{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:03:49Z","timestamp":1772136229112,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-73852-4","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T13:01:59Z","timestamp":1730725319000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Health related quality of life and associated factors among children living in previous leprosarium and nonleprosarium areas of Eastern Ethiopia"],"prefix":"10.1038","volume":"14","author":[{"given":"Assefa","family":"Desalew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siraj Aliyi","family":"Adem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fitsum","family":"Weldegebreal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Getachew Kabew","family":"Mekonnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temam Beshir","family":"Raru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ukash","family":"Umer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulualem","family":"Keneni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kedir","family":"Urgesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"73852_CR1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1590\/S0034-8910.2014048004912","volume":"48","author":"PAB Silva","year":"2014","unstructured":"Silva, P. A. B., Soares, S. M., Santos, J. F. G. & Silva, L. B. Ponto De corte para o WHOQOL-bref como preditor de qualidade de vida de idosos. Rev. Sa\u00fade P\u00fablica. 48, 390\u2013397 (2014).","journal-title":"Rev. Sa\u00fade P\u00fablica"},{"issue":"1","key":"73852_CR2","doi-asserted-by":"publisher","first-page":"e000577","DOI":"10.1136\/bmjdrc-2018-000577","volume":"7","author":"T Gebremedhin","year":"2019","unstructured":"Gebremedhin, T., Workicho, A. & Angaw, D. A. Health-related quality of life and its associated factors among adult patients with type II diabetes attending Mizan Tepi University Teaching Hospital, Southwest Ethiopia. BMJ Open. Diabetes Res. Care. 7 (1), e000577 (2019).","journal-title":"BMJ Open. Diabetes Res. Care"},{"key":"73852_CR3","unstructured":"WHO. Global leprosy (Hansen disease) update, 2019: Time to step up prevention initiatives. (2020)."},{"issue":"5","key":"73852_CR4","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1590\/S0037-86822011000500019","volume":"44","author":"AA Lustosa","year":"2011","unstructured":"Lustosa, A. A., Nogueira, L. T., Pedrosa, J. I., Teles, J. B. & Campelo, V. The impact of leprosy on health-related quality of life. Rev. Soc. Bras. Med. Trop. 44 (5), 621\u2013626 (2011).","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"73852_CR5","doi-asserted-by":"crossref","unstructured":"Xu, L. et al. (eds) Self-Care Ability and Life Quality of Cured Leprosy Patients: The Mediating Effects of Social Support (MDPI, 2023).","DOI":"10.3390\/healthcare11233059"},{"issue":"8","key":"73852_CR6","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.3201\/eid2908.220367","volume":"29","author":"A Bhukhan","year":"2023","unstructured":"Bhukhan, A., Dunn, C. & Nathoo, R. Case report of leprosy in Central Florida, USA, 2022. Emerg. Infect. Dis. 29 (8), 1698 (2023).","journal-title":"Emerg. Infect. Dis."},{"issue":"5","key":"73852_CR7","doi-asserted-by":"publisher","first-page":"e0009436","DOI":"10.1371\/journal.pntd.0009436","volume":"15","author":"T Hambridge","year":"2021","unstructured":"Hambridge, T., Nanjan Chandran, S. L., Geluk, A., Saunderson, P. & Richardus, J. H. Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review. PLoS Negl. Trop. Dis. 15 (5), e0009436 (2021).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"12","key":"73852_CR8","doi-asserted-by":"publisher","first-page":"e0190363","DOI":"10.1371\/journal.pone.0190363","volume":"12","author":"C Otto","year":"2017","unstructured":"Otto, C. et al. Risk and protective factors of health-related quality of life in children and adolescents: Results of the longitudinal BELLA study. PloS One. 12 (12), e0190363 (2017).","journal-title":"PloS One"},{"key":"73852_CR9","unstructured":"WHO. Global leprosy (Hansen disease) update, 2021: Moving towards interruption of transmission. Weekly epidemiological record; 09\/20222022. 