2013122 (2022).","journal-title":"JBRA Assist. Reprod."},{"key":"73828_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s10815-013-9944-x","volume":"30","author":"DZ Yang","year":"2013","unstructured":"Yang, D. Z., Yang, W., Li, Y. & He, Z. Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction. J. Assist. Reprod. Genet. 30, 213\u2013219 (2013).","journal-title":"J. Assist. Reprod. Genet."},{"key":"73828_CR9","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12958-022-01033-x","volume":"20","author":"E Esencan","year":"2022","unstructured":"Esencan, E., Beroukhim, G. & Seifer, D. B. Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes\u2014A narrative review. Reprod. Biol. Endocrinol. 20, 156 (2022).","journal-title":"Reprod. Biol. Endocrinol."},{"key":"73828_CR10","doi-asserted-by":"publisher","first-page":"822816","DOI":"10.3389\/fcell.2022.822816","volume":"10","author":"L Hu","year":"2022","unstructured":"Hu, L. et al. Why senescent cells are resistant to apoptosis: An insight for senolytic development. Front. Cell. Dev. Biol. 10, 822816 (2022).","journal-title":"Front. Cell. Dev. Biol."},{"key":"73828_CR11","doi-asserted-by":"publisher","first-page":"e13314","DOI":"10.1111\/acel.13314","volume":"20","author":"I Katzir","year":"2021","unstructured":"Katzir, I. et al. Senescent cells and the incidence of age-related diseases. Aging Cell. 20, e13314 (2021).","journal-title":"Aging Cell."},{"key":"73828_CR12","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1038\/nm.4000","volume":"21","author":"BG Childs","year":"2015","unstructured":"Childs, B. G., Durik, M., Baker, D. J. & van Deursen, J. M. Cellular senescence in aging and age-related disease: From mechanisms to therapy. Nat. Med. 21, 1424\u20131435 (2015).","journal-title":"Nat. Med."},{"key":"73828_CR13","doi-asserted-by":"publisher","first-page":"781404","DOI":"10.3389\/fendo.2022.781404","volume":"13","author":"X Dai","year":"2022","unstructured":"Dai, X. et al. PQQ dietary supplementation prevents alkylating agent-induced ovarian dysfunction in mice. Front. Endocrinol. 13, 781404 (2022).","journal-title":"Front. Endocrinol."},{"key":"73828_CR14","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1262\/jrd.2023-021","volume":"69","author":"N Maruyama","year":"2023","unstructured":"Maruyama, N. et al. Accumulation of senescent cells in the stroma of aged mouse ovary. J. Reprod. Dev. 69, 328\u2013336 (2023).","journal-title":"J. Reprod. Dev."},{"key":"73828_CR15","doi-asserted-by":"crossref","unstructured":"Xu, Z. et al. The role of cellular senescence in cyclophosphamide-induced primary ovarian insufficiency. Int. J. Mol. Sci. 24 (2023).","DOI":"10.3390\/ijms242417193"},{"key":"73828_CR16","doi-asserted-by":"crossref","unstructured":"Du, D. et al. Senotherapy protects against cisplatin-induced ovarian injury by removing senescent cells and alleviating DNA damage. Oxid. Med. Cell Longev. 9144644 (2022).","DOI":"10.1155\/2022\/9144644"},{"key":"73828_CR17","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1007\/s11357-022-00573-9","volume":"44","author":"JD Hense","year":"2022","unstructured":"Hense, J. D. et al. Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary. Geroscience 44, 1747\u20131759 (2022).","journal-title":"Geroscience"},{"key":"73828_CR18","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","volume":"68","author":"C Tse","year":"2008","unstructured":"Tse, C. et al. ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68, 3421\u20133428 (2008).","journal-title":"Cancer Res."},{"key":"73828_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nm.4010","volume":"22","author":"J Chang","year":"2016","unstructured":"Chang, J. et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat. Med. 22, 78\u201383 (2016).","journal-title":"Nat. Med."},{"key":"73828_CR20","doi-asserted-by":"crossref","unstructured":"Mylonas, K. J. et al. Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair. Sci. Transl. Med. 13 (2021).","DOI":"10.1126\/scitranslmed.abb0203"},{"key":"73828_CR21","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1002\/1878-0261.12761","volume":"14","author":"T Saleh","year":"2020","unstructured":"Saleh, T. et al. Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X(L)-BAX interaction. Mol. Oncol. 14, 2504\u20132519 (2020).","journal-title":"Mol. Oncol."},{"key":"73828_CR22","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1111\/jdv.18051","volume":"36","author":"H Kim","year":"2022","unstructured":"Kim, H. et al. Attenuation of intrinsic ageing of the skin via elimination of senescent dermal fibroblasts with senolytic drugs. J. Eur. Acad. Dermatol. Venereol. 36, 1125\u20131135 (2022).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"73828_CR23","doi-asserted-by":"publisher","first-page":"12750","DOI":"10.18632\/aging.103177","volume":"12","author":"H Yang","year":"2020","unstructured":"Yang, H. et al. Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis. Aging 12, 12750\u201312770 (2020).","journal-title":"Aging"},{"key":"73828_CR24","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ijrobp.2017.02.216","volume":"99","author":"J Pan","year":"2017","unstructured":"Pan, J. et al. Inhibition of Bcl-2\/xl with ABT-263 selectively kills senescent type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice. Int. J. Radiat. Oncol. Biol. Phys. 99, 353\u2013361 (2017).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"73828_CR25","doi-asserted-by":"publisher","first-page":"13606","DOI":"10.1038\/s41598-024-64441-6","volume":"14","author":"H Yan","year":"2024","unstructured":"Yan, H. et al. Primary oocytes with cellular senescence features are involved in ovarian aging in mice. Sci. Rep. 14, 13606 (2024).","journal-title":"Sci. Rep."},{"key":"73828_CR26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fendo.2014.00032","volume":"5","author":"ML Zenclussen","year":"2014","unstructured":"Zenclussen, M. L., Casalis, P. A., Jensen, F., Woidacki, K. & Zenclussen, A. C. Hormonal fluctuations during the estrous cycle modulate heme Oxygenase-1 expression in the uterus. Front. Endocrinol.  5, 32 (2014).","journal-title":"Front. Endocrinol."},{"key":"73828_CR27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12884-023-05476-x","volume":"23","author":"F Liu","year":"2023","unstructured":"Liu, F. et al. Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents. BMC Pregnancy Childbirth 23, 151 (2023).","journal-title":"BMC Pregnancy Childbirth"},{"key":"73828_CR28","doi-asserted-by":"publisher","first-page":"e2846","DOI":"10.1038\/cddis.2017.231","volume":"8","author":"TG Meng","year":"2017","unstructured":"Meng, T. G. et al. Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice. Cell. Death Dis. 8, e2846 (2017).","journal-title":"Cell. Death Dis."},{"key":"73828_CR29","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1177\/0192623315613452","volume":"44","author":"AP Hall","year":"2016","unstructured":"Hall, A. P. et al. PDGFR inhibition results in pericyte depletion and hemorrhage into the corpus luteum of the rat ovary. Toxicol. Pathol. 44, 98\u2013111 (2016).","journal-title":"Toxicol. Pathol."},{"key":"73828_CR30","doi-asserted-by":"publisher","first-page":"V5","DOI":"10.1530\/REP-20-0489","volume":"161","author":"KG Foley","year":"2021","unstructured":"Foley, K. G., Pritchard, M. T. & Duncan, F. E. Macrophage-derived multinucleated giant cells: Hallmarks of the aging ovary. Reproduction 161, V5\u2013V9 (2021).","journal-title":"Reproduction"},{"key":"73828_CR31","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1530\/REP-16-0129","volume":"152","author":"SM Briley","year":"2016","unstructured":"Briley, S. M. et al. Reproductive age-associated fibrosis in the stroma of the mammalian ovary. Reproduction 152, 245\u2013260 (2016).","journal-title":"Reproduction"},{"key":"73828_CR32","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/leu.2010.6","volume":"24","author":"LJ Mah","year":"2010","unstructured":"Mah, L. J., El-Osta, A. & Karagiannis, T. C. gammaH2AX: A sensitive molecular marker of DNA damage and repair. Leukemia 24, 679\u2013686 (2010).","journal-title":"Leukemia"},{"key":"73828_CR33","doi-asserted-by":"publisher","first-page":"9390","DOI":"10.1074\/jbc.275.13.9390","volume":"275","author":"EP Rogakou","year":"2000","unstructured":"Rogakou, E. P., Nieves-Neira, W., Boon, C., Pommier, Y. & Bonner, W. M. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J. Biol. Chem. 275, 9390\u20139395 (2000).","journal-title":"J. Biol. Chem."},{"key":"73828_CR34","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1080\/15548627.2022.2094671","volume":"19","author":"W Liu","year":"2023","unstructured":"Liu, W. et al. Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells. Autophagy 19, 644\u2013659 (2023).","journal-title":"Autophagy"},{"key":"73828_CR35","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/s41467-020-14936-3","volume":"11","author":"M Wagner","year":"2020","unstructured":"Wagner, M. et al. Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells. Nat. Commun. 11, 1147 (2020).","journal-title":"Nat. Commun."},{"key":"73828_CR36","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1210\/edrv.18.3.0301","volume":"18","author":"KL Parker","year":"1997","unstructured":"Parker, K. L. & Schimmer, B. P. Steroidogenic factor 1: A key determinant of endocrine development and function. Endocr. Rev. 18, 361\u2013377 (1997).","journal-title":"Endocr. Rev."},{"key":"73828_CR37","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1146\/annurev-pharmtox-050120-105018","volume":"61","author":"PD Robbins","year":"2021","unstructured":"Robbins, P. D. et al. Senolytic drugs: Reducing senescent cell viability to extend health span. Annu. Rev. Pharmacol. Toxicol. 61, 779\u2013803 (2021).","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"73828_CR38","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1530\/JOE-15-0246","volume":"226","author":"YG Wu","year":"2015","unstructured":"Wu, Y. G. et al. Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval. J. Endocrinol. 226, 167\u2013180 (2015).","journal-title":"J. Endocrinol."},{"key":"73828_CR39","doi-asserted-by":"crossref","unstructured":"Kloc, M. et al. Giant multinucleated cells in aging and senescence\u2014An abridgement. Biology 11 (2022).","DOI":"10.3390\/biology11081121"},{"key":"73828_CR40","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1756-9966-28-44","volume":"28","author":"T Ariizumi","year":"2009","unstructured":"Ariizumi, T. et al. Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferation. J. Exp. Clin. Cancer Res. 28, 44 (2009).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"73828_CR41","doi-asserted-by":"publisher","first-page":"643146","DOI":"10.3389\/pore.2021.643146","volume":"27","author":"ME Maros","year":"2021","unstructured":"Maros, M. E. et al. Cell cycle regulatory protein expression in multinucleated giant cells of giant cell tumor of bone: Do they proliferate?? Pathol. Oncol. Res. 27, 643146 (2021).","journal-title":"Pathol. Oncol. Res."},{"key":"73828_CR42","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1016\/j.celrep.2015.10.065","volume":"13","author":"R Milde","year":"2015","unstructured":"Milde, R. et al. Multinucleated giant cells are specialized for complement-mediated phagocytosis and large target destruction. Cell. Rep. 13, 1937\u20131948 (2015).","journal-title":"Cell. Rep."},{"key":"73828_CR43","doi-asserted-by":"publisher","first-page":"eabq1475","DOI":"10.1126\/sciadv.abq1475","volume":"8","author":"DA Landry","year":"2022","unstructured":"Landry, D. A. et al. Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. Sci. Adv. 8, eabq1475 (2022).","journal-title":"Sci. Adv."},{"key":"73828_CR44","doi-asserted-by":"crossref","unstructured":"Lagares, D. et al. Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. Sci. Transl Med. 9 (2017).","DOI":"10.1126\/scitranslmed.aal3765"},{"key":"73828_CR45","doi-asserted-by":"publisher","first-page":"eabn4564","DOI":"10.1126\/sciadv.abn4564","volume":"8","author":"T Umehara","year":"2022","unstructured":"Umehara, T. et al. Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary. Sci. Adv. 8, eabn4564 (2022).","journal-title":"Sci. Adv."