429\u2009\u2013\u200952."},{"key":"73852_CR10","unstructured":"Letta, T. Challenges in Implementation of the Current Strategies (editor. National TBL Program, 2020). MOH."},{"issue":"4","key":"73852_CR11","doi-asserted-by":"publisher","first-page":"313","DOI":"10.4314\/ejhs.v25i4.4","volume":"25","author":"T Shumet","year":"2015","unstructured":"Shumet, T., Demissie, M. & Bekele, Y. Prevalence of disability and associated factors among registered leprosy patients in all Africa tb and leprosy rehabilitation and training center (ALERT), Addis Ababa, Ethiopia. Ethiop. J. Health Sci. 25 (4), 313\u2013320 (2015).","journal-title":"Ethiop. J. Health Sci."},{"key":"73852_CR12","doi-asserted-by":"crossref","unstructured":"Ephrem Mamoa, K. B. et al. Anne Schoenmakerse,f, Robin Van Wijke,f, Christa Kasang, Liesbeth Mieras & Jan Hendrik Richardus. Epidemiological Trends of Leprosy and case Detection Delay in East Hararghe Zone (A baseline survey, 2022).","DOI":"10.47276\/lr.93.3.184"},{"issue":"9","key":"73852_CR13","doi-asserted-by":"publisher","first-page":"e0009640","DOI":"10.1371\/journal.pntd.0009640","volume":"15","author":"K Urgesa","year":"2021","unstructured":"Urgesa, K. et al. Evidence for hidden leprosy in a high leprosy-endemic setting, Eastern Ethiopia: The application of active case-finding and contact screening. PLoS Negl. Trop. Dis. 15 (9), e0009640 (2021).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"2","key":"73852_CR14","first-page":"65","volume":"85","author":"N Yamaguchi","year":"2016","unstructured":"Yamaguchi, N., Poudel, K. & Jimba, M. Health-related quality of life, depression, and self-esteem in adolescents with leprosy-affected parents: Results of a cross-sectional study in Nepal. Nihon Hansenbyo Gakkai Zasshi Jpn. J. Lepr. Off. Organ. Jpn. Lepr. Assoc. 85(2), 65\u201368 (2016).","journal-title":"Nihon Hansenbyo Gakkai Zasshi Jpn. J. Lepr. Off. Organ. Jpn. Lepr. Assoc."},{"key":"73852_CR15","unstructured":"FMOH E. National leprosy strategy.\u00a0Final leprosy elimination strategy for Ethiopia From. -20202017. 24 p. (2016)."},{"key":"73852_CR16","unstructured":"Remme, J. H. et al. Tropical diseases targeted for elimination: Chagas Disease, Lymphatic Filariasis, Onchocerciasis, and Leprosy. Int. J. Biomedical Health Sci. 9(4). (2021)."},{"key":"73852_CR17","doi-asserted-by":"crossref","unstructured":"Thacker, S. B., Sencer, D. J. & Jaffe, H. W. Centers Disease Control Int. Encyclopedia Public. Health\u00a0448 (2017).","DOI":"10.1016\/B978-0-12-803678-5.00057-6"},{"issue":"9","key":"73852_CR18","doi-asserted-by":"publisher","first-page":"e0010673","DOI":"10.1371\/journal.pntd.0010673","volume":"16","author":"A Abebaw","year":"2022","unstructured":"Abebaw, A., Atnafu, A., Worku, N. & Hagos, A. Health-related quality of life and associated factors among adult podoconiosis patients in Debre Elias district Northwest, Ethiopia. PLoS Negl. Trop. Dis. 16 (9), e0010673 (2022).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"73852_CR19","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3390\/ijerph17010104","volume":"17","author":"C Chen","year":"2020","unstructured":"Chen, C. et al. Understanding adolescents\u2019 need support, need satisfaction, and health-related outcomes: A self-determination health behavior perspective. Int. J. Environ. Res. Public Health. 17 (1), 104 (2020).","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"73852_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s12955-020-01446-5","volume":"18","author":"M Gil-Lacruz","year":"2020","unstructured":"Gil-Lacruz, M., Gil-Lacruz, A. I. & Gracia-P\u00e9rez, M. L. Health-related quality of life in young people: the importance of education. Health Qual. Life Outcomes. 18 (1), 187 (2020).","journal-title":"Health Qual. Life Outcomes"},{"key":"73852_CR21","unstructured":"Kebede, M. T. in\u00a0Leprosy, Leprosaria and Society in Ethiopia: A Historicalstudy of Selected Sites 1901\u20132001. 276 (Addis Ababa, 2005)."},{"key":"73852_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12887-018-1120-0","volume":"18","author":"T Petek","year":"2018","unstructured":"Petek, T., Herti\u0161, T. & Mar\u010dun Varda, N. Health-related quality of life in pediatric arterial hypertension: A cross-sectional study. BMC Pediatr. 