},{"key":"73828_CR46","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1530\/REP-19-0501","volume":"160","author":"HM Kinnear","year":"2020","unstructured":"Kinnear, H. M. et al. The ovarian stroma as a new frontier. Reproduction 160, R25\u2013R39 (2020).","journal-title":"Reproduction"},{"key":"73828_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.omtn.2022.11.020","volume":"31","author":"Y Wei","year":"2023","unstructured":"Wei, Y. et al. Single-cell profiling of mouse and primate ovaries identifies high levels of EGFR for stromal cells in ovarian aging. Mol. Ther. Nucleic Acids 31, 1\u201312 (2023).","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"73828_CR48","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jsbmb.2013.06.005","volume":"138","author":"M Qiu","year":"2013","unstructured":"Qiu, M. et al. Effects of granulosa cells on steroidogenesis, proliferation and apoptosis of stromal cells and theca cells derived from the goat ovary. J. Steroid Biochem. Mol. Biol. 138, 325\u2013333 (2013).","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"73828_CR49","doi-asserted-by":"publisher","first-page":"4150","DOI":"10.1016\/j.cell.2024.05.059","volume":"187","author":"M Ogrodnik","year":"2024","unstructured":"Ogrodnik, M. et al. Guidelines for minimal information on cellular senescence experimentation in vivo. Cell 187, 4150\u20134175 (2024).","journal-title":"Cell"},{"key":"73828_CR50","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.cell.2020.01.009","volume":"180","author":"S Wang","year":"2020","unstructured":"Wang, S. et al. Single-cell transcriptomic Atlas of primate ovarian aging. Cell 180, 585\u2013600e519 (2020).","journal-title":"Cell"},{"key":"73828_CR51","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0039-128X(96)00159-6","volume":"62","author":"KM Caron","year":"1997","unstructured":"Caron, K. M., Clark, B. J., Ikeda, Y. & Parker, K. L. Steroidogenic factor 1 acts at all levels of the reproductive axis. Steroids 62, 53\u201356 (1997).","journal-title":"Steroids"},{"key":"73828_CR52","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13048-015-0202-y","volume":"8","author":"Y Hattori","year":"2015","unstructured":"Hattori, Y. et al. Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: Aromatase and SF-1 expressions. J. Ovarian Res. 8, 73 (2015).","journal-title":"J. Ovarian Res."},{"key":"73828_CR53","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1111\/cas.14569","volume":"111","author":"K Ohgino","year":"2020","unstructured":"Ohgino, K. et al. Intracellular levels of reactive oxygen species correlate with ABT-263 sensitivity in non-small-cell lung cancer cells. Cancer Sci. 111, 3793\u20133801 (2020).","journal-title":"Cancer Sci."},{"key":"73828_CR54","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.canlet.2020.10.018","volume":"497","author":"Y Oh","year":"2021","unstructured":"Oh, Y. et al. Targeting antioxidant enzymes enhances the therapeutic efficacy of the BCL-X(L) inhibitor ABT-263 in KRAS-mutant colorectal cancers. Cancer Lett. 497, 123\u2013136 (2021).","journal-title":"Cancer Lett."},{"key":"73828_CR55","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3389\/fendo.2019.00811","volume":"10","author":"H Sasaki","year":"2019","unstructured":"Sasaki, H. et al. Impact of oxidative stress on age-associated decline in oocyte developmental competence. Front. Endocrinol.  10, 811 (2019).","journal-title":"Front. Endocrinol."},{"key":"73828_CR56","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12958-018-0391-5","volume":"16","author":"J Lu","year":"2018","unstructured":"Lu, J., Wang, Z., Cao, J., Chen, Y. & Dong, Y. A novel and compact review on the role of oxidative stress in female reproduction. Reprod. Biol. Endocrinol. 16, 80 (2018).","journal-title":"Reprod. Biol. Endocrinol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73828-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73828-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73828-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T11:05:43Z","timestamp":1728385543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73828-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,5]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["73828"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-73828-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,5]]},"assertion":[{"value":"21 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23178"}}