18, 1\u20139 (2018).","journal-title":"BMC Pediatr."},{"key":"73852_CR23","doi-asserted-by":"publisher","first-page":"2333794X110308","DOI":"10.1177\/2333794X211030879","volume":"8","author":"D Girma","year":"2021","unstructured":"Girma, D. et al. Health-related quality of life and its associated factors in children and adolescents with Type1 diabetes, Addis Ababa, Ethiopia. Global Pediatr. Health. 8, 2333794X110308 (2021).","journal-title":"Global Pediatr. Health"},{"issue":"4","key":"73852_CR24","first-page":"521","volume":"145","author":"M Raj","year":"2017","unstructured":"Raj, M. et al. Health-related quality of life in Indian children: A community-based cross-sectional survey. Indian J. Med. Res. 145 (4), 521\u2013529 (2017).","journal-title":"Indian J. Med. Res."},{"key":"73852_CR25","doi-asserted-by":"crossref","unstructured":"Yamaguchi, N. & KCPaMJ. Health-related quality of life, depression, and self-esteem in adolescents with leprosy-affected parents: Results of a cross-sectional study in Nepal. BMC Public. Health (2013).","DOI":"10.1186\/1471-2458-13-22"},{"issue":"1","key":"73852_CR26","doi-asserted-by":"publisher","first-page":"P38","DOI":"10.1186\/1546-0096-12-S1-P38","volume":"12","author":"L Neder","year":"2014","unstructured":"Neder, L. et al. Decrease health-related quality of life in pediatric leprosy patients with musculoskeletal manifestations. Pediatr. Rheumatol. 12 (1), P38 (2014).","journal-title":"Pediatr. Rheumatol."},{"issue":"2","key":"73852_CR27","doi-asserted-by":"publisher","first-page":"e0009131","DOI":"10.1371\/journal.pntd.0009131","volume":"15","author":"EA Ochola","year":"2021","unstructured":"Ochola, E. A., Karanja, D. M. & Elliott, S. J. The impact of neglected tropical diseases (NTDs) on health and well-being in sub-saharan Africa (SSA): A case study of Kenya. PLoS Negl. Trop. Dis. 15 (2), e0009131 (2021).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"12","key":"73852_CR28","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/trstmh\/trz001","volume":"113","author":"H Kuper","year":"2019","unstructured":"Kuper, H. Neglected tropical diseases and disability\u2014What is the link? Trans. R. Soc. Trop. Med. Hyg. 113 (12), 839\u2013844 (2019).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73852-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73852-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73852-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T13:07:11Z","timestamp":1730725631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-73852-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["73852"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-73852-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4586808\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]},"assertion":[{"value":"15 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was conducted in accordance with the guidelines and regulations of the Declaration of Helsinki. The study protocol was approved by Haramaya University, College of Health and Medical Sciences Institution Health Research Ethical Review Committee. (Ref. No. IHRERC\/025\/2024. An official cooperation letter was sent to Amir Nur and Babile districts Health Bureau and other concerned bodies. A written letter of permission was granted by the Districts\u2019 concerned bodies to conduct the study in Ganda Fero and Bisidimo kebeles. To participate in the study, every parent or guardian of a child under eighteen years was informed of its objectives and significance before their child\u2019s participation. Children aged 12 to 18 were asked to give their verbal consent. Parents who agreed to participate in the study were informed and allowed to give their informed, written, and signed consent before data collection began. Confidentiality was maintained at all levels of the study by excluding names and identifiers in the questionnaire, and the data were used only for this purpose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"26716